Clinical trials: Rosuvastatin
Drug Interaction Potentiation
Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin
This is a single-center, randomized, 2-period, 2-sequence, cross-over study.
- Trial name
- NCT01146483
- Testing
- Rosuvastatin, Pantoprazole
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Dyslipidemia Associated With Type II Diabetes Mellitus
Moderate-intensity Statin vs. Individualized LDL-C Target-based Therapy in Older Adults With Type 2 Diabetes (iTARGET-Elderly Study)
Statins are the cornerstone of cardiovascular disease (CVD) prevention through the lowering of low-density lipoprotein cholesterol (LDL-C).
- Trial name
- NCT07359105
- Testing
- Moderate-intensity statin monotherapy, Ezetimibe or ezetimibe-statin combination therapy
- Where
- 2 sites in South Korea
- Volunteers
- 2,186 people
- Sponsor
- Sin Gon Kim
Pulmonary Tuberculosis
Rosuvastatin Evaluation as a Tuberculosis Treatment Adjunct
This trial aims to determine whether the addition of rosuvastatin to standard TB therapy in pulmonary tuberculosis results in accelerated of sputum culture conversion.
- Trial name
- ROSETTA (NCT04504851)
- Testing
- Rosuvastatin 10mg, Rifampicin, Isoniazid
- Where
- 6 sites in Philippines, Singapore and 2 more
- Volunteers
- 154 people
- Sponsor
- National University Hospital, Singapore
HIV Infections
Darunavir/Ritonavir and Rosuvastatin Pharmacokinetic Study
This is a phase I, open-label, controlled drug interaction study to determine the effects of darunavir plus ritonavir on the pharmacokinetics of the hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, rosuvastatin, in…
- Trial name
- NCT00885495
- Testing
- darunavir, ritonavir, rosuvastatin, rosuvastatin, darunavir, ritonavir
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Healthy Volunteer
A Randomized, Open-label, Multiple-dose, Crossover Study to Investigate the Pharmacokinetic Drug Interaction Between Rosuvastatin and Telmisartan in Healthy Volunteer
This clinical trial is designed to compare the pharmacokinetic characteristics of combination and separate administration of Crestor(Rosuvastatin) and Micardis(Telmisartan).
- Trial name
- YH16410 DDI (NCT01992601)
- Testing
- Crestor 20mg(Rosuvastatin 20mg), Micardis 80mg(Telmisartan 80mg)
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yuhan Corporation
Stable Coronary Artery Disease, Percutaneous Coronary Intervention
Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery Disease
The purpose of this study is to conduct a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, evaluating the effects and change of endothelial function and gut microbiota after berberine…
- Trial name
- NCT04434365
- Testing
- Berberine, Aspirin, Clopidogrel
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Healthy Participants
A Drug-Drug Interaction Study Evaluating the Perpetrator Potential of DC-806 on Cocktails of CYP450 Enzyme and Transporter Substrates in Healthy Participants
The main objective of this study is to assess the effect of DC-806 on the pharmacokinetics (PK) of cytochrome 3A4 (CYP3A4) substrate, midazolam and its active metabolite, 1-hydroxymidazolam, cytochrome 2C8 (CYP2C8) substrate…
- Trial name
- NCT06092931
- Testing
- DC-806, Midazolam, Repaglinide
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- DICE Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company
Hypercholesterolemia
Phase 3 Study to Evaluate the Efficacy and Safety of the DW0929 in Patients With Primary Hypercholesterolemia
The purpose of this study is to evaluate the efficacy and safety of the DW0929 in patients with primary hypercholesterolemia
- Trial name
- NCT02390375
- Testing
- DW-0929, Rosuvastatin
- Where
- South Korea
- Volunteers
- 348 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Hyperlipidemia
Comparison of the Efficacy and Safety of Cresnon® and Crestor® in Patients With Hyperlipidemia
Comparison of the efficacy and safety of Cresnon® and Crestor® in patients with hyperlipidemia 8-week, active-controlled, open-label, randomized, parallelgroup, fixed-dose, noninferiority, multicenter, phase 4 design
- Trial name
- NCT02280590
- Testing
- Rosuvastatin(Cresnon®), Rosuvastatin(Crestor®)
- Where
- South Korea
- Volunteers
- 223 people
- Sponsor
- Dong-A ST Co., Ltd.
Healthy Volunteers
A Phase 1 Study to Evaluate the Drug-Drug Interaction Potential Between ALG-055009 and Statin Therapy(Ies)
This Phase 1 study consists of two parts, all conducted in healthy volunteers (HVs). In Parts 1 and 2, the drug-drug interaction (DDI) potential of ALG-055009 will be explored, where subjects will be assigned to receive multiple…
- Trial name
- NCT06191991
- Testing
- Atorvastatin, ALG-055009, Rosuvastatin
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Aligos Therapeutics
HCC
Statin With Palliative Therapy for HCC
Statin is a preventive medicine for hepatitis B and hepatitis C which decreases the risk turning into liver cancer,however, the investigators also discovered that patients taking Statin live longer than patients who didn't take…
- Trial name
- NCT02785874
- Testing
- Statin
- Where
- Taiwan
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
ST Elevation (STEMI) Myocardial Infarction
Microcirculation In Acute Coronary Syndromes
In this mechanistic pilot study in 40 patients the investigators will compare the findings in patients treated with very early high dose statin therapy with historic controls from the KOMPIS study published in EHJ 200925.
- Trial name
- MICROS (NCT01382472)
- Testing
- Rosuvastatin, Simvastatin
- Where
- 3 sites in Norway
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Venous Thromboembolism, Dyslipidemias
Role of Statin in Venous Dysfunction in Patients With Venous Thromboembolism Event
Participants between the ages of 19 and 70 who were initially diagnosed with venous thromboembolism and were accompanied by dyslipidemia (LDL> = 100 mg / dl) were enrolled.
- Trial name
- NCT03988101
- Testing
- Rosuvastatin 20mg, Control
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Healthy Volunteers
Single and Multiple Dose Study to Evaluate Safety and Pharmacokinetics of BMS-986533 in Healthy Participants and Assessments of Food and pH Effects on Relative Bioavailability, and Drug-Drug Interaction Potential in Healthy Participants
The purpose of this study is to evaluate the safety and pharmacokinetics of BMS-986533 in healthy participants receiving single and multiple doses, to assess food and pH effects on the relative bioavailability of BMS-986533, and…
- Trial name
- NCT07629999
- Testing
- BMS-986533, Famotidine, Dabigatran Etexilate
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Hypercholesterolemia
Effect of an Internet Based Compliance Enhancement Tool in Subjects With Hypercholesterolemia
The purpose of the study is to determine whether an Internet based compliance tool is superior to common diet counselling in patients with hypercholesterolemia.
- Trial name
- NCT00240357
- Testing
- Lifestyle Regulation
- Where
- 109 sites in Denmark
- Volunteers
- 1,175 people
- Sponsor
- AstraZeneca
Prostate Cancer
A Study to Evaluate the Effect of Multiple Doses of Enzalutamide on the Pharmacokinetics of Substrates of P-glycoprotein (Digoxin) and Breast Cancer Resistant Protein (Rosuvastatin) in Male Subjects With Prostate Cancer
The primary purpose of this study is to determine the effect of multiple once daily administrations of enzalutamide on the pharmacokinetics of a single dose of digoxin (P-glycoprotein (P-gp) substrate) and rosuvastatin (breast…
- Trial name
- NCT04094519
- Testing
- enzalutamide, digoxin, rosuvastatin
- Where
- Moldova
- Volunteers
- 24 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Acute Coronary Syndrome, Diabetes Mellitus
Peking and Rotterdam on Mission to Reduce Coronary Artery Disease
The purpose of this study is to explore the effect of 20mg high loading dose of rosuvastatin on recurrent events in patients with established DM who is admitted for an ACS.
- Trial name
- PROMISS (NCT01653119)
- Testing
- Rosuvastatin
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University Third Hospital
Coronary Artery Disease, Angina Pectoris
Effect of Alirocumab(Proprotein Convertase Subtilisin/Kexin type9 Inhibitor) and Rosuvastatin or Rosuvastatin Alone on Lipid Core Plaques in Coronary Artery Disease Evaluated by Near-infrared Spectroscopy Intravascular Ultrasound
The purpose of this study is to verify whether additional administration of Alirocumab exerts a stronger stabilizing effect on the vulnerable plaque in CAD, compared with statin alone administration in patients receiving PCI.
- Trial name
- ANTARES (NCT03529253)
- Testing
- Alirocumab 75 MG/ML [Praluent]+ Rosuvastatin 10mg/daily, Rosuvastatin calcium10mg
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Kobe University
Atherosclerosis, Cardiovascular Disease
Is Augmentation of PORH by Rosuvastatin Adenosine-receptor Mediated?
Rationale: Statins form a class of drugs that is widely prescribed for hypercholesterolaemia, specifically to reduce the risk on atherosclerosis by lowering LDL-cholesterol.
- Trial name
- NCT00851175
- Testing
- rosuvastatin, caffeine
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Atherosclerotic Cardiovascular Disease, Type 2 Diabetes
High-intensity Rosuvastatin vs. Moderate-intensity Rosuvastatin/Ezetimibe in High Atherosclerotic Cardiovascular Disease Risk Patients With Type 2 Diabetes
To assess the efficacy and safety of moderate-intensity rosuvastatin/ezetimibe compared to high-intensity rosuvastatin in high atherosclerotic cardiovascular disease risk patients with type 2 diabetes
- Trial name
- NCT03403556
- Testing
- Rosuvamibe, Monorova
- Where
- 6 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Yuhan Corporation