Clinical trials: Propofol, completed
Obstructive Sleep Apnea, Obesity
Effect of Nasal Positive Airway Pressure Versus Standard Care on Oxygenation and Ventilation During Propofol-based Sedation for Colonoscopy in Patients With High Risk of Airway Obstruction
The purpose of this study is to to compare oxygenation and ventilation on spontaneously ventilating obese patients or those with diagnosed or undiagnosed Obstructive sleep apnea (OSA) undergoing day colonoscopy under Propofol…
- Trial name
- NCT05524220
- Testing
- Standard care with a facemask., SuperNO2VA™EtCO2 (Nasal Oxygenating Ventilating Apparatus)
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- The University of Texas Health Science Center, Houston
Conscious Sedation
Conscious Sedation for Cataract Operations Under Topical Anaesthesia
Topical anaesthesia of the eye for ophthalmologic procedures avoids pain and discomfort of local anaesthetic injection in the peribulbar or retrobulbar block so that patient comfortability is achieved.
- Trial name
- NCT03933280
- Testing
- Nalbuphine, Propofol, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Menoufia University
Measure Time to First Rescue Analgesia Following Extubation
Opioid Free Anesthesia in Shoulder Arthroscope
The investigators will assess opioid free anesthesia technique as regards effectiveness \& duration of post operative analgesia in shoulder arthroscpe surgeries
- Trial name
- NCT06834854
- Testing
- fentanyl, Lidocaine (drug)
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Children Under General Anesthesia
Target-controlled Infusion of Propofol for Induction of Pediatric Anesthesia
The purpose of this study is to determine a effect-site concentration of propofol in children 3 to 11 years effective to make a induction of general anesthesia.
- Trial name
- NCT01411020
- Testing
- endotracheal intubation
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Depression
The Use of Ketamine as an Anaesthetic During Electroconvulsive Therapy
The main aim of this research is to ascertain whether Ketamine would be a more effective anaesthetic for Electroconvulsive Therapy (ECT) than the standard anaesthetic.
- Trial name
- KANECT (NCT01306760)
- Testing
- Ketamine, Propofol
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Aberdeen
Anesthesia
The TI.VA Algorithm: A First-in-Humans Test.
The TI.VA algorithm is a new method to titrate the anesthetic drug concentrations whenever the planned level of anesthesia results to be not appropriate to blunt the patient's reaction to surgical stimulation.
- Trial name
- TIVAly (NCT05199883)
- Testing
- TI.VA algorithm: decision support system
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Premedication, Endotracheal Intubation
Premedication Trial for Tracheal Intubation of the NEOnate
Multicenter double blind randomized controlled trial comparing "atropine+propofol" vs "atropine+atracurium+sufentanil" as a premedication prior to endotracheal intubation of the neonate.
- Trial name
- PRETTINEO (NCT01490580)
- Testing
- atropine+ propofol, atropine + atracurium + sufentanil
- Where
- 6 sites in France
- Volunteers
- 173 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Breast Cancer
Natriuretic Peptide Concentrations of B-type (BNP) During Anesthesia in Patients Previously Sensitized to Anthracyclines
The cardiotoxicity of anthracyclines chemotherapy remains a major problem, despite clinical and echocardiographic monitoring. In the case of treatment for breast cancer, surgery requiring general anesthesia may follow…
- Trial name
- PEP-NAT-B (NCT01754597)
- Testing
- Dosage of B-type natriuretic peptide (NT-proBNP)
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Institut Bergonié
Disorder; Mental, Sedative, Pain, Postoperative
Comparison of Hemodynamics Between Dexmedetomidine and Propofol for Sedation in Patients With Abdominal Surgery
This is a single-blind randomized clinical trial. Patients undergoing abdominal tumor surgery were recruited to participate in the study.
- Conditions
- Disorder; Mental, Sedative, Pain, Postoperative, Surgery
- Trial name
- NCT02393066
- Testing
- Propofol, Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Hypoxemia, Gastrointestinal Endoscopy
THRIVE in Sedated Gastrointestinal Endoscopy
This prospective observational study aims to evaluate the effectiveness of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) compared to standard nasal cannula (SNC) oxygen supplementation in patients…
- Trial name
- NCT07487051
- Testing
- High-Flow Nasal Oxygen (THRIVE), Standard Nasal Cannula Oxygen
- Where
- Turkey (Türkiye)
- Volunteers
- 222 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Valvular Heart Disease, Aortic Disease
Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery
CD39 and CD73 was known protein expressed on surface of Th1 and Th17 cell and modulate immune related reaction. Cardiopulmonary bypass (CPB) can induce inflammatory reaction during cardiac surgery, and induce immunosuppression.
- Trial name
- NCT02136979
- Testing
- Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Konkuk University Medical Center
Anesthesia
Comparison of Different Propofol Formulations With or Without Remifentanil
The objective of this study is to evaluate the influence of different propofol formulations (plain or with remifentanil) on anesthetic induction.
- Trial name
- PropofolRemi (NCT01592162)
- Testing
- Propofol (Astra-Zeneca), NaCl 0.9%, propofol 1% (Astra-Zeneca) and remifentanil, Propofol (Astra-Zeneca) and remifentanil
- Where
- 2 sites in France
- Volunteers
- 409 people
- Sponsor
- Hopital Foch
Anesthesia-induced Negative Hemodynamic Effects
Atropine-effect During Propofol/Remifentanil Induction
Remifentanil is a widely used potent intravenous opioid with the advantage of having a short time of action. Compared to other opiates however remifentanil generates more intense hemodynamic side-effects.
- Trial name
- NCT01871922
- Testing
- Atropine
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University Medical Center Groningen
Aspiration
Study on General Population of the Effect on Airway Protection of Drugs Used During Induction of General Anesthesia
Upper esophageal sphincter is a high pressure zone of the pharynx and protects airway from aspiration of esophageal or gastric contents.
- Trial name
- NCT04413422
- Testing
- type of hypnotic used for induction of general anesthesia
- Volunteers
- 20 people
- Sponsor
- Hospital San Carlos, Madrid
Sleep
The Effect of Ketamine on Sleep Quality in Patients Undergoing Colonoscopy
Sedation typically begins with 2 mg of midazolam (0.025-0.1 mg/kg), followed by propofol given initially at 0.5-1.0 mg/kg bolus doses, with additional 0.25-0.5 mg/kg boluses as needed every 1-3 minutes to maintain sedation.
- Trial name
- NCT06498869
- Testing
- Ketamine Hcl 50Mg/Ml Inj
- Where
- Turkey (Türkiye)
- Volunteers
- 178 people
- Sponsor
- Kocaeli City Hospital
Early Gastric Cancer, Gastric Adenoma
Performance of Endoscopic Submucosal Dissection According to the Sedation Method
Although proper sedation is mandatory for endoscopic procedures such as endoscopic submucosal dissection, the effects of sedation on ESD performance and complications have not been fully evaluated.
- Trial name
- NCT01806753
- Testing
- Intermittent midazolam/propofol injection controlled by endoscopist, Continuous propofol infusion with opioid administration
- Where
- South Korea
- Volunteers
- 157 people
- Sponsor
- Yonsei University
Burst Suppression, Electroencephalogram
Impact of Interscalene Block Combined With General Anesthesia on Burst Suppression in Shoulder Surgery Patients
This prospective, randomized, double-blind clinical study aimed to investigate the effects of combining general anesthesia with an interscalene brachial plexus block (ISB) on burst suppression ratio (BSR) and…
- Conditions
- Burst Suppression, Electroencephalogram, Interscalene Brachial Plexus Block
- Trial name
- NCT07081672
- Testing
- Ultrasound-guided interscalene brachial plexus block (ISB), General Anesthesia (control group)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
General Anesthesia
The Affecting Factors on Airway Temperature and Moisture
There is no literature information about the flow rate of fresh gas mixture (air+O2) in the patients who underwent general anesthesia.
- Trial name
- NCT04204746
- Testing
- We will observe and evaluate the temperature and moisture in the respiratory circuit by a thermo-hygrometer.
- Volunteers
- 240 people
- Sponsor
- Selcuk University
Shock,, Sepsis
Effects of Sedatives on Sublingual Microcirculation of Patients With Septic Shock
Previous studies have demonstrated that altered microvascular blood flow is an important marker of severe sepsis. Usually, these patients need invasive ventilatory support, frequent use of sedatives and it is unknown if these…
- Trial name
- NCT01618396
- Testing
- Sedation drug (Propofol and Midazolam)
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- Casa de Saúde São José
Autonomic Nervous System Imbalance
Effects of Propofol Induction Anaesthesia on the Heart Rate Variability
The ANS plays an important role in the regulation of hemodynamics during anesthesia. Manually blous of propofol during induction anesthesia is reported to reduce both sympathetic and parasympathetic tone; however, it is not clear…
- Trial name
- NCT03613961
- Testing
- Anesthetics
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Central University