Clinical trials: Paracetamol, completed
Insulin Resistance
Gastric Emptying and Insulin Response to Test Drink
Surgery is a stress on the body and recovering well after surgery is very important to patients and their doctors. It is therefore important to prepare patient's bodies for the stress of surgery, and one way to do this is to…
- Trial name
- NCT01971229
- Testing
- Carbohydrate based drink, Whey protein based drink
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Franco Carli
Pain, Postoperative
Preemptive Analgesia With Celecoxib for Acute Dental Pain Management
The purpose of this study is to compare the effect on postoperative pain of a single agent nonsteroidal anti-inflammatory drug (NSAID) [celecoxib plus placebo] to an NSAID combination [celecoxib plus acetaminophen] administered…
- Trial name
- NCT04790812
- Testing
- Celecoxib, Acetaminophen
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Tendon Injuries
Multimodal Analgesia Strategies After Major Shoulder Ambulatory Surgery
This study evaluates the addition of tramadol, or nefopam or opioid to paracetamol and ketoprofene in the treatment of pain in adults after shoulder ambulatory surgery.
- Trial name
- Shoulder1 (NCT04110665)
- Testing
- Tramadol, Nefopam 20 MG/ML, Morphine Sulfate
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Healthy
Bioequivalence Study of One Tablet of Paracetamol 1000 mg + Codeine 30 mg vs. Two Tablets of Paracetamol 500 mg + Codeine 30 mg
The purpose of this study is to evaluate the bioequivalence of a new paracetamol 1000 mg/codeine 30 mg formulation vs. the marketed reference Co-efferalgan® 500 mg/30 mg in terms of rate and extent of absorption, when…
- Trial name
- NCT02902666
- Testing
- Paracetamol 1000 mg/codeine phosphate hemihydrate 30 mg tablet, Paracetamol 500 mg/codeine phosphate hemihydrate 30 mg tablet
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Diabetes Mellitus Type 2
A Study of the Effect of Taspoglutide on Gastric Emptying in Patients With Type 2 Diabetes
This 3 arm, placebo-controlled study will investigate the effect of Taspoglutide on gastric emptying in patients with type 2 diabetes.
- Trial name
- NCT00809705
- Testing
- taspoglutide
- Where
- 3 sites in Germany, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Hoffmann-La Roche
Nephrolithiasis
Ureteral Stent-related Pain and Mirabegron (SPAM) Trial
Ureteric stents are used often following ureteroscopy for prevention of obstruction from edema and or stone fragments. They are often associated with pain, voiding often, the need to urinate quickly and finding blood in the urine…
- Trial name
- SPAM (NCT02095665)
- Testing
- Mirabegron, Tamsulosin, Tylenol #3
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Nova Scotia Health Authority
Breech Presentation, Pregnancy
Remifentanil Versus Paracetamol for Pain Treatment External Cephalic Versions.
BACKGROUND: Between 3-4% of pregnancies carried to term, the fetuses are in breech presentation. The external version is a maneuver gynecological used to turn a breech in cephalic presentation.
- Trial name
- NCT01048398
- Testing
- remifentanil, paracetamol
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Contraception, Inhalation of Nitrous Oxide
Nitrous Oxide for Pain Management During In-office Transcervical Sterilization
This is a randomized, double blind study that aims to measure the difference in maximum pain experienced during in-office transcervical sterilization (Essure®) for women receiving either inhaled nitrous oxide or standard oral…
- Trial name
- NEST (NCT02312739)
- Testing
- In-office Transcervical Sterilization (Essure®), Standard Oral pain medications, Intramuscular Ketorolac
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Sepsis
Effect of Montelukast Versus Co Enzyme in Sepsis
Sepsis is a leading cause of morbidity and mortality in intensive care units. Sepsis is a life-threatening organ dysfunction linked to a dysregulated host response to infection.
- Trial name
- NCT05293132
- Testing
- Montelukast Sodium 10 mg, Co-Enzyme Q10, Standard Treatment
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Post-Dural Puncture Headache
Different Approaches for the Management of Post-dural Puncture Headache
Detecting the efficacy and safety of trans-nasal sphenopalatine ganglion block using either lidocaine 2% or bupivacaine 0.5 % as a treatment line for post-dural puncture headache
- Trial name
- NCT05253014
- Testing
- sphenopalatine ganglion block, paracetamol
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Bahaa Mohammed Refaie
Fever
Ibuprofen Alone and in Combination With Acetaminophen for Treatment of Fever
Currently, when a child has fever either ibuprofen (e.g. Motrin, Advil) or acetaminophen (e.g. Tylenol) is given. Both Ibuprofen and Acetaminophen are approved for over the counter use for treatment of fever by the Food and Drug…
- Trial name
- NCT00267293
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Penn State University
Pain Management
Opioid-Free Orthopaedic Surgery
To compare the safety and effectiveness of two pain control pathways following routine orthopaedic surgical procedures (single level or two-level ACDF/ACDA, 1st CMC arthroplasty, Hallux Valgus/Rigidus corrections, diagnostic knee…
- Trial name
- CORE (NCT04176783)
- Testing
- Opioids, Opioid-Free
- Where
- United States
- Volunteers
- 511 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Pyloric Stenosis
Institutional Audit of the Use of Intravenous Acetaminophen in Infants Undergoing Pyloromyotomy
This is a retrospective chart review. The objective of the current study is to determine the analgesic efficacy and side effect profile of intravenous acetaminophen when administered to infants undergoing pyloromyotomy.
- Trial name
- NCT02359305
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Arlyne Thung
Headache
A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective.
To determine if the intravenous administration of Metoclopramide and diphenhydramine in combination can effectively treat headaches in pregnant patients in those refractory to acetaminophen when compared to codeine
- Trial name
- MAD (NCT02295280)
- Testing
- Metoclopramide, Diphenhydramine, Codeine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- St. Louis University
Dementia, Pain
Pain in Patients With Dementia and Behavioural Disturbances
In nursing homes (NHs) 80% of the patients have dementia, between 60%-80% exhibit behavioural disturbances (BPSD), and more than 60% have pain. Both pain and BPSD is more common in those with severe dementia.
- Conditions
- Dementia, Pain, Agitation
- Trial name
- NCT01021696
- Testing
- Paracetamol, Morphine, Buprenorphine plaster
- Where
- 18 sites in Norway
- Volunteers
- 352 people
- Sponsor
- University of Bergen
Osteoarthritis
An Effectiveness and Safety Study of Two Doses of Acetaminophen Extended Release Caplets in the Treatment of Osteoarthritis of the Hip or Knee
The purpose of this study is to determine the safety and effectiveness of 650 mg and 1300 mg acetaminophen extended release given three times a day for the relief of signs and symptoms of osteoarthritis of the hip or knee for a…
- Trial name
- NCT00240786
- Testing
- acetaminophen extended release
- Volunteers
- 483 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Respiratory Tract Infections
To Test Bioequivalence Between Two Formulations of Paracetamol/Phenylephrine
This study is designed to assess bioequivalence between two paracetamol/ phenylephrine combination products.
- Trial name
- NCT01112462
- Testing
- Paracetamol 500 mg/Phenylephrine 5 mg tablets, Paracetamol 1000 mg/Phenylephrine 10 mg sachet
- Where
- Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McNeil AB
Adenotonsillar Hypertrophy,Under 12 Years.
Intravenous Enhancin[Co-amoxiclav] Versus Postoperative Enhancin in Prevention of Postadenotonsillectomy Morbidity.
Null hypothesis; The efficacy of Enhancin]Co-Amoxiclav given as a single intravenous dose at induction is not better than a five days oral course of the same given postoperatively in reducing postoperative morbidity after…
- Trial name
- NCT01267942
- Testing
- Enhancin
- Where
- Kenya
- Volunteers
- 126 people
- Sponsor
- University of Nairobi
Postoperative Pain
Preemptive and Preventive Acetaminophen/Ibuprofen Fixed-dose Combination After Robot-assisted Radical Prostatectomy
This prospective, randomized, double-blinded study is designed to compare opioid-sparing effect of preemptive and preventive intravenous acetaminophen/ibuprofen fixed-dose combination in patients undergoing robot-assisted radical…
- Trial name
- NCT05685342
- Testing
- Acetaminophen/Ibuprofen fixed-dose combination
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Seoul National University Hospital
Healthy
Acetaminophen's Antinociceptive Effect When Associated With N-Acetylcysteneine
Acetaminophen is one of the most widely used analgesic in the world, recommended for the symptomatic treatment of fever and pain.
- Trial name
- PANACE (NCT02206178)
- Testing
- N-acetylcysteine combination with acetaminophen
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
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