Clinical trials: Radiation
Prevention
Evaluation of the Effect of Alpha Lipoic Acid on Radiation Induced Dermatitis in Breast Cancer Patients
the purpose of this study is to evaluate the Effect of Alpha Lipoic Acid on Radiation Induced Dermatitis in Breast Cancer Patients
- Trial name
- NCT07256119
- Testing
- Alpha Lipoic Acid
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Advanced Hepatocellular Carcinoma
Concurrent Nivolumab and External Beam Radiation Therapy for Patients With Advanced HCC
To investigate the efficacy and safety of nivolumab for patients with advanced HCC undergoing EBRT
- Trial name
- Nextrah (NCT04611165)
- Testing
- Nivolumab
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Lung Disease, Pneumothorax
Study of the Disease Process of Lymphangioleiomyomatosis
Pulmonary lymphangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor.
- Conditions
- Lung Disease, Pneumothorax, Tuberous Sclerosis, Lymphangioleiomyomatosis
- Trial name
- NCT00001465
- Testing
- Toshibia Aquilion One CT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Oral Mucositis, Osteoradionecrosis
Photobiomodulation in Oral Lesions Resulting From Anti-neoplastic Prevention
Introduction: There are several manifestations in the oral mucosa resulting from antineoplastic treatments by chemo (QT) or radiotherapy (RT).
- Conditions
- Oral Mucositis, Osteoradionecrosis, Osteonecroses, Bisphosphonate, Osteonecrosis Due to Drugs, Jaw
- Trial name
- NCT04717765
- Testing
- Preventive, LLL Phototherapy and topical Vit E, Curative, LLL Phototherapy and topical Vit E, Preventive, LLL Phototherapy and LPRF
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
Rectal Cancer Stage III
UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer
To explore whether the application of irinotecan under the guidance of UGT1A1 gene in neoadjuvant chemotherapy and radiotherapy for locally advanced rectal cancer could improve the clinical efficacy in the real world.
- Trial name
- NCT05148767
- Testing
- Neoadjuvant chemoradiotherapy based on irinotecan
- Where
- China
- Volunteers
- 606 people
- Sponsor
- Zhejiang Cancer Hospital
Metastatic Cancer, Radiation Toxicity
Melatonin and Radiation Therapy in Treating Patients With Brain Metastases
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as melatonin may make tumor cells more sensitive to radiation therapy and may protect normal cells from the side effects of radiation therapy.
- Conditions
- Metastatic Cancer, Radiation Toxicity, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00031967
- Testing
- therapeutic melatonin, radiation therapy
- Where
- 234 sites in United States, Canada
- Sponsor
- Radiation Therapy Oncology Group
Tendinopathy
Efficacy of Therapeutic Percutaneous Electrolysis Simple vs Multiple vs Laser Therapy in Supraspinatus Tendinopathy.
Supraspinatus tendinopathy is one of the main pathologies that cause functional alterations in the glenohumeral joint. It reduces the quality of life of the population suffering from this injury.
- Trial name
- NCT07695792
- Testing
- Simple electrolysis percutaneous, Multifiliar Electrolysis percutaneus, Laser
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Universidad Pontificia de Salamanca
Toripalimab, Radiation
A Phase III Trial of Anus-preservation in Low Rectal Adenocarcinoma Based on MMR/MSI Status
pMMR/MSS and 32 dMMR/MSI-H patientspatients were planned to be enrolled. Patients with dMMR/MSI-H will be randomly assigned to the immunotherapy arm or short-course radiotherapy sequential immunotherapy arm; pMMR/MSS patients…
- Trial name
- NCT05669092
- Testing
- Toripalimab, CRT, SCRT
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Zhejiang Cancer Hospital
Acute Myeloid Leukemia, Myeloproliferative Neoplasm
Automated Total Marrow and Lymphoid Irradiation for Allogeneic Hematopoietic Cell Transplant
Intensive conditioning regimens used in allogeneic hematopoietic cell transplant (HCT) help to eliminate hematologic tumors and reduce the risk of relapse, but are also characterized by high toxicity.
- Conditions
- Acute Myeloid Leukemia, Myeloproliferative Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT07634536
- Testing
- VMAT-Based Total Marrow and Lymphoid Irradiation (TMLI), Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Glioblastoma
Efficacy and Safety Study of Lomustine/Temozolomide Combination Therapy vs. Standard Therapy for Glioblastoma Patients
The prognosis of patients with newly diagnosed glioblastoma is dismal despite recent therapeutic improvements Using standard therapy with temozolomide (TMZ) and radiotherapy (60 Gy), the median overall survival time (mOS) is 14.6…
- Trial name
- CeTeG (NCT01149109)
- Testing
- Temozolomide and lomustine, Temozolomide
- Where
- 12 sites in Germany
- Volunteers
- 141 people
- Sponsor
- University Hospital, Bonn
Oral Cancer
The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor
Cervical nodal metastasis is the most certain prognostic factor in oral cancer. Appropriate management of the neck is therefore of paramount importance in the treatment of oral cancer.
- Trial name
- NCT03017053
- Testing
- Radiotherapy, Elective neck dissection
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Locally Advanced Rectal Cancer
Irinotecan Liposomes in Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer
This study enrolled patients with locally advanced rectal cancer. The experimental group received irinotecan liposomes combined with standard total neoadjuvant therapy (TNT), while the control group received standard TNT.
- Trial name
- CinClare-2 (NCT07074353)
- Testing
- NALIRI, LCRT, FOLFOX
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Zhejiang Cancer Hospital
Solid Tumor
A Study of LY3200882 in Participants With Solid Tumors
The main purpose of this study is to evaluate the safety of the study drug known as LY3200882 in participants with solid tumors.
- Trial name
- NCT02937272
- Testing
- LY3200882, LY3300054, Gemcitabine
- Where
- 18 sites in United States, Australia and 6 more
- Volunteers
- 223 people
- Sponsor
- Eli Lilly and Company
Primary Central Nervous System Lymphoma, Secondary Central Nervous System Lymphoma
Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas
This study is being conducted to evaluate the safety and efficacy of the combination of pemetrexed and zanubrutinib (called induction therapy) followed by zanubrutinib treatment alone (also called maintenance therapy) in people…
- Conditions
- Primary Central Nervous System Lymphoma, Secondary Central Nervous System Lymphoma, Relapsed Cancer, Refractory Cancer
- Trial name
- NCT05681195
- Testing
- Pemetrexed, Zanubrutinib, Autologous Stem Cell Transplant (ASCT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baptist Health South Florida
Emergencies, Diagnostic Imaging
Abdominal Plain X-ray in the Emergency Departement
There are only few recognized indications for the realization of plain abdominal X-rays in the emergency departement. The objective of this study is to explore the reasons for abdominal plain X-rays prescription in the Emergency…
- Conditions
- Emergencies, Diagnostic Imaging, Abdomen, Acute
- Trial name
- NCT02980081
- Testing
- abdominal plain x-ray
- Where
- Switzerland
- Volunteers
- 1,997 people
- Sponsor
- University Hospital, Geneva
Prostate Cancer
PSMA-PET Guided De-escalation of Salvage Radiation Treatment in Recurrent Prostate Cancer
Purpose: Prospective, single-site Phase II study testing whether PSMA-PET/MRI-guided, de-escalated salvage radiation reduces acute Grade ≥2 toxicity versus a 44% historical rate, while maintaining cancer control after…
- Trial name
- NCT07234981
- Testing
- PSMA-guided Salvage Radiation
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Nebraska
Women Infertility
"Magnetic Resonance Imaging Hysterosalpingography for the Integral Evaluation of the Infertile Patient."
Abstract: Recent advances in reproductive medicine have generated a demand for more accurate imaging methods for identifying the specific cause of female infertility and other gynecologic disorders.
- Trial name
- HSG-RM (NCT02398630)
- Testing
- TC Virtual Hysterosalpingography, MRI Virtual Hysterosalpingography, Antimullerian Hormone dosing
- Where
- Argentina
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Diagnostico Maipu
Cardiac Surgery, Sternotomy
ESP/PIF for Sternotomy
This is a randomized study. The purpose of this study is to evaluate the effect of post-surgical pain control of two types of peripheral nerve blocks, specifically erector spinal plane (ESP) block and pecto-intercostal fascial…
- Trial name
- NCT04985500
- Testing
- ESP block, PIF block, Ultrasound
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Sarcoma
Establishment of a Prospective Clinical-biological Database
A Clinical and Biological Database will provide to the scientific community a collection of blood and tissues with clinical data to improve knowledge about cancer and help to develope new cancer treatments.
- Trial name
- BCBSarcome (NCT04458792)
- Testing
- Paraffin tissue samples, blood sample
- Where
- France
- Volunteers
- 450 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Soft Tissue Sarcoma
Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy
This pilot study will evaluate the feasibility of applying CEUS as imaging guidance for planning RT and predicting RT response. The investigators will determine if US-CT/MRI fusion is feasible and if tumor vascularity and…
- Trial name
- NCT07436364
- Testing
- Definity, Contrast-Enhanced Ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Thomas Jefferson University