Clinical trials: Rosuvastatin
Hypercholesterolemia
High Potency Statins and Acute Kidney Injury
Statins are a class of cholesterol lowering medications that are prescribed for the prevention and treatment of cardiovascular disease.
- Trial name
- NCT02518516
- Testing
- Rosuvastatin (≥10 mg), Atorvastatin (≥20 mg), Simvastatin (≥40 mg)
- Where
- Canada
- Volunteers
- 2,067,639 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Diabetic Polyneuropathy
The Effect of Rosuvastatin in Diabetic Polyneuropathy: A Phase IIa Randomized Double-blind Placebo-controlled Study
To evaluate the impact of oral rosuvastatin in diabetic polyneuropathy, and the role of lipid peroxidation and nerve growth factor.
- Trial name
- NCT01622777
- Testing
- Rosuvastatin
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Alejandra Guillermina Miranda Diaz
Healthy Volunteers, Statins
Effects of Rosuvastatin on the Immune System in Healthy Volunteers With Normal Cholesterol
Background: The drug rosuvastatin (also called Crestor) is used to lower cholesterol levels in people with elevated cholesterol levels.
- Conditions
- Healthy Volunteers, Statins, Immune Modulation
- Trial name
- NCT01200836
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Healthy
Study of PF-04965842 Effect on Rosuvastatin Pharmacokinetics in Healthy Participants
This is a Phase 1, randomized, 2 way crossover, multiple dose, open label study of the effect of PF 04965842 on rosuvastatin PK in healthy participants. Participants will be randomized to 1 of the 2 treatment sequences.
- Trial name
- NCT03806101
- Testing
- PF-04965842, Rosuvastatin
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Hypercholesterolemia
Efficacy of Lapaquistat Acetate Co-Administered With Statins in Subjects With Hypercholesterolemia
The purpose of the study is to determine the efficacy of lapaquistat acetate, once daily (QD), taken with statins on cholesterol levels in subjects with hypercholesterolemia
- Trial name
- NCT00532311
- Testing
- Lapaquistat acetate and stable statin therapy, Stable statin therapy
- Where
- 86 sites in United States
- Volunteers
- 411 people
- Sponsor
- Takeda
Healthy
Evaluating of Pharmacokinetic Profile of BCWP_C003 and Co-administration of Rosuvastatin and Metformin
The purpose of this study is to evaluate the pharmacokinetic Profile and Safety/Tolerability of BCWP_C003 compared to Co-Administration of Crestor 10mg and Glucophage XR 1000mg, and to evaluate the food effect of Pharmacokinetic…
- Trial name
- NCT01992211
- Testing
- Rosuvastatin, Metformin, BCWP_C003
- Where
- South Korea
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- BC World Pharm Co. Ltd.
Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome
Early Initiation of Tafolecimab for Patients With Acute Coronary Syndromeundergoing Percutaneous Coronary Intervention in Chinese Population
For patients with ACS undergoing PCI, intensive lipid-lowering including PCSK9 monoclonal antibody should be started as soon as possible, that is, lower LDL-C level should be achieved as soon as possible.
- Conditions
- Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome, Lipid Lowering, Vascular Inflammation
- Trial name
- NCT06096909
- Testing
- Tafolecimab, Cholesterol Absorption Inhibitor, Statin
- Where
- 2 sites in China
- Volunteers
- 3,684 people
- Sponsor
- China National Center for Cardiovascular Diseases
Healthy
A Phase 1 Study of ABBV-CLS-7262, Rosuvastatin, and Digoxin in Healthy Subjects
This study follows an open-label, single arm design with two periods with rosuvastatin, digoxin and ABBV-CLS-7262
- Trial name
- NCT05763459
- Testing
- ABBV-CLS-7262
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Calico Life Sciences LLC
Dyslipidemia, Type 2 Diabetes
Evaluate the Efficacy and Safety of CMG190303 in Patients With Type 2 Diabetes and Dyslipidemia
The goal of this clinical trial is to learn if drug CMG190303 to treat Type 2 Diabetes and Dyslipidemia in adults. It will also learn about the safety of CMG190303.
- Trial name
- NCT06772168
- Testing
- CMG190303(Dapagliflozin/Rosuvastatin)
- Where
- 24 sites in South Korea
- Volunteers
- 240 people
- Sponsor
- CMG Pharmaceutical Co. Ltd
Hypertension, Hyperlipidemia
A Study to Compare the Pharmacokinetics and Safety of a Fixed Dose Combination of Fimasartan/Amlodipine/Rosuvastatin
An open-label, randomized, single-dose, 2X3X3 partial replicate, crossover study to compare the pharmacokinetics and safety between a fixed dose combination of Fimasartan/Amlodipine/Rosuvastatin and Co-administration of a fixed…
- Trial name
- NCT02995720
- Testing
- Fimasartan/Amlodipine combination drug, Rosuvastatin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Acute Coronary Syndrome, Hyperlipidemias
PCSK 9 Inhibitor Added to High-Intensity Statin Therapy to Prevent Cardiovascular Events in Patients With ACS After PCI
The primary objective was to evaluate the effect of PCSK 9 Inhibitor (initiated within 4 h from PCI for the culprit lesion) with high-intensity statin treatment, compared to placebo with high-intensity statin treatment, on…
- Conditions
- Acute Coronary Syndrome, Hyperlipidemias, Percutaneous Coronary Intervention, Cardiovascular Events
- Trial name
- SHAWN (NCT05457582)
- Testing
- PCSK 9 Inhibitor plus high-intensity statin
- Where
- China
- Volunteers
- 1,212 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Coronary Artery Disease
Statin and Atheroma Vulnerability Evaluation
The purpose of this study is to evaluate the effect of statin therapy on the modification of atherosclerotic plaque composition and vulnerability in non-intervened coronary arteries with mild to moderate stenosis using VH-IVUS…
- Trial name
- STABLE (NCT00997880)
- Testing
- Rosuvastatin calcium 40mg, Rosuvastatin calcium10mg
- Where
- South Korea
- Volunteers
- 312 people
- Sponsor
- Seung-Jung Park
Ischemic Stroke
Effects of Short-term Intensive Statin Therapy on Lipid Levels
Acute cerebral infarction (ACI), often linked to arterial stenosis, is a major cause of death and disability. Statins are cornerstone therapies for secondary prevention, effectively lowering LDL-C and stabilizing plaques.
- Trial name
- NCT07344610
- Testing
- statin
- Where
- China
- Volunteers
- 800 people
- Sponsor
- General Hospital of Shenyang Military Region
Primary Hypercholesterolemia
Efficacy and Safety of a Generic Rosuvastatin in a Real-world Setting
This study assessed the safety and efficacy of generic Rosuvastatin in reducing plasma low density lipoprotein (LDL) cholesterol in Lebanese adult patients (18 years or older) with dyslipidemia for both primary and secondary…
- Trial name
- NCT03516955
- Testing
- Rosuvastatin
- Volunteers
- 317 people
- Sponsor
- Hikma Pharmaceuticals LLC
Acute Ischemic Stroke
Efficacy and Safety of Early Combined Therapy With PCSK9 Inhibitors and Statins in Acute Ischemic Stroke
This study is an investigator-initiated, multicenter, prospective, open-label, endpoint-blinded, randomized controlled trial (PROBE design) that includes patients with moderate or severe symptomatic intracranial large vessel…
- Trial name
- CAPTAIN (NCT06696820)
- Testing
- PCSK9 inhibitors combined with atorvastatin/rosuvastatin, Atorvastatin/Rosuvastatin
- Where
- 2 sites in China
- Volunteers
- 429 people
- Sponsor
- Xiang Luo
HCC
Statin With Palliative Therapy for HCC
Statin is a preventive medicine for hepatitis B and hepatitis C which decreases the risk turning into liver cancer,however, the investigators also discovered that patients taking Statin live longer than patients who didn't take…
- Trial name
- NCT02785874
- Testing
- Statin
- Where
- Taiwan
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Hypertension, Hyperlipidemia
Safety and Pharmacokinetics Between Fixed-dose Combination VR 160/20 mg and Co-administration of Diovan® (Valsartan) Film-coated Tablet 160 mg and Crestor® (Rosuvastatin) 20 mg
To compare the safety and pharmacokinetics between ROVATITAN tab. 160/20 mg (ROVATITAN tab 160/20mg-1, ROVATITAN tab. 160/20mg-2) and coadministration of Diovan® (Valsartan) 160 mg and Crestor® (Rosuvastatin) 20 mg in healthy…
- Trial name
- NCT01918358
- Testing
- Sequence 1 : Period 1 (VR 160/20 mg-1), Period 2(VR 160/20 mg-2), Period (V+R), Sequence 2 : Period 1 (VR 160/20 mg-2), Period 2 (V+R), Period 3 (VR 160/20 mg-1), Sequence 3 : Period 1 (V+R), Period 2 (VR 160/20 mg-2), Period 3 (VR 160/20 mg-1)
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Left Ventricular Diastolic Dysfunction, Hyperlipidemias
Compare the Efficacy and Safety of Rosuvastatin/Ezetimibe Combination Therapy Versus Rosuvastatin Monotherapy in Korean Patients With Left Ventricular Diastolic Dysfunction and Hyperlipidemia
preserved left ventricular ejection fraction (LVEF ≥ 50%) and are accompanied by dyslipidemia (LDL ≥ 100 mg / dl) will be enrolled. Only patients who do not meet the exclusion criteria should be enrolled in the study.
- Trial name
- NCT04433533
- Testing
- Rosuvastatin 20, Rosuvamibe 10/10
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Acute Coronary Syndrome
Influence of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Plaque Composition in Patients With ST-Segment Elevation Myocardial Infarction (MI)
In patients with ST-segment elevation acute myocardial infarction (STEMI) increased LDL-cholesterol reduction (rosuvastatin 40 mg) will provide incremental plaque stabilization (changes in plaque composition) and plaque…
- Trial name
- VIRHISTAMI (NCT01058915)
- Testing
- Rosuvastatin 5mg, Rosuvastatin 40mg
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Odense University Hospital
Drug Interactions
Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation
The purpose of this study is to identify and validate a probe cocktail for use in future drug-drug interaction studies. Cytochrome P450 enzymes and transport proteins play important roles in the disposition of drugs.
- Trial name
- NCT00964106
- Testing
- Caffeine, Rosiglitazone, Flurbiprofen
- Where
- 2 sites in South Korea
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline