Clinical trials: Paracetamol, completed
Idiopathic Intracranial Hypertension
Idiopathic Intracranial Hypertension Treatment Trial
Idiopathic intracranial hypertension (IIH), also called pseudotumor cerebri, is a disorder of elevated intracranial pressure of unknown cause [Corbett, et al., 1982; Wall, et al., 1991].
- Trial name
- IIHTT (NCT01003639)
- Testing
- Acetazolamide, Formal weight loss counselling program
- Where
- 41 sites in United States, Canada
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Acute Pain
IV Acetaminophen as an Analgesic Adjunct
To determine the efficacy of intravenous (IV) acetaminophen as an analgesic adjunct to IV hydromorphone in the treatment of acute severe pain in the elderly Emergency Department (ED) patients.
- Trial name
- NCT02621619
- Testing
- IV acetaminophen + 0.5 mg IV hydromorphone, Normal saline + 0.5 mg IV hydromorphone
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Montefiore Medical Center
Cleft Palate
Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair
The purpose of this investigator-initiated study is to determine whether acetaminophen is an effective pain reliever for primary cleft palate repair in children and possesses opioid sparing effects.
- Trial name
- NCT01500109
- Testing
- Oral acetaminophen, Ofirmev®, Opioid only
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Loma Linda University
Chronic Low Back Pain
Phase 2 Chronic Low Back Pain Study
The primary purpose of this study was to evaluate the analgesic effect and safety of hydrocodone/acetaminophen extended release compared to placebo.
- Trial name
- NCT01364922
- Testing
- hydrocodone/acetaminophen extended release
- Where
- 17 sites in United States
- Volunteers
- 168 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Pain
Fixed Dose Combination of COdeine + DIpyrone to Mitigate Moderate to Intense Pain Post-impacted Third Lower Molar Extraction
A clinical, multicenter, randomized, parallel-group, double-blind, double-dummy, comparative study of non-inferiority. ⚠️Study will only be conducted in research centers in Brazil (please do not send e-mail if your center is…
- Trial name
- CODI (NCT04972292)
- Testing
- FDC of codeine 30 mg/dipyrone 500 mg, Tylex
- Where
- 2 sites in Brazil
- Volunteers
- 288 people
- Sponsor
- Eurofarma Laboratorios S.A.
Healthy
A Study to Investigate the Efficacy of Pain Bloc-R in Healthy Participants With Non-pathological Aches and Discomfort
A randomized, double-blind, placebo-controlled, cross-over pilot study to investigate the efficacy of Pain Bloc-R in healthy participants with non-pathological aches and discomfort. The study will have 3 study periods.
- Trial name
- NCT03965819
- Testing
- Pain Bloc-R, Active Comparator - Acetaminophen
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- LifeSeasons Inc.
Lumbar Spinal Stenosis, Lumbar Spinal Instability
Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients
Patients presenting for lumbar spine surgery experience pain related to their spine condition. Following surgery, these patients also experience surgical pain resulting from disruption of skin, muscle tissue, vertebrae…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Spinal Instability, Lumbar Spine Degeneration
- Trial name
- IPaRO (NCT03088306)
- Testing
- Standard analgesia use [Oxygen], Standard analgesia use [Hydromorphone], Standard analgesia use [Volatile Anesthesia]
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Johns Hopkins University
Poisoning
Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects
Paracetamol overdose is the leading cause of acute liver failure in the Western World. N-acetylcysteine (NAC) has been the antidote of choice for over 30 years but its use is associated with adverse effects in 40% of cases.
- Trial name
- NCT01209455
- Testing
- Chlorphenamine and Ranitidine, Paracetamol
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Soft Tissue Injuries
Cost-effectiveness of Two Painkillers for Treating Pain After Limb Injuries
Background: Paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are commonly used oral analgesics in emergency departments (ED) not only in Hong Kong but throughout the world.
- Trial name
- NCT00528658
- Testing
- Paracetamol, Ibuprofen
- Where
- Hong Kong
- Volunteers
- 782 people
- Sponsor
- Chinese University of Hong Kong
Tuberculosis, Pulmonary
Adjunctive NAC in Adult Patients With Pulmonary Tuberculosis
To determine if adjunctive N-acetylcysteine 1200 mg twice a day (BID) accelerates sputum culture conversion and normalization of cellular glutathione in tuberculosis (TB), and to assess its potential effects on lung and immune…
- Trial name
- NAC-TB (NCT03702738)
- Testing
- N-acetyl cysteine
- Where
- Tanzania
- Volunteers
- 110 people
- Sponsor
- The Aurum Institute NPC
Regional Anesthesia
USG Thoracolumbar Interfascial Plane (TLIP) in Lumbar Spine Surgeries
The study aims to evaluate the effect of US guided bilateral Thoracolumbar Interfascial plane (TLIP) block performed at the level of the lumbar spine surgery (involving 1 up to 3 adjacent lumbar vertebrae) after induction of…
- Trial name
- NCT03193658
- Testing
- Thoracolumbar Interfascial Plane (TLIP) block, I.V drug based multimodal approach
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Eslam Ayman Mohamed Shawki
Acute Pain
Clinical Study Comparing the Efficacy of Transbuccal Paracetamol 125 mg Versus Paracetamol Injection 1g in Slow Infusion IV in Patients With Acute Pain
This is a clinical study that aims to investigate and compare the efficacy of transbuccal paracetamol 125 mg with that of paracetamol 1g administered intravenously in patients with acute pain of moderate intensity accepted to…
- Trial name
- PARAJUG (NCT01586143)
- Testing
- paracetamol
- Where
- France
- Volunteers
- 43 people
- Sponsor
- University Hospital, Clermont-Ferrand
Urolithiasis
Intravenous Paracetamol or Morphine for the Treatment of Acute Flank Pain
STUDY OBJECTIVE: This randomized, controlled trial evaluates the analgesic efficacy and safety of intravenous single-dose paracetamol and morphine for the treatment of acute flank pain.
- Trial name
- NCT01318187
- Testing
- paracetamol, morphine
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Pamukkale University
Pain
A Trial Assessing the Outcome of Celecoxib Administration Versus Placebo Following Anterior Cruciate Ligament (ACL) Reconstruction
The aim of this study is to directly compare the clinical outcomes of both the celecoxib and placebo groups following anterior cruciate ligament (ACL) reconstruction. The study will have short and long term goals.
- Trial name
- NCT01186887
- Testing
- Celecoxib
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Hospital Research Institute
COVID-19 Pandemic
Adjuvant Use Of Colchicine With The Standard Therapy In Moderate And Severe Corona Virus Disease-19 Infection
The study included 2 arms Colchicine group: Colchicine + standard therapy of COVID-19 Control group: Standard therapy of COVID-19
- Trial name
- NCT05151614
- Testing
- Colchicine 0.5 MG
- Where
- Iraq
- Volunteers
- 160 people
- Sponsor
- University of Baghdad
Chronic Periodontitis
To Compare Efficacy of Low Dose Diclofenac (25mg) in Management of Postoperative Pain After Periodontal Flap Surgery
Pain after periodontal surgical procedures is a common manifestation. The perception of pain is highly subjective and varies substantially among individuals.
- Trial name
- NCT03519152
- Testing
- low dose diclofenac
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tatyasaheb Kore Dental College
Common Cold
Effects of a Common Cold Treatment on Cognitive Function
A reduction in alertness and lower levels of performance are commonly associated with the common cold. Paracetamol has been shown to be more effective than placebo in treating symptoms associated with upper respiratory tract…
- Trial name
- NCT01466348
- Testing
- Paracetamol and Caffeine, Paracetamol
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- GlaxoSmithKline
Chronic Pain
Virtual Reality, Debriefing and Chronic Pain
This study will determine if occupational therapy or the combination of occupational therapy and virtual reality is the better treatment for chronic low back pain (CLBP)patients.
- Trial name
- NCT05254509
- Testing
- Occupational Therapy, Occupational Therapy +Virtual Reality
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, B Cell
CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies
Background: B-cell leukemias and lymphomas are cancers that are often difficult to treat. The primary objective of this study is to determine the ability to take a patient's own cells (T lymphocytes) and grow them in the…
- Conditions
- Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, B Cell, B-Cell Lymphoma, B-Cell Leukemia
- Trial name
- NCT03448393
- Testing
- CD19/CD22 CAR T-Cells, Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Cancer Institute (NCI)
Pain, Postoperative Pain
A Comparative Study of JNS013 in Participants With Post-Tooth-Extraction Pain
The purpose of this study is to evaluate the efficacy and safety of JNS013 with single oral dose administration in participants with pain after tooth-extraction of mandibular impacted wisdom tooth.
- Trial name
- NCT00737048
- Testing
- Tramadol Hydrochloride, Acetaminophen, Tramadol plus Acetaminophen
- Where
- 11 sites in Japan
- Volunteers
- 328 people
- Sponsor
- Janssen Pharmaceutical K.K.
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