Clinical trials: Paracetamol, completed
Cesarean Section
MgSO4 as Adjuvants to Bupivacaine vs Neostigmine in TAP Block in Cesarean Section
The aim of this study is to compare the duration of analgesia obtained by addition of Neostigmine versus MgSO4 as adjuvants to bupivacaine in TAP block in patients undergoing Cesarean Section and to evaluate postoperative…
- Trial name
- NCT06513013
- Testing
- transversus abdominis plane (TAP) block in cesarean section, Magnesium sulfate, Neostigmine
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Assiut University
Neck Pain
Effect of Exercise Among Turtle Neck Syndrome in Pakistani Patients
Turtle neck also known as Text neck or anterior head syndrome is an overuse syndrome which occurs due to repetitive stress to neck, either by hanging it down or forward using phone or electronic devices.
- Trial name
- NCT05730868
- Testing
- myofascial release, muscle energy technique, MFR & MET
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- University of Karachi
Postoperative Acute Pain, Video-Assisted Thoracoscopic Surgery
Thoracic Paravertebral Block vs Intrathecal Morphine in VATS
The purpose of this study is to find out which pain relief method works better for people having video-assisted thoracoscopic surgery.
- Conditions
- Postoperative Acute Pain, Video-Assisted Thoracoscopic Surgery, Intrathechal Morphine, Paravertebral Peripheral Nerve Block
- Trial name
- NCT07126483
- Testing
- Thoracic paravertebral block, Morphine
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ondokuz Mayıs University
Erector Spinae Plane Block
Effectiveness of Bilateral Ultrasound-Guided Erector Spinae Plane Block
The proposed mechanism of action of the ESPB is via blockade of the dorsal and ventral rami of the spinal nerves and sympathetic nerve fibers.
- Trial name
- NCT04110210
- Testing
- Bilateral Ultrasound-Guided Erector Spinae Plane Block, Morphine Consumption
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Osteoarthritis, Total Knee Arthroplasty
Tourniquet and Quadricepsforce
The purpose for this study is to investigate the quadriceps (thigh) function preoperatively and 48 hours postoperatively during knee arthroplasty (total replacement of the knee joint) in a randomised study with or without the use…
- Trial name
- NCT01808859
- Testing
- Tourniquet
- Where
- Sweden
- Volunteers
- 64 people
- Sponsor
- Region Skane
Persistent Ductus Arteriosus, Complication of Prematurity
The Preterm Infants' Paracetamol Study
Present randomized, controlled, double-blind trial investigates the efficacy and safety of early (<24 h) intravenous paracetamol therapy for pain medication in very small premature infants.
- Conditions
- Persistent Ductus Arteriosus, Complication of Prematurity, Pain or Discomfort in Intensive Care of Preterm Infants
- Trial name
- PreParaS (NCT01938261)
- Testing
- paracetamol, 0.45 % saline solution
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- University of Oulu
Fever
Acetaminophen Concentration in Cerebrospinal Fluid in Infants
Acetaminophen is the most commonly used drug in children. Inhibition of COX-3 in the brain has been suggested as the primary central mechanism by which acetaminophen decrease pain and possibly fever.
- Trial name
- NCT00389454
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Postoperative Dental Pain
A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo
Researchers are looking for a better way to relieve pain in people, such as after dental surgery. Participants in this study, have had 3 or 4 third molars (cheek teeth) removed and subsequently have moderate to severe tooth pain.
- Trial name
- NCT05485805
- Testing
- Naproxen sodium and caffeine (BAY2880376), Naproxen sodium (Aleve), Caffeine
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Bayer
Acute Toothache Patients Above Moderate Pain After Teeth Extraction Surgery
Phase 3 Study of Tramadol Hydrochloride/Acetaminophen SR Tab. & Tramadol Hydrochloride/Acetaminophen Tab. in Acute Toothache Patients After Teeth Extraction Surgery
A randomized, double-blind, active-controlled, parallel, multicenter Phase 3 study of Tramadol hydrochloride/Acetaminophen SR Tab. \& Tramadol hydrochloride/Acetaminophen Tab.
- Trial name
- NCT01920386
- Testing
- Tramadol hydrochloride/Acetaminophen Tab., Tramadol hydrochloride/Acetaminophen SR Tab.
- Volunteers
- 240 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Epilepsy, Depression
Measuring Blood Flow in the Brain After Epileptic Activity
In this clinical trial, postictal phenomena (i.e., headache, delirium) will be investigated after administration of acetaminophen and nimodipine in depressed patients receiving electroconvulsive therapy (ECT).
- Conditions
- Epilepsy, Depression, Postictal Delirium, Electroconvulsive Therapy
- Trial name
- SYNAPSE (NCT04028596)
- Testing
- Paracetamol, Nimotop
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Rijnstate Hospital
Labor Pain
Efficacy and Safety of Intravenous Paracetamol in Manament of Labour Pain
to compare between the use of single dose of paracetamol and pethidine hydrochloride intravenously in management of labour pains
- Trial name
- NCT04744727
- Testing
- paracetamol-pethidine
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Drug Toxicity
Cytokines Polymorphisms and Acetaminophen Toxicity
Genotyping assays for polymorphisms in the interleukin 10(IL10)gene and the inducible nitric oxide synthase (iNOS) gene will be performed. Genotypes will be compared to the severity of toxicity following overdose.
- Trial name
- NCT00166608
- Testing
- Blood sampling
- Where
- 7 sites in United States
- Volunteers
- 111 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Prostatic Neoplasm
The Effects of Method of Anaesthesia on the Safety and Effectiveness of Radical Retropubic Prostatectomy
Prostate cancer is one of the most commonly diagnosed neoplasm in men worldwide. The gold standard of therapy is radical prostatectomy, a wide surgical excision of the neoplasm and can be performed either open, laparoscopic or…
- Trial name
- NCT05566405
- Testing
- General Anaesthesia, Combined (Epidural and Spinal) Anaesthesia, Open Retropubic Radical Prostatectomy
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Sismanoglio General Hospital
Pain
Clinical Confirmation of a Pharmacodynamic Interaction Between Tropisetron and Paracetamol
A previous study has shown that tropisetron inhibits the analgesic effect of paracetamol in healthy volunteers. This study aims at confirming this pharmacodynamic interaction in patients with post-surgery pain.
- Trial name
- Tropisétron (NCT00487110)
- Testing
- Tropisetron, paracetamol
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Kidney Diseases, Kidney Failure
Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy
Ultrasound (US) guided Quadratus Lumborum Block (QLB) is performed at the level of the 12th rib, in the parasagittal oblique plane, at the L1-L2 level.
- Trial name
- NCT06298227
- Testing
- Postoperative analgesia management with Paracerol® and IV PCA with Talinat®, Erector spinae plane block, Quadratus lumborum plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Istanbul Medipol University Hospital
Congenital Heart Disease, Cardiopulmonary Bypass
Acetaminophen for Oxidative Stress After Cardiopulmonary Bypass
The current proposal tests the central hypothesis that acetaminophen will attenuate the oxidative stress response associated with cardiopulmonary bypass (CPB)-induced hemolysis in children undergoing cardiac surgery.
- Trial name
- NCT01228305
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Tendinopathy
Can Amino Acid Supplementation Augment the Anabolic Response in Tendon After Exercise
The goal of this study is to determine if an oral provision of amino acids will enhance exercise-induced increases in markers of Achilles tendon collagen production.
- Trial name
- NCT04067479
- Testing
- Amino Acids
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Purdue University
Arthropathy of Knee, Anesthesia
IPACK Nerve Block for Total Knee Arthroplasty
Double-blind, randomized controlled clinical trial to test the efficacy of IPACK on postoperative opioid consumption, patient satisfaction, pain scores, mobility, and several other secondary outcomes in adults undergoing primary…
- Trial name
- NCT03921034
- Testing
- Ropivacaine, Saline
- Volunteers
- 72 people
- Sponsor
- Ochsner Health System
Osteoarthritis, Hip
Effect of Local Infiltration Anesthesia With Ropivacaine on Pain After Primary Total Hip Arthroplasty
Background: The Local infiltration analgesic (LIA) technique has been widely used to reduce opioid requirements and improve the patient's mobilization after total hip arthroplasty (THA).
- Trial name
- NCT02359136
- Testing
- local infiltration anesthesia using Ropivacaine and Epinephrine, local infiltration anesthesia using saline, Multimodal analgesic regimen
- Where
- Norway
- Volunteers
- 116 people
- Sponsor
- St. Olavs Hospital
Ligament Injury
Correlation Between Acute Analgesia and Long-Term Function Following Ankle Injuries
In this 4-arm pragmatic randomized control trial, the investigators hope to decipher whether the use of non-opioid analgesics (naproxen, celecoxib, acetaminophen) in addition to standardized physiotherapy during the acute phase…
- Trial name
- CALF (NCT02667730)
- Testing
- Acetaminophen, Naproxen, Celecoxib
- Where
- Canada
- Volunteers
- 168 people
- Sponsor
- Canadian Department of National Defence
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