Clinical trials: Physical activity
Pulmonary Diseases, Oxygen Therapy
Effects of High-Flow Nasal Cannula on Exercise Outcomes in Lung Transplant Candidates: A Pilot Study
The study evaluated patients on the national lung transplant waiting list. It was pioneering in assessing high-complexity patients with severe pulmonary diseases subjected to a cardiopulmonary rehabilitation protocol using a…
- Conditions
- Pulmonary Diseases, Oxygen Therapy, High-flow Nasal Cannula, Exercise Tolerance
- Trial name
- NCT06620081
- Testing
- Performance Tests, Functional Tests
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Israelita Albert Einstein
Physical Disability, CP (Cerebral Palsy)
Evaluating the Impacts of a Single Session of Robot Assisted Gait Training With a Trexo
Early use of robotic gait trainers have shown many benefits, however why these benefits occur and how to maximize them is unknown.
- Conditions
- Physical Disability, CP (Cerebral Palsy), Developmental Disability
- Trial name
- NCT06407219
- Testing
- Robot Assisted Gait Training
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Advanced or Metastatic KRAS-mutant Tumor in Pancreatic Adenocarcinoma, Advanced or Metastatic KRAS-mutant Tumor in Colorectal Cancer
Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.
This is a study designed to assess the safety, tolerability, pharmacokinetics and preliminary efficacy of WEF-001 as monotherapy in patients with Advanced KRAS-mutant solid tumours.
- Conditions
- Advanced or Metastatic KRAS-mutant Tumor in Pancreatic Adenocarcinoma, Advanced or Metastatic KRAS-mutant Tumor in Colorectal Cancer, Advanced or Metastatic KRAS-mutant Tumor in Non Small Cell Lung Cancer, Advanced Solid Tumors
- Trial name
- NCT07148128
- Testing
- WEF-001
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 110 people
- Sponsor
- Auricula Biosciences Inc.
Advanced Malignancies
A Phase 1 Study of HCB303 in Participants With Advanced Malignancies
A Phase 1, Open-label, Multi-regional, Multicenter, Dose escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity, and Preliminary Antitumor Activity of HCB303 in Participants with…
- Trial name
- NCT07859228
- Testing
- HCB303
- Volunteers
- 150 people
- Sponsor
- FBD Biologics Limited
Skeletal Muscle Hypertrophy, Muscle Weakness
The Effects of Lifting Light or Heavy Weights on Muscle Growth and Strength in Trained Young Men
When practicing weightlifting regularly the body makes new proteins within the muscle. These new proteins can increase the size of the cells within the muscle to make them larger, a process called hypertrophy.
- Trial name
- NCT02139865
- Testing
- 30% 1RM, 80% 1RM
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Obstructive Pulmonary Disease
Effects of Breathing Retraining in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Conventional pulmonary rehabilitation programs improve exercise tolerance, peripheral muscle strength, and health related quality of live but not pulmonary function in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01175265
- Testing
- respiratory biofeedback
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital, Essen
Stroke
A Closed Loop Neural Activity Triggered Stroke Rehabilitation Device
The purpose of this research is to determine if two non-invasive brain stimulation techniques, muscle stimulation of the arm and neuro-stimulation through the tongue, can increase the extent of stroke recovery.
- Trial name
- NCT02098265
- Testing
- Functional Electric Stimulation (FES), Behavioral Assessments, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Breast Cancer, Advanced Solid Tumor
An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-75202 (KAT6A/B inhibitor) alone and in combination with other therapies in…
- Trial name
- NCT07222267
- Testing
- BG-75202, CDK4 Inhibitor, Estrogen Receptor Antagonist
- Where
- 32 sites in United States, Australia and 4 more
- Volunteers
- 86 people
- Sponsor
- BeOne Medicines
Healthy Aging
A Health-social Partnership Programme for Improving Health Self-management of Community-dwelling Older Adults
Health-social partnership has been governed by regulations in many developed countries for some years. For instance, the government of United Kingdom has implemented a policy specifically designed to facilitate the discharge of…
- Trial name
- NCT04442867
- Testing
- Case management, Social call
- Where
- Hong Kong
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Decompression Sickness, Endothelial Dysfunction
Exercise and Repetitive Diving
SCUBA diving frequently involves repetitive exposures over multiple days. The goal of this study was to see how exercise impacts microparticles (MPs), endothelial function, and venous gas emboli (VGE) over a series of dives.
- Conditions
- Decompression Sickness, Endothelial Dysfunction, Neutrophil Activation, Venous Gas Emboli
- Trial name
- NCT02118207
- Testing
- Aerobic running exercise
- Where
- 2 sites in United States, Croatia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Split
Cardiac Diseases Requiring Surgery
Investigating the Related Factors and Outcome of Kinesiophobia and the Effects of Multidimensional Interventions in Cardiac Surgery Patients
The primary objective of this two-year research project is to investigate the status of activity fear, its related factors, and prognosis in cardiac surgery patients in the first year.
- Trial name
- NCT06625892
- Testing
- the multidimensional interventions
- Where
- Taiwan
- Volunteers
- 245 people
- Sponsor
- Ai-Ling Chang
Parkinson Disease
Post-Physical Therapy Extension of In-Home Dynamic Standing Table Use in Parkinson Disease
When postural imbalance and gait difficulties emerge in subjects with Parkinson disease, patients are typically referred for a number of physical therapy sessions.
- Trial name
- NCT03045211
- Testing
- Dynamic Standing Table
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Michigan
Weight Loss, Starvation
Resistance Exercise and Protein During Weight Loss
The purpose of this study is to determine if post-exercise protein supplementation can rescue the anabolic response of muscle and bone to resistance exercise during caloric restriction.
- Trial name
- RIDE (NCT03600311)
- Testing
- Caloric Restriction, Post-Exercise Protein, Energy Balance
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Cervical Radiculopathy
Transcutaneous Electrical Nerve Stimulation Versus Repetitive Transcranial Magnetic Stimulation on Pain and Functional Outcome in Cervical Radiculopathy
this study will be conducted to compare between transcutaneous electrical nerve stimulation versus repetitive transcranial magnetic stimulation on pain and functional outcome in cervical radiculopathy
- Trial name
- CR (NCT07557511)
- Testing
- Transcutaneous Electrical Nerve Stimulation, repetitive Transcranial Magnetic Stimulation
- Volunteers
- 50 people
- Sponsor
- Cairo University
Parenting Stress, Positive Mental Health
Preliminary Efficacy of the AdoptMindful2Care@Web: A Web-Based Mindful Parenting Post-Adoption Intervention for Adoptive Parents
The development of post-adoption interventions aimed at promoting parental well-being and positive parenting is an urgent need. Mindful Parenting-based interventions appear to be particularly promising in this field, as they…
- Trial name
- NCT07534111
- Testing
- pAdoptMindful2Care@Web
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- University of Coimbra
Advanced Solid Tumors, Non-small Cell Lung Cancer
Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung Cancer
This is the first human study to use X-396 (ensartinib), a drug being developed for treatment of advanced cancers. The initial purpose of the study is to determine the largest amount of X-396 that can be safely given to humans…
- Trial name
- NCT01625234
- Testing
- Phase I: X-396 (ensartinib), Phase II: X-396 (ensartinib)
- Where
- 14 sites in United States
- Volunteers
- 131 people
- Sponsor
- Xcovery Holdings, Inc.
Post-COVID-19 Syndrome
Physiotherapy in Post COVID-19 Syndrome Patients
Patients who have undergone COVID-19 infection often have long-term sequelae. One of the most prevalent sequelae is pain. The main objective of this research is to investigate the efficacy of a cognitive behavioral…
- Trial name
- NCT05477199
- Testing
- Cognitive behavioral principles-based treatment program, Control intervention
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Universidad de Granada
Diabetic Neuropathies, Peripheral Nervous System Diseases
Effect of Physical Therapy in Improving the Health of Patients With Diabetic Peripheral Neuropathy
People with diabetes can have nerve damage in their extremities (peripheral neuropathy), and this can lead them to being less able to maintain their balance when they are standing, walking or performing complex movement tasks in…
- Trial name
- DPN-QoL (NCT02115932)
- Testing
- Strength & Balance Training
- Where
- Singapore
- Volunteers
- 143 people
- Sponsor
- National University Health System, Singapore
Exercise Physiology, Ventilatory Threshold
Modality-Specific Heart Rate Differences at Ventilatory Thresholds During Unified Ramp Testing
The purpose of this study was to investigate the heart rate bias between cycling and treadmill exercise at ventilatory thresholds. This was a randomized crossover trial involving 23 healthy participants.
- Conditions
- Exercise Physiology, Ventilatory Threshold, Heart Rate, Cycling and Treadmill Exercise
- Trial name
- NCT07718594
- Testing
- Cycle Ergometer CPET, Motorized Treadmill CPET (Porszász Protocol)
- Where
- Taiwan
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Cathay General Hospital
Burn Pit Exposure
Tele-Exercise for MERP
During Operations Desert Shield and Desert Storm, Veterans in combat were exposed to a variety of airborne hazards, including oil well fire smoke, emissions from burn pits, and other substances associated with negative health…
- Trial name
- TEMPO (NCT07018466)
- Testing
- Tele-exercise, Standard of Care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
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