Clinical trials: Radiation, completed
Metastatic Pancreatic Adenocarcinoma, Refractory Pancreatic Adenocarcinoma
SD-101, Nivolumab, and Radiation Therapy in Treating Patients With Chemotherapy-Refractory Metastatic Pancreatic Cancer
This phase I trial studies the side effects of SD-101 when given together with nivolumab and radiation therapy in treating patients with pancreatic cancer that does not respond to treatment with chemotherapy (chemotherapy…
- Conditions
- Metastatic Pancreatic Adenocarcinoma, Refractory Pancreatic Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8
- Trial name
- NCT04050085
- Testing
- Nivolumab, Radiation Therapy, TLR9 Agonist SD-101
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, Davis
Esophageal Neoplasms
Quality of Life in Neoadjuvant Versus Adjuvant Therapy of Esophageal Cancer Treatment Trial
The purpose of this study is to compare the results of preoperative chemotherapy and radiation followed by surgery to surgery followed by postoperative chemotherapy and radiation for esophageal cancer.
- Trial name
- QUINTETT (NCT00907543)
- Testing
- Preoperative treatment of chemotherapy and radiation, Postoperative treatment of chemotherapy and radiation
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- Richard Malthaner
Prospective Study
Physical Activity During Radiation Therapy for Lung Cancer
The primary objective of this trial is to evaluate patterns of physical activity during radiation therapy for lung cancer and to estimate the within-patient change in physical activity between Week 1 and Week 5 of radiation…
- Trial name
- APART-LUNG (NCT07380815)
- Where
- 7 sites in Denmark, Georgia and 2 more
- Volunteers
- 20 people
- Sponsor
- University Hospital Schleswig-Holstein
Head and Neck Squamous Cell Carcinoma
Non Inferiority Trial of Standard RT Versus Hypofractionated Split Course in Elderly Vulnerable Patients With HNSCC
Randomized comparison between standard radiotherapy and hypofractionated split course schedule. Compared to standard radiotherapy, the investigators expect that hypofractionated split course (interruption of 2 weeks) radiotherapy…
- Trial name
- ELAN-RT (NCT01864850)
- Testing
- Standard RT, Hypofractionated RT
- Where
- 2 sites in France, Monaco
- Volunteers
- 202 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Rosacea
A Study to Evaluate Safety and Equivalence of Generic Azelaic Acid Foam and Finacea® Foam in Participants With Rosacea
The objectives of this study were to compare the safety and efficacy profiles of a generic Azelaic Acid Foam, 15% to the reference listed Finacea® (azelaic acid) Foam, 15% and to demonstrate therapeutic equivalence and safety of…
- Trial name
- NCT03287791
- Testing
- Generic Azelaic Acid Foam, Finacea® (Azelaic Acid) Foam, Vehicle Foam
- Where
- 26 sites in United States
- Volunteers
- 924 people
- Sponsor
- Actavis Inc.
Head and Neck Cancer
Phase II Study of Concurrent C225, Cisplatin and Radiation in Stage IV Squamous Cell Carcinoma of the Head and Neck
RATIONALE: Monoclonal antibodies such as cetuximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00096174
- Testing
- cetuximab C225, cisplatin, radiation therapy
- Volunteers
- 69 people
- Sponsor
- Eastern Cooperative Oncology Group
Radiotherapy, Nasopharyngeal Carcinoma
3DV+TPS Software Outlines the Radiotherapy of Nasopharyngeal Carcinoma
Comparing the accuracy and speed of 3DV+TPS software with imported TPS and domestic TPS to outline the contours of crisis organs, it is proved that 3DV+TPS has superiority compared with domestic TPS, and it has non-inferiority…
- Trial name
- NCT03810274
- Testing
- 3DV+TPS；VARIAN TPS；FonicsPlan
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xinqiao Hospital of Chongqing
Metastatic Thyroid Gland Carcinoma, Poorly Differentiated Thyroid Gland Carcinoma
Iodine I-131 With or Without Selumetinib in Treating Patients With Recurrent or Metastatic Thyroid Cancer
This phase II trial studies how well iodine I-131 works with or without selumetinib in treating patients with thyroid cancer that has returned (recurrent) or has spread from where it started to other places in the body…
- Conditions
- Metastatic Thyroid Gland Carcinoma, Poorly Differentiated Thyroid Gland Carcinoma, Recurrent Thyroid Gland Carcinoma, Stage IV Thyroid Gland Follicular Carcinoma AJCC v7
- Trial name
- NCT02393690
- Testing
- Iodine I-131, Selumetinib
- Where
- 11 sites in United States
- Volunteers
- 60 people
- Sponsor
- Academic and Community Cancer Research United
Thoracic Cancer, Spine Cancer
Studying a New Piece of Equipment That Can Help Plan Radiation Therapy of the Spine
Participants will receive an MRI with a custom-built MRI coil for each participant. The purpose is to find out whether this custom-built MRI coil can help doctors see the different parts of the spine as well as or better than…
- Conditions
- Thoracic Cancer, Spine Cancer, Thoracic Diseases, Spine Disease
- Trial name
- NCT04227717
- Testing
- MRI with custom MRI spine coil
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Glioblastoma
Avelumab With Hypofractionated Radiation Therapy in Adults With Isocitrate Dehydrogenase (IDH) Mutant Glioblastoma
The purpose of this study is to test how safe and effective treatment with the combination of Avelumab and radiation is for IDH mutant gliomas that have transformed to glioblastoma after chemotherapy.
- Trial name
- NCT02968940
- Testing
- Avelumab, Hypofractionated radiation therapy (HFRT)
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- NYU Langone Health
Bone Metastases
Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases
This research is being done because is is not known if dexamethasone can prevent pain flare (their pain temporarily gets worse before it gets better) caused by the radiation used to treat painful bone metastases.
- Trial name
- NCT01248585
- Testing
- Dexamethasone
- Where
- 22 sites in Canada
- Volunteers
- 298 people
- Sponsor
- NCIC Clinical Trials Group
Carcinoma, Non Small Cell Lung (NSCLC)
Locally Advanced NSCLC Hyperfractionated RT
This is a prospective phase II study designed to evaluate an accelerated and adaptive RT approach for locally-advanced non-small cell lung cancer (NSCLC).
- Trial name
- ADAPT (NCT03128008)
- Testing
- Carboplatin, Paclitaxel, Daily hyperfractionated radiation therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Breast Cancer
Digi-Do - a Digital Information Tool to Help Patients Diagnosed With Breast Cancer
This project uses participatory design combined with qualitative and quantitative methods to develop, explore and evaluate the usefulness of a digital information tool to prepare and support patients before, during and after RT…
- Trial name
- NCT04394325
- Testing
- Digital information tool
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Jonkoping University
Circulating Tumor Cells
Culture of Circulating Tumor Cells Isolated From Cancer Patients With Metastatic Disease
The purpose of this study is to investigate the feasibility of using novel decellularized tissue matrices to isolate and culture circulating tumor cells (CTCs) collected from patients with metastatic solid tumor malignancies.
- Trial name
- NCT02781025
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Pulpitis Reversible
Clinical, Radiographic and Patient Acceptance Evaluation of LASER Compared to Formocresol Pulpotomies inPrimary Molars
The goal of this clinical trial was to compare the clinical and radiographic success of laser versus formocresol pulpotomy in primary molars.
- Trial name
- NCT06200818
- Testing
- Diode laser, Er:CrYSGG, Formocresol
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Osteoarthritis, Arthroplasty Complications
Varus Stem Positioning of a Cementless Anatomical THA. (VARABG)
Varus positioning is the most common femoral malposition in total hip arthroplasty (THA). The aim of this study was to compare the long-term results of an anatomical cementless femoral stem positioned in varus with those in…
- Trial name
- VARABG (NCT04653090)
- Testing
- Xray
- Where
- France
- Volunteers
- 283 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cancer of Head and Neck, Head Cancer
Cisplatin and Docetaxel Plus Docetaxel and Radiotherapy With Amifostine for Squamous Cell Carcinoma of the Head and Neck
This trial seeks to accomplish both local and regional control of head and neck cancer and reduce systemic metastatic disease. To do this, patients will received chemotherapy followed by chemotherapy and radiation (given…
- Conditions
- Cancer of Head and Neck, Head Cancer, Head and Neck Cancer, Neck Cancer
- Trial name
- NCT00318890
- Testing
- Cisplatin, Docetaxel, Radiotherapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Breast Cancer
Paclitaxel and Radiation Therapy in Treating Patients Undergoing Surgery for Stage II or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00647218
- Testing
- Post-operative adjuvant therapy, neoadjuvant therapy, therapeutic surgical procedure
- Where
- 6 sites in United States
- Volunteers
- 38 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Prostate Cancer Adenocarcinoma
Hypofractionated Focal Lesion Ablative Microboost in prostatE Cancer
The hypo-FLAME study is a multicenter phase II study (n=100) to investigate whether a focal SBRT boost to the MRI-defined macroscopic tumor volume is feasible and associated with acceptable toxicity in addition to whole gland…
- Trial name
- Hypo-FLAME (NCT02853110)
- Testing
- Hypo-FLAME study
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
Major Depressive Disorder, Bipolar Disorder
Imaging mGluR5 and Synaptic Density in Psychiatric Disorders
This research study is designed to look at the involvement of the glutamate system and synaptic density in depression and bipolar disorder. Each participant will undergo a screening appointment to determine study eligibility.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Healthy
- Trial name
- NCT03898297
- Testing
- [18F]FPEB, [11C]APP311
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Yale University
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