Clinical trials: Paracetamol, completed
Pain
IV Acetaminophen for Postoperative Pain Analgesia After Laparoscopic Hysterectomy
The objective of this study is to quantify the change in post-operative pain scores and narcotic requirements in women receiving pre and post-operative IV acetaminophen compared to placebo in women undergoing laparoscopic…
- Trial name
- NCT02400580
- Testing
- IV acetaminophen
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Radiculopathy Lumbar
Glucocorticoid Injection in Patients With Lumbar Radicular Pain
The purpose of this study is to demonstrate the efficacy of intramuscular betamethasone injection on pain and other clinical parameters in patients with radicular pain due to lumbar disc herniation.
- Trial name
- NCT05571046
- Testing
- Glucocorticoids
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cukurova University
Neuropathy
Scrambler Therapy in the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy
The purpose of this study is to see if Scrambler Therapy with the Calmare MC5-A machine will relieve chemotherapy induced peripheral neuropathy (CIPN).
- Trial name
- NCT02111174
- Testing
- Scrambler Therapy
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Emergence Delirium
Ketamine Versus Dexmedetomidine for Prevention of Postoperative Delirium
Delirium is a common postoperative complication in the elderly, often caused by multiple factors. It is defined as an acute neuropsychiatric disorder characterized by fluctuating disturbances in attention, awareness, and…
- Trial name
- NCT05341154
- Testing
- Ketamine Hcl 50Mg/Ml Inj
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Huda Fahmy Mahmoud, PhD
Postoperative Pain
A Multicenter Active Comparator Study of HC-ER in Adults Following Bunionectomy Surgery
The purpose of the study is to establish a dose-response relationship among several capsule strengths of Hydrocodone Bitartrate Extended Release (HC-ER) and to compare the efficacy to placebo following bunionectomy surgery
- Trial name
- NCT02197156
- Testing
- 10 mg HC-ER, 20 mg HC-ER, 30 mg HC-ER
- Volunteers
- 241 people
- Sponsor
- Zogenix, Inc.
Post Operative Pain
Quadratus Luborum Block Using Bupivacaine Versus Bupivacaine-Dexamethasone in Laparoscopic Cholecystectomy
The aim of the present study was to compare the effectiveness of transmuscular Quadratus Lumborum block using Bupivacaine versus Bupivacaine- Dexamethasone in providing analgesia in patients undergoing laparoscopic…
- Trial name
- NCT03956966
- Testing
- TQL block with saline, TQL block with Bupivacaine, TQL block with Bupivacaine and dexamethasone
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Opioid-Free Anaesthesia
Accelerated Recovery Following Opioid-free Anaesthesia in Supratentorial Craniotomy
Anaesthesia for craniotomy (open skull/brain) surgery focuses on maintaining blood supply to brain, avoiding factors that may lead to increased pressure in brain and aim for early neurological recovery.
- Trial name
- NCT05681429
- Testing
- Lignocaine, Dexmedetomidine, Sevoflurane, Paracetamol, Parecoxib
- Where
- Malaysia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Pain
Open-Label CA-008 (Vocacapsaicin) in Bunionectomy
A Phase 2, open-label study of CA-008 to evaluate post-surgical pain control with CA-008.
- Trial name
- NCT03885596
- Testing
- CA-008, Ketorolac, Acetaminophen IV
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Concentric Analgesics
Papillomavirus Infections, Cervical Intraepithelial Neoplasia
E7 TCR T Cells for Human Papillomavirus-Associated Cancers
Background: Human papillomavirus (HPV) can cause cervical, throat, anal, and genital cancers. Cancers caused by HPV have an HPV protein called E7 inside of their cells.
- Conditions
- Papillomavirus Infections, Cervical Intraepithelial Neoplasia, Carcinoma In Situ, Vulvar Neoplasms
- Trial name
- NCT02858310
- Testing
- E7 TCR cells, Aldesleukin, Fludarabine
- Where
- 2 sites in United States
- Volunteers
- 224 people
- Sponsor
- National Cancer Institute (NCI)
Cesarean Section, Pain, Postoperative
RCT (Randomized Controlled Trial) of IV Acetaminophen for Post Cesarean Pain Relief
This study is being done to evaluate the scheduled use of intravenous (IV) acetaminophen among cesarean section patients. The study hopes to find out if patients who receive scheduled IV acetaminophen for 48 hours following…
- Trial name
- NCT02046382
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- TriHealth Inc.
Analgesia
Study Comparing a Nerve Block With Spinal Opiate to Provide Pain Relief for Hip Replacement Surgery
Pain control after hip replacement surgery is important to ensure patient comfort, allow mobilisation, and aid recovery. The investigators propose a simple and pragmatic study comparing two different anaesthetic techniques in the…
- Trial name
- NCT01217294
- Testing
- ultrasound guided fascia iliaca block, spinal morphine
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- Rachel Kearns
Caesarian Section
Oral Self Medication Versus IV Administration of Pain Killers After Caesarian Delivery
C-section deliveries are painful and need adequate analgesia. In the same time, mothers need early rehabilitation to take care of the baby.
- Trial name
- NCT01566253
- Testing
- Acetaminophen, ketoprofen, morphine, Acetaminophen, ketoprofen,morphine
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Pain
Analgesic Efficacy & Safety of Intravenous (IV) Acetaminophen Versus Placebo for the Treatment of Postop Pain
This research study will look at the pain relieving ability and safety of using repeated doses of intravenous (into the vein [IV]) acetaminophen in the treatment of moderate postoperative pain after planned or elective abdominal…
- Trial name
- NCT00564486
- Testing
- IV Acetaminophen
- Where
- 17 sites in United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Migraine With or Without Aura
An Acute Migraine Factorial Study
The study consists of a screening visit, out-patient treatment of a moderate or severe migraine attack with a single dose of the study medication within 8 weeks, and End-of-Study Visit 2-7 days after dosing.
- Trial name
- ANODYNE-1 (NCT06245902)
- Testing
- Naltrexone and Acetaminophen, Naltrexone and Acetaminophen-High Dose, Naltrexone Alone (regular dose)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Allodynic Therapeutics, Inc
Low Back Pain, Sleep Hygiene
The Effect of Breathing Exercise and Stabilization Exercise With Chronic Low Back Pain
The aim of this study is to compare the effect of sleep hygiene, breathing exercises, and stabilization exercises on pain, sleep quality, and anxiety level in patients with non-specific chronic low back pain.
- Conditions
- Low Back Pain, Sleep Hygiene, Anxiety
- Trial name
- NCT05212753
- Testing
- Conventional physical therapy, Lumbar stabilization exercises, Breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Malaria, Vivax
Radical CUREfor MAlaria Among Highly Mobile and Hard-to-reach Populations in the Guyanese Shield
The investigators are proposing a new malaria control strategy to reach the group of garimpeiros not reached by the usual actions of the health services.
- Trial name
- CUREMA (NCT05540470)
- Testing
- PART, Malakit, CROSS-SECTIONAL PRE- AND POST-INTERVENTION SURVEYS
- Where
- 2 sites in Brazil, Suriname
- Volunteers
- 1,991 people
- Sponsor
- Centre Hospitalier de Cayenne
Mammoplasty, Postoperative Pain
Study of EXPAREL in Patients Undergoing Breast Augmentation
This is a Phase 4, prospective, open-label, non-randomized, sequential study with two treatment groups differing only in the technique used for EXPAREL administration (instillation or infiltration).
- Trial name
- NCT01582490
- Testing
- Instillation - EXPAREL, Infiltration - EXPAREL
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Pain, Postoperative, Osteoarthritis, Knee
Comparing Local Anesthetic Injections to Nerve Blocks for Pain Control After Total Knee Replacement
Why are we doing this study? People who have knee replacement surgery often feel pain afterward. Doctors use different methods to control this pain.
- Conditions
- Pain, Postoperative, Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
- Trial name
- LIA-PNB-TKA (NCT07744503)
- Testing
- Continuous Femoral and Sciatic Nerve Block (Ropivacaine), Local Infiltration Analgesia (Ropivacaine, Ketorolac, Epinephrine)
- Where
- Austria
- Volunteers
- 78 people
- Sponsor
- Christopher Male
Postoperative Nausea and Vomiting
Dexamethasone Versus Local Infiltration Technique for Tonsillectomy in Children
Tonsillectomy is one of the most frequent surgical operations performed in children [1-4]. It is usually associated with postoperative nausea and vomiting (PONV) with an incidence ranging from 23% to 73% [2].
- Trial name
- NCT02355678
- Testing
- dexamethasone, Local anesthetic infiltration, General anesthesia
- Where
- Lebanon
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Makassed General Hospital
Healthy
Influence of Medication Taste on Pediatric Prescribers' Prescribing Habits
The purpose of this study is to see if a medication taste test influences the prescribing habits of pediatric prescribers at Mayo Clinic.
- Trial name
- NCT01734759
- Testing
- Taste Test
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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