Clinical trials: Prednisolone, completed
Multiple Myeloma
A Study of JNJ-26866138 (Bortezomib) in Untreated Multiple Myeloma Patients Who Are Not Candidates for Hematopoietic Stem Cell Transplant (HSCT)
The purpose of the study in Phase I is to select the recommended dose of bortezomib in combination with melphalan and prednisolone in Japanese participants.
- Trial name
- NCT00985959
- Testing
- JNJ-26866138 0.7 mg/m2, JNJ-26866138 1.0 mg/m2, JNJ-26866138 1.3 mg/m2
- Where
- 28 sites in Japan
- Volunteers
- 101 people
- Sponsor
- Janssen Pharmaceutical K.K.
Pneumonia
Steroid Dosing by bioMARker Guided Titration in Critically Ill Patients With Pneumonia
This research study is being done to determine the appropriate dose of steroids and the appropriate duration for steroid use to reduce inflammation in severe pneumonia needing a form of breathing support.
- Trial name
- NCT03852537
- Testing
- Methylprednisolone, Usual Care
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Mayo Clinic
Idiopathic Thrombocytopenic Purpura
Platelet Function in Idiopathic Thrombocytopenic Purpura (ITP) Patients With Eltrombopag
This is a single-center, prospective, controlled study with one eltrombopag treatment group and 2 control groups, one on standard steroid treatment, and another one untreated.
- Trial name
- PLATEFUN (NCT00888901)
- Testing
- eltrombopag, corticosteroids (Aprednislon)
- Volunteers
- 30 people
- Sponsor
- Ingrid Pabinger, MD
Renal Impairment
A Single Dose Evaluation of the Effects of Renal Impairment on Deflazacort Pharmacokinetics
This is a non-randomized, open-label, single-dose study to compare the PK of 21 desacetyl-DFZ and, if data permits, deflazacort in 8 subjects with ESRD to that of 8 healthy matched control subjects (age, body mass index [BMI]…
- Trial name
- NCT02286622
- Testing
- Deflazacort
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- PTC Therapeutics
Tracheal Stenosis
Investigation of the Effect of Systemic Steroids on Treatment and Prevention of Recurrent Tracheal Stenosis in Postoperative Patients
tracheal stenosis is the result of abnormal wound-healing processes leading to hypertrophic scar formation and obstruction of the airway lumen by excess granulation tissue.
- Trial name
- NCT02855502
- Testing
- Prednisolone
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- National Research Institute of Tuberculosis and Lung Disease, Iran
Healthy
CIRcadian Rhythms and CortisoL. Effects on Substrate Metabolism and Clock Gene Expression and Functioning
The aim of this project is to study the effects of exogenous glucocorticoid exposure on substrate metabolism, energy expenditure and correlates of circadian rhythmicity in healthy adults.
- Trial name
- CIRCLE (NCT06035081)
- Testing
- Prednisolone
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Prostate Neoplasms
An Safety and Efficacy Study of Abiraterone Acetate in Participants With Advanced Prostate Cancer Who Failed Androgen Deprivation and Docetaxel-Based Chemotherapy
The purpose of this study is to assess the anti-tumor activities and safety of abiraterone acetate in participants with prostate cancer (a disease in which cells in the prostate gland [a gland in the male reproductive system…
- Trial name
- NCT00474383
- Testing
- Abiraterone acetate, Glucocorticoid
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 47 people
- Sponsor
- Cougar Biotechnology, Inc.
Kidney Transplantation
Effectiveness and Safety of Campath in Combination With Tacrolimus Monotherapy to Prevent Kidney Graft Rejection
The purpose of this study is to determine whether Campath following Tacrolimus monotherapy is more effective in the prevention of renal graft rejection (considering an acute rejection rate of 5% for Campath-1H/Tacrolimus and of…
- Trial name
- NCT00147381
- Testing
- Alemtuzumab, Tacrolimus
- Where
- Austria
- Volunteers
- 197 people
- Sponsor
- Dr. Claudia Bösmüller
Leukemia
Imatinib Mesylate and Combination Chemotherapy With or Without a Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
RATIONALE: Giving chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells.
- Trial name
- NCT00618501
- Testing
- cytarabine, daunorubicin hydrochloride, etoposide
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Asan Medical Center
Metastatic Castration-Resistant Prostate Cancer, Metastatic Breast Cancer
Study to Evaluate CCS1477 in Advanced Tumours
A Phase 1/2a study to assess the safety, tolerability, PK and biological activity of CCS1477 in patients with metastatic castration resistant prostate cancer, metastatic breast cancer, non-small cell lung cancer or advanced solid…
- Conditions
- Metastatic Castration-Resistant Prostate Cancer, Metastatic Breast Cancer, Non-small Cell Lung Cancer, Advanced Solid Tumors
- Trial name
- NCT03568656
- Testing
- CCS1477, Abiraterone acetate, Enzalutamide
- Where
- 19 sites in United States, France and 4 more
- Volunteers
- 219 people
- Sponsor
- CellCentric Ltd.
PD-1 Antibody, Hemophagocytic Lymphohistiocytosis
L-DEP Regimen Combined With PD-1 Antibody as Induction Therapy for Epstein-Barr Virus-positive LA-HLH
The efficacy and safety of L-DEP (aspargase, liposomal doxorubicin, etoposide, and methylprednisolone) regimen combined with PD-1 Antibody an induction therapy for Epstein-Barr virus (EBV)-positive lymphoma-associated…
- Conditions
- PD-1 Antibody, Hemophagocytic Lymphohistiocytosis, Epstein-Barr Virus, Lymphoma
- Trial name
- NCT05775705
- Testing
- L-DEP and PD-1 antibody
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Beijing Friendship Hospital
Vitiligo
ERASE VITILIGO Early Repigmentation Approach for Stopping the Evolution of VITILIGO Prospective Multicentric Interventional Study With Blinded Evaluation
Vitiligo affects 1 to 2% of worldwide population and has a demonstrated impact on the quality of life. Optimal treatment of vitiligo requires to target the auto-immune inflammatory response (to halt the depigmentation process)…
- Trial name
- ERASE (NCT04843059)
- Testing
- The resident memory T-cell infiltrate in perilesional vitiligo skin
- Where
- 2 sites in France
- Volunteers
- 51 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lymphoma
Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Hodgkin Lymphoma
RATIONALE: Imaging procedures, such as fludeoxyglucose F 18 (FDG)-PET/CT scan, done before, during, and after chemotherapy may help doctors assess a patient's response to treatment and help plan the best treatment.
- Trial name
- NCT00678327
- Testing
- bleomycin sulfate, filgrastim, pegfilgrastim
- Where
- United Kingdom
- Volunteers
- 1,202 people
- Sponsor
- University College, London
Cataract Surgery
A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery
The primary objective was to demonstrate that two days of treatment with 0.5% prednisolone acetate eye-drops after cataract surgery are superior to vehicle in reducing the flare in the anterior chamber of the operated eye.
- Trial name
- NCT00170729
- Testing
- Prednisolone acetate
- Volunteers
- 62 people
- Sponsor
- Novartis
Multisystem Inflammatory Syndrome-Children
MIS-C Comparative Effectiveness Study
In March 2020, children exposed to the virus that causes the COVID-19 illness, SARS-CoV-2, presented with fever and significant inflammation about a month after exposure to the virus.
- Trial name
- MISTIC (NCT04898231)
- Testing
- Infliximab, Anakinra, Methylprednisolone
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- University of California, San Diego
Graft Versus Host Disease
Phase II Trial of Natalizumab + Prednisone for Initial Therapy of Acute GI GVHD
This research study is a Phase II clinical trial, which tests the safety and effectiveness of an investigational drug Natalizumab in treating Acute Graft-Versus-Host Disease (GVHD) in the Gastrointestinal (GI) Tract.
- Trial name
- NCT02176031
- Testing
- Natalizumab, Methylprednisolone
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Dana-Farber Cancer Institute
Dermatitis, Contact
A Study To Assess Safety And Effectiveness Of Medrol In Contact Dermatitis In Indian Patients
This study will be a prospective, non-interventional, single arm and open label study, in patients with contact dermatitis requiring systemic steroid therapy with a purpose to obtain the real life effectiveness and tolerability…
- Trial name
- NCT00929981
- Testing
- Tablet Methylprednisolone (4 or 16 mg)
- Where
- 4 sites in India
- Volunteers
- 80 people
- Sponsor
- Pfizer
Post Procedural Infection
Assessing Dextenza Insert After SMILE Procedure
This three-month prospective, open-label, single-center, randomized investigator initiated clinical study seeks to investigate the efficacy of DEXTENZA when placed in the lower canaliculus (study eye) compared to topical…
- Trial name
- NCT04380857
- Testing
- Dexamethasone ophthalmic insert 0.4 mg, Topical Prednisolone Acetate Ophthalmic Drops
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- William Wiley, MD
Diffuse B-Cell Lymphoma
Study of Safety and Efficacy of Avadomide (CC-122) Combined With RCHOP for Newly-diagnosed DLBCL With Poor Risk Factors
This is Phase 1/2 study of avadomide (CC-122) in combination with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy, for first-line treatment of patients with Diffuse B-Cell Large B-Cell…
- Trial name
- NCT03283202
- Testing
- Avadomide (CC-122), Rituximab, Cyclophosphamide 750mg/m2 by IV infusion
- Where
- 15 sites in United States, Belgium and 2 more
- Volunteers
- 35 people
- Sponsor
- Celgene
Carpal Tunnel Syndrome, Tenosynovitis
Comparison of the Efficacy of Corticosteroid Injection and ESWT in Patients With CTS
In this study, the investigators aimed to demonstrate the efficacy of ESWT (extracorporeal shock wave therapy) and local corticosteroid injection in patients with carpal tunnel syndrome(CTS) compared to participants receiving…
- Trial name
- NCT03792945
- Testing
- local injection, extracorporeal shock wave therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ahi Evran University Education and Research Hospital
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