Clinical trials: Propranolol
Healthy Volunteers
Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
Background: Changes in how a person's body burns energy or calories can affect their weight over time. The lowest level of energy the body needs to function is called basal metabolic rate.
- Trial name
- NCT01950520
- Testing
- Propranolol, Pindolol, Dantrolene
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Posttraumatic Stress Disorder, Anxiety Disorder
Pilot Study of Pharmaceutical and Behavioral Interventions to Treat Anxiety Disorders
The aim of this project is to create fear conditioning paradigm within which the relative strengths of various novel pharmacological and behavioral interventions can be tested.
- Trial name
- NCT01631682
- Testing
- Propranolol, Reactivation, Mifepristone
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Migraine
An Efficacy and Tolerability Study of Topiramate in Participants With Migraine
The purpose of this study is to investigate the adequacy (reasonably good) of topiramate therapy (medicine or medical care given to a participant for a disease or condition) in prevention of migraine (type of severe headache that…
- Trial name
- NCT01060111
- Testing
- Topiramate Standard, Topiramate Slow, Propranolol booster
- Where
- 6 sites in South Korea
- Volunteers
- 250 people
- Sponsor
- Janssen Korea, Ltd., Korea
Hypertension
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/Sotalol
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the…
- Trial name
- NCT05794997
- Testing
- Propranolol or Carvedilol, Atenolol, Bisoprolol or Sotalol
- Where
- United States
- Volunteers
- 817,337 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pregnancy, Prolonged
Propranolol Rescue of Prolonged Labor
A double-blind placebo controlled randomized trial comparing cesarean delivery rates in women given IV propranolol versus placebo for treatment of prolonged labor.
- Trial name
- PROPEL (NCT04299438)
- Testing
- Propranolol Hydrochloride, Saline
- Where
- 2 sites in United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Lisa Levine
Heart Failure, Heart Failure, Diastolic
Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF
In this study, we will test the feasibility of N-of-1 trials for deprescribing beta-blockers in patients with Heart Failure with Preserved Ejection Fraction.
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- NCT04757584
- Testing
- Beta blockers
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Weill Medical College of Cornell University
Migraine Headache
Drug and Non-Drug Treatment Of Severe Migraine
The purpose of this study is to determine if the addition of preventive medication, behavior migraine management or the combination of preventive medication and behavior migraine management improves the outcome of optimal acute…
- Trial name
- TSM (NCT00910689)
- Testing
- Propranolol or nadolol, Behavioral Migraine Management (BMM), Optimal Acute Therapy
- Where
- 2 sites in United States
- Volunteers
- 232 people
- Sponsor
- Ohio University
Infantile Hemangioma
Assessing the Impact of Dosage Frequency of Propranolol on Sleep Patterns in Patients With Infantile Hemangiomas
The purpose of this study is to assess the baseline sleep pattern disruption for patients starting oral propranolol at the standard BID dosing regimen compared to the control (timolol) group and to determine if there is a…
- Trial name
- NCT05479123
- Testing
- Propranolol three times a day, Propranolol twice a day, Timolol
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- The University of Texas Health Science Center, Houston
Locally Advanced Malignant Neoplasm, Breast Cancer
Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
This study is being conducted in patients with newly diagnosed breast cancer that will be undergoing chemotherapy prior to surgery - neoadjuvant chemotherapy.
- Trial name
- NCT01847001
- Testing
- Propranolol, DOT imaging, Paclitaxel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Posttraumatic Stress Disorder
A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation Propranolol
The consolidation of learning is enhanced by adrenalin and other stress hormones. This memory enhancing effect is opposed by propranolol.
- Trial name
- NCT00709735
- Testing
- Propranolol
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Induction of Labor Affected Fetus / Newborn
Propranolol Versus Placebo for Induction of Labor in Nulliparous Patients
A randomized, prospective trial will be offered to women admitted to the labor floors at Mount Sinai Medical Center for labor induction.
- Trial name
- NCT03348683
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Essential Vocal Tremor, Essential Voice Tremor
Propranolol and Botulinum Toxin for Essential Vocal Tremor
Essential tremor is the most common adult-onset movement disorder, and essential voice tremor is the vocal manifestation of essential tremor.
- Conditions
- Essential Vocal Tremor, Essential Voice Tremor, Essential Tremor, Voice Tremor
- Trial name
- NCT02111369
- Testing
- Propranolol, Botulinum Toxin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Essential Tremor, Tremor
Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response
Essential Tremor (ET) is the most common tremor disorder, currently affecting an estimated 2.9 million Americans and leading to disability and decreased quality of life in 75% of cases.
- Trial name
- NCT02495883
- Testing
- Ethanol, Propranolol
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Type1diabetes, Hypoglycemia
Adrenergic System in Islet Transplantation
To determine the effect of sympathetic neural and hormonal (epinephrine) input on islet cell hormonal responses to insulin-induced hypoglycemia in type 1 diabetic recipients of intrahepatic islet transplantation.
- Conditions
- Type1diabetes, Hypoglycemia, Hypoglycemia Unawareness, Islet Cell Transplantation
- Trial name
- NCT03079921
- Testing
- Phentolamine, Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pennsylvania
Temporomandibular Disorders
Study of Orofacial Pain and PropRANOlol
Purpose: Primary: To evaluate the efficacy of extended-release (ER) propranolol compared to placebo in the reduction of a pain index in patients with temporomandibular disorder (TMD).
- Trial name
- SOPPRANO (NCT02437383)
- Testing
- Propranolol ER
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of North Carolina, Chapel Hill
Cannabis, Post Traumatic Stress Disorder
Nabilone in Cannabis Users With PTSD
Despite the prevalence of cannabis use among the PTSD population and self-reports that it is used to help cope with PTSD symptoms, the direct effects of cannabis on PTSD symptomology are unknown.
- Trial name
- NCT03251326
- Testing
- Nabilone, Cannabis, Propranolol
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- New York State Psychiatric Institute
Smoking Cessation
Memory Reconsolidation Blockade as a Novel Intervention for Nicotine Dependence
Smoking is the leading cause of preventable morbidity and mortality in the US. While approximately 70% of smokers attempt to quit each year, only 5-15% maintain abstinence for 12 months, even with effective pharmacological and…
- Trial name
- SCP (NCT00916721)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Brain Injuries, Craniocerebral Trauma
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury
The investigators intend to determine the effect of adrenergic blockade on 1) short-term physiology, behavior, and cognition and 2) long-term neuropsychological outcomes after severe Traumatic Brain Injury (TBI).
- Conditions
- Brain Injuries, Craniocerebral Trauma, Trauma, Nervous System, Traumatic Brain Injury
- Trial name
- NCT01322048
- Testing
- IV Propranolol and Per Tube Clonidine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University
Traumatic Brain Injury
Early Propranolol After Traumatic Brain Injury: Phase II
The primary objective of this study is to determine in patients with traumatic brain injury (TBI) the safe dosing of propranolol.
- Trial name
- EPAT: Phase II (NCT01202110)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cedars-Sinai Medical Center
Hemangioma
Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma
The purpose of this study is to compare the efficacy of orally administered propranolol versus atenolol in the treatment of potentially disfiguring or functionally threatening IHs.
- Trial name
- NCT02342275
- Testing
- Propranolol, Atenolol
- Where
- China
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- West China Hospital