Clinical trials: Prednisolone, completed
Acute GVH Disease
MTX and Steroid as First-line Therapy for aGVHD
The aim of the study is to identify the efficacy and safety of methotrexate (MTX) combined corticosteroid as first-line therapy for acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation…
- Trial name
- NCT04960644
- Testing
- MTX, Corticosteroid
- Where
- China
- Volunteers
- 157 people
- Sponsor
- Peking University People's Hospital
Lymphoma, Follicular
To Demonstrate Equivalence of Pharmacokinetics and Noninferiority of Efficacy for CT-P10 in Comparison With Rituxan
This study is a Phase 3 prospective, randomised, parallel-group, active controlled, double blind, multicentre, international study with 2 coprimary endpoints designed to demonstrate equivalence in pharmacokinetics (Part 1), as…
- Trial name
- rituximab (NCT02162771)
- Testing
- Rituxan, CT-P10, Cyclophosphamide
- Volunteers
- 140 people
- Sponsor
- Celltrion
Healthy
A Study to Compare Ocular Safety and Tolerability of Prednisolone Acetate 0.5% Eye Drops Versus Vehicle in Healthy Volunteers
The objective of this trial was to confirm the tolerability of prednisolone acetate 0.5% eye drops by testing the hypothesis that the ocular safety and tolerability of prednisolone acetate 0.5% eye drops are equivalent to…
- Trial name
- NCT00134992
- Testing
- Prednisolone acetate
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Novartis
Covid19, Cytokine Release Syndrome
Investigational Treatments for COVID-19 in Tertiary Care Hospital of Pakistan
Beyond supportive care, there are currently no proven treatment options for coronavirus disease (COVID-19) and related pneumonia, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).Investigators have seen…
- Conditions
- Covid19, Cytokine Release Syndrome, Critical Illness, ARDS
- Trial name
- NCT04492501
- Testing
- Therapeutic Plasma exchange, Convalescent Plasma, Tocilizumab
- Where
- Pakistan
- Volunteers
- 600 people
- Sponsor
- UNICEF
Allergic Conjunctivitis
Evaluation of Efficacy of Coadministration of FOV1101-00 and Prednisolone Acetate in Patients With Mild Ongoing Ocular Allergic Inflammation
This is a phase 2 study that will consist of 3 visits during a 3 week period conducted at up to 5 sites. The purpose of this study is to determine how effective the combination of Pred Mild® and FOV1101-00 is compared to either…
- Trial name
- NCT00833495
- Testing
- Prednisolone Acetate 0.12% (Pred Mild®), FOV1101-00, Prednisolone Acetate 1% (Pred Forte®)
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Fovea Pharmaceuticals SA
Covid19
Evaluation of the Efficacy of High Doses of Methylprednisolone in SARS-CoV2 ( COVID-19) Pneumonia Patients
This double blind, randomized study is aiming to evaluate the efficacy of three doses (1gr/day) of methylpredisolone added to standard therapy in patients, with documented COVID-19 pneumonia, requiring hospitalization but not…
- Trial name
- NCT04673162
- Where
- 20 sites in Italy
- Volunteers
- 260 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Healthy
Urinary Aquaporin 2 Excretion After Methylprednisolone in Fasting Healthy Humans
We wanted to test the hypotheses that methylprednisolone up regulates u-AQP-2 in fasting healthy humans
- Trial name
- NCT00281710
- Testing
- Methylprednisolone
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Healthy
CIRcadian Rhythms and CortisoL. Effects on Substrate Metabolism and Clock Gene Expression and Functioning
The aim of this project is to study the effects of exogenous glucocorticoid exposure on substrate metabolism, energy expenditure and correlates of circadian rhythmicity in healthy adults.
- Trial name
- CIRCLE (NCT06035081)
- Testing
- Prednisolone
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diffuse Large B Cell Lymphoma
Ibrutinib and Standard Immuno-Chemotherapy in Younger, High-Risk Patients With Diffuse Large B-Cell Lymphoma
This study will investigate if treatment results obtained with R-CHOEP in young high-risk patients with diffuse large B-cell lymphoma can be further improved by the addition of ibrutinib to this regimen.
- Trial name
- R-CHOEP-brut (NCT03399513)
- Testing
- Ibrutinib Oral Capsule [Imbruvica], R-CHOEP chemotherapy
- Where
- 12 sites in Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital Muenster
Frozen Shoulder
Oral Corticosteroids Versus Exercises On Treatment Of Frozen Shoulder,
The purpose of this study is to compare the efficacy of exercise and oral corticosteroids the treatment of a FS.
- Trial name
- NCT05212740
- Testing
- Corticosteroid, Exercise
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 33 people
- Sponsor
- Istanbul University
Cataract
Study to Evaluate the Safety for the Treatment of Inflammation Associated With Cataract Surgery
The study is a prospective, randomized, parallel-design, multicenter trial in patients ≥40 years of age undergoing cataract surgery.
- Trial name
- NCT02547623
- Testing
- Dexamethasone, Prednisolone
- Where
- 11 sites in United States
- Volunteers
- 194 people
- Sponsor
- ICON Bioscience Inc
Lymphoma
Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00433459
- Testing
- cyclophosphamide, dacarbazine, prednisolone
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 2,134 people
- Sponsor
- Christine Mauz-Körholz
Idiopathic Pulmonary Fibrosis With Acute Exacerbation
Efficacy of Steroid Pulse Therapy in Acute Exacerbation of Idiopathic Pulmonary Fibrosis (AE-IPF) Admitted in ER
Idiopathic pulmonary fibrosis is the most severe form of interstitial lung disease. It is known that the prognosis is poor due to extensive inflammation and fibrosis of the lung parenchyma.
- Trial name
- NCT04996303
- Testing
- Routine steroid administration group, Steroid pulse therapy group
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Cough
The Utility of feNO in the Differential Diagnosis of Chronic Cough
In this study the investigators wish to explore the difference in 24 hr. cough counts measured using the Hull Automated Cough Counter (HACC), from baseline and after two weeks treatment with either montelukast or prednisolone in…
- Trial name
- TUF (NCT02479074)
- Testing
- Montelukast (High FeNO group), Prednisolon, Montelukast (High FeNO), Montelukast (Low FeNO group)
- Where
- United Kingdom
- Volunteers
- 49 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
IGA Nephropathy
Inhibition of the Renin Angiotensin System Plus Corticosteroids for the Treatment of Proteinuria in IGA Nephropathy
TO ASSESS THE EFFICACY OF THE RENIN ANGIOTENSIN SYSTEM PLUS STEROIDS TO DECREASE THE AMOUNT OF PROTEINURIA IN IGA NEPHROPATHY
- Trial name
- NCT00367562
- Testing
- ENALAPRIL VALSARTAN METHYLPREDNISONE
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Hospital Britanico
Fanconi Anemia
Hematopoietic Stem Cell Transplantation in High Risk Patients With Fanconi Anemia
RATIONALE: A bone marrow or umbilical cord blood transplant may be able to replace blood-forming cells that were destroyed by chemotherapy.
- Trial name
- NCT00258427
- Testing
- anti-thymocyte globulin, filgrastim, busulfan
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Alcoholic Hepatitis
Short Course Steroids in Alcohol Associated Hepatitis
Alcohol-associated hepatitis (AAH) is one of the most severe manifestations of the spectrum of alcohol related liver disease (ARLD), with high morbidity and mortality.
- Trial name
- STASHII (NCT06919458)
- Testing
- Prednisolone 40 mg
- Where
- 2 sites in India
- Volunteers
- 151 people
- Sponsor
- Asian Institute of Gastroenterology, India
VKH Syndrome
Oral Prednisolone Versus Posterior Sub-Tenon Triamcinolone for Acute Ocular VKH
Vogt-Koyanagi-Harada (VKH) disease is a rare autoimmune disorder characterized by bilateral ocular inflammation that may lead to serous retinal detachment and permanent visual impairment if not promptly treated.
- Trial name
- VKH-OC (NCT07405489)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma
Study of Ibrutinib in Combination With Rituximab-CHOP in Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma
This study was conducted to evaluate the complete response rate of Ibrutinib + R-CHOP in patients with Epstein-Barr virus-positive diffuse large B-cell lymphoma.
- Trial name
- NCT02670616
- Testing
- Ibrutinib, Rituximab, Cyclophosphamide
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Samsung Medical Center
Osteoarthritis of the Knee
Treatment Of Knee Osteoarthritis With Intra-Articular Infliximab
The purpose of this study is to determine if an anti-inflammatory drug, called infliximab, will reduce inflammation in the synovial lining in patients with an early stage of osteoarthritis of the knee.
- Trial name
- NCT01144143
- Testing
- Infliximab, Standard of Care: Methylprednisolone acetate
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Herbert Lindsley, MD
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