Clinical trials: Rosuvastatin
Dyslipidemia & Hypertension
PK Study of Telmisartan/Rosuvastatin FDC Compared to Combination of Telmisartan and Rosuvastatin
This is a 2 by 2 cross-over study to evaluate pharmacokinetics of telmisartan and rosuvastatin FDC compared to reference telmisartan and rosuvastatin coadministered in two groups enrolling healthy adult male and female subjects…
- Trial name
- NCT01975961
- Testing
- Crestor 20mg(Rosuvastatin 20mg), Micardis 80mg(Telmisartan 80mg) , FDC
- Where
- South Korea
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Carotid Artery Stenosis, Hypercholesterolemia
Progression of Carotid Artery Atheroma in Moderately Hypercholesterolemic Subjects
The purpose of this study is to examine the changes in the carotid artery when subjects receive high or low doses of rosuvastatin.
- Trial name
- NCT00654394
- Testing
- Rosuvastatin
- Volunteers
- 200 people
- Sponsor
- AstraZeneca
Primary Hypercholesterolemia
Efficacy and Safety of Combination of Rosuvastatin and Ezetimibe in Patients With Primary Hypercholesterolemia
The purpose of this study is to evaluate efficacy and safety of HL140 in patients with primary hypercholesterolemia.
- Trial name
- NCT03571087
- Testing
- HL140 5/10, HL140 10/10, HL140 20/10
- Volunteers
- 374 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
SARS-CoV-2
Colchicine/Statins for the Prevention of COVID-19 Complications (COLSTAT) Trial
This is a pragmatic randomized open-label study of the safety and efficacy of the combination of colchicine and Rosuvastatin in addition to standard of care (SOC) compared to SOC alone in hospitalized patients with SARS-CoV-2
- Trial name
- COLSTAT (NCT04472611)
- Testing
- Standard of Care (SOC) and Colchicine+Rosuvastatin
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- Yale University
Head Injury
Effect of Rosuvastatin on Amnesia and Orientation Through Galveston Outcome Amnesia Test in Moderate Head Injury
The purpose of this study is to determine whether rosuvastatin is effective in the management of moderate head injury by improving amnesia and orientation.
- Trial name
- NCT00329758
- Testing
- rosuvastatin
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Diabetes Mellitus, Type 2, Overweight
Influence of JY09 on Pharmacokinetics of Metformin , Rosuvastatin , and Digoxin and the QT Interval Study in Overweight Chinese Subjects
This trial is conducted in china. The aim of the trial is as follows: To assess the effect of multiple subcutaneous injections of JY09 injection on the pharmacokinetic (PK) profile of multiple oral doses of metformin…
- Trial name
- NCT06247748
- Testing
- Exendin-4 Fc fusion protein (JY09) injection, Metformin Hydrochloride tablet, Rosuvastatin calcium tablets
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Beijing Dongfang Biotech Co., Ltd.
Dyslipidemia
Pharmacokinetics of Rosuvastatin and Atorvastatin in Pediatric Dyslipidemia Patients
This will be a single center, open label, randomized, cross-over study in patients with dyslipidemia comparing the pharmacokinetics of rosuvastatin and atorvastatin in patients with greater than or equal to one variant allele in…
- Trial name
- SD2 (NCT02364258)
- Testing
- Rosuvastatin, Atorvastatin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Atypical Endometrial Hyperplasia
Megestrol Acetate Plus Rosuvastatin in Young Women With Atypical Endometrial Hyperplasia
To see if megestrol acetate plus rosuvastatin will be superior to reversing the endometrial lesion to a normal endometrium than megestrol acetate alone in patients with atypical endometrial hyperplasia (AEH).
- Trial name
- NCT04491682
- Testing
- Megestrol Acetate, Rosuvastatin
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Fudan University
Coronary Artery Disease
Influence of Intensive Lipid-lowering on FFRCT (The FLOW-PROMOTE Study)
The FLOW-PROMOTE Study is an investigator-initiated, Danish multicenter study of patients with stable chest pain investigating whether lipid lowering is associated with recovery of impaired coronary flow as assessed by CT derived…
- Trial name
- FlowPromote (NCT04737408)
- Testing
- Rosuvastatin 40mg
- Where
- 3 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Bjarne Linde Noergaard
Hypercholesterolemia, Dyslipidemias
Clinical Trial to Evaluate Efficacy and Safety of ROVASRO 10mg Versus CRESTOR 10mg in Hypercholesterolemic Patients
This 8 weeks, prospective, single center, randomized, open-label, parallel-group, non-inferiority study was performed from October 2015 to April 2018.
- Trial name
- NCT03949374
- Testing
- CRESTOR, reference formulation of rosuvastatin, ROVASRO, generic formulation of rosuvastatin
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity
Patients with coronary artery disease (CAD) are often treated with dual antiplatelet therapy (DAT), including aspirin and clopidogrel, to prevent from recurrent atherothrombotic events.
- Trial name
- PEARL (NCT01567774)
- Testing
- Atorvastatin, Rosuvastatin
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Atherosclerosis, Cardiovascular Disease
Is Augmentation of PORH by Rosuvastatin Adenosine-receptor Mediated?
Rationale: Statins form a class of drugs that is widely prescribed for hypercholesterolaemia, specifically to reduce the risk on atherosclerosis by lowering LDL-cholesterol.
- Trial name
- NCT00851175
- Testing
- rosuvastatin, caffeine
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease
Randomized Trial of Creatine-kinase Leak After Rosuvastatin At the Time of Percutaneous Coronary Intervention
Patients with stable coronary disease when undergoing percutaneous coronary intervention may present periprocedural myocardial infarction defined at present as a creatine kinase-myocardial isoenzyme (CK-MB) elevation 3 times…
- Trial name
- CLEAR-PCI (NCT01968577)
- Testing
- Rosuvastatin
- Where
- Brazil
- Volunteers
- 528 people
- Sponsor
- Kleber Bomfim Araujo Martins
Heart Failure With Reduced Ejection Fraction
Comparison of Effects of Atorvastatin Versus Rosuvastatin on Cardiac Function in Heart Failure Patients
Statins have a protective effect in patients with established heart failure because of their lipid-lowering and pleiotropic effects.
- Trial name
- ASTRO-CHF (NCT05072054)
- Testing
- Atorvastatin Oral Tablet, Rosuvastatin Oral Tablet
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Coronary Syndromes
Effect of Genetic Variation on Efficacy and Safety of Lipid-Lowering Drugs
The primary end point was to reduce LDL-C levels by at least 50%, while the secondary end point was to achieve an LDL-C level below 55 mg/dL.
- Trial name
- NCT07008794
- Testing
- Atorvastatin 40 mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Endothelial Dysfunction, Atherosclerosis
Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Endothelial Function
The aim of this study was to measure the effect of moderate and intensive lipid-lowering treatment with rosuvastatin on the endothelial function.
- Trial name
- NCT01223625
- Testing
- Rosuvastatin 5mg/day, Rosuvastatin 40mg/day
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Odense University Hospital
Healthy Subjects
Bio Equivalence Study of Torrent Pharmaceutical Ltd's Rosuvastatin Calcium Tablets Under Fasting Condition.
Subjects to compare the single dose bioavailability of Torrent's Rosuvastatin Calcium Tablets 40 mg and Crestor® 40 mg Tablets of AstraZeneca Pharmaceuticals LP, USA.
- Trial name
- NCT02962310
- Testing
- Torrent's Rosuvastatin Calcium Tablets 40 mg, Crestor 40 mg Tablets of AstraZeneca LP, USA
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Torrent Pharmaceuticals Limited
Healthy
A Clinical Trial of Enlicitide and Rosuvastatin in Healthy Adults (MK-0616-039)
This goal of this trial is to learn about two medicines, enlicitide and rosuvastatin, in healthy people. Researchers will compare the amounts of enlicitide and rosuvastatin in a person's body over time, when they are given as…
- Trial name
- NCT07300280
- Testing
- MK-0616A, Enlicitide, Rosuvastatin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy Volunteers
A Study to Evaluate the Drug-drug Interactions (DDIs) of GP681 With Rosuvastatin, Digoxin, Itraconazole, Oseltamivir in Chinese Healthy Volunteers
This study is a four-part, single-center, Open label phase I clinical study to characterize the DDIs potential of GP681 With Rosuvastatin, Digoxin, Itraconazole or Oseltamivir in Chinese healthy volunteers.
- Trial name
- NCT05789342
- Testing
- GP681, Rosuvastatin, Digoxin
- Where
- China
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Jiangxi Qingfeng Pharmaceutical Co. Ltd.
Acute Coronary Syndrome, Angioplasty
Acute Rosuvastatin for Preventing Myocardial Damage in Patients With ACS
Rosuvastatin reload may prevent myocardial damage in ACS patients undergoing PCI
- Trial name
- AVATAR (NCT01245803)
- Testing
- additional rosuvastatin loading
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Anzhen Hospital