Clinical trials: Sertraline
Major Depressive Disorder
Riluzole Augmentation Pilot in Depression (RAPID) Trial
The investigators are doing a research study to find out if riluzole, when taken along with a standard antidepressant (sertraline) can help people with major depression.
- Trial name
- RAPID (NCT01703039)
- Testing
- Riluzole, Sertraline
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Obsessive-Compulsive Disorder
The Gut Microbiota in Obsessive-Compulsive Disorder
This study will examine the gut microbiota and serum inflammatory markers in patients with Obsessive-Compulsive Disorder vs. healthy controls.
- Trial name
- NCT02285699
- Testing
- SSRIs
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- McMaster University
Major Depressive Disorder (MDD)
Switching Medication and Augmentation Strategies for SSRI-Resistant Adolescent Depression（SMART-I)
This project aims to investigate the effectiveness of existing common antidepressants in adolescents with MDD who did not respond to their first treatment.
- Trial name
- SMART-I (NCT07011693)
- Testing
- Sertraline, Agomelatine, Aripiprazole
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xinyu Zhou
Hypoactive Sexual Desire Disorder, Sexual Dysfunctions, Psychological
Ginkgo Biloba: Antidepressant-Induced Sexual Dysfunction
The purpose of this study is to provide the first empirical examination of the effects of Ginkgo biloba (GBE), sex therapy, and a combination of the two on subjective and physiological measures of sexual function in women who are…
- Trial name
- NCT00034021
- Testing
- Ginkgo Biloba, Sex Therapy (genital focus)
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Depressive Disorder
Randomized Double Blinding Controlled Study on" Jia Wei Xiao Yao Jiaonang" Treating Mild to Moderate Major Depressive Disorder
This is a randomized, double-blind multi centric clinic study. Both of therapist and patient are blind. There are 180 patients from 3 hospitals included, who meet DSM-IV criteria for major depressive disorder, the score of…
- Trial name
- NCT01467804
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Su Rui
Acute Myeloid Leukemia
Sertraline and Cytosine Arabinoside in Adults With Relapsed and Refractory AML
This is a Phase I study with the goals of determining the feasibility, safety, and toxicity of administering sertraline in combination with timed-sequential cytosine arabinoside (ara-C) in adults with relapsed and refractory…
- Trial name
- NCT02891278
- Testing
- Sertraline, Cytosine arabinoside, allogeneic stem cell transplantation
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Columbia University
Depression, Major Depressive Disorder
eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients
The objective of this randomized controlled trial is to evaluate whether the investigators modernized IMPACT intervention for depression (eIMPACT), delivered before the onset of cardiovascular disease (CVD), reduces the risk of…
- Conditions
- Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms
- Trial name
- NCT02458690
- Testing
- Beating the Blues (BtB), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Indiana University
Healthy
Bioequivalence Study of Sertraline Hydrochloride 100mg Tablets Under Fasting Conditions
The purpose of this study was to evaluate the relative bioavailability of the test formulation of sertraline 100 mg tablets with an already marketed reference formulation Zoloft® 100 mg tablets (Pfizer), under fasted conditions…
- Trial name
- NCT00779350
- Testing
- sertraline 100 mg tablets
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Obsessive-Compulsive Disorder
Treatment of Obsessive Compulsive Disorder in Children
This study will determine whether cognitive behavioral therapy delivered by either psychologists or psychiatrists can improve the effectiveness of serotonin reuptake inhibitor treatment in children with obsessive compulsive…
- Trial name
- NCT00074815
- Testing
- Serotonin reuptake inhibitors management, Cognitive behavioral therapy by a psychologist, Instructional cognitive behavioral therapy by a psychiatrist
- Where
- 3 sites in United States
- Volunteers
- 124 people
- Sponsor
- Duke University
Post Traumatic Stress Disorder, Post Traumatic Stress Disorder PTSD
Building Ukraine's Strength in PTSD Treatment and Research
The Lux4UA project aims to support mental health treatment in Ukraine, especially for those who have experienced traumatic events due to the ongoing conflict and forced displacement.
- Conditions
- Post Traumatic Stress Disorder, Post Traumatic Stress Disorder PTSD, Post-Traumatic Stress Disorder, PTSD
- Trial name
- Lux4UA (NCT07318181)
- Testing
- Reconsolidation of Traumatic Memories Protocol, Trauma-Focused Cognitive Behavioral Therapy, Eye Movement Desensitization and Reprocessing
- Where
- 2 sites in Ukraine
- Volunteers
- 120 people
- Sponsor
- University of Luxembourg
Dementia, Depression
Pharmacovigilance in Gerontopsychiatric Patients
The purpose of this multicenter-study is to investigate safety of psychopharmacological treatment and rates of adverse drug reactions in gerontopsychiatric inpatients.
- Conditions
- Dementia, Depression, Schizophrenia, Psychosomatic Disorders
- Trial name
- GAP (NCT02374567)
- Testing
- Phenobarbital, Phenytoin, Carbamazepine
- Where
- 5 sites in Germany
- Volunteers
- 407 people
- Sponsor
- Hannover Medical School
Stress Disorders, Post-Traumatic
Pharmacologic Treatment of PTSD in Sexually Abused Children
This study will evaluate the benefit of adding sertraline (Zoloft®) to Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) for sexually abused children who have Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT00078767
- Testing
- Trauma-Focused Cognitive Behavioral Therapy, Sertraline Pill
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Depression
RESIST: Understanding the Role of Depression in Heart Disease
This study will investigate the biological pathways involved in anti-depressant resistance that increase risk of cardiovascular disease in people with depression.
- Trial name
- NCT02657798
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University College, London
Depression, Antidepressant Drug Adverse Reaction
Development of Pharmacogenomic Method to Predict Antidepressant Responsiveness
The Purpose of this study is to predict antidepressant response in advance using pharmacogenomics and peripheral biological markers in depressed patients.
- Trial name
- PG (NCT00817011)
- Testing
- SSRI treated group, non-SSRI treated group
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Treatment-resistant Depression
A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
The purpose of this study is to compare the efficacy and safety of switching treatment-resistant depression (TRD) participants from a prior antidepressant treatment (to which they have not responded) to either intranasal…
- Trial name
- TRANSFORM-1 (NCT02417064)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral antidepressant)
- Where
- 90 sites in United States, Belgium and 7 more
- Volunteers
- 346 people
- Sponsor
- Janssen Research & Development, LLC
Acupuncture, Depression
Moderate Depressive Disorder With Cheek Acupuncture
This study intends to use a randomized controlled clinical study to clarify the clinical efficacy of cheek acupuncture therapy in patients with moderate depressive disorder.
- Trial name
- NCT05923021
- Testing
- cheek acupuncture
- Volunteers
- 126 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Depressive Disorder, Depression
Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)
To assess the long-term safety and tolerability of oral OPC-34712 (brexpiprazole), given in addition to an FDA approved antidepressant (ADT) for the treatment of adults with Major Depressive Disorder (MDD)
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major, Mood Disorders
- Trial name
- Orion (NCT01360866)
- Testing
- OPC-34712, Escitalopram, Fluoxetine
- Where
- 142 sites in United States, Canada and 9 more
- Volunteers
- 2,944 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Prodromal Schizophrenia, Psychotic Disorders
Antidepressant and Antipsychotic to Treat Attenuated Positive and Negative Symptoms
The Recognition and Prevention (RAP) Program is conducting a research study comparing an antidepressant, sertraline, alone versus in combination with a second-generation antipsychotic, risperidone, to evaluate their ability to…
- Trial name
- NCT00169988
- Testing
- risperidone, sertraline-primary
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Northwell Health
Major Depressive Disorder
Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder
Achieving results from RCTs with high internal and external validity is a major challenge within psychiatry due to the nature of psychiatric illnesses.
- Trial name
- NCT05952713
- Testing
- Antidepressant
- Where
- Denmark
- Volunteers
- 73,336 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Depression, Coronary Artery Disease
Acute Myocardial Necrosis and Depression: Antiplatelet Effect of Reuptake Inhibition of Serotonin
Primary purpose: To evaluate the evolution in time of the antiaggregant platelet effect of sertraline (SSRI) compared to placebo in depressive patients with ACS (Acute Coronary Syndrome) and treated as recommended by a double…
- Trial name
- ANDROS (NCT02463110)
- Testing
- Sertraline, No treatment
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris