Clinical trials: Ropivacaine
Underdosing of Local Anesthetics, Initial Encounter
Formulations of Liposomal Local Anesthetics
This blinded cross-over study aim to evaluate the efficacy of liposome-encapsulated ropivacaine formulation for dental anesthesia.
- Trial name
- NCT01307969
- Testing
- Ropivacaine
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Depression, Postpartum, Analgesia, Obstetrical
CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery)
Postnatal depression affects about 10-15% of women after childbirth. Approximately 3-5% of women experience a moderate-to-severe depression that requires medical attention.
- Conditions
- Depression, Postpartum, Analgesia, Obstetrical, Anesthesia, Obstetrical
- Trial name
- CODEPAD (NCT03167905)
- Testing
- Epidural delivery system, Entonox, Meperidine
- Where
- Singapore
- Volunteers
- 881 people
- Sponsor
- KK Women's and Children's Hospital
Postoperative Pain
Ropivacaine After Sternotomy
Continuous ropivacaine infusion to sternotomy wound after coronary artery bypass grafting (CABG) or heart valve surgery to diminish postoperative pain.
- Trial name
- NAROSYD (NCT02449486)
- Testing
- Ropivacaine
- Where
- Finland
- Volunteers
- 90 people
- Sponsor
- Kuopio University Hospital
Rib Fracture, Rib Fracture Multiple
Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma
Thoracic trauma frequently involve rib fractures which can be very painful for 2-3 months. Unfortunately, pain is not simply a "symptom" of the injuries, but a significant cause of additional medical problems: pain causes people…
- Trial name
- NCT06069154
- Testing
- Cryoneurolysis, Local anesthetic peripheral nerve block
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Analgesia, Total Knee Arthroplasty
GENIFEM Trial: Postoperative Pain After Total Knee Arthroplasty (TKA)
Motor-sparing analgesic interventions for patients undergoing total knee arthroplasty (TKA) are a key component of fast-track surgery.
- Trial name
- GENIFEM (NCT05156476)
- Testing
- Genicular nerve block-iPACK group, Femoral triangle block-iPACK group, Local infiltration analgesia
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Ziekenhuis Oost-Limburg
Postoperative Pain
Method Study: Bilateral TAP Block With 24 Hours Infusion
The purpose of this method study in healthy volunteers is to determine the extent of sensory block following Transversus Abdominis Plane (TAP) block with 24 hours infusion of ropivacaine versus infusion of saline.
- Trial name
- NCT01577940
- Testing
- Infusion of ropivacaine, Infusion of saline
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Postoperative Pain, Adverse Effects
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
The investigators undertook this prospective, randomized trial to compare the recovery profile throughout the first postoperative week in patients receiving continuous (CISB) interscalene brachial plexus block, single injection…
- Trial name
- NCT01881776
- Testing
- ISB
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Anesthesia
Ultrasound-guided Serratus Plane Block for the Quality of Recovery After Modified Radical Mastectomy
Regional anesthesia improves quality of recovery after surgery in many studies. Ultrasound-guided serratus plane block is a novel technique which may be a viable alternative to current regional anesthetic techniques.
- Trial name
- NCT02691195
- Testing
- Ropivacaine, 0.9% Nacl
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Fujian Provincial Hospital
Ankle Sprain, Ankle (Ligaments); Instability (Old Injury)
Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy
Ankle arthroscopy is increasingly performed as a day-case procedure, making rapid recovery and efficient discharge critical. Anesthetic technique substantially influences postoperative recovery, yet high-quality evidence…
- Conditions
- Ankle Sprain, Ankle (Ligaments); Instability (Old Injury), Pain Management, ERAS
- Trial name
- NCT07460310
- Testing
- Total intravenous anesthesia combined with peripheral nerve block (TIVA + PNB) group, General anesthesia combined with peripheral nerve block (GA + PNB) group, Spinal anesthesia
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Respiratory Insufficiency
Incidence Of Hemidiaphragmatic Paralysis After Usg Guided Low Dose Interscalene Brachial Plexus Block
to put a catheter in interscalene brachial plexus USG guided and give a bolus of drug followed by 24 hours continous infusion of drug
- Trial name
- NCT03081728
- Testing
- Interscalene Block with Ropivacaine Hcl 0.2% Inj Vil 10Ml, IV diclofenac and IV paracetamol
- Where
- India
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Effect of Drug
Comparison Between Bupivacaine and Ropivacaine in Patients Undergoing Forearm Surgeries Under Brachial Plexus Block
This prospective comparative randomized study was done to compare Bupivacaine and Ropivacaine in patients undergoing forearm surgeries under axillary brachial plexus block.
- Trial name
- NCT04729842
- Testing
- Axillary Brachial plexus block
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assam Medical College
Other Peripheral Nerve Disease
Comparison of the Analgesic Effect of Different Local Anesthetics in Interscalene Nerve Block for Shoulder Surgery
Several reports have compared the duration of action of levobupivacaine and ropivacaine as local anesthetic. The most widely used method for sensory function evaluation is though means of a pinprick test.
- Trial name
- NCT02691442
- Testing
- Ropivacaine 0.75%, Levobupivacaine 0.5%, Levobupivacaine 0.5% + epinephrin 1/200000
- Volunteers
- 30 people
- Sponsor
- University Hospital, Antwerp
Postoperative Pain
Efficacy of Transversus Thoracis Muscle Plane Block in Patients Undergoing Cardiac Surgery
The goal of this randomized double blind study is to evaluate the analgesic efficacy of Transversus Thoracis Muscle Plane Block in patients undergoing cardiac surgery with median sternotomy.
- Trial name
- TTMP_Block (NCT06239025)
- Testing
- ultrasound-guided Transversus Thoracis Muscle Plane Block
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Hôpital du Valais
Coronary Artery Occlusion
Neuroaxial Prophylaxis for CABG
Investigators plan to study the effect of thoracic epidural analgesia on postoperative parameters (complication rate, duration of hospitalization, mortality, etc.) of coronary artery bypass grafting.
- Trial name
- NCT04244435
- Testing
- CABG, thoracic epidural analgesia, analgesia of opioids
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Volgograd State Medical University
Anesthesia Recovery Period, Pain, Postoperative
Controlled-Release Oxycodone For Postoperative Analgesia After Video-Assisted Thoracic Surgery
The main hypothesis of this study is that preoperative administration of controlled-release (CR) oxycodone may reduce acute postoperative pain and improve time to discharge from the post-anesthesia care unit in patients…
- Trial name
- NCT00681174
- Testing
- Morphine, oxycodone, Paravertebral block
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- University of Parma
Knee Osteoarthritis
Comparing Exparel & Ropivacaine for Pain Relief in Total Knee Arthroplasty
The purpose of this prospective study is to examine the effect of two local anesthetics used in adductor canal blocks, with relation to pain, analgesic consumption, mobility, and pain related interference with activities and…
- Trial name
- NCT02607579
- Testing
- Exparel, Ropivacaine
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Monmouth Medical Center
Drug Safety, Self Efficacy
Efficacy and Safety Study of Dexmedetomidine as an Additive to Local Anesthetics in Shoulder Surgery
The purpose of this study is to test the efficacy and safety of dexmedetomidine added to ropivacaine in patients undergoing shoulder surgery.
- Trial name
- NCT01557270
- Testing
- dexmedetomidine, saline
- Where
- Austria
- Volunteers
- 62 people
- Sponsor
- Prof. Peter Gerner, M.D.
Stoma Closure, Postoperative Pain
Revised-Paravertebral Nerve Blocks for Enhanced Recovery After Stoma Closure
After stoma closure, pain remains an important problem affecting patient recovery. A revised paravertebral block (r-PVB) was developed as a single-shot, large-volume intercostal-space injection performed at the exposed…
- Conditions
- Stoma Closure, Postoperative Pain, Quality of Recovery
- Trial name
- r-PVB III (NCT07571902)
- Testing
- Revised-Paravertebral Nerve Block
- Volunteers
- 250 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Post-craniotomy, Pain
Pre-emptive Scalp Infiltration With Low-dose Flurbiprofen and Ropivacaine for Postoperative Analgesia After Craniotomy
Post-craniotomy pain is common and often associated with poor outcomes. Flurbiprofen axetil (FA) is an injectable NSAID for postoperative analgesia, however, the impact of local FA, remains elusive on post-craniotomy pain.
- Trial name
- NCT07209345
- Testing
- FA+Ropivacaine, Ropivacaine
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Beijing Tiantan Hospital
Surgery of Arthroscopic Anterior Cruciate Ligament Repair
Assessment of Adductor Canal Blockade in Anterior Cruciate Ligament Surgery
Assessment of sensory and motor blockade of adductor canal blockade performed for anterior cruciate ligament repair in comparison with femoral nerve blockade.
- Trial name
- ACB (NCT02419261)
- Testing
- Analgesic nerve blockade (Ropivacaine), Arthroscopic surgical repair of the anterior cruciate ligament
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University of Liege
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