Clinical trials: Propofol, completed
Diagnostic Gastroscopy
Intravenous Lidocaine to Reduce Propofol Consumption During Gastroscopy.
The goal of this clinical trial is to assess if intravenous administration of linisol reduce the propofol consumption and the sides effects of sedation during gastroscopy in healthy patients (ASA 1 and 2 patients).
- Trial name
- NCT05944887
- Testing
- Lidocaine 2% Injectable Solution, Propofol injection, gastroscopy
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- Erasme University Hospital
Consciousness, Level Altered
The Neural Mechanisms of Anesthesia and Human Consciousness
The explanation of consciousness poses one of the greatest challenges to science and philosophy in the 21st century. It remains unclear what consciousness is and how it emerges from brain activity.
- Trial name
- LOC-2013 (NCT01889004)
- Testing
- Dexmedetomidine, Propofol
- Where
- Finland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Turku
Conscious Sedation
Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH
The investigators hypothesize that magnesium sulphate owing to its analgesic and sedative properties is not inferior to fentanyl in providing conscious sedation as adjuvants to propofol and local injection of lidocaine in…
- Trial name
- CSDH (NCT03548493)
- Testing
- Magnesium sulphate, Fentanyl, Propofol
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Kasr El Aini Hospital
Sedation
Acute Neurological ICU Sedation Trial (ANIST)
Dexmedetomidine (Precedex, Hospira) is a "super" selective alpha2-agonist - 8-10x more avid binding to alpha2 receptors than clonidine - and may have particularly favorable characteristics as a continuous i.v.
- Trial name
- ANIST (NCT00390871)
- Testing
- Fentanyl/Dexmedetomidine, Fentanyl/Propofol, Fentanyl
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Critical Illness
The Use of Nociception Flexion Reflex and Pupillary Dilatation Reflex in ICU Patients.
The aim of the study was to describe the feasibility of the nociception flexion reflex and the pupillary dilatation reflex as objective pain assessment tools in the Intensive Care Unit (ICU).
- Trial name
- NCT02916004
- Testing
- Measurement of NFR and PDR
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp
Major Depressive Disorder, Recurrent Depressive Disorder
Deep Brain Stimulation in Patients With Chronic Treatment Resistant Depression
Major depressive disorders are real public health issues in terms of diagnosis and treatment. Some forms of depression are chronic and resistant to treatment (TRD). In these forms suicide risk is important.
- Conditions
- Major Depressive Disorder, Recurrent Depressive Disorder, Bipolar Disorder
- Trial name
- STHYM (NCT01973478)
- Testing
- DBS
- Where
- 5 sites in France
- Volunteers
- 9 people
- Sponsor
- Rennes University Hospital
Delirium, Emergence Delirium
EEG - Guided Anesthetic Care and Postoperative Delirium
The study is a prospective, double blinded, randomized and controlled parallel trial to investigate the effect of the anesthetic care guided by EEG monitor (SedLine) on postoperative delirium.
- Conditions
- Delirium, Emergence Delirium, Anesthesia, General, Electroencephalography
- Trial name
- EMODIPOD (NCT03330236)
- Testing
- Anesthetic "depth" management
- Where
- China
- Volunteers
- 1,560 people
- Sponsor
- Yale University
Monitored Anesthesia Care, Respiratory Monitoring
Importance of Integrated Pulmonary Index in Pediatric Bronchoscopy
Integrated Pulmonary Index (IPI) is a tool that provides numerical values on a scale of 1-10 based on physiological parameters such as peripheral oxygen saturation (SpO2), pulse rate, respiratory rate, end-tidal carbon dioxide…
- Trial name
- NCT05137587
- Testing
- Integrated Pulmonary Index (IPI) monitoring, propofol, ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Colorectal Cancer
Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery
Objectives: To compare free-opioid anesthesia (the combination of epidural anesthesia, intravenous lidocaine, ketamine, propofol, and sevoflurane) and opioid anesthesia (fentanyl, propofol and sevoflurane) regarding…
- Trial name
- NCT06042816
- Testing
- Free-opioid anesthesia, opioid anesthesia
- Where
- Vietnam
- Volunteers
- 49 people
- Sponsor
- Vietnam Military Medical University
Dexmedetomidine, Thoracoscopy
Dexmedetomidine in Non-intubated VATS
This prospective study aims to evaluate the effectiveness of intraoperative DEX for postoperative analgesia and recovery after non-intubated VATS.
- Conditions
- Dexmedetomidine, Thoracoscopy, Analgesia
- Trial name
- NCT05863416
- Testing
- Dexmedetomidine infusion
- Where
- Taiwan
- Volunteers
- 144 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Moderate Sedation, Deep Sedation
Sedation and Neuromediators Concentration
Propofol (Propofol Kabi, Registration number from the State Register of Medicines - 000875) is a widely used intravenous anesthetic.
- Trial name
- NCT04695509
- Testing
- moderate propofol sedation (Bispectral index monitoring 70-90; The Richmond Agitation and Sedation scale (RASS) "-2" - "-3", deep propofol sedation (BIS 60-70, The Richmond Agitation and Sedation scale (RASS) "-4")
- Where
- Russia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Parkinson's Disease (PD)
A General Anesthesia Regimen for DBS Surgery in Patients With PD
Patients who meet the enrollment criteria and voluntarily join this study will be admitted to the operating room on the day of surgery, and will receive endotracheal intubation under general anesthesia.
- Trial name
- GADBS (NCT06658132)
- Testing
- 0.5~1ug/kg/min remifentanil combined with 0.2~0.5mg/kg/h esketamine for the physiological testing phase of DBS surgery.
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Surgery, Anesthesia
Propofol Versus Sevoflurane Recovery After Gynecological Surgery
80% of 25 million American who undergo surgery describe moderate to severe pain. The use of multimodal analgesic techniques can attenuate patient's postoperative pain and several different medication have been found to be…
- Trial name
- NCT01755234
- Testing
- Sevoflurane, Propofol
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Northwestern University
Sedation
Sedation MRI - Propofol Versus Propofol-Ketamin in Children
Children < 10 years of age often need deep sedation or anaesthesia to allow elective diagnostic magnetic resonance imaging; standard routine protocols are 1.
- Trial name
- NCT01519154
- Testing
- Propofol, Ketamine-Propofol
- Where
- Switzerland
- Volunteers
- 347 people
- Sponsor
- Achim Schmitz
General Anesthesia
Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas
This study should compare the propofol concentration in breathing gas and in plasma (before and) after lung passage. Propofol concentrations in breathing gas are continuously measured by a sensor.
- Trial name
- NCT00532402
- Where
- 2 sites in Germany
- Volunteers
- 16 people
- Sponsor
- University of Luebeck
PREGNANCY
Prophylactic Subhypnotic Propofol for Nausea and Vomiting During for Cesarean Section Under Subarachnoid Anesthesia.
Perioperative nausea and vomiting may occur in 50-80% of patients undergoing cesarean section. Metoclopramide is a well known Dopamine receptor antagonist that acts at the Chemoreceptor trigger zone and is used effectively for…
- Trial name
- NCT01781377
- Testing
- PROPOFOL, METOCLOPRAMIDE
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- G. d'Annunzio University
Cognition Disorder
Inflammatory Markers and Level of Cortical Hyperactivity
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease that is manifested by severe cognitive impairment mainly from late life (>65 years).
- Trial name
- IMCH (NCT05991830)
- Testing
- General anesthesia
- Where
- 2 sites in Chile
- Volunteers
- 20 people
- Sponsor
- University of Chile
Delirium, Lumbar Radiculopathy
Shaping Anesthetic Techniques to Reduce Post-operative Delirium
The purpose of this study is to determine if light sedation with spinal anesthesia reduces the incidence of delirium compared to receiving general anesthesia during spinal surgery in older adults.
- Conditions
- Delirium, Lumbar Radiculopathy, Lumbar Osteoarthritis, Lumbar Spine Disc Degeneration
- Trial name
- SHARP (NCT03133845)
- Testing
- Light sedation with propofol, Induction with propofol, Maintenance anesthetic using a volatile anesthetic
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- Johns Hopkins University
Renal Failure
Caudal Epidural Catheterization in Pediatric Renal Transplant: Effect on Hemodynamics and Pain After Surgery
pain control in pediatric renal transplant is a major concern. the main goal during anesthesia of renal transplant in pediatrics is to maintain hemodynamics in a range close to that of the adult donor.
- Trial name
- NCT02037802
- Testing
- B-Braun, Perifix® ONE Paed, Germany, Pethidine, Propofol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Oxidative Stress, Anesthesia
Effects of TIVA and Inhalation Anesthesia on Oxidative Stress Factors During Hypotensive Anesthesia
Total intravenous anesthesia (TIVA) and inhalation anesthesia are two anesthesia methods that can be preferred for the maintenance of anesthesia. Sevoflurane and propofol are drugs used frequently in these methods.
- Trial name
- NCT04310748
- Testing
- Total Intravenous Anesthesia(TIVA), Inhalation Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University