Clinical trials: Routine care
Diabetes Mellitus, Type 1
Testing an Integrated Care Model Trial
This study aims to test the use of an adapted collaborative care model for improving the health outcomes of adults diagnosed with type 1 diabetes (T1D). The duration of the study is 18 months with 4 study survey points.
- Trial name
- NCT06448429
- Testing
- Usual care, Collaborative care model (CoCM)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Breast Cancer, Invasive Breast Carcinoma
Tissue- and Serum-Derived Exosomal microRNAs as Predictors of Neoadjuvant Chemotherapy Response in Breast Cancer
This prospective observational study aims to evaluate whether exosomal microRNA profiles derived from tumor tissue and blood serum are associated with pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in…
- Conditions
- Breast Cancer, Invasive Breast Carcinoma, Exosomal microRNA, Neoadjuvant Chemotherapy Response
- Trial name
- ExoTSS-BC (NCT07500129)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Atlas University
Phage Therapy, Bacteriophage Therapy
Randomized Controlled Study on the Safety and Efficacy of Phage Cocktail in the Treatment of Multidrug-Resistant Bacterial Skin Infections
This study addresses the increasingly severe global public health challenge of antibiotic resistance, focusing on exploring phage therapy as a potential treatment strategy for multidrug-resistant bacterial skin infections.
- Conditions
- Phage Therapy, Bacteriophage Therapy, Skin and Soft Tissue Infections
- Trial name
- NCT07619924
- Testing
- Bacteriophage Treatment
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Osteoarthritis, Knee
Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement
Osteoarthritis (OA), the most common type of arthritis, affects more than 32.5 million adults in the United States. It is also among the most expensive condition to treat when joint replacement surgery is required.
- Trial name
- NCT04732962
- Testing
- AposHealth, Total Knee Replacement (TKR)
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Geisinger Clinic
Cancer
Capillary Blood Accuracy
Entia is a health technology company that has developed a blood testing device called Entia Liberty, which analyses blood collected by a finger prick.
- Trial name
- CAPYBARA (NCT06544070)
- Testing
- Entia Liberty System
- Sponsor
- Entia Ltd
Alzheimer Disease, Dementia
Assistive Technology and Reduced Caregiver Burden
The study investigated a six-week randomized controlled trial study in a small cohort of 16 family caregivers of individuals living with Alzheimer's disease and related dementias.
- Conditions
- Alzheimer Disease, Dementia, Caregiver Burden, Quality of Life
- Trial name
- ck (NCT05352529)
- Testing
- The MapHabit system, Dementia educational videos
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- MapHabit, Inc.
Phlebitis
Ointment Therapy and Prevention of Cannulation-Induced Superficial Phlebitis
The aim of this study was to determine the effect of Clobetasol ointment with nitroglycerin ointment on the prevention of superficial phlebitis caused by cannulation.
- Trial name
- OT (NCT04685031)
- Testing
- Nitroglycerin ointment, Clobetasol Topical
- Volunteers
- 110 people
- Sponsor
- Komar University of Science and Technology
Burn Injury
Therapy by Led (Light Emission Diode) in Cutaneous Lesion: in Vivo
Light Emitting Diode (LED) therapy has been investigated in burns and skin ulcers, as it has a bactericidal effect and promotes tissue repair.
- Trial name
- NCT03343353
- Testing
- LED (Light Emission Diode)
- Where
- 2 sites in Brazil
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Urinary Tract Infections, Urological System Complication of Procedure
Potentiated Aminoglycosides in Postoperative Urinary Tract Infection Prophylaxis
Urinary tract hardware such as pig-tail catheters are are frequently used for management of urolithiasis or other obstructive pathologies. They are readily colonized by urogenital flora leading to asymptomatic bacteriuria.
- Trial name
- UROPOT (NCT05761405)
- Testing
- mannitol-enhanced aminoglycoside, Ceftriaxon, Amikacin
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cystic Fibrosis
DNA Methylation and Lung Disease in Cystic Fibrosis
Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease-modifier genes and environmental exposure.
- Trial name
- METHYLCF (NCT02884622)
- Testing
- nasal epithelial, Blood sampling
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Pain
The Effect of Palmar Grip Reflex Stimulation on Pain During Heel Blood Collection in Newborns
Pain is defined by the International Association for the Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with or defined in terms of actual or potential tissue damage" .
- Trial name
- NCT06813183
- Testing
- The palmar grasping reflex
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Erzincan Binali Yildirim Universitesi
Cataract
AI-Driven IOL Prediction Using SS-OCT Biometry
This prospective, multicenter, non-interventional observational study aims to evaluate the agreement between a novel swept-source optical coherence tomography (SS-OCT) biometer and the IOLMaster 700 for ocular biometric…
- Trial name
- NCT07733154
- Testing
- IOLMaster 700, Novel SS-OCT Biometer
- Where
- 3 sites in Australia, China and 1 more
- Volunteers
- 2,500 people
- Sponsor
- The Hong Kong Polytechnic University
Sarcopenia
Effect of Elastic Resistance Training on Handgrip Strength in Older Adults With Sarcopenia
Sarcopenia is an age-related condition characterized by loss of muscle strength and muscle mass, which may contribute to reduced physical function and independence in older adults.
- Trial name
- NCT07863037
- Testing
- Elastic Resistance Training, Routine Physical Exercise
- Where
- Indonesia
- Volunteers
- 34 people
- Sponsor
- Dr. Soetomo General Hospital
Head and Neck Cancer (H&N)
Effects of Far Infrared Rays and Transcutaneous Electrical Nerve Stimulation on Short Term Prognosis of Head and Neck Cancer Patients Receiving Curative Treatment
This clinical trial aims to evaluate whether far infrared radiation therapy and transcutaneous electrical nerve stimulation can reduce treatment-related side effects in patients with head and neck cancer undergoing concurrent…
- Trial name
- NCT07689019
- Testing
- Standard Care (in control arm), Transcutaneous Electrical Nerve Stimulation, Far-Infrared Therapy
- Where
- Taiwan
- Volunteers
- 102 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Chronic Perineal Pain
Effect of Myofascial Release Combined With Acupressure on BL23 On Chronic Perineal Pain
This study aims to determine the effect of the myofascial release combined with acupressure on BL23 on chronic perineal pain.
- Trial name
- NCT07117019
- Testing
- Self-care and lifestyle intervention advice, Myofascial release, Acupressure
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Preterm Infant, Parents
Transition Model-Based Discharge Training in Parents of Preterm Infants
Infant and Child Monitoring Protocol prepared by the General Directorate of Mother and Child Health and Family Planning of the Ministry of Health regarding the monitoring of postpartum processes in our country.
- Conditions
- Preterm Infant, Parents, Premature Birth, Randomized Controlled Trial
- Trial name
- TRAMPRE (NCT05525624)
- Testing
- TRAMPRE, Control Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Cigarette Smoking-Related Carcinoma
Evaluating the Effect of Nicotine on Eye Movements and Related Behaviors in Electronic Cigarette Users, NICS-EYES Trial
This clinical trial evaluates the effect of nicotine on eye movements and related behaviors in people who use electronic (e)-cigarettes. Nicotine is an addictive, poisonous chemical found in tobacco.
- Trial name
- NCT07604246
- Testing
- Avoidance, Biospecimen Collection, Cigarette Smoking
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Rheumatoid Arthritis
Microbiota Analysis to Predict Outcomes of Rheumatoid Arthritis Patients Treated With JAK-inhibitor
Personalized medicine in which each patient would receive the ideal personalized treatment and regimen, holds great promise to improve patient's care.
- Trial name
- MARAJA (NCT04530305)
- Testing
- Upadacitinib <15 MG [Rinvoq]
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Clostridioides Difficile Infection
Clostridioides Difficile: Understanding Responses and Treatment Effects
The goal of this observational study is to learn how different treatments for Clostridioides difficile infection (CDI) work, and which biological mechanisms are involved in recovery.
- Trial name
- CURE-CDI (NCT07374094)
- Testing
- Antibiotic treatment, Fecal microbiota transplantation (FMT)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Chronic Disease
Effect of Music Therapy on Hospital Anxiety/Depression and Comfort Level
Aim: It has been determined that there are limited studies in our country where music is used as a nursing intervention and the effects of music therapy on the psychological symptoms and comfort levels of individuals with chronic…
- Trial name
- NCT06865729
- Testing
- Music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people
- Sponsor
- Amasya University
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