Clinical trials: Paracetamol
Anesthesia, Opioid Use
PROUD Study - Preventing Opioid Use Disorders
The objective of this study is to pilot an opioid free anesthetic protocol for patients undergoing total hip replacement.
- Trial name
- NCT04766996
- Testing
- Guided mindfulness exercises, Self-administered aromatherapy, Baby aspirin
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Emory University
Oxidative Stress
Metabolic Effects of Chemical Interactions in Toxicity
This pilot study tests the feasibility of using GSH redox state and high resolution proton NMR spectroscopy (1H-NMR) to detect metabolic changes due to acetominophen and sulfur amino acid deficiency.
- Trial name
- NCT00253773
- Testing
- acetominophen, sulfer amino acids; cysteine and methionine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Lung Cancer
Postoperative Pain After Single Port, Two Ports and Three Ports VATS Lobectomy
This single-center, prospective, randomized controlled trial was designed to assess and compare the postoperative pain after VATS lobectomy performed though one, two and three incisions.
- Trial name
- NCT03228056
- Testing
- pain intensity measured in VAS scale
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Pulmonary Hospital Zakopane
Breast Cancer
Benson Relaxation Technique Effectiveness on Pain and Quality of Life Post Reconstructive Mammoplasty
The purpose of this study is to evaluate effectiveness of benson relaxation technique on pain and quality of life post mammoplasty.
- Trial name
- NCT07032883
- Testing
- Benson relaxation technique, Routine physiotherapy program, Medications
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Cairo University
Laparoscopic Bariatric Surgery
The Effects of Erector Spinae Plane Block on Bariatric Surgery.
The erector spinae plane block (ESPB) is a new technique that is increasingly used in the treatment of acute and chronic pain. Bariatric surgery is a surgical treatment method used in the treatment of morbid obesity and related…
- Trial name
- NCT05020379
- Testing
- Perioperative and postoperative multimodal analgesia, ESP Block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
Healthy
Emulsion Lipid Digestion & Satiety Study - Effect of Physical State and Acid Stability
The purpose of this study is to compare the changes in blood lipids and feelings of satiety after consumption of acid stable or acid unstable oil-in-water emulsions in which the droplets are in either the liquid or partially…
- Trial name
- NCT03990246
- Testing
- Acid stable emulsion with solid droplets, Acid stable emulsion with liquid droplets, Acid unstable emulsion with solid droplets
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Intraventricular Haemorrhage Neonatal
Prophylactic Acetaminophen for Prevention Intraventricular Hemorrhage in Premature Infants
The purpose of this study is to determine whether acetaminophen is effective in prevention or reducing the severity of IVH in premature infants.
- Trial name
- NCT03024814
- Testing
- Acetaminophen, Dextrose 5
- Where
- Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- King Saud Medical City
Hairy Cell Leukemia
Moxetumomab Pasudotox-tdfk (Lumoxiti(TM)) and Either Rituximab (Rituxan(R)) or Ruxience for Relapsed Hairy Cell Leukemia
Background: Hairy cell leukemia (HCL) is a rare, slow-growing blood cancer in which the bone marrow makes too many of certain white blood cells.
- Trial name
- NCT03805932
- Testing
- Moxetumomab Pasudotox-tdfk, Rituximab, Ruxience
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Osseointegrated Dental Implantation, Pain, Acute
OTC Naproxen and Acetaminophen Anti-Inflammatory Action in Dental Implant Patients
This double-blind pilot study will evaluate the anti-inflammatory and analgesic effects of an over-the-counter (OTC) regimen of naproxen sodium versus acetaminophen in patients receiving one or two (adjacent) dental implants.
- Trial name
- NCT04694300
- Testing
- Naproxen, Acetaminophen, Tramadol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hersh, Elliot V., DMD, MS, PhD
Pain, Acute
Acetaminophen IV vs Hydromorphone IV in the ED
The purpose of the current study is to compare the analgesic efficacy of intravenous acetaminophen and intravenous hydromorphone in the treatment of acute pain in the ED.
- Trial name
- NCT03107481
- Testing
- Acetaminophen, Hydromorphone
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain, Postoperative, Lung Diseases
Efficacy of Intercostal CryoAnalgesia in Robotic Lung Resection
This is a single center, single surgeon, prospective, randomized trial examining the addition of Cryo Nerve Block during robot assisted thoracoscopic anatomic lung resection surgery
- Trial name
- NCT05144828
- Testing
- Intercostal Nerve Cryoablation, Patient-controlled analgesia (PCA)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical College of Wisconsin
Pain, Postoperative, ACL
Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction
Liposomal bupivacaine injectable suspension (Exparel), manufactured by Pacira Pharmaceuticals, is an FDA-approved, long-lasting nonopioid analgesic that is indicated for single-dose infiltration in adults to produce postsurgical…
- Trial name
- NCT05161221
- Testing
- OxyCODONE 5 mg Oral Tablet, Naproxen 500 Mg, Tylenol Pill
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Trauma, Rib Fractures
Pain as Indication for Operative Treatment of Traumatic Rib Fractures
The purpose of this prospective randomized controlled study is to determine whether acute and chronic pain in patients who suffer multiple traumatic rib fractures is decreased after surgical management as compared to conservative…
- Conditions
- Trauma, Rib Fractures, Surgery, Pain
- Trial name
- potf (NCT02094807)
- Testing
- NSAID, thoracic epidural anesthesia, opioids
- Where
- Sweden
- Sponsor
- Sahlgrenska University Hospital
Analgesia; Postoperative
Effect of Single Dose Intravenous Magnesium Sulfate on Postoperative Analgesic Consumption in Patients Undergoing Laparoscopic Cholecystectomy
This study describes a randomized controlled trial designed to evaluate the impact of a single intravenous dose of magnesium sulfate on postoperative analgesic consumption in patients undergoing laparoscopic cholecystectomy.
- Trial name
- NCT07328893
- Testing
- Magnesium Sulfate 30 mg/kg intravenous diluted in 100 ml Normal Saline.
- Where
- 2 sites in India
- Volunteers
- 106 people
- Sponsor
- Tata Main Hospital
Delirium, Postoperative, Delirium in Old Age
The SCOPE Trial: Sleep, Cognition, and Pain Bundle vs. ERAS-cardiac for Postoperative Delirium
Sleep disturbances, cognitive reserve, and continuing pain and inflammation are other risk factors contributing to delirium (confusion and agitation) and neurocognitive decline (in the long term) following heart surgery.
- Trial name
- SCOPE (NCT06721819)
- Testing
- Sleep Hygiene, Brain Game, and IV Acetaminophen Intervention, Control
- Where
- 3 sites in United States
- Volunteers
- 406 people
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy
A Relative Bioavailability Study of Acetaminophen 650 mg Extended Release Gelcaps Under Fasting Condition
The study was conducted as an open labeled, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioavailability study comparing acetaminophen extended release gelcaps 650 mg of OHM Laboratories…
- Trial name
- NCT01073709
- Testing
- Acetaminophen
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Miscarriage
Sublingual Versus Vaginal Misoprostol In Medical Treatment of Second Trimestric Missed Miscarriage
The aim of this work is to compare the effectiveness of vaginal versus sub-lingual misoprostol for medical treatment of the second trimester missed miscarriage
- Trial name
- NCT05088707
- Testing
- sublingual misoprostol, vaginal misoprostol
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Shoulder Instability Subluxation Bilateral
Physiotherapist Supervised Training in Patients With Anterior Shoulder Instability
The goal of this clinical trial is to investigate if physiotherapist supervised training improves neuromuscular control in patients suffering from traumatic anterior shoulder instability.
- Trial name
- ASIST (NCT06033157)
- Testing
- Physiotherapist supervised training
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Hvidovre University Hospital
Postoperative Pain
Intravenous Acetaminophen/Ibuprofen Fixed-dose Combination on Postoperative Opioid Consumption
This prospective, randomized, double-blinded study is designed to evaluate the postoperative analgesic effect of the intravenous acetaminophen/ibuprofen fixed-dose combination in patients undergoing video-assisted thoracic…
- Trial name
- NCT05366777
- Testing
- acetaminophen/ibuprofen fixed-dose combination, Saline
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Seoul National University Hospital
ACL Injury, Pain
Effect of Biophysical Stimulation on Intraspongious Bone Edema in Anterior Cruciate Ligament Reconstruction
The following study has as main objective to evaluate whether the use of I-ONE® therapy can reduce post-operative pain thanks to the modulation of inflammation in patients with bone bruise on the knee after anterior cruciate…
- Conditions
- ACL Injury, Pain, Magnetic Field Exposure
- Trial name
- NCT04255407
- Testing
- I-ONE® therapy, Anti-inflammatory drug
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Istituto Ortopedico Rizzoli
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