Clinical trials: Prednisolone, completed
Vitiligo
ERASE VITILIGO Early Repigmentation Approach for Stopping the Evolution of VITILIGO Prospective Multicentric Interventional Study With Blinded Evaluation
Vitiligo affects 1 to 2% of worldwide population and has a demonstrated impact on the quality of life. Optimal treatment of vitiligo requires to target the auto-immune inflammatory response (to halt the depigmentation process)…
- Trial name
- ERASE (NCT04843059)
- Testing
- The resident memory T-cell infiltrate in perilesional vitiligo skin
- Where
- 2 sites in France
- Volunteers
- 51 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Obstructive Pulmonary Disease
Intravenous Versus Oral Administration of Prednisolone in Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
Treatment with systemic corticosteroids for acute exacerbations of COPD results in the improvement of clinical outcomes. The optimal route of administration has not been rigorously studied in COPD.
- Trial name
- NCT00311961
- Testing
- Intravenous prednisolone, Oral prednisolone
- Where
- Netherlands
- Volunteers
- 256 people
- Sponsor
- Isala
Coccydynia
TARGETING DUAL PATHWAYS IN REFRACTORY COCCYDYNIA
This retrospective cohort study included 60 patients aged 18-65 years treated at a tertiary pain clinic between June 2022 and June 2024.
- Trial name
- NCT07060313
- Testing
- Ganglion Impar Block, Ganglion Impar Block and Pericoccygeal Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Multiple Sclerosis, Chronic Progressive, Nervous System Diseases
Intrathecal Rituximab in Progressive Multiple Sclerosis
The goal of investigators is to study the kinetics of action of a single dose of intrathecally-infused rituximab upon cerebro-spinal fluid (CSF) biological targets in progressive MS patients.
- Trial name
- EFFRITE (NCT02545959)
- Testing
- Rituximab IT, methylprednisolone IV, Rituximab IV
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier de PAU
Rheumatoid Arthritis
A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study
The purpose of the study is to compare the effects of methotrexate (MTX) alone or in combination with intravenous (IV) methylprednisolone (MP) or infliximab (IFX) on MRI-detected synovitis, bone edema and erosive changes in early…
- Trial name
- NCT00396747
- Testing
- Infliximab, methylprednisolone, methotrexate, Methotrexate, Methotrexate + Methylprednisolone
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Université Catholique de Louvain
Asthma
Inflammation Following Mepolizumab and Oral Corticosteroids in Asthma
The aim of the project is to study the persistence of inflammation after addition of an interleukin-5 (IL-5) blocker in severe eosinophilic asthma as a study of untreated pathways in these patients.
- Trial name
- MAPLE (NCT03610685)
- Testing
- Prednisolone
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Cataract
Prophylactic Treatment: Lessdrops™ vs Standard Drops Regimen
To compare the use of a compounded eye drop containing an antibiotic, a non-steroidal and steroidal anti-inflammatory to standard of care that is the use of 3 different topical medications to prevent inflammation and infection…
- Trial name
- NCT03578276
- Testing
- Pred-Gati-Brom, Prednisolone acetate 1% ophthalmic suspension, Gatifloxacin Ophthalmic
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Carolina Eyecare Physicians, LLC
Complications
Preoperative Glucocorticoid Use in Major Hepatectomy
Background: Reducing postoperative complications remains a dominant challenge for all clinicians. By minimizing the incidence of adverse outcomes, health care costs and patient recovery can be improved.
- Trial name
- NCT01997658
- Testing
- Methylprednisolone
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Calgary
Non Hodgkin Lymphoma
A Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL)
Previously untreated CD20 positive diffuse large B-cell lymphoma (DLBCL) requiring full course chemoimmunotherapy.
- Trial name
- ACCEPT (NCT03571308)
- Testing
- R-CHOP + acalabrutinib
- Where
- 7 sites in United Kingdom
- Volunteers
- 39 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Bronchopulmonary Dysplasia
Phase III Randomized, Double-Blind Study of Dexamethasone Vs Dexamethasone/Methylprednisolone Vs Placebo for Bronchopulmonary Dysplasia
OBJECTIVES: I. Compare the efficacy of dexamethasone (DM) vs. DM/methylprednisolone treatment vs. placebo, initiated within the first month of life, on long-term pulmonary and developmental outcomes in premature infants with…
- Trial name
- NCT00004785
- Testing
- dexamethasone, methylprednisolone
- Volunteers
- 54 people
- Sponsor
- National Center for Research Resources (NCRR)
Healthy Participants
Pharmacokinetic Interaction Trial of Clofutriben With Midazolam and Prednisolone
Drug: 2 single oral doses of midazolam, 2 single oral doses of prednisolone , and clofutriben once daily for 16 days.
- Trial name
- DDI (NCT07226635)
- Testing
- midazolam, clofutriben once daily for 16 days, 2 single oral doses of prednisolone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sparrow Pharmaceuticals
Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty
The type of anti-inflammatory medication used post selective laser trabeculoplasty (SLT) may have an impact on the intra-ocular pressure (IOP) lowering effect of SLT.
- Trial name
- NCT00485108
- Testing
- prednisolone 1%, ketorolac 0.5%, Artificial Tears (Methyl cellulose drops)
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University
Osteoarthritis of the Carpometacarpal Joint, Thumb Osteoarthritis
The Use of Intra-articular Corticosteroid Injection to Treat Osteoarthritis of the Carpometacarpal Joint
This randomized clinical trial (RCT) will evaluate 6-month outcomes following intra-articular injections for arthritis of the thumb carpometacarpal (CMC) joint by comparing corticosteroid plus local anesthetic versus saline…
- Trial name
- NCT04177433
- Testing
- Depo-Medrol Injectable Product, Saline
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Alberta
Prostate Cancer
A Phase 2 Study to Evaluate Safety and Efficacy of Abiraterone in Participants With Prostate Cancer
The purpose of this study is to investigate safety and efficacy of abiraterone in participants with metastatic castration-resistant prostate cancer (mCRPC) and who have not received prior chemotherapy (treatment of disease…
- Trial name
- NCT01756638
- Testing
- Abiraterone, Prednisolone
- Where
- 19 sites in Japan
- Volunteers
- 48 people
- Sponsor
- Janssen Research & Development, LLC
Graft Versus Host Disease
Efficacy and Safety of Prochymal® Infusion in Combination With Corticosteroids for the Treatment of Newly Diagnosed Acute Graft Versus Host Disease (GVHD)
This is a Phase III, randomized, double-blind, placebo-controlled study to investigate the efficacy and safety of Prochymal® versus placebo in combination with corticosteroids as initial therapy for acute GVHD.
- Trial name
- NCT00562497
- Testing
- Prochymal®, Corticosteroid
- Where
- 53 sites in United States, Australia and 1 more
- Volunteers
- 192 people
- Sponsor
- Mesoblast, Inc.
Corneal Ulcer, Eye Infections, Bacterial
Steroids for Corneal Ulcers Trial
The purpose of this study is to determine whether adding topical steroids improves the outcomes of bacterial corneal ulcers, especially visual acuity.
- Trial name
- SCUT (NCT00324168)
- Testing
- Antibiotics, Topical corticosteroid
- Where
- 5 sites in United States, India
- Volunteers
- 500 people
- Sponsor
- Thomas M. Lietman
Age Related Cataract, Pain Management During Cataract Surgery
Iris Vascular Area Density-Based Preoperative Pain-Risk Screening and Intervention in Second-Eye Cataract Surgery
This clinical trial aims to evaluate the effectiveness of pranoprofen or prednisolone acetate eye drops for pain management in patients undergoing second-eye surgery for age-related cataracts.
- Trial name
- NCT07291089
- Testing
- Pranoprofen eye drops, Prednisolone acetate eye drops, Sodium hyaluronate eye drops
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Asses Immunosuppression Modulation on Renal Recovery Post LT
Examination of Immunosuppression Adjustment Impact on Kidney Function in Liver Transplant
This is a study to help understand how well new combinations of immunosuppressive medications (medications that weaken your immune system to prevent your body from rejecting the transplanted liver) work compared to standard…
- Trial name
- NCT04104438
- Testing
- Basiliximab 20 MG
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Fady M Kaldas, M.D., F.A.C.S.
Bell's Palsy, Facial Nerve Paresis
Intratympanic Steroid for Bell's Palsy
Facial nerve paralysis is due to inflammation around the facial nerve. Current treatment for facial nerve paralysis is a 10 day course of oral steroids (which will reduce the inflammation), with electrodiagnostic testing.
- Trial name
- NCT03508440
- Testing
- Intratympanic injection, Prednisone
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Missouri-Columbia
Rheumatoid Arthritis
Comparison of Combination Disease Modifying Antirheumatic Drugs With Methotrexate Therapy in Early Rheumatoid Arthritis
This study will be conducted to find out how well a patient of rheumatoid arthritis (RA) will respond to disease-modifying antirheumatic drugs (DMARDs).
- Trial name
- NCT02644499
- Testing
- Methotrexate, Leflunomide, Hydroxychloroquine
- Where
- India
- Volunteers
- 186 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
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