Clinical trials: Paracetamol, completed
Dental Pain
Study of Long-Acting Acetaminophen in Postoperative Dental Pain
The purpose of the study is to evaluate the efficacy and safety of acetaminophen ER 1500 mg (two 750 mg tablets) over 10 to 12 hours in the dental pain model following third molar extraction(s) and to evaluate the…
- Trial name
- NCT01960114
- Testing
- Acetaminophen ER
- Where
- United States
- Volunteers
- 403 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Sore Throat
Comparison of the Efficacy of Intravenous Dexketoprofen and Paracetamol in the Treatment of Sore Throat
Currently, paracetamol and nonsteroidal antiinflammatory drugs are widely used by emergency physicians in Turkey for the treatment of sore throat.
- Trial name
- NCT03768882
- Testing
- paracetamol, Dexketoprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Pamukkale University
Hormones, Anesthesia, Conduction
The Impact of Regional Anaesthesia on Hormone Levels in Thoracic Surgery.
Basic aspects of thoracic anaesthesia are general anesthesia often combined with regional anesthesia, intubation with double lumen tube and separation of lung ventilation.
- Conditions
- Hormones, Anesthesia, Conduction, Thoracic Surgical Procedure
- Trial name
- NCT04414488
- Testing
- Thoracic paravertebral block (ThPVB)
- Where
- Poland
- Volunteers
- 119 people
- Sponsor
- Medical University of Silesia
Fever
A New Formulation of Intravenous Paracetamol for Fever Management
The efficacy of intravenous paracetamol has never been compared with other drugs for the management of fever due to infections. Available data come from clinical studies conducted in healthy volunteers subject to experimental…
- Trial name
- NCT02283203
- Testing
- APOTEL max
- Where
- 6 sites in Greece
- Volunteers
- 80 people
- Sponsor
- Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.
Readiness to Discharge
Analgesia After Total Knee Arthroplasty: Peri-Articular Injection Versus Epidural + Femoral Nerve Blockade
There are 2 common ways to manage pain after total knee arthroplasty at our institution. Some patients receive an epidural analgesia, a femoral nerve block and pills for pain.
- Trial name
- PAI vs FNB (NCT01335542)
- Testing
- Peri-Articular Injection, Epidural Pathway (PCEA+FNB)
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Hospital for Special Surgery, New York
Malaria
Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria
Acute kidney injury is a common complication of severe Plasmodium knowlesi malaria, and an important contributor to mortality. The exact pathogenic mechanisms of AKI in knowlesi malaria are not known, however it is hypothesised…
- Trial name
- PACKNOW (NCT03056391)
- Testing
- Paracetamol
- Where
- 4 sites in Malaysia
- Volunteers
- 360 people
- Sponsor
- Menzies School of Health Research
Acute Traumatic Pain
Trauma Acute Pain Treatment With Methoxyflurane Vaporized (PENTHROX®): Efficacy and Safety Study (MEDITA)
The prompt treatment of pain due to minor trauma is often an unmet need in both Emergency Room Department and Ambulance Rescue. Most of the available drugs are intravenously administered and such route of administration may…
- Trial name
- MEDITA (NCT03585374)
- Testing
- Methoxyflurane and Penthrox inhaler, Morphine, Paracetamol
- Where
- 16 sites in Italy
- Volunteers
- 272 people
- Sponsor
- Mundipharma Pharmaceuticals srl
CNS Disease
Blood-Brain Barrier Penetration of Therapeutic Agents in Human
This is a phase 1, open-label, non-randomized, exploratory, repeated dose PK study performed at a single centre. Up to 6 evaluable subjects are planned. The subjects will receive p.o. doses of ODM-104 for 5-7 days.
- Trial name
- BRIAN (NCT04571996)
- Testing
- ODM-104, Paracetamol
- Where
- Finland
- Volunteers
- 4 people
- Sponsor
- Orion Corporation, Orion Pharma
Osteoarthritis, Knee
The Effect on Knee Joint Loads of Analgesic Use Compared With Exercise in Patients With Knee Osteoarthritis - An RCT
The purpose of this study is to compare the effects of neuromuscular exercise and analgesic use on knee joint load, in patients with mild to moderate knee osteoarthritis (OA).
- Trial name
- EXERPHARMA (NCT01638962)
- Testing
- Instruction on analgesic use for pain relief (acetaminophen and NSAIDs), Neuromuscular exercise
- Where
- Denmark
- Volunteers
- 93 people
- Sponsor
- University of Southern Denmark
Ventral Hernia, Postoperative Pain
Evaluation of Ultrasound-guided Erector Spinae Block for Postoperative Analgesia in Laprascopic Ventral Hernia Repair.
Ventral hernia repair is associated with significant postoperative pain, and regional anesthetic techniques are of potential benefit.
- Conditions
- Ventral Hernia, Postoperative Pain, Regional Anesthesia
- Trial name
- NCT04438369
- Testing
- Erector Spinae Plane Block
- Where
- Norway
- Volunteers
- 70 people
- Sponsor
- Ostfold Hospital Trust
Osteoarthritis
Impact of a Free Distribution of Paracetamol to Osteoarthritic Patients on Non-steroidal Anti-inflammatory Drugs (NSAID) and Proton Pump Inhibitors (PPI) Prescription
Paracetamol is recommended as first line treatment for pain control in osteoarthritis, but it is not included in list of drugs than can be prescribed in charge of National Health System by General Practitioners.
- Trial name
- NCT02691754
- Testing
- free paracetamol
- Volunteers
- 16 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Shivering
Prophylactic Paracetamol or Dexamethasone for Post-spinal Anesthesia Shivering
This study was conducted to evaluate the effects of a prophylactic dose of oral paracetamol on shivering compared with prophylactic intravenous infusion (IVI) dexamethasone in patients undergoing non-obstetric surgeries under…
- Trial name
- NCT03679065
- Testing
- Paracetamol, Dexamethasone
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ain Shams University
Knee Osteoarthritis
To Assess the Lanconone® (E-OA-07) Efficacy in Physical Activity-related Pain- LEAP Study
The current study is designed to assess the pain relieving effect of 4-weeks ingestion of this commercialized dietary supplement (Lanconone®, Enovate Biolife, LLC, 1000 mg twice per day) in mild to moderate OA subjects.
- Trial name
- LEAP (NCT03262805)
- Testing
- Lanconone
- Where
- 3 sites in India
- Volunteers
- 73 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Healthy
Bioequivalence of a Fixed Dose Combination Tablet Containing 200 mg Ibuprofen and 30 mg Pseudoephedrine-HCl Compared to RhinAdvil(R)(200 mg Ibuprofen and 30 mg Pseudoephedrine-HCl) as a Fixed Dose Combination Tablet Administered in Healthy Volunteers.
The objective of the current study is to demonstrate bioequivalence of a fixed dose combination tablet containing ibuprofen 200 mg and pseudoephedrine-HCl 30 mg (Test) and RhinAdvil® (Reference) a fixed dose combination tablet…
- Trial name
- NCT01170637
- Testing
- Ibuprofen, Pseudoephedrine-HCl
- Where
- Germany
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Total Knee Anthroplasty, Genicular Nerves Block
Efficacy of Genicular Block on Total Knee Arthroplasty Surgery
This prospective, randomized, double-blind, placebo-controlled trial evaluated the analgesic efficacy of preoperative ultrasound-guided genicular nerve block (GNB) in patients undergoing total knee arthroplasty.
- Trial name
- NCT06942702
- Testing
- Genicular blocks (bupivakain), Paracetamol (acetaminophen)+diclofenac, Patient Control Analgesia (PCA) Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Mersin University
Osteoarthritis
Feasibility of n-of-1 Trials - a Pilot Study
The aim of this study was to provide essential pilot data on the feasibility of conducting n-of-1 trials within secondary care within the UK, notably to: test the process of recruitment and design aspects of such trials; assess…
- Trial name
- NCT00371696
- Testing
- diclofenac, paracetamol, heat retaining knee support
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Bristol
Low Back Pain, Cesarean Section Complications
Osteopathic Manipulations of Post Cesarean Section Adhesions on Low Back Pain
Chronic low back pain post cesarean section adhesions represents a restricting dysfunction, mainly influences abdominal fascia that leads to major welfare and economic restrictions.
- Trial name
- NCT06907394
- Testing
- Osteopathic Manipulations, Control Group
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Postoperative Pain, Total Hip Arthroplasty
Comparing Pericapsular Nerve Group Block with Lumbar Erector Spinae Plain Block in Total Hip Arthroplasty Surgery
Total hip arthroplasty is a common surgical procedure aiming to improve mobility and quality of life in patients suffering from hip pain.
- Trial name
- NCT06059339
- Testing
- Procedure/Surgery: Regional Block Comparison Comparing postoperative pain and opioid consumption in groups
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Marmara University
Pain, Postoperative, Analgesia
Pre-operative Analgesics for Postoperative Pain Relief After Dental Treatment
The aim of the study is to compare the efficacy of the pre-operative administration of Paracetamol and placebo in reducing postoperative pain after routine dental treatment in children.
- Trial name
- NCT02393339
- Testing
- paracetamol
- Where
- Israel
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Opioid Consumption, Visual Analog Score
Perioperative Effects of Lateral Quadratus Lumborum Block in Percutaneous Transhepatic Cholangiography
The frequency of non-operating room anesthesia (ADA) applications is increasing and has gained an important place in anesthesia practice.
- Conditions
- Opioid Consumption, Visual Analog Score, Demographic Data, Rescue Analgesic Status and Time
- Trial name
- NCT06618781
- Testing
- Sedation, Sedation + Quadratus Lumborum Block
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Ankara Etlik City Hospital
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