Clinical trials: Propofol, completed
Use of Dexmedetomidine in Cardiac Surgery (CABG, Valve Replacement or Total Aortic Arch Replacement)
Effect of Dexmedetomidine on Hemodynamics in Cardiac Surgery
It is important to establish a stable haemodynamics in patients undergoing cardiac surgery. Haemodynamic depression is common during induction of anaesthesia [1].
- Trial name
- NCT06958913
- Testing
- Propofol group, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Pamukkale University
Cancer of Liver, Cancer of Pancreas
Effects of Dexmedetomidine During IRE Procedures for Solid Tumours
The purpose of the study is to evaluate effects of dexmedetomidine on anaesthesia during IRE procedures for solid tumours
- Trial name
- NCT02044224
- Testing
- Dexmedetomidine
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University Hospital
Comparison of the Effects of Propofol and Nasal Dexmedetomidine
Propofol vs. Nasal Dexmedetomidine in Pediatric Agitation and Delirium
Dental pain and anxiety are quite common in pediatric patients. However, due to children's inability to express their fears and lack of knowledge about the procedures to be performed, these symptoms have often been misunderstood…
- Trial name
- NCT06466915
- Testing
- Dexmedetomidine, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Anesthesia, Spinal
Sedation by Dexmedetomidine and Propofol
Under the hypothesis that dexmedetomidine sedation would result in less upper airway obstruction, we evaluated the occurrence of upper airway collapse or the requirement of airway intervention in patients with obstructive sleep…
- Trial name
- NCT02993718
- Testing
- Dexmedetomidine, Propofol
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Seoul National University Bundang Hospital
Post-Mastectomy Chronic Pain Syndrome
Radiofrequency for Chronic Post-mastectomy Pain: is it Better to Target Intercostal Nerves or Corresponding Dorsal Root Ganglia?
neuropathic pain can occur following any surgical procedure on the breast ..
- Trial name
- NCT03374423
- Testing
- radiofrequency
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Cardiac Surgery
Post Operative Hemodynamic Function After Anesthetic Induction With Etomidate for Cardiac Surgery With ECC
Because of its hemodynamic safety, etomidate is widely used for anaesthesia induction of cardiac surgery. It can also cause adrenal insufficiency during the following 48 hours ( 11 betahydroxylase inhibition ).
- Trial name
- NCT00451776
- Testing
- etomidate, propofol
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Inguinal Hernia
Inflammatory Response: General vs Spinal Anesthesia
Objective: This study aimed to compare the effects of general and spinal anesthesia on the inflammatory response by measuring intercellular adhesion molecule-1 (ICAM-1), P-selectin (SELP), and thrombomodulin (TM) levels in…
- Trial name
- NCT07567534
- Testing
- inflammatory response during inguinal hernia repair.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sezen Kumaş Solak
Anesthesia, General
Comparison of Sugammadex With Neostigmine During Laparoscopic Cholecystectomy or Appendectomy (P05699)
The current trial was designed to demonstrate faster recovery from a neuromuscular blockade (NMB) induced by rocuronium after reversal at 1-2 Post Tetanic Count (PTC) by 4.0 mg.kg-1 sugammadex compared to 50 µg.kg-1 neostigmine…
- Trial name
- NCT00724932
- Testing
- Rocuronium, Sugammadex, Neostigmine
- Volunteers
- 140 people
- Sponsor
- Merck Sharp & Dohme LLC
Procedural Sedation
Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy
Nonanesthesiologist administration of propofol for sedation is actually a field of growing interest for endoscopists, as demonstrated by recent American and European guidelines on this issue.
- Trial name
- MIDAPROP (NCT01428882)
- Testing
- Midazolam, Propofol
- Where
- Spain
- Volunteers
- 135 people
- Sponsor
- Infante, Javier Molina, M.D.
Intubation; Difficult
Intubation Time With Low Dose Rocuronium
The investigators hypothesized that increasing the cardiac output by use of atropine in children might result in a reduction of the intubation time needed to facilitate tracheal intubation.
- Trial name
- NCT01464489
- Testing
- Atropine, Normal saline
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Gachon University Gil Medical Center
Pediatric Anesthesia, Airway Management
Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children
This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA)…
- Conditions
- Pediatric Anesthesia, Airway Management, General Anesthesia, LMA
- Trial name
- NCT07581665
- Testing
- Alfentanil
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Postoperative Delirium, Postoperative Recovery in Elderly Patients
Recovery After Upper Extrimety Surgery
The goal of this randomized clinical trial is to determine whether Bispectral Index (BIS)-guided general anesthesia improves postoperative cognitive recovery and overall quality of recovery in adults undergoing elective hand or…
- Conditions
- Postoperative Delirium, Postoperative Recovery in Elderly Patients, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- Recovery (NCT07714928)
- Testing
- BIS-Guided General Anesthesia, Clinically Guided General Anesthesia
- Where
- Sweden
- Volunteers
- 112 people
- Sponsor
- Region Örebro County
Arthropathy of Knee, Anesthesia
IPACK Nerve Block for Total Knee Arthroplasty
Double-blind, randomized controlled clinical trial to test the efficacy of IPACK on postoperative opioid consumption, patient satisfaction, pain scores, mobility, and several other secondary outcomes in adults undergoing primary…
- Trial name
- NCT03921034
- Testing
- Ropivacaine, Saline
- Volunteers
- 72 people
- Sponsor
- Ochsner Health System
Elective Thyroidectomy
Effect of Remifentanil on Cough During Emergence From General Anesthesia : Trial to Compare Between Sevoflurane Anesthesia and Propofol Anesthesia
The objective of this study was to compare the effect of remifentanil on suppression cough reflex during emergence in patient anesthetized using either propofol or sevoflurane additionally under infusion of the identical…
- Trial name
- NCT01240109
- Testing
- Remifentanil
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Endothelial Dysfunction, Ischemia Reperfusion
Effects of Anesthesia Technique on Endothelial Function
The aim of this study was to compare the effects of two different anesthesia methods, general anesthesia and infraclavicular block, on oxidative stress and endothelial dysfunction in upper extremity forearm operations.This…
- Conditions
- Endothelial Dysfunction, Ischemia Reperfusion, Oxidative Stress
- Trial name
- NCT06515028
- Testing
- Group GA, Group IB
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Bagcilar Training and Research Hospital
Hemodynamics Instability, Anesthesia, General
Hemodynamics During Induction of General Anesthesia With High and Low Propofol Dose.
The study objective is to examine if a high propofol dose is non-inferior to a low dose in respect to hemodynamic stability in healthy patients during induction of general anesthesia with propofol and remifentanil.
- Conditions
- Hemodynamics Instability, Anesthesia, General, Anesthesia, Intravenous
- Trial name
- PH (NCT03861364)
- Testing
- Propofol
- Where
- Norway
- Volunteers
- 68 people
- Sponsor
- Helse Fonna
Postoperative Pain
Ketamine or Neostigmine for Serratus Anterior Plane Block in Modified Radical Mastectomy
The aim of this study is to Investigate the analgesic efficacy of adding ketamine compared to neostigmine to local anesthetic in Ultrasound guided Serratus anterior plane block for patients undergoing Modified Radical Mastectomy.
- Trial name
- NCT04544228
- Testing
- Serratus Anterior Plane Block Technique, General anesthesia, bupivacaine +ketamine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Joint Dislocation, Perianal Abscess
Adjunctive Nitrous Oxide During Emergency Department Propofol Sedation in Adults
The purpose of this study is to describe the safety and efficacy of nitrous oxide administration for pain and anxiety before propofol in patients requiring any procedure under sedation in the Emergency Department.
- Conditions
- Joint Dislocation, Perianal Abscess, Abscess
- Trial name
- NCT02410707
- Testing
- Nitrous Oxide arm, Propofol, Oxygen
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Albert Einstein Healthcare Network
Supratentorial Tumor
Desflurane and Brain Relaxation in Craniotomy
Optional brain relaxation improves the surgeon's operating conditions and is likely to minimize the degree of retraction injury ,with the potential for providing patients with a better outcome.
- Trial name
- NCT04691128
- Testing
- Desflurane, Propofol
- Where
- China
- Volunteers
- 111 people
- Sponsor
- Beijing Tiantan Hospital
Phobias
The Effect of Intravenous Anesthetics on Fear Learning and Memory
People often develop fearful responses to things, but have no conscious control over the fear. This is a basic form of unconscious memory, called "fear conditioning." Intravenous anesthetic drugs have remarkable effects on…
- Trial name
- NCT00767767
- Testing
- Propofol 0.45mcg/mL, Propofol 0.90mcg/mL, Thiopental 1.5mcg/mL
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University