Clinical trials: Propofol, completed
Advanced Lung Carcinoma, Non-small Cell Lung Cancer
Efficacy and Safety of First-line Anti-PD-1/PD-L1 Monoclonal Antibody in Combination With Chemotherapy and Bronchoscopy-assisted Interventional Therapy in Patients With Advanced Central Non-small Cell Lung Cancer
Lung cancer is one of the malignant tumors with high morbidity and mortality. Several PD-1/PD-L1 immune checkpoint inhibitors have been approved for the treatment of advanced non-small cell lung cancer (NSCLC).
- Trial name
- NCT04702009
- Testing
- Chemoimmunotherapy (CIT): Sintilimab + Platinum-Based Doublet Chemotherapy
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
DNA Damage, Anesthesia
Comparison of the Genotoxicity of Desflurane and Propofol
The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.
- Trial name
- NCT05185167
- Testing
- Anesthetics, General Desflurane Maintenance, Anesthetics, General Propofol Maintenance
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Hip Fracture
Effect of Anesthesia Technique on Outcome After Hip Fracture Surgery in Elderly Adult Patients
Despite many previous studies, whether anesthetic technique will significantly affect overall patient outcome, morbidity and mortality in elderly hip fracture patients is controversial.
- Trial name
- NCT02458547
- Testing
- Desflurane, Propofol, Bupivacaine
- Where
- South Korea
- Volunteers
- 186 people
- Sponsor
- Yonsei University
Nausea, Vomiting
Sevoflurane-Remifentanil Anaesthesia. The Risk of Post Operative Nausea
The purpose of this study is to determine whether sevoflurane-remifentanil anaesthesia is similar to propofol-remifentanil anaesthesia concerning post- operative nausea and vomiting.
- Trial name
- NCT00452855
- Testing
- Sevoflurane-remifentanil anaesthesia
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Central Jutland Regional Hospital
Osteoarthritis, Hip, Osteoarthritis, Knee
Spinal Anaesthesia vs. General Anaesthesia for THA, TKA and UKA
The goal of this randomized clinical trial is to investigate the postoperative recovery following hip and knee arthroplasty procedures depending on the use of either spinal anaesthesia (SA) or general anaesthesia (GA).
- Trial name
- RCT SAGA (NCT05706844)
- Testing
- Spinal anesthesia, General anaesthesia
- Where
- 2 sites in Denmark
- Volunteers
- 222 people
- Sponsor
- Anders Troelsen
Anesthesia
Lidocaine and Closed-Loop Anesthesia System
The objective is to evaluate the sparing effect of Lidocaine on doses of propofol and remifentanil.
- Trial name
- LoopLido (NCT01154738)
- Testing
- Lidocaine
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Hopital Foch
Anesthesia
MAPD: Modifiable Factors Affecting Propofol Dosing
The investigators aim to understand the effect of a caffeine intake, sleep habits, anxiety about surgery, alcohol intake and smoking status upon the dose of the anaesthetic drug, propofol, required for anaesthetic induction.
- Trial name
- NCT03453099
- Testing
- Preoperative Questionnaires, Postoperative Subjective Pain Scores
- Where
- United Kingdom
- Volunteers
- 91 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Thyroid Operation Under General Anesthesia
Comparison Between Propofol-remifentanil Total Intravenous Anesthesia and Desflurane-remifentanil Balanced Anesthesia With Regard to Post-anesthetic Functional Recovery Measured With QoR-40
Total intravenous anesthesia (TIVA) and inhalation anesthesia are both widely and safely used, and there are many clinical trials comparing these on various aspects of anesthesia.
- Trial name
- NCT01760018
- Testing
- desflurane group, TIVA group
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Yonsei University
Obesity
Adiponectin Polymorphisms, Insulin Resistance, and Pharmacokinetics in Obesity
The primary objective of this study is to determine the influence of insulin resistance on drug metabolism and response in obese subjects.
- Trial name
- NCT01593397
- Testing
- Propofol and Fentanyl administration
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Awareness, Anesthesia, Recall Phenomenon
Awareness in Old Aged Patients During Laryngoscopy and Intubation Using Isolated Forearm Technique
Awareness during general anesthesia - that has an incidence between 0.1% and 0.9% of cases and may be more in elderly - remains a concern for anesthesiologists.
- Conditions
- Awareness, Anesthesia, Recall Phenomenon, Inhalation; Gas
- Trial name
- NCT05019560
- Testing
- Sevoflurane, TIVA
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Upper Gastrointestinal Endoscopy, Topical Anesthesia
Oropharyngeoesophageal Topical Anesthesia Versus Propofol - Ketamine Sedation for Upper Gastrointestinal Endoscopy
Esophagogastroduodenoscopy (EGD) is an essential and widely used diagnostic and therapeutic procedure in gastroenterology. EGD can be performed in association with topical anesthesia of the pharynx, intravenous anesthesia, or…
- Conditions
- Upper Gastrointestinal Endoscopy, Topical Anesthesia, Intravenous Sedation
- Trial name
- NCT06566326
- Testing
- Propofol and ketamine, Modified Oropharyngeo-esophygeal Topical Anesthesia by OPETA Prototype tool
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
GERD, Reflux
Role of ARMA in Selective Subset of Refractory GERD Patients.
To study the role of a novel endoscopic treatment technique (ARMA) in GERD patients who doesn't respond to PPI therapy (Proton Pump Inhibitor).
- Conditions
- GERD, Reflux, Reflux Esophagitis
- Trial name
- NCT05899491
- Testing
- ARMA, UGI Endoscopy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Test the Differences Between Schinder's TCI Model and MCI
Total Intravenous Anesthesia: TCI Versus MCI
test the following differences between Schinder's Target Controlled Infusion (TCI ) model and manually controlled infusion (MCI) : remifentanil and propofol total dose given incidence of awareness or inadequate anesthesia number…
- Trial name
- NCT02077478
- Testing
- Remifentanil and propofol administration using TCI, Remifentanil and propofol administration using MCI
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Università degli Studi di Ferrara
Monitored Anesthesia Care, Cardiac Surgery
Monitored Anesthesia Care Versus Intubated General Anesthesia for Open Heart Surgery Under Cardiopulmonary Bypass
Though Cardiac surgery under cardiopulmonary bypass (CPB) under epidural anesthesia in conscious patients is associated with increased risk of epidural hematoma.
- Conditions
- Monitored Anesthesia Care, Cardiac Surgery, Postoperative Recovery
- Trial name
- NCT05011617
- Testing
- Non-intubation and monitoring anesthesia care (MAC)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- ShuGuang Hospital
General Anesthesia, Obesity
Plasmatic Concentrations of Propofol and Remifentanil in Obese and Non Obese Patients.
This prospective monocentric phamacokinetics study aims to compare plasmatic concentrations of Propofol and Remifentanil required to target a specific range of monitored anesthesia and analgesia during sus-mesocolic surgery in…
- Trial name
- COCOPOPONO (NCT04492813)
- Testing
- Pharmacokinetic of propofol and remifentanil
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Postoperative Pain Intensity
Effect of Opioid-Free Versus Opioid-Based Anesthesia in Discectomy Surgery
This prospective randomized double-blind clinical trial compares opioid-free anesthesia (OFA) versus opioid-based anesthesia (OBA) on postoperative analgesia in patients undergoing elective lumbar discectomy surgeries at Zagazig…
- Trial name
- NCT07787858
- Testing
- Dexmedetomidine and Ketamine-based Opioid-free Anesthesia, Fentanyl-based Opioid Anesthesia
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Zagazig University
Liver Cancer, Hepatectomy
Effects of Different Anesthetic Techniques on Intraoperative and Postoperative Pain Levels and Cognitive Function in Patients Undergoing Hepatectomy for Liver Cancer
To evaluate the effects of general anesthesia (GA) versus combined general and epidural anesthesia (GEA) on postoperative pain, cognitive dysfunction (POCD), hospital stay, and recovery quality in liver cancer patients undergoing…
- Conditions
- Liver Cancer, Hepatectomy, Anesthesia Techniques, Postoperative Pain
- Trial name
- NCT07097220
- Testing
- General Anesthesia (GA) group, General-Epidural Anesthesia (GEA) group
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Sir Run Run Shaw Hospital, Qingchun Campus, Zhejiang University School of Medicine,
Laparoscopic Gastric Bypass Surgery, Ketamine
Perioperative Ketamine for Pain With Gastric Bypass
Opioid medications such as morphine, hydrocodone and oxycodone are standard for treating pain after surgery, however there are disadvantages.
- Trial name
- NCT03448068
- Testing
- Ketamine, Standard therapy
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Postoperative Pain
Effects of TIVA With Propofol Versus Inhalational Anaesthesia on Postoperative Pain After Hepatectomy
Propofol is a commonly used intravenous anaesthetic drugs both for induction and maintenance of general anaesthesia. Advantages of total intravenous anaesthesia (TIVA) with propofol include reduced nausea and vomiting, reduced…
- Trial name
- NCT03597997
- Testing
- Propofol, Sevoflurane
- Where
- 2 sites in Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Hemodynamic Instability, Anesthesia
Hemodynamic Changes and Propofol Pharmacokinetic Variation During Anesthesia Induction and Knee-chest Positioning
Induction of anesthesia and the knee-chest position are associated with hemodynamic changes that may impact patient outcomes. Changes from baseline in cardiac output and other hemodynamic variables following induction of…
- Conditions
- Hemodynamic Instability, Anesthesia, Surgery
- Trial name
- NCT03961958
- Testing
- Propofol reduction
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
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