Clinical trials: Rifampin
Advanced Solid Tumors, Neoplasms
Effect of Rifampin on the Pharmacokinetics of Ixabepilone in Patients With Advanced Cancer
The purpose of this study is to test how rifampin affects the removal of BMS-247550 (ixabepilone) from the body.
- Trial name
- NCT00207090
- Testing
- ixabepilone, Rifampin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- R-Pharm
Tuberculosis
TBTC Study 28: Moxifloxacin Versus Isoniazid for TB Treatment
This double-blind, randomized controlled trial evaluates moxifloxacin versus isoniazid in daily treatment during the first two months of treatment with rifampin, pyrazinamide and ethambutol for sputum smear-positive pulmonary…
- Trial name
- NCT00144417
- Testing
- Moxifloxacin (with rifampin, pyrazinamide, and ethambutol), isoniazid
- Where
- 26 sites in United States, Brazil and 4 more
- Volunteers
- 433 people
- Sponsor
- Centers for Disease Control and Prevention
Tuberculosis
A 14 Day Early Bactericidal Activity Study of Nitazoxanide for the Treatment of Tuberculosis
This research is being done to determine if Nitazoxanide (NTZ) will cause a significant decrease in the number of M. tuberculosis bacteria in sputum after 14 days of treatment.
- Trial name
- NCT02684240
- Testing
- Nitazoxanide, Control
- Where
- Haiti
- Volunteers
- 30 people
- Sponsor
- Weill Medical College of Cornell University
Tuberculosis, Pulmonary, Drug-Susceptible Pulmonary Tuberculosis
Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible Tuberculosis
# Brief Summary This study aims to evaluate the early bactericidal activity (EBA), safety, and tolerability of 4-month short-course regimens containing bedaquiline, moxifloxacin, and pyrazinamide in patients with drug-susceptible…
- Trial name
- Beams (NCT07129629)
- Testing
- Bedaquiline (B), Moxifloxacin, Pyrazinamide (PZA)
- Volunteers
- 45 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Women, Contraception
Annovera™ Drug-Drug Interaction Study
A Drug-Drug Interaction (DDI) study to evaluate the effects of itraconazole and rifampin on the Pharmacokinetics of Segesterone Acetate and Ethinyl Estradiol from the Annovera Contraceptive Vaginal System (CVS)
- Trial name
- NCT04290390
- Testing
- Segesterone Acetate and Ethinyl Estradiol, Rifampin, Itraconazole
- Where
- Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- TherapeuticsMD
Endometriosis
Drug-drug Interaction Study Between Orally Administered Rifampicin and Vilaprisan
This study will be conducted in a single center, open-label study with a single group fixed sequence design to evaluate the effect of repeated oral administration of 600 mg RIF(Rifampicin) given once daily over 11 days on the…
- Trial name
- NCT02975440
- Testing
- Rifampicin, Midazolam, BAY1002670_Vilaprisan
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bayer
Glucose Tolerance
Pregnane X Receptor (PXR) Agonist Rifampicin Effects on Glucose, Lipid and Hormone Homeostasis
This clinical trial is designed to study the effects of rifampicin on the glucose, lipid and hormone homeostasis in healthy volunteers.
- Trial name
- NCT00985270
- Testing
- Rifampicin
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Drug Interaction
A Drug-drug Interaction Study to Evaluate the Effect of Rifampicin and Febuxostat on the Pharmacokinetics of Methotrexate in Healthy Subjects
To investigate the effect of rifampicin and febuxostat on pharmacokinetics of methotrexate in healthy volunteers
- Trial name
- NCT05575297
- Testing
- Methotrexate Sodium, Rifampicin Sodium, Febuxostat Tablets
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Latent Tuberculosis
Implementation of an Integrated Care Strategy for Children Contacts of Patients With Tuberculosis
Introduction: childhood tuberculosis continues to be a major public health problem, despite the fact that the visibility of the epidemic in this population group has increased, studies are still lacking that can resolve the gaps…
- Trial name
- NCT04331262
- Where
- Colombia
- Volunteers
- 163 people
- Sponsor
- Corporacion para Investigaciones Biologicas
Healthy
Study to Determine the Impact of Multiple Doses of Rifampin on Single-dose Pharmacokinetics of HCV-796
An open label, 2-period, sequential study to determine the impact of multiple doses of rifampin on single-dose pharmacokinetics of HCV-796
- Trial name
- NCT00384280
- Testing
- Rifampin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Solid Tumours
Study to Assess the Effect of Rifampicin (CYP Inducer) on Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours
This is a 2-part study in patients with advanced solid tumours. Part A will investigate the effect of rifampicin on the PK parameters of olaparib in patients; Part B will allow patients continued access to olaparib after the PK…
- Trial name
- NCT01929603
- Testing
- Pharmacokinetic sampling, Rifampicin, Olaparib tablet dosing
- Where
- 5 sites in Belgium, Netherlands
- Volunteers
- 32 people
- Sponsor
- AstraZeneca
CYP3A4 Induction
Cholesterol Metabolites as Markers for CYP3A Induction
The objectives of this study are: To investigate if the endogenous cholesterol metabolite, 4beta-OHcholesterol could be used as a marker for induction of cytochrome P450 (CYP) 3A4.
- Trial name
- NCT01340456
- Testing
- Rifampicin treatment
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
HIV Infections, Tuberculosis
Efavirenz (EFV) in HIV-Infected and HIV/Tuberculosis (TB) Coinfected Children
Efavirenz (EFV) is an anti-HIV medicine that is commonly used to treat HIV infection in adults and children older than 3 years of age.
- Trial name
- NCT00802802
- Testing
- Efavirenz (EFV), Rifampin-containing anti-TB therapy
- Where
- 7 sites in India, South Africa and 2 more
- Volunteers
- 67 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tuberculosis
Phenotyping of High Dose Rifampicin
Higher doses of rifampicin as a means of more efficient use of this pivotal TB drug has shown promising results and might become standard in future.
- Trial name
- PHENORIF (NCT04525235)
- Testing
- phenotyping cocktail, rifampicin
- Where
- 2 sites in South Africa
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Healthy
A Study to Evaluate the Effect of Rifampicin on the Pharmacokinetics of Abiraterone in Healthy Male Participants
The purpose of this study is to assess the effects of repeated daily administration of rifampicin on the pharmacokinetics (what the body does to the medication) of abiraterone following single-dose administration of abiraterone…
- Trial name
- NCT01655147
- Testing
- Abiraterone acetate, Rifampicin
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Healthy Subjects
Effect of Rifampicin on the Pharmacokinetics of SHR6390 in Healthy Subjects
The primary objective of the study is to evaluate the effect of rifampicin on pharmacokinetics of healthy Chinese adult subjects after oral administration of SHR6390 tablets.
- Trial name
- NCT04439578
- Testing
- SHR6390 tablet single oral dose of SHR6390 or co-administered with rifampicin
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy Subjects
Drug-Interaction Study to Evaluate the Effect of Rifampin, a Potent CYP3A4 Inducer, on the Systemic Exposure of Pacritinib in Healthy Subjects
The primary objective is to evaluate the effect of rifampin, a potent cytochrome P450 3A4 inducer, at steady-state on the systemic exposure of a single dose of pacritinib in healthy subjects.
- Trial name
- NCT02807116
- Testing
- Pacritinib, Rifampin, Pacritinib and Rifampin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- CTI BioPharma
Healthy Subjects
A Clinical Trial to Evaluate the Effect of Itraconazole and Rifampicin on ABSK021
This study is a single center, open lable and fixed sequence test conducted in healthy subjects to evaluate the pharmacokinetic effects of Itraconazole and Rifampicin on a single dose of ABSK021 Oral administration.
- Trial name
- NCT06089733
- Testing
- Part A ABSK201 and Itraconazole, Part A ABSK201 and Rifampicin
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Abbisko Therapeutics Co, Ltd
Low-Birth-Weight Infant, Tuberculosis
IMPAACT P1106: Pharmacokinetic Characteristics of Antiretrovirals and Tuberculosis Medicines in Low Birth Weight Infants
P1106 is Phase IV prospective pharmacokinetic (PK) study of low birth weight infants who are receiving or will be receiving as part of clinical care nevirapine (NVP) prophylaxis, tuberculosis (TB) prophylaxis or treatment and/or…
- Conditions
- Low-Birth-Weight Infant, Tuberculosis, HIV
- Trial name
- NCT02383849
- Where
- 2 sites in South Africa
- Volunteers
- 124 people
- Sponsor
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Scrub Typhus
Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus
New antibiotics are required to have not only the antibacterial activity against doxycyline-resistant O. tsutsugamushi but also lower risk for resistance or any cross-resistance to others.
- Trial name
- NCT00568711
- Testing
- doxycycline, rifampin
- Where
- South Korea
- Volunteers
- 476 people
- Sponsor
- Dong-Min Kim