Clinical trials: Propranolol
Cirrhosis, Decompensated Cirrhosis of Liver
Effect of Non-Selective Beta-Blockers on Outcomes in Cirrhosis Patients After Hospitalization: A Retrospective Cohort Using Target Trial Design
The goal of this observational study is to learn if non-selective beta-blockers (NSBB) improve outcomes in patients with chronic hepatitis B or C who are discharged after hospitalization for acute decompensation of cirrhosis.
- Trial name
- NCT06977685
- Testing
- Non-selective beta-blockers
- Where
- South Korea
- Volunteers
- 7,725 people
- Sponsor
- Samsung Medical Center
Supraventricular Tachycardia
Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia
This is a randomized, double-blind, multi-centered study to compare 6 months of medical treatment with digoxin or propranolol in infants with SVT Background: SVT is the most common sustained arrhythmia of infancy.
- Trial name
- NCT00390546
- Testing
- Digoxin, Propranolol
- Where
- 14 sites in United States, Canada
- Volunteers
- 72 people
- Sponsor
- University of British Columbia
Supraventricular Tachycardia
Shortening Duration of Antiarrhythmic Medication for SVT in Infants
The infants diagnosed with SVT are treated with antiarrhythmic medication to prevent the recurrence of SVT. This prospective observational cohort study evaluates efficacy and safety of shortening duration of antiarrhythmic…
- Trial name
- NCT04837261
- Testing
- Propranolol, Flecainide, Amiodarone
- Where
- 18 sites in Finland
- Volunteers
- 107 people
- Sponsor
- Tampere University Hospital
Postpartum Hemorrhage
In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol
The rates of cesarean deliveries (CD) and postpartum hemorrhage (PPH) are on the rise, with failed induction and augmentation of labor as major contributing factors.
- Trial name
- NCT03434444
- Testing
- Oxytocin, Propranolol
- Where
- Canada
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Bleeding Gastric Varices, Liver Cirrhosis
A Randomized Trial of GVS Alone vs. Propranolol
Design a randomized trial to compare the effect of endoscopic cyanoacrylate injection obliteration versus non-selective beta-blocker in the primary prevention of gastric variceal bleeding.
- Trial name
- P-GVO (NCT01298271)
- Testing
- propranolol
- Where
- 2 sites in Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Trauma, Brain
Beta Blocker Effects in Traumatic Brain Injury
The study will be conducted on polytrauma patient who are admitted from emergency room or postoperative with head trauma to evaluate effects of beta blocker on patients with TBI.
- Trial name
- NCT05195996
- Testing
- Propranolol, Saline
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Post-Traumatic Stress Disorder
Patient-Centered Collaborative Care for Preventing Post-Traumatic Stress Disorder After Traumatic Injury
This study will evaluate the effectiveness of patient-centered collaborative care that combines behavioral therapy and drug therapy as compared to usual care in reducing symptoms of post-traumatic stress disorder in people who…
- Trial name
- TSOS II (NCT00270959)
- Testing
- Cognitive Behavioral Therapy, Motivational Interviewing, FDA-Approved Anti-Anxiety Medications
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- University of Washington
Cirrhosis, Variceal Bleeding
EBL Versus EBL and Propranolol for the Prevention of Variceal Rebleeding in Pts With Previous Variceal Treatment
This study is performed to compare the efficacy and safety of EBL alone and EBL combined with propranolol in patients who were previously performed endoscopic variceal treatment.
- Trial name
- NCT00966082
- Testing
- endoscopic band ligation, endoscopic band ligation+Propranolol
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Korea University
Aphasia, Primary Progressive
Propranolol in Primary Progressive Aphasia
The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia.
- Trial name
- NCT06066710
- Testing
- Propranolol, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Missouri-Columbia
Retinopathy of Prematurity
Safety and Efficacy of Propranolol Eye Drops in Treating Retinopathy of Premature
The aim of the present study is to evaluate the safety and efficacy of propranolol eye drops in preterm newborns with a precocious stage of retinopathy of prematurity (ROP).
- Trial name
- DROP-PROP (NCT02014454)
- Testing
- Propranolol eye drops
- Where
- 2 sites in Italy
- Volunteers
- 23 people
- Sponsor
- Meyer Children's Hospital IRCCS
Portal Hypertension, Portal Vein Thrombosis
Preemptive TIPS for Variceal Bleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis
Portal vein thrombosis (PVT) can lead to a further increase in portal venous pressure and increase the risk of rebleeding. Whether patients with acute esophagogastric variceal bleeding with occlusive PVT benefit from preemptive…
- Conditions
- Portal Hypertension, Portal Vein Thrombosis, Esophageal Varix Bleeding, Portosystemic Shunt
- Trial name
- NCT06122753
- Testing
- preemptive TIPS, standard second prophylaxis
- Where
- China
- Volunteers
- 120 people
- Sponsor
- West China Hospital
Syncope
Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance
This study will examine the effectiveness of the drug propranolol in preventing fainting in patients with sympathoadrenal imbalance (SAI).
- Trial name
- NCT00093860
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hemangioendothelioma of Liver
Sirolimus in the Treatment for Infantile Hepatic Hemangioendothelioma(IEEH)
Infantile hepatic hemangioendothelioma (IHHE) is an infantile hemangioma involving the liver.Since 2008, propranolol has been used for the treatment of hemangioma, and some researchers have also started to report the use of…
- Trial name
- PRL-SRL-IHHE (NCT04406870)
- Testing
- Sirolimus Oral Product, propranolol
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai Children's Medical Center
Post-Traumatic Stress Disorder, PTSD
Women Who Are Victims of Violence: Treatment of PTSD Through Reactivation of Traumatic Memories Using Propranolol
Post-traumatic stress disorder (PTSD) develops after life-threatening events, with domestic violence and sexual assault being major risk factors.
- Trial name
- VIOFEM (NCT07792122)
- Testing
- Propranolol, Psychotherapy
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Toulouse
Menopause
Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular…
- Trial name
- NCT06787066
- Testing
- Propranolol Hydrochloride, Phentolamine Injection
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Pulmonary Disease, Chronic Obstructive
A Study to Investigate the Pharmacology of a Dual Pharmacophore in Healthy Volunteers
Study will investigate the pharmacodynamics of a dual pharmacophore in which a combination of GSK961081 and Propanolol is used to give a total effect of bronchodilation.
- Trial name
- NCT00687700
- Testing
- GSK961081, Propranolol
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Diabetes Mellitus, Type 1, Inflammation
The Role of the Adrenergic System in Hypoglycaemia Induced Inflammatory Response in People With Type 1 Diabetes and People Without Type 1 Diabetes-RAID-II
The goal of this trial is to study the effect that adrenaline has on the immune reaction seen during a low blood sugar. People with type 1 diabetes do not produce their own insulin.
- Trial name
- RAID-II (NCT06422494)
- Testing
- hyperinsulinaemic hypoglycaemic clamp, Propranolol Hydrochloride 1 MG/ML, Phentolamine
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cocaine Dependent Subjects
Establishing and Eliminating Cue-drug Associations in Human Cocaine Addiction
We will develop a procedure for conditioning cue-cocaine associations in human drug users. Next, we will reactivate that learning and intervene pharmacologically to prevent the reconsolidation of cue-drug memories.
- Trial name
- NCT01978457
- Testing
- cocaine hydrochloride, propranolol
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Yale University
Supraventricular Tachycardia
Management of Supraventricular Tachycardia of Children
Supraventricular tachycardia (SVT) is defined as an abnormally rapid heart rhythm originating above the ventricles. It usually has narrow complex tachycardia but this is not always the case.
- Trial name
- NCT03528616
- Testing
- adenosine,Propranolol,flecainide, amiodarone, propranolol, digoxin and procainamide.
- Volunteers
- 50 people
- Sponsor
- Assiut University
Labour;Obstructed, Labor Dystocia
Propranolol for Protracted Labor
Induction of labor is one of the most common procedures performed on labor and delivery. In the United States, more than 20 percent of pregnant women undergo an induction of labor [1].
- Trial name
- PRO-Labor (NCT04741698)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services