Clinical trials: Rosuvastatin
Coronary Artery Disease, Atherosclerosis of Coronary Artery
Comparison of Moderate-Intensity Statin Plus Ezetimibe vs. High-Intensity Statin for Coronary Plaque Stabilization
This study is a prospective, multicenter, randomized clinical trial aimed at comparing the effects of moderate-intensity statin plus ezetimibe combination therapy versus high-intensity statin monotherapy on coronary plaque…
- Conditions
- Coronary Artery Disease, Atherosclerosis of Coronary Artery, Plaque, Atherosclerotic
- Trial name
- NCT06767345
- Testing
- Rosuvastatin, Rosuvastatin/ezetimibe
- Where
- 7 sites in South Korea
- Volunteers
- 410 people
- Sponsor
- Korea University Anam Hospital
Healthy
Clinical Trial to Investigate the Efficacy and Safety of DWJ1351
The purpose of this study is to compare the safety and pharmacokinetic characteristics of combination of amlodipine, olmesartan and rosuvastatin and DWJ1351 in healthy male volunteers
- Trial name
- NCT03753477
- Testing
- DWJ1351(FDC Amlodipine/Olmesartan/Rosuvastatin), Sevikar and Crestor
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Hyperlipidemia, Coronary Artery Disease
Rosuvastatin Effect on Reducing Coronary Atherosclerosis Plaques Volume
This multicentre, open-label, single-arm Study is to evaluate the effect of Rosuvastatin 20 mg 76 weeks on coronary atherosclerosis plaque versus baseline in Chinese coronary heart disease (CHD) patients with hyperlipidemia by…
- Trial name
- REDUCT (NCT01382277)
- Testing
- Rosuvastatin
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Peking University First Hospital
Advanced Non-small Cell Lung Cancer, EGFR Mutation
A Study to Learn About How BAY2927088 Affects the Level of Dabigatran or Rosuvastatin in the Blood When These Drugs Are Taken Together in Healthy Participants
Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor…
- Conditions
- Advanced Non-small Cell Lung Cancer, EGFR Mutation, HER2 Mutation, Healthy Volunteers
- Trial name
- NCT06329895
- Testing
- BAY2927088, Dabigatran etexilate, Rosuvastatin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bayer
Hypertension, Dyslipidemia
Clinical Trail to Evaluate the Efficacy and Safety of DWJ1451
the change of sitSBP based on baseline between Treatment arm and control 1 arm [ Time Frame: 8 weeks ] the change of LDL-C based on baseline between Treatment arm and control2 arm [ Time Frame: 8 weeks ]
- Trial name
- NCT04161001
- Testing
- Amlodipine/Olmesartan 10/40mg (Combination drug), Ezetimibe/Rosuvastatin 10/20mg(Combination drug), Olmesartan 40mg, Ezetimibe/Rosuvastatin 10/20mg(Combination drug), Amlodipine/Olmesartan 10/40mg (Combination drug)
- Where
- South Korea
- Volunteers
- 237 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Hypercholesterolemia With Concomitant Type 2 Diabetes
LIpid Lowering With Highly Potent Statins in Hyperlipidaemia With Type 2 Diabetes patiENts
The purpose of this study is to compare the effect of rosuvastatin and atorvastatin on lipid lowering effect and glucose metabolism in hypercholesterolemia patients with diabetes mellitus.
- Trial name
- LISTEN (NCT01544309)
- Testing
- Atorvastatin, Rosuvastatin
- Where
- 133 sites in Japan
- Volunteers
- 1,049 people
- Sponsor
- Listen Trial Group
Healthy
A Drug-Drug Interaction Study of LY3537982 on Midazolam, Digoxin, and Rosuvastatin in Healthy Participants
The main purpose of this study is to evaluate the effects of multiple doses of LY3537982 on the pharmacokinetics (PK) of digoxin (a P-glycoprotein [P-gp] substrate), rosuvastatin (a breast cancer resistance protein [BCRP)]…
- Trial name
- NCT06111521
- Testing
- LY3537982, Digoxin, Rosuvastatin
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Heart Failure
Impact of Rosuvastatin on Endothelial Function and Inflammation in Patients With Chronic Heart Failure
Statin therapy has been shown to efficiently reduce mortality in patients with coronary artery disease and myocardial infarction, partially as a result of the lipid-lowering properties of statins.
- Trial name
- NCT00176332
- Testing
- rosuvastatin
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Leipzig
ASCVD
High-intensity Rosuvastatin and Moderate-intensity Rosuvastatin/Ezetimibe in ASCVD Patients
This study will evaluate the efficacy and safety of high-intensity rosuvastatin and moderate-intensity rosuvastatin/ezetimibe in ASCVD patients.
- Trial name
- NCT03494270
- Testing
- Rosuvamibe, Monorova
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Yuhan Corporation
Critically Ill, H1N1/Influenza Infection
Collaborative H1N1 Adjuvant Treatment Pilot Trial
Study Design: A, multinational, double blind, placebo-controlled pilot RCT involving 80 patients in the general ICUs of 30 centres.
- Trial name
- CHAT (NCT01033955)
- Testing
- Rosuvastatin
- Where
- 9 sites in Canada
- Volunteers
- 8 people
- Sponsor
- Canadian Critical Care Trials Group
ASCVD, Diabetes
Comparison of Pitavastatin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus
The AVOID-DM trial is a multicenter, prospective, randomized study comparing the risk of new-onset diabetes mellitus (DM) between two cholesterol-lowering strategies in patients with prediabetes and established atherosclerotic…
- Conditions
- ASCVD, Diabetes, Statin
- Trial name
- NCT06767774
- Testing
- Combination therapy, High intensity statin monotherapy
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Korea University Anam Hospital
Hypercholesterolemia
Effect of Crestor on Lipoprotein Metabolism in Humans
The objective of this research is to understand how Crestor can effectively reduce the levels of the bad cholesterol, LDL, in blood.
- Trial name
- NCT00214617
- Testing
- Rosuvastatin at 5 mg/day and 40 mg/day
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Foundation for Atlanta Veterans Education and Research, Inc.
Cardiovascular Diseases, Myocardial Infarction
Real World Evidence Study of Statin Use in Brazil
A cross-sectional real-world data study designed to assess the use of statins in individuals assisted within the primary care system in Brazil.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Stroke, Hypertension
- Trial name
- RWE-Statins (NCT05285085)
- Testing
- Statin
- Where
- Brazil
- Volunteers
- 2,133,900 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
Stroke
Wake up Symptomatic Stroke - Benefit of Intravenous Clot Busters or Endovascular Intervention
The purpose of the trial is to study the safety and the effectiveness of using CT Perfusion studies as an indicator to treat stroke patients with unknown time of onset.
- Trial name
- WASSABI (NCT01455935)
- Testing
- Anti-platelets and statin, alteplase, intra arterial intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Jacobs Neurological Institute
Hypercholesterolemia
Effectiveness of Treatment of Hypercholesterolemia With Rosuvastatin and Ezetimibe
The aim of the study is to demonstrate, whether the time of day of administration of the study drug (containing rosuvastatin and ezetimibe) has an impact on the effectiveness of lipid-lowering therapy.
- Trial name
- ROSEZE (NCT02772640)
- Testing
- Rosuvastatin and Ezetimibe morning or evening administration
- Where
- Poland
- Volunteers
- 83 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Carotid Stenosis
Alirocumab for Stabilisation of Symptomatic Vulnerable Carotid Plaque
CAROTID-STABILISE is a phase III, multicentre, randomised, double-blind, placebo-controlled trial evaluating whether alirocumab 150 mg subcutaneously every 2 weeks, added to high-intensity statin therapy, produces greater…
- Trial name
- CAROTID-STABIL (NCT07586540)
- Testing
- Alirocumab, Atorvastatin
- Where
- 14 sites in Egypt, Jordan and 6 more
- Volunteers
- 280 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Drug Interaction
Drug-Drug Interaction Study to Evaluate the Effects of Ecopipam on the Pharmacokinetics of Multiple Substrates for Drug Metabolism and Transport
This is a single center, open-label, fixed sequence Phase 1, drug-drug interaction (DDI) study in healthy subjects.
- Trial name
- NCT05334108
- Testing
- Ecopipam, Cohort 1 Probe Substrate Cocktail, Cohort 2 Probe Substrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Emalex Biosciences Inc.
Intracranial Atherosclerosis, Intracranial Artery Stenosis
PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis
This is a prospective, multicenter, open-label, blinded-endpoint, randomized controlled trial designed to evaluate the efficacy and safety of PCSK9 inhibitor combined with statin therapy compared to statin monotherapy in…
- Conditions
- Intracranial Atherosclerosis, Intracranial Artery Stenosis, Atherosclerotic Plaque
- Trial name
- PISTIAS-2 (NCT06902740)
- Testing
- Recaticimab and Statin, Statin
- Where
- 19 sites in China
- Volunteers
- 300 people
- Sponsor
- Peking Union Medical College Hospital
Type 2 Diabetes, Dyslipidemias
To Evaluate the Safety and Pharmacokinetic Interaction Between HODO-22251 and HODO-22252 in Healthy Adults
The purpose of this study is to evaluate pharmacokinetic interaction and safety of co-administrated 25mg of Empagliflozin and 10/10mg Ezetimibe/Rosuvastatin in steady state in healthy volunteers.
- Trial name
- NCT06578676
- Testing
- Empagliflozin 25 MG, Ezetimibe/Rosuvastatin 10/10mg, Empagliflozin 25 MG with Ezetimibe/Rosuvastatin 10/10mg
- Where
- South Korea
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hyundai Pharm
Hypercholesterolemia
A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808)
The purpose of this study is to investigate the effect of an investigational cholesterol-lowering drug in patients who are currently taking an approved medication for hypercholesterolemia (high cholesterol levels) and have been…
- Trial name
- NCT00132717
- Testing
- MK0653A (ezetimibe [+] simvastatin), Comparator: atorvastatin, Comparator: fluvastatin
- Volunteers
- 450 people
- Sponsor
- Organon and Co