Clinical trials: Propranolol, completed
Type1diabetes, Hypoglycemia
Adrenergic System in Islet Transplantation
To determine the effect of sympathetic neural and hormonal (epinephrine) input on islet cell hormonal responses to insulin-induced hypoglycemia in type 1 diabetic recipients of intrahepatic islet transplantation.
- Conditions
- Type1diabetes, Hypoglycemia, Hypoglycemia Unawareness, Islet Cell Transplantation
- Trial name
- NCT03079921
- Testing
- Phentolamine, Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pennsylvania
Hypertension
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/Sotalol
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the…
- Trial name
- NCT05794997
- Testing
- Propranolol or Carvedilol, Atenolol, Bisoprolol or Sotalol
- Where
- United States
- Volunteers
- 817,337 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Autism Spectrum Disorder, Developmental Disability
Propranolol for Challenging Behaviors in Autism
Severe challenging behaviors such as aggression and self-injury can cause significant morbidity and decrease the quality of life for individuals with Autism Spectrum Disorders (ASD).
- Conditions
- Autism Spectrum Disorder, Developmental Disability, Aggression, Self-Injurious Behavior
- Trial name
- NCT04047355
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rutgers, The State University of New Jersey
Healthy Volunteers
Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
Background: Changes in how a person's body burns energy or calories can affect their weight over time. The lowest level of energy the body needs to function is called basal metabolic rate.
- Trial name
- NCT01950520
- Testing
- Propranolol, Pindolol, Dantrolene
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obstructive Sleep Apnea
Propranolol for Sleep Apnea Therapy
The primary objective of this study is to test whether a beta blocker, propranolol, lowers the overnight heart rate sleep in obstructive sleep apnea (OSA) during CPAP withdrawal.
- Trial name
- ProSAT (NCT03049306)
- Testing
- Propranolol Oral Tablet
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
Heart Failure, Heart Failure, Diastolic
Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF
In this study, we will test the feasibility of N-of-1 trials for deprescribing beta-blockers in patients with Heart Failure with Preserved Ejection Fraction.
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- NCT04757584
- Testing
- Beta blockers
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Weill Medical College of Cornell University
Autism
Combined Effects of Early Behavioral Intervention and Propranolol on ASD
The purpose of this study is to explore the effects of propranolol in combination with early intensive behavioral intervention on social interaction, and secondarily on language, anxiety, adaptive behaviors, and global function…
- Trial name
- NCT02428205
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Missouri-Columbia
Heart Failure, Heart Failure, Diastolic
Impact of Beta-blockers on Physical Function in HFpEF
The purpose of this study is to understand the impact of beta-blockers on physical function in older adults with heart failure. We will achieve this objective by conducting N-of-1 trials.
- Conditions
- Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction, Cardiac Failure
- Trial name
- NCT04767061
- Testing
- Beta blockers
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Weill Medical College of Cornell University
Burns
Assessment of Mechanisms of Improved Wound Healing
The purpose of this study is to find ways to improve wound healing and decrease the negative effects of trauma from burn injury.
- Trial name
- NCT00673309
- Testing
- Stable Isotope Infusion study, Insulin High Dose, oxandrolone
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Anxiety Disorder
Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety
Objective: The overall aim of this protocol is to examine the effect of pharmacological manipulations of affective and cognitive processes on anxiety and task performance.
- Trial name
- NCT02153944
- Testing
- Propranolol, Methylphenidate
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- National Institute of Mental Health (NIMH)
Shoulder Pain
Biopsychosocial Influence on Shoulder Pain
Chronic shoulder pain is a common, costly, and disabling problem for society. The identification of factors predictive of the development of chronic shoulder pain is necessary to develop innovative and effective treatments to…
- Trial name
- BISP (NCT02620579)
- Testing
- Propranolol LA (60 mg), Shoulder Anatomy Education, Pain Processing Education
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Duke University
Hemangioma
Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma
The purpose of this study is to compare the efficacy of orally administered propranolol versus atenolol in the treatment of potentially disfiguring or functionally threatening IHs.
- Trial name
- NCT02342275
- Testing
- Propranolol, Atenolol
- Where
- China
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Locally Advanced Malignant Neoplasm, Breast Cancer
Study of Propranolol in Newly Diagnosed Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
This study is being conducted in patients with newly diagnosed breast cancer that will be undergoing chemotherapy prior to surgery - neoadjuvant chemotherapy.
- Trial name
- NCT01847001
- Testing
- Propranolol, DOT imaging, Paclitaxel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Multiple Myeloma
Study of Propranolol to Decrease Gene Expression of Stress-Mediated Beta-Adrenergic Pathways in HCT Recipients
This is a randomized controlled pilot study designed to evaluate whether the beta-adrenergic antagonist propranolol is effective in decreasing gene expression of stress-mediated beta-adrenergic pathways among a cohort of…
- Trial name
- NCT02420223
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical College of Wisconsin
Hypertension Secondary to Kidney Transplant
Reduction of Night-time Blood Pressure in Pediatric Renal Transplant Recipients
The proposed study investigated the effect of chronotherapeutic alteration of anti-hypertensive medication on nocturnal hypertension and end-organ injury in pediatric renal transplant recipients who are non-dippers.
- Trial name
- NCT01007994
- Testing
- New Medication: Enalapril, Isradipine, Propranolol
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- Northwell Health
Essential Tremor, Tremor
Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response
Essential Tremor (ET) is the most common tremor disorder, currently affecting an estimated 2.9 million Americans and leading to disability and decreased quality of life in 75% of cases.
- Trial name
- NCT02495883
- Testing
- Ethanol, Propranolol
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cigarette Smoking
Neurobehavioral Substrates of Propranolol's Effects on Drug Cue Reactivity
The central objective of this project is to obtain proof-of-concept data demonstrating the effects of propranolol (a beta-adrenergic antagonist) on neurobiological responses to personal smoking environments and behavioral…
- Trial name
- ProCue (NCT03309943)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University
Brain Injuries, Traumatic
Beta Blockade in in Traumatic Brain Injury
The purpose of this study is test the effect of beta-adrenergic blockade on mortality in patients with traumatic brain injury with the hypothesis being that the addition of beta blockade to the treatment regime of this patient…
- Trial name
- NCT02957331
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Tennessee
Induction of Labor Affected Fetus / Newborn
Propranolol Versus Placebo for Induction of Labor in Nulliparous Patients
A randomized, prospective trial will be offered to women admitted to the labor floors at Mount Sinai Medical Center for labor induction.
- Trial name
- NCT03348683
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cocaine Addiction
Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving
The investigators' recently completed study has provided the first evidence that administration of the medication propranolol, following exposure to cocaine cues, can alter drug-associated memories and reduce craving and other…
- Trial name
- NCT01822587
- Testing
- Propranolol, 40 mg, Propranolol, 80 mg
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Medical University of South Carolina