Clinical trials: Rifampin
Tuberculosis, Pulmonary, Tuberculosis
Treating Tuberculosis With the Lipid Lowering Drug Atorvastatin in Nigeria(ATORvastatin in Pulmonary TUBerculosis)
Tuberculosis (TB) is caused by mycobacterial organism. It is the leading infectious disease cause of death globally, with more than 10 million new cases and over 2 million deaths annually.
- Trial name
- ATORTUB (NCT04721795)
- Testing
- Atorvastatin with standard anti tuberculosis drugs, Standard anti tuberculosis drugs only
- Where
- 2 sites in Nigeria, United Kingdom
- Volunteers
- 150 people
- Sponsor
- Obafemi Awolowo University Teaching Hospital
HIV Infections, Tuberculosis
Tuberculosis Prevention for HIV Infected Adults
This study compares three different tuberculosis (TB) prevention regimens against the standard regimen of 6 months of isoniazid. It is being conducted in Soweto, South Africa.
- Trial name
- NCT00057122
- Testing
- Isoniazid, Rifapentine, Rifampin
- Where
- South Africa
- Volunteers
- 1,148 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Volunteers
Study of the Effects of Itraconazole and Rifampin on LOXO-305 in Healthy Participants
The main purpose of this study is to learn about how itraconazole and rifampin affect LOXO-305 in healthy participants. Participation could last about 8 weeks.
- Trial name
- NCT05134337
- Testing
- LOXO-305, Itraconazole, Rifampin
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Loxo Oncology, Inc.
Tuberculous Uveitis
The Effectivity of Anti Tuberculosis Therapy in Idiopathic Uveitis with Positive IGRA
The reported incidence of uveitis is 52 persons per year per 100,000 population, with a greater incidence estimated in developing countries, including Indonesia.
- Trial name
- NCT05005637
- Testing
- Anti Tuberculosis Drug, Methylprednisolone
- Where
- Indonesia
- Volunteers
- 78 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Pulmonary Tuberculosis
Pharmacokinetic Study for Anti-tuberculosis Drugs
The purpose of this study is to evaluate the effect of food on pharmacokinetic profile of multiple doses orally administered first-line anti-tuberculosis drugs in subjects with pulmonary tuberculosis.
- Trial name
- TBPK (NCT00948077)
- Testing
- Rifater and EMB
- Where
- Taiwan
- Volunteers
- 16 people
- Sponsor
- Taipei Medical University WanFang Hospital
Cystic Fibrosis
Study of VX-770 and Rifampin in Healthy Male Subjects
The objectives of this study are to evaluate the effects of multiple doses of rifampin on the single-dose pharmacokinetics of VX 770.
- Trial name
- NCT01018368
- Testing
- VX-770, Rifampin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated
HIV Infections, Tuberculosis
Efavirenz-based Versus Nevirapine-based Antiretroviral Therapy Among HIV-infected Patients Receiving Rifampin
The randomized controlled trial is conducted among antiretroviral naive co-infected HIV and tuberculosis patients who receiving rifampicin-based antituberculous regimen fro at least 4 weeks butt not exceed 16 weeks before…
- Trial name
- N2R (NCT00483054)
- Testing
- efavirenz, nevirapine
- Where
- Thailand
- Volunteers
- 142 people
- Sponsor
- Bamrasnaradura Infectious Diseases Institute
Prosthetic Joint Infection
Tedizolid Prolonged Treatment for Prosthetic Joint Infections
Pilot study the aim of which is to obtain reliable data on the tolerance, compliance and efficacy of Tedizolid used as prolonged (≥ 6 weeks) monotherapy or in combination therapy for the treatment of patients with orthopedic…
- Trial name
- TEDIZOAM (NCT03378427)
- Testing
- Tedizolid Phosphate 200 MG [Sivextro]
- Where
- 2 sites in France
- Volunteers
- 35 people
- Sponsor
- Tourcoing Hospital
Glucose Tolerance
Pregnane X Receptor (PXR) Agonist Rifampicin Effects on Glucose, Lipid and Hormone Homeostasis
This clinical trial is designed to study the effects of rifampicin on the glucose, lipid and hormone homeostasis in healthy volunteers.
- Trial name
- NCT00985270
- Testing
- Rifampicin
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Tuberculosis (TB)
Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial)
People living in high TB burden communities who undergo active case finding for TB may have chest X-ray changes suggestive of TB but their sputum test can be negative for the TB bacteria or they are unable to provide a sputum…
- Trial name
- RADIO-TB (NCT07163143)
- Testing
- Isoniazid (H), Rifampicin (R), Pyrazinamide (Z)
- Where
- 4 sites in Pakistan, South Africa and 1 more
- Volunteers
- 784 people
- Sponsor
- University College, London
Pulmonary Tuberculosis
Efficacy of HUEXC030 in Subjects With Pulmonary Tuberculosis
Assess the Efficacy of HUEXC030 as Add-on Excipient to Eradicate Anti-Tuberculosis Drugs Induced Hepatic Injury ( ATDH ) in Subjects with Pulmonary Tuberculosis
- Trial name
- NCT02467608
- Testing
- Isoniazid with HUEXC030 and RZE, HRZE
- Where
- 18 sites in Taiwan
- Volunteers
- 557 people
- Sponsor
- Orient Pharma Co., Ltd.
Adverse Drug Interactions
Sulforaphane as an Antagonist to Human PXR-mediated Drug-drug Interactions
Adverse drug-drug interactions (DDIs) are responsible for approximately 3% of all hospitalizations in the US, perhaps costing more than $1.3 billion per year.
- Trial name
- NCT00621309
- Testing
- Rifampicin, sulforaphane plus rifampicin, sulforaphane alone
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Washington
Tuberculosis, Pulmonary
Probe Melting Technology for Rapid Detection of Drug Resistant Tuberculosis
Background: Drug resistant tuberculosis is a serious public health problem that threatens the health of human life and the development of society and economy.
- Trial name
- PMTforDR-TB (NCT02776150)
- Volunteers
- 3,100 people
- Sponsor
- Beijing Hospital
HIV Infection, Tuberculosis
An Evaluation of the Pharmacological Interaction of Lopinavir/r and Rifampin
This is a pharmacokinetic, descriptive, open-label, prospective, multicentric, national study in Aids and tuberculosis co-infected patients, to be laboratory and clinically monitored during the treatment with lopinavir-ritonavir…
- Trial name
- A06-295 (NCT00771498)
- Testing
- Lopinavir
- Where
- 3 sites in Brazil
- Volunteers
- 30 people
- Sponsor
- Oswaldo Cruz Foundation
Healthy Volunteers
A Bioequivalence Study Comparing A Fixed Dose Combination Formulation, Rin 150 And Individual Reference Drugs In Healthy Volunteers
This is a bioequivalence study to evaluate the bioequivalence of RIN 150 against individual reference drugs in healthy volunteers.
- Trial name
- NCT02014272
- Testing
- RIN 150, reference drugs
- Where
- Singapore
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Rifampicin- and Isoniazid-Susceptible Pulmonary Tuberculosis (TB)
A Phase 2 Trial to Evaluate the EBA, Safety and Tolerability of Eto Alone and in Combination With BVL-GSK098
To evaluate the 7-day early bactericidal activity (EBA), pharmacokinetics (PK), safety and tolerability of ethionamide (Eto) with or without BVL-GSK098 in participants with rifampicin- and isoniazid-susceptible pulmonary TB.
- Trial name
- BETO (NCT05473195)
- Testing
- BVL-GSK098 9mg, Ethionamide 250mg, Ethionamide 250 mg
- Where
- South Africa
- Volunteers
- 105 people
- Sponsor
- TASK Applied Science
Healthy Subjects
Genetic Variability in the Response to Warfarin at Baseline and During Induction of CYP2C9
The genetic factors associated with variability in CYP2C9 induction have not been elucidated. The hypothesis underlying this study is that following 7 days treatment with rifampicin, a known CYP450 inducer, the genetic…
- Trial name
- NCT01388075
- Testing
- Rifampicin
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Staphylococcal Infections
Daptomycin With Rifampin for Treatment of Staphylococcal Prosthetic Joint Infection
To determine the outcome and safety of a combined antimicrobial treatment involving daptomycin and surgical approach involving retention or short-interval two-stage exchange of the implant.
- Trial name
- Dapto-Studie (NCT01144000)
- Testing
- Daptomycin
- Where
- 3 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Andrej Trampuz
Tuberculosis
Study of Daily Rifapentine for Pulmonary Tuberculosis
The goal of this Phase 2 study is to determine the microbiological activity and safety of rifapentine when given as a component of multidrug intensive phase treatment of smear-positive pulmonary tuberculosis (TB).
- Trial name
- NCT00814671
- Testing
- Rifapentine 450, Rifapentine 600, Rifampin
- Where
- South Africa
- Volunteers
- 153 people
- Sponsor
- Johns Hopkins University
Cystic Fibrosis
A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects
The purpose of this study is to examine the drug-drug interaction effects of ciprofloxacin, itraconazole, and rifampin on the pharmacokinetics of lumacaftor in combination with ivacaftor as well as to evaluate the potential…
- Trial name
- NCT01768663
- Testing
- Lumacaftor, Ivacaftor, Ciprofloxacin
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vertex Pharmaceuticals Incorporated