Clinical trials: Probiotic
Irritable Bowel Syndrome
A Single-arm, Open-label Clinical Trial to Evaluate the Effect of SMT04 in Irritable Bowel Syndrome (IBS)
Probiotic supplements improve IBS symptoms through manipulation of the gut microbiota. Metabolites derived from microbiota metabolism and host-microbiota co-metabolism have an impact on host intracellular signalling pathways.
- Trial name
- NCT06636513
- Testing
- SMT04 (M3XTRA)
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Changi General Hospital
Healthy Volunteers
Effects of S. Boulardii and Amoxicillin/Clavulanate on Gut Microbiota
The purpose of this study is to compare and contrast the effects of the probiotic Saccharomyces boulardii, the antibiotic amoxicillin/clavulanate and the combination on the gut microbiota of healthy volunteers.
- Trial name
- NCT01473368
- Testing
- Saccharomyces boulardii, Amoxicillin Clavulanate
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Severe Depression
Probiotic Supplementation in Severe Depression
Recent research demonstrates that the composition of the gut microbiome is a master regulator of key neurophysiological processes that are affected in depression.
- Trial name
- NCT02957591
- Testing
- Vivomixx®
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Psychiatric Hospital of the University of Basel
Irritable Bowel Syndrome
Exploring the Mechanism of a Probiotic Combination VSL#3 in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a very common chronic gastrointestinal disorder. Existing therapies for IBS are still far from satisfactory and new therapies are being constantly sought.
- Trial name
- NCT00786123
- Testing
- VSL#3
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National University Hospital, Singapore
Gestational Diabetes Mellitus
The Effect of Oral Probiotics on Glycemic Control of Women With Gestational Diabetes Mellitus
Scientific background: Uncontrolled gestational diabetes mellitus (GDM) is associated with severe maternal and neonatal morbidities. Treatment of GDM is multidisciplinary and includes lifestyle changes and medications.
- Trial name
- NCT03864549
- Testing
- Femina II
- Where
- 4 sites in Israel
- Volunteers
- 93 people
- Sponsor
- HaEmek Medical Center, Israel
Viral Diarrhea
Effect of the Use of Probiotic S. Boulardii on Acute Viral Inflammatory Diarrhea Diagnosed With Multiplex PCR.
Acute diarrhea (AD) has been a public health problem throughout the history of Mexico. According to the epidemiological surveillance system, between 2008-2017, five to six million new cases of AD occurred per year.
- Trial name
- NCT05226052
- Testing
- Saccharomyces boulardii (Floratil 600mg)
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Instituto Mexicano del Seguro Social
Bacterial Vaginosis, Yeast Infection
A Study to Evaluate the Effects of a Prebiotic and Probiotic Supplement to Provide Relief From Symptoms Associated With Bacterial Vaginosis and Yeast Infections.
This virtual randomized controlled trial evaluates the efficacy of a prebiotic and probiotic supplement in providing relief from symptoms associated with bacterial vaginosis and yeast infections.
- Trial name
- NCT06665126
- Testing
- Prebiotic + Probiotic Supplement
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Happy V
Diarrhea, Atopic Dermatitis
Cesarean Section Study
Effect, tolerance and safety of a supplementation with a probiotic on the risk of gastrointestinal infections, on growth, and on gut microbiota in healthy newborn term infants born by Cesarean section.
- Trial name
- NCT01992497
- Testing
- Probiotic
- Where
- Germany
- Volunteers
- 721 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Gut Resistome
Effect of Probiotics on the Fecal Resistome During Helicobacter Pylori Eradication Therapy
Eradication therapy against Helicobacter pylori (Hp) carries adverse effects, such as altering the intestinal microbiota's structure and function and selecting commensals and pathogens resistant to antibiotics.
- Trial name
- NCT04786938
- Testing
- Saccharomyces Boulardii-Containing Product in Oral Dose Form
- Volunteers
- 72 people
- Sponsor
- Universidad San Francisco de Quito
Healthy
Evaluation of the Vaginal Colonization of Two New Lactobacillus Strains After Oral Administration in Healthy Volunteers
Randomized study to determine whether the vaginally isolated strains of Lactobacillus gasseri and/or Lactobacillus crispatus can colonize the vagina when taken orally for 18 days.
- Trial name
- NCT05688397
- Testing
- Experimental 1, Experimental 2
- Where
- Spain
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AB Biotics, SA
Diarrhea
Prevention of Traveler's Diarrhea
The prevention of traveller's diarrhea makes use of the selection of foods and drinks, the purification of water, the use of pharmacological substances such as bismuth salicylate and rifaximin (which can only be taken for short…
- Trial name
- NCT06125626
- Testing
- Probiotical
- Where
- Italy
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Black Stains
Investigating the Bactericidal Effect of Probiotics on Chromogenic Bacteria in Children An In Vivo and In Vitro Study
To investigate the bactericidal effect of probiotics (Streptococcus salivarius M18 and Lactobacillus reuteri) on two types of bacteria (Aggregatibacter actinomycetemcomitans and Actinomyces naeslundii) causing black stains of…
- Trial name
- NCT06834815
- Testing
- Probiotic with Prebiotic
- Where
- Egypt
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Oral Lichen Planus
Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus
Lichen planus is a chronic inflammatory mucocutaneous disease, which often results in oral manifestations, receiving the name of oral lichen planus (OLP).
- Trial name
- NCT03386643
- Testing
- Bifidobacterium animalis subsp. lactis HN019, Clobetasol propionate 0.05%
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo
Gingivitis, Inflammation
Assessment of a Probiotic to Treat Gingivitis in Pediatric Patients
This study investigates the efficacy of a proprietary probiotic formulation comprising 6 strains of bacteria in reducing inflammation and gingivitis in pediatric patients between 11 and 18 years old undergoing orthodontics…
- Trial name
- NCT01954849
- Testing
- Probiotic formulation
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Recurrent Respiratory Tract Infections
Evaluation of Lactobacillus Reuteri DSM 17938 + Vitamin D3 in the Prevention of RRI in Paediatric Patients
The aim of this protocol is to evaluate, in a multicenter, randomized, double blind vs placebo clinical trial the effects of a marketed food supplement containing Lactobacillus reuteri DSM 17938 and vitamin D3 (Reuterin® D3) in…
- Trial name
- LR_D3 (NCT04408443)
- Testing
- Lactobacillus reuteri DSM 17938 + Vitamine D3
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Noos S.r.l.
Streptococcus Pyogenes Pharyngotonsillitis
Prophylactic Effect of Probiotic Streptococcus Salivarius eK12 Against Recurrent Streptococcus Pyogenes Pharyngotonsillitis Infection in Pediatrics
Recurrent Group A Streptococcus (GAS) infections, primarily presenting as strep throat, are a significant health concern in pediatric populations, leading to symptoms like sore throat, fever, and swollen lymph nodes.
- Trial name
- NCT06370208
- Testing
- Probiotic Bactoblis® EVOL (Streptococcus salivarius eK12), Oral vit D3
- Where
- 4 sites in Pakistan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Liaquat University of Medical & Health Sciences
Irritable Bowel Syndrome With Subthreshold Depression
Lactobacillus-containing Cultured Milk Drink Alleviates Depression Score Among Adults With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is frequently associated with any form of psychiatric comorbidities including subthreshold or subclinical depression.
- Trial name
- NCT05266443
- Testing
- Lactobacillus containing cultured milk drink
- Where
- Malaysia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Healthy
Effect of Consumption of a Novel Functional Yogurt on Blood Biomarkers of Healthy Participants
The purpose of the study is to assess the effect of a dietary intervention that includes the consumption of a novel functional yogurt (enriched with probiotics and polyphenols) on the blood biomarkers of healthy participants.
- Trial name
- FB-CL1 (NCT05612243)
- Testing
- Consumption of a meal with yogurt enriched with probiotics immobilized on oat flakes and polyphenols, Consumption of a meal with yogurt enriched with probiotics immobilized on oat flakes, Consumption of a meal with plain Yogurt with oat flakes
- Where
- Greece
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- ANTONIOS KOUTELIDAKIS
Obesity, Abdominal, Adiposity
Probiotics and the Gut Microbiome in Obese Hispanic Youth
This study will recruit 40 obese Hispanic youth (12 - 18 years of age who are greater than or equal to Tanner stage 4) from hospitals, clinics, and community centers.
- Trial name
- NCT03115385
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Breast Cancer, Hair Loss
Alleviation of Alopecia in Breast Cancer Patient Using Synbiotics Formula
This study aims to explore the efficacy and safety of a synbiotic formula (BLHK03) in alleviating chemotherapy-induced alopecia (CIA) in breast cancer patients and the compositional and functional changes in the gut microbiome of…
- Trial name
- NCT06560385
- Testing
- BLHK03
- Where
- 2 sites in Hong Kong
- Volunteers
- 7 people
- Sponsor
- GenieBiome Limited