Clinical trials: Rosuvastatin
Healthy Adult Subject, Overweight Subject
A Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects.
The purpose of this study is to characterize the effect of HDM1002 on the PK of single dose of repaglinide, atorvastatin, digoxin and rosuvastatin in healthy adult subjects.
- Trial name
- NCT06601517
- Testing
- Repaglinide, Atorvastatin, Digoxin
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Atherosclerosis, Cardiovascular Disease
High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly
The purpose of this study is to investigate the added benefits of increased high-density lipoprotein (HDL) cholesterol serum levels over and above those achieved by lipid lowering therapy guided by current guidelines, in older…
- Trial name
- NIA-Plaque (NCT00127218)
- Testing
- any statin, niacin
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Johns Hopkins University
Hypercholesterolaemia
OLE Study to Evaluate Safety / Efficacy of ZD4522
The purpose of this study is to assess the long term safety of Crestor.
- Trial name
- NCT00654303
- Testing
- Rosuvastatin
- Volunteers
- 3,500 people
- Sponsor
- AstraZeneca
Interaction Drug Food
Assessing Goldenseal-drug Interactions Using a Probe Drug Cocktail Approach
Goldenseal is a botanical natural product commonly used to self-treat symptoms of the common cold and many digestive disorders. Goldenseal products typically contain the isoquinoline alkaloids berberine, hydrastine, and…
- Trial name
- NCT03772262
- Testing
- goldenseal, Metformin, Furosemide
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Washington State University
Cardiovascular Diseases (CVD)
Comparative Study Between Antihyperlipidemic Agents in Treatment of Cardiovascular Diseases
The goal of this clinical trial is to study the efficiency and safety of using combinations of antihyperlipidemic agents with a single drug to treat cardiovascular diseases.
- Trial name
- NCT07313124
- Testing
- rosuvastatin drug, Patients received rosuvastatin ezetimibe10/10mg
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Beni-Suef University
PRS-based Primary Prevention of CVD
Polygenic Risk Driven Pragmatic Statin Trial for Heart Disease Prevention
This research investigates the potential advantages of intensive preventive statin treatment for healthy men aged 45-80 and women aged 55-80 who possess a high genetic predisposition to coronary artery disease (CAD).
- Trial name
- EE-PRS (NCT06820086)
- Testing
- Rosuvastatin 20mg
- Where
- 2 sites in Estonia
- Volunteers
- 2,714 people
- Sponsor
- Mikk JÜRISSON
Coronary Artery Disease, Coronary Disease
Dose-dependent Effect of Rosuvastatin on Long-term Clinical Outcomes After PCI
This study is a prospective, randomized, open-label, single-center trial designed to compare the 30 month-safety and efficacy between low-dose (5mg/dL) and high-dose (20mg/dL) rosuvastatin treatment for patients with coronary…
- Conditions
- Coronary Artery Disease, Coronary Disease, Cardiovascular Diseases
- Trial name
- ROSUVA-30 (NCT02859480)
- Testing
- Rosuvastatin 5mg, Rosuvastatin 20mg
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Korea University Anam Hospital
Dyslipidemia
Observational Study To Evaluate Statins Patterns Of Use In Spain
The present project is aimed at describing the statins prescription pattern in Spanish patients. It will also look into how adequate these prescriptions are accordingly to the recommendations given in Treatment Guidelines and in…
- Trial name
- NCT01023503
- Where
- Spain
- Sponsor
- AstraZeneca
Endometriosis, Uterine Fibroids
A Phase 1 Clinical Study to Evaluate the Effects of SHR7280 on the Pharmacokinetics of Midazolam, S-warfarin, Omeprazole, Digoxin, and Rosuvastatin in Healthy Subjects
The purpose of this study is to evaluate the effects of SHR7280 on the pharmacokinetics of midazolam, S-warfarin, omeprazole, digoxin and rosuvastatin in healthy subjects.
- Conditions
- Endometriosis, Uterine Fibroids, Assisted Reproduction
- Trial name
- NCT06949124
- Testing
- SHR7280 Tablets
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Venous Thromboembolism, Blood Clot
Statins for Venous Event Reduction in Patients With Venous Thromboembolism
The standard or usual treatment for patients diagnosed with deep vein thrombosis or pulmonary embolism is treatment with blood thinners (called anticoagulants).
- Conditions
- Venous Thromboembolism, Blood Clot, Post Thrombotic Syndrome
- Trial name
- SAVER (NCT04319627)
- Testing
- Rosuvastatin Calcium
- Where
- 31 sites in Canada, France and 4 more
- Volunteers
- 2,700 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Periodontitis
Locally Delivered Atorvastatin & Rosuvastatin for Treatment of Furcation Defects in Chronic Periodontitis
Statins are one of the lipid lowering drugs that help in reducing cholesterol levels in the body by specifically inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase; which is a rate limiting enzyme for cholesterol…
- Trial name
- NCT02800902
- Testing
- Rosuvastatin, Atorvastatin
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Non-small Cell Lung Cancer
Assessing the Effect of DZD9008 on the Pharmacokinetics of the Cocktail Probes Representative for CYP3A4, P-gp, BCRP and OATP1B1 in Patients with EGFR or HER2 Mutant Advanced Non-small Cell Lung Cancer (WU-KONG19)
This study will treat patients with advanced NSCLC who have progressed following prior therapy in order to assess the effect of DZD9008 on exposure of midazolam, digoxin and rosuvastatin, through multiple PK parameters, when…
- Trial name
- NCT05926180
- Testing
- DZD9008 and Probe drugs (midazolam, digoxin, rosuvastatin)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Dizal Pharmaceuticals
Hypercholesterolaemia
Registry On Efficacy and Safety Of Rosuvastatin, and Atorvastatin and Simvastatin In Hypercholesterolaemia
The objective of this follow-up retrospective study is to evaluate the long term efficacy and safety of rosuvastatin in reducing lipid parameters in clinical practice.
- Trial name
- NCT01352897
- Where
- Singapore
- Volunteers
- 800 people
- Sponsor
- AstraZeneca
Healthy
A Study of Imlunestrant (LY3484356) in Female Healthy Participants
The main purpose of this study is to evaluate the effect of imlunestrant on repaglinide, omeprazole and dextromethorphan, and rosuvastatin and digoxin.
- Trial name
- NCT05444556
- Testing
- Imlunestrant, Repaglinide, Omeprazole
- Where
- 3 sites in United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy
Drug Interaction Study of MGL-3196 With Rosuvastatin and Simvastatin
The purpose of this study is to determine whether MGL-3196 alters the pharmacokinetics of rosuvastatin and/or simvastatin in healthy male subjects and female subjects not of child-bearing potential.
- Trial name
- NCT02542969
- Testing
- Simvastatin, Rosuvastatin, MGL-3196
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Madrigal Pharmaceuticals, Inc.
Malaria
A First Time in Human Study in Healthy Volunteers to Investigate a New Medicine to Treat Malaria
The purpose of this study is to determine if the study drug (antimalarial medication) is safe when given to healthy subjects as a single dose or as repeated doses, to understand the effect of food on single doses of study drug…
- Trial name
- NCT00811356
- Testing
- GSK932121; Rosiglitazone; Rosuvastatin
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Stroke, Acute
Statins Role in Acute Ischemic Stroke
Strokes is amajor cause of death and disabilities in different countried
- Trial name
- observation (NCT06371495)
- Testing
- rosuvastatin
- Volunteers
- 105 people
- Sponsor
- Assiut University
Healthy Subjects
A Study to Investigate The Effect of Pimicotinib on The Pharmacokinetics of Metformin, Fexofenadine and Rosuvastatin In Healthy Subjects
This is a an open-label, fixed-sequence DDI study conducted in Chinese healthy subjects to investigate the effect of multiple oral doses of pimicotinib on the pharmacokinetics of fexofenadine , rosuvastatin and metformin .
- Trial name
- NCT06779253
- Testing
- pimicotinib capsules
- Where
- China
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Abbisko Therapeutics Co, Ltd
Hyperlipidemia, Atherosclerosis
Rosuvastatin Evaluation of Atherosclerotic Chinese Patients (REACH)
This study is to evaluate the effect of rosuvastatin 10-20 mg on carotid atherosclerosis progression in Chinese patients by evaluating the change in the percentage of volume of lipid rich necrotic core (LRNC) using…
- Trial name
- REACH (NCT00885872)
- Testing
- Rosuvastatin (Crestor)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese PLA General Hospital
Healthy Subjects
Bioequivalence Study of CJ-30060 in Healthy Volunteers
To compare the pharmacokinetics and safety after a single dose administration of CJ-30060 and Exforge® 5/160mg, Crestor® 10mg in healthy volunteers.
- Trial name
- NCT03757390
- Testing
- Exforge® tab 5/160mg, Crestor® tab 10mg, CJ-30060 5/160/10mg
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation