Clinical trials: Paracetamol
Breast Cancer, Breast Cancer Female
PECS Block vs. Multimodal Analgesia for Prevention of Persistent Postoperative Pain in Breast Surgery
In this double blinded randomized placebo-controlled trial, 160 subjects scheduled for breast surgery involving the axilla will be administered a multimodal pain regimen including acetaminophen, dexamethasone, celecoxib, and…
- Conditions
- Breast Cancer, Breast Cancer Female, Cancer of Breast
- Trial name
- NCT03084536
- Testing
- Bupivacaine, Gabapentin, Celecoxib
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Washington University School of Medicine
Intra-operative Anesthesia
Comparison of Transversus Abdominis Plane Block and Ilioinguinal / Iliohypogastric Nerve Block
the aim of this study is to compare the effects of Transversus abdominis plane block and ilioinguinal / iliohypogastric block combined with sedation in pediatric surgeon on the anesthesia and analgesia contributions during…
- Trial name
- NCT02991053
- Testing
- ketamine
- Volunteers
- 100 people
- Sponsor
- Erzincan University
Infections, Respiratory Tract
An Efficacy and Safety Study of Theraflu Night Powder as Oral Solution for Cold and Flu
The purpose of the study is to assess the short term efficacy of the Theraflu Night powder for oral solution in the Russian population in "Short term relief of the symptoms of colds, chills and influenza, including mild to…
- Trial name
- NCT02730364
- Testing
- Paracetamol, phenylephrine HCl, pheniramine maleate, and vitamin C
- Sponsor
- GlaxoSmithKline
Dementia, Alzheimer Disease, Pain
Pain Management and Behavioral Outcomes in Patients With Dementia
Dementia illness often co-exists with painful medical conditions associated with aging (e.g., degenerative joint disease, osteoarthritis, skin ulcers, back pain, headaches, cancer, or angina).
- Conditions
- Dementia, Alzheimer Disease, Pain, Behavior, Agitation
- Trial name
- NCT00012857
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- US Department of Veterans Affairs
Ductus Arteriosus, Patent
Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants
Patent Ductus Arteriosus is a developmental condition commonly observed among preterm infants. It is a condition where the opening between the two major blood vessels leading from the heart fail to close after birth.
- Trial name
- PIVOTAL (NCT05547165)
- Testing
- Percutaneous Patent Ductus Arteriosus Closure (PPC), Responsive Management Intervention, Echocardiogram, cardiac
- Where
- 24 sites in United States
- Volunteers
- 240 people
- Sponsor
- Nationwide Children's Hospital
Joint Pain, Knee Osteoarthritis
Efficacy and Safety of Celecoxib/Acetaminophen Versus Celecoxib for Diagnosed Osteoarthritis in Acute Exacerbation
This is a Phase III, longitudinal, multicenter, randomized, double-blind clinical trial designed to evaluate the efficacy and safety of a fixed-dose combination of celecoxib and acetaminophen compared to celecoxib monotherapy for…
- Conditions
- Joint Pain, Knee Osteoarthritis, Hip Osteoarthritis
- Trial name
- PRECEDENT (NCT06863636)
- Testing
- Celecoxib + Acetaminophen, Celecoxib
- Where
- Mexico
- Volunteers
- 231 people
- Sponsor
- Laboratorios Silanes S.A. de C.V.
Low Back Pain
Efficacy of the Combination of Ibuprofen and Paracetamol in Acute Non-specific Low Back Pain
The aim of the present study is to assess the efficacy and safety of paracetamol/ibuprofen Fixed Dose Combination (FDC) compared to ibuprofen in patients with uncomplicated non-specific acute low back pain after a 3-day treatment…
- Trial name
- NCT05222724
- Testing
- Tachifene, Brufen
- Where
- 11 sites in Italy, Poland
- Volunteers
- 176 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Pain
A Bioequivalence Study of Advil Dual Action Liquid Filled Capsules (125 mg/250 mg) Versus Advil Dual Action Caplets (125 mg/250 mg) and Bioavailability Assessment of Advil Dual Action Liquid Filled Capsules (125 mg/250 mg) and Advil Liqui-Gels (200 mg) in Healthy Adult Subjects
The primary purpose of this study is to demonstrate the bioequivalence of new formulation Advil Dual Action (ADA) liquid filled capsules (Test) compared to the currently marketed ADA Caplet (Reference) under fasted conditions and…
- Trial name
- NCT06802185
- Testing
- ADA Liquid Filled Capsules (Test Product), ADA Caplets (Reference Product), Advil Liqui-gels (Reference Product)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- HALEON
Pain
Randomized Trial of Two Analgesics in Elderly ED Patients
The purpose of this study is to perform a randomized, double blind 2-arm clinical trial of the comparative efficacy of 2 oral analgesics in the the management of acute pain in elderly patients who present and then are discharged…
- Trial name
- NCT02703610
- Testing
- Oxycodone/acetaminophen, Ibuprofen/acetaminophen
- Where
- United States
- Sponsor
- Albany Medical College
Melanoma (Skin)
Combination Chemotherapy in Treating Patients With Stage III or Stage IV Melanoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003346
- Testing
- acetaminophen, acetylcysteine, carmustine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Osteoarthritis
A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hip or Knee
To assess the safety and tolerability of orally-administered CR845 in patients with osteoarthritis (OA) of the hip or knee. The study drug is being tested to reduce OA pain, and will be taken twice a day for two weeks, with four…
- Trial name
- NCT02524197
- Testing
- CR845 0.25 mg, CR845 0.50 mg, CR845 1 mg
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- Cara Therapeutics, Inc.
Pain
Ultrasound Guided Bilateral Erector Spinae Plane Block in Caesarean Delivery
Erector Spinae plane block (ESPB) is a regional anesthesia technique described three years ago. Its use for many indications has been identified by case reports in the literature.
- Trial name
- NCT04118413
- Testing
- erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cigli Regional Training Hospital
Post Electrophysiology Procedure Pain
Oral Acetaminophen Use for Pain Reduction in Electrophysiology Procedures
The investigators are purposing a study to evaluate the use of acetaminophen given prior to an electrophysiology procedure and post procedural pain control.
- Trial name
- NCT03702023
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Ascension Health
Hernia, Inguinal, Pain, Postoperative
Evaluating Pain Outcomes of Caudal vs Ilioinguinal Nerve Block in Children Undergoing Hernia Repair
Surgical intervention to treat a inguinal hernia is a very common pediatric surgical procedure, often performed using an inguinal incision.
- Trial name
- NCT03041948
- Testing
- Ilioinguinal/iliohypogastric nerve block, Caudal-epidural nerve block, Acetaminophen
- Where
- 2 sites in Canada
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Alberta Children's Hospital
Healthy Volunteers
Paracétamol PMB by Sublingual et Buccal Routes
Paracetamol is the analgesic most used, indicated in the symptomatic treatment of fever and pain of mild to moderate. It comes in different dosage forms intended for oral, intravenous and rectal.
- Trial name
- NCT01206985
- Testing
- Von Frey electronic
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Covid19
TOCILIZUMAB - An Option for Patients With COVID-19 Associated Cytokine Release Syndrome; A Single Center Experience
Investigators conducted this study to see the effectiveness of Tocilizumab in COVID-19 participants who were in cytokine release syndrome and there was also a control group who received steroids(RECOVERY TRIAL wasn't published or…
- Trial name
- NCT04730323
- Testing
- Tocilizumab
- Where
- Pakistan
- Volunteers
- 93 people
- Sponsor
- FMH College of Medicine and Dentistry
Influenza, Influenza, Human
A Phase 2 Trial Comparing Antiviral Treatments in Early Symptomatic Influenza
This trial will use a previously validated platform, to quantitatively assess antiviral effects in low-risk patients with high viral burdens and uncomplicated influenza, to determine in-vivo antiviral activity.
- Trial name
- AD ASTRA (NCT05648448)
- Testing
- Oseltamivir, Favipiravir, Zanamivir
- Where
- 4 sites in Brazil, Laos and 2 more
- Volunteers
- 3,000 people
- Sponsor
- University of Oxford
Parkinson's Disease
Effect of Paracetamol on Opicapone Pharmacokinetics in Healthy Volunteers
Single-centre, open-label, randomised, two-way cross-over study consisting of 2 periods separated by a washout period of 14 days or more.
- Trial name
- NCT02305017
- Testing
- BIA 9-1067, Paracetamol
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Periapical Abscess
Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess
Aim: The aim of this study was to compare the analgesic efficacy of two combinations of opioid and non-opioid analgesics for acute periradicular abscesses.
- Trial name
- NCT02750696
- Testing
- Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days, Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days
- Volunteers
- 27 people
- Sponsor
- Federal University of Rio Grande do Sul
Patent Ductus Arteriosus
Oral Paracetamol Versus Oral Ibuprofen in Management of Patent Ductus Arteriosus in Preterm Infants: A Randomised Controlled Trial
The purpose of this study is to determine whether oral paracetamol or ibuprofen has a better or same efficacy and tolerance in closure of patent ductus arteriosus in preterm infants.
- Trial name
- NCT01536158
- Testing
- Oral paracetamol, Oral ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
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