Clinical trials: Paracetamol
Scorpion Stings
Analgesic Use for Pain Relief in Scorpion Sting
In scorpion stings, patients mostly apply with the complaint of pain. Emergency physicians need to relieve this pain quickly.
- Trial name
- NCT05125796
- Testing
- paracetamol, Dexketoprofen Trometamol, Lidocaine topical
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Adiyaman University Research Hospital
Provide Evidence-based Recommendations for Clinicians to Optimize Pain Control After CXL
Pain Relief After Corneal Collagen Cross-Linking
Keratoconus is a progressive corneal ectasia that can lead to significant visual impairment and decreased quality of life. The introduction of corneal cross-linking (CXL) with riboflavin and ultraviolet-A (UVA) light has…
- Trial name
- NCT06212830
- Testing
- Gabapentin, Targin, NSAID
- Where
- Israel
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Pain, Post Partum Depression
Vaginal Postpartum Pain Management Protocol Comparison
Untreated postpartum pain has been associated with increased risk of opioid use, postpartum depression and development of persistent pain.
- Conditions
- Pain, Post Partum Depression, Opioid Use, Breast Feeding
- Trial name
- NCT04087317
- Testing
- Paracetamol 1000 Mg Oral Tablet, Ibuprofen 400Mg Tab, Ibuprofen 400 mg
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Pain, Postoperative
Study of Pain Control in Diagnostic Hysteroscopy
The goal of this clinical trial study is to learn about how to decrease the pain during the diagnostic hysteroscopy. The main question it aims to answer is "Do the Paracetamol and Ibuprofen taken before the procedure can lower…
- Trial name
- NCT06188143
- Testing
- Ibuprofen-Paracetamol
- Where
- Thailand
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Celiac Disease in Children
Effect of Acetaminophen Versus Ibuprofen in Treating Recurrent Apthous Ulcers in Pediatric Celiac Disease
Celiac disease (CD) is a chronic autoimmune enteropathy. It results from genetic predisposition and exposure to gluten-containing food.
- Trial name
- NCT06149507
- Testing
- Acetaminophen, Ibuprofen
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Migraine, Headache
Bioequivalence Study to Compare Ibuprofen/ Paracetamol Tablets (200mg Ibuprofen/ 500mg Paracetamol) Versus Nuromol® Tablets (200mg Ibuprofen/ 500mg Paracetamol)
Randomized, two-way, two-period, single oral dose, open-label, crossover, bioequivalence study to compare Ibuprofen/ Paracetamol tablets (200mg Ibuprofen/ 500mg Paracetamol) versus Nuromol® tablets (200mg Ibuprofen/ 500mg…
- Conditions
- Migraine, Headache, Backache
- Trial name
- NCT06180070
- Testing
- Ibuprofen/ Paracetamol tablets, Nuromol® tablets
- Where
- Jordan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Vitreoretinal Surgeries, Postoperative Nausea and Vomiting
Paracetamol and Metamizole With SPI-guided Anaesthesia for VRS
The aim of this randomized trial is to assess the efficacy of preemptive analgesia using paracetamol or metamizole or both of them under SPI-guided anaesthesia for vitreoretinal surgery (VRS), presence of PONV (postoperative…
- Conditions
- Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain
- Trial name
- P&MSPIVRS (NCT03389243)
- Testing
- Metamizol, paracetamol, paracetamol and metamizole
- Where
- Poland
- Volunteers
- 165 people
- Sponsor
- Medical University of Silesia
Patent Ductus Arteriosus
Comparision Between Paracetamol and Ibuprofen in Closure of Patent Ductus Arteriosus
To compare efficacy and safety of paracetamol and ibuprofen for the pharmacological closure of patent ductus arteriosus (PDA) in preterm infants.
- Trial name
- NCT06152796
- Testing
- Paracetamol, Ibuprofen
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pain
Pharmacokinetic Study of Paracetamol in Patients Over 80 Years Hospitalized to an Acute Geriatric Ward
The goal of this exploratory study is the characterization of the pharmacokinetic (PK) profile of paracetamol in older patients and the specific PK (pharmacokinetic) variables associated with plasma exposure in this population.
- Trial name
- NCT03617471
- Testing
- Venopuncture for PK profiling
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cesarean Section, Pain Management
Comparison of Two Pain-treatment Techniques After Cesarean Section
Comparison of two types of analgesia after cesarean section. All patients will anaesthetised with spinal technique. Ultrasound-guided transversus abdominis plane or quadratus lumborum block to treat postoperative pain.
- Conditions
- Cesarean Section, Pain Management, Neuropathic Pain
- Trial name
- NCT02804126
- Testing
- TAP (transversus abdominis plane block), QL (quadratus lumborum block), Bupivacaine
- Where
- Poland
- Volunteers
- 232 people
- Sponsor
- Michał Borys
Postoperative Pain, Mitral Valve Disease
Postoperative Analgesia After Minithoracotomy
Patients scheduled for minimally invasive mitral valve replacement. Each patient will be treated with intravenous (i.v.) oxycodone - patient-controlled analgesia (PCA).
- Trial name
- NCT03415555
- Testing
- Erector Spinae Plane blockade, Oxycodone, general anesthesia
- Where
- Poland
- Volunteers
- 19 people
- Sponsor
- Medical University of Lublin
Cesarean Section, Postoperative Pain
TAP vs QLB in Patients After Cesarean Delivery
Comparison of two types of analgesia after cesarean section All patients will be anesthetized with spinal technique. Ultrasound-guided transversus abdominis plane or quadratus lumborum block to treat postoperative pain.
- Trial name
- NCT03404908
- Testing
- TAP (transversus abdominis plane block), QL (quadratus lumborum block), Ropivacaine
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Lublin
Epilepsy, Depression
Measuring Blood Flow in the Brain After Epileptic Activity
In this clinical trial, postictal phenomena (i.e., headache, delirium) will be investigated after administration of acetaminophen and nimodipine in depressed patients receiving electroconvulsive therapy (ECT).
- Conditions
- Epilepsy, Depression, Postictal Delirium, Electroconvulsive Therapy
- Trial name
- SYNAPSE (NCT04028596)
- Testing
- Paracetamol, Nimotop
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Rijnstate Hospital
SARS-CoV-2 Infection (COVID-19)
PREEMPTIVE THERAPY WITH COLCHICINE IN PATIENTS OLDER THAN 60 YEARS WITH HIGH RISK OF SEVERE PNEUMONIAE DUE TO CORONAVIRUS
This is a phase 3 clinical trial, randomized, single-center, opened, controlled, to evaluate efficacy and safety of early administration of colchicines in patients older than 60 years, with high risk of pulmonary complications…
- Trial name
- COLCHI-COVID (NCT04416334)
- Testing
- Colchicine plus symptomatic treatment (paracetamol), Symptomatic treatment (paracetamol or best symptomatic treatment based on doctor recommendations)
- Where
- 4 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Analgesia
Management of Post Dural Pucture Headache After Lower Limb Surgeries: Oral Prednisolone vs Oral Pregabalin
The aim of this study is to compare between oral prednisolone and oral pregabalin in management of PDPH to detect effectiveness of the treatment in reducing severity of PDPH, total rescue analgesic consumption and adverse effects…
- Trial name
- NCT04662125
- Testing
- caffeine, paracetamol tablet, Oral prednisolone, oral pregabalin
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Patent Ductus Arteriosus
PAIR (Paracetamol and Ibuprofen Research) Pilot Trial
Presence of Patent Ductus Arteriosus is detrimental to an infant born prematurely. The primary objective is to study the efficacy of Paracetamol (proposed new treatment) in treating haemodynamic significant Patent Ductus…
- Trial name
- PAIR (NCT04986839)
- Testing
- Paracetamol injection, Ibuprofen injection
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- Manchester University NHS Foundation Trust
Lymphoma, Large B-Cell, Diffuse
A Study on Pharmacokinetics (PK), Efficacy and Safety of Subcutaneous (SC) Versus Intravenous (IV) Rituximab, in Combination With CHOP (Cyclophosphamide, Doxorubicin, Vincristine, Prednisone) in Previously Untreated Participants With CD20 Positive Diffuse Large B-Cell Lymphoma (DLBCL)
This is a multicenter China-only study to investigate the PK, efficacy and safety of SC rituximab versus IV rituximab, both in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) in previously untreated…
- Trial name
- NCT04660799
- Testing
- Rituximab IV, Rituximab SC, Cyclophosphamide
- Where
- 8 sites in China
- Volunteers
- 50 people
- Sponsor
- Hoffmann-La Roche
Septic Shock, Sepsis
Heamodynamic Effects of Paracetamol in Septic Shock Patients
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. Septic shock is defined as sepsis that has circulatory, cellular, and metabolic abnormalities that are associated with a greater…
- Trial name
- NCT06076980
- Testing
- Paracetamol, Normal saline
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Ayah Mohammed Khalil
Atrophic Acne Scar
Simultaneous Versus Sequential Fractional CO2 Laser and Subcision Combination for Post-acne Atrophic Scars: A Split-face Comparative Study.
Acne vulgaris, a disease of the pilosebaceous unit, is estimated to afflict 9.4% of the global population, making it the eighth most prevalent and third most significant disease according to the global burden of disease.
- Trial name
- NCT05688202
- Testing
- Simultaneous combination of fractional CO2 laser and subcision, Sequential combination of fractional CO2 laser and subcision, Fractional CO2 laser
- Where
- Vietnam
- Volunteers
- 34 people
- Sponsor
- Ho Chi Minh City Hospital of Dermato-Venereology
Fibromyalgia
Micronized and Ultramicronized Palmitoylethanolamide in Fibromyalgia Patients
The onset of chronic Fibromyalgia symptomatology is due to central alterations, together with peripheral neuroimmune modifications.
- Trial name
- NCT04488926
- Testing
- micronized and ultra-micronized Palmitoylethanolamide (mPEA and umPEA, 300mg + 600mg) microgranules, Standard Therapy, Rescue Drug
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Epitech Group SpA