Clinical trials: Sertraline
Obsessive-Compulsive Disorder
Effectiveness of Sertraline and Cognitive Behavioral Therapy in Treating Pediatric Obsessive-Compulsive Disorder
This study measures the occurrence of certain side effects linked to antidepressant use and evaluates the effectiveness of the medication sertraline plus cognitive behavioral therapy to treat people with obsessive-compulsive…
- Trial name
- NCT00382291
- Testing
- Regular Titration, Slow Titration
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- University of Florida
Major Depressive Disorder, Partner Relational Disorder (V61.10)
Treatment of Mood and Marriage Study (TOMMS)
The primary goal of this study is to develop and test a depression-specific marital therapy tailored for use with older adult populations.
- Trial name
- NCT00612807
- Testing
- Weekly marital therapy, As indicated: Sertraline, bupropion, venlafaxine, mirtazepine, nortriptyline, tranylcypromine, lithium augmentation, etc.
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Duke University
Depression
Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression
Low frequency rTMS (repetitive Transcranial Magnetic Stimulation) for the treatment of patients with depression, is responsible for a decrease in the expression of the C-FOS and DUSP1 genes in peripheral blood leukocytes.
- Trial name
- TMSFOS (NCT02042573)
- Testing
- rTMS, SSRI (SEROPLEX ou ZOLOFT), Genetic samples
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Perinatal Depression, HIV-1-infection
A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women
This pilot study will evaluate, through quantitative and qualitative methods, whether different treatments for postpartum depression are feasible and acceptable in postpartum HIV infected women on antiretrovirals (ART).
- Trial name
- NCT04094870
- Testing
- Sertraline, Interpersonal therapy
- Where
- 2 sites in Zambia
- Volunteers
- 80 people
- Sponsor
- University of North Carolina, Chapel Hill
Premenstrual Dysphoric Disorder (PMDD)
Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder
Premenstrual dysphoric disorder (PMDD) is a severe affective disorder impacting millions of women worldwide, thought to be due to altered sensitivity to hormone fluctuations across the menstrual cycle.
- Trial name
- BLOOM (NCT06704594)
- Testing
- sertraline 50 mg daily
- Where
- 2 sites in United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Major Depressive Disorder
The Effect of Problem Solving Therapy and Antidepressant Therapy on Cerebral Perfusion and Brain Derived Neurotropic Factor (BDNF) in Depressed Elders
The focus of this study is to gather preliminary data regarding the effects of a psychological therapy-Problem Solving Therapy-and an antidepressant medication-sertraline-on 1) cerebral perfusion (CP), 2) brain derived…
- Trial name
- NCT01305889
- Testing
- problem solving therapy, Sertraline
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of California, San Francisco
Depression, Coronary Artery Disease
Acute Myocardial Necrosis and Depression: Antiplatelet Effect of Reuptake Inhibition of Serotonin
Primary purpose: To evaluate the evolution in time of the antiaggregant platelet effect of sertraline (SSRI) compared to placebo in depressive patients with ACS (Acute Coronary Syndrome) and treated as recommended by a double…
- Trial name
- ANDROS (NCT02463110)
- Testing
- Sertraline, No treatment
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression
The ISLAND Study: InSuLa Assessed Needs for Depression
While there are many effective options for treating a major depressive episode, there are no clinical markers that predict the likelihood of remission with an initial trial of either an antidepressant medication or psychotherapy.
- Trial name
- ISLAND (NCT02137369)
- Testing
- Selective serotonin re-uptake inhibitor, Cognitive Behavioral Therapy, Combination treatment (SSRI + CBT)
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Emory University
Depressive Disorder, Lactation
Antidepressants During Pregnancy and Lactation: Pharmacokinetics and Clinical Implications
Background: The childbearing years are a time of increased vulnerability to the onset of mood disorders in women and a high prevalence of exposure to antidepressant drugs during pregnancy and postpartum has been reported.
- Trial name
- NCT01796132
- Testing
- SSRI/SNRI
- Where
- 5 sites in France, Switzerland
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Hyperinsulinemia, Miscarriages
Maternal Lifestyle and Neonatal Hypoglycemia
tPA has a pivotal role in placentation, mediationg activation of growth factors, such as vascular endothelial growth factor and brain-derived neurotrophic factor, degradation of extracellular matrix and basement membrane…
- Conditions
- Hyperinsulinemia, Miscarriages, Pregnancy, Sedentary Lifestyle
- Trial name
- NCT01409382
- Testing
- Daily brisk walking plus a carbohydrate-restricted diet
- Where
- Brazil
- Volunteers
- 480 people
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro
Depression
Effects of Adding Motivational Interviewing to Antidepressant Treatment for Hispanic Adults With Depression
This study will evaluate the effectiveness of adding motivational interviewing to antidepressant treatment for major depressive disorder in Hispanic adults.
- Trial name
- NCT00564278
- Testing
- Standard antidepressant therapy (SADT), Motivational antidepressant therapy (MADT)
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder
Analisis of Facors Involved in Antidepressant Treatment Response of Major Depressive Disorder
The purpose of this study is to predict and visualize sertraline treatment response in major depressive disorder with clinical symptoms, demographic and stress state, personality, eight genetic polymorphisms at baseline.
- Trial name
- AFADTRMDD (NCT01454635)
- Testing
- Sertraline
- Where
- Japan
- Volunteers
- 96 people
- Sponsor
- Showa University
Obesity
A Preliminary Comparison of the Blood Levels of Medications in Obese Subjects Compared to Post-Gastric Bypass Subjects
The purpose of this study is to determine the difference, if any, in the area under the sertraline plasma level time curve (AUC) between patients who are nine to fifteen months post Roux-en-Y Bariatric Surgery and control…
- Trial name
- NCT01015976
- Testing
- bariatric surgery, control
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Neuropsychiatric Research Institute, Fargo, North Dakota
Depression
A Study of Chinese Medicine Treating Depression
Chinese Medicine syndrome differentiation has been a prevalent therapy in China for thousands of years. It is based on patients' symptoms, pulse, tongue and coating on the tongue.
- Trial name
- NCT02873234
- Testing
- Traditional Chinese Medicine, Antidepressants
- Where
- China
- Volunteers
- 4,600 people
- Sponsor
- The Third Affiliated Hospital of Beijing University of Chinese Medicine
Emotional Distress
Mechanism of Mindfulness Based Online Intervention in Reducing Emotional Distress
This study hopes to: 1. explore whether, at the individual level, the improvement of mindfulness ability can promote peace of mind, reduce the frequency of mental wandering, weaken or cut off the cycle between negative mood and…
- Trial name
- NCT05600790
- Testing
- Mindfulness Intervention for Emotional Distress
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University
Autism Spectrum Disorder
A Trial of Sertraline in Young Children With Autism Spectrum Disorder
This study is a control trial of sertraline (Zoloft) in children aged 2 to 5 years old inclusive with Autism Spectrum Disorder. The trial is six months long, and each participant will receive a series of tests at both the…
- Trial name
- Sert2 (NCT02385799)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Randi J. Hagerman, MD
Major Depressive Disorder
Algorithm Guided Treatment Strategies for Major Depressive Disorder
The purpose of this study is to compare treatment outcomes between measurement based Algorithm Guided Treatment and Treatment As Usual strategies in a Chinese population with major depressive disorder.
- Trial name
- AGTs-MDD (NCT01764867)
- Testing
- Escitalopram, Mirtazapine, modified electroconvulsive therapy
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Shanghai Mental Health Center
Depression
A Study of the Efficacy of Fecal Microbiota Transplantation(FMT) in the Treatment of Depression
Patients with depression were enrolled and randomly divided into two groups, namely FMT combined with antidepressant group and Antidepressant alone group.The former received FMT capsules and antidepressants, and the latter…
- Trial name
- NCT05850572
- Testing
- Fecal microbiota transplantation(FMT)
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Impulse Control Disorders
Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania
The purpose of this study is to assess the extent of symptom remission in patients with trichotillomania following treatment with sertraline and/or behavior therapy.
- Trial name
- NCT00118014
- Testing
- Sertraline, Habit Reversal Training
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Stress Disorders, Post-Traumatic
A Ten-Week Study Evaluating The Effectiveness And Safety Of Zoloft In Children And Adolescents With A Diagnosis Of PTSD
To evaluate the safety and efficacy of sertraline compared to placebo in children and adolescents (6 to 17 years of age) who are outpatients with Posttraumatic Stress Disorder.
- Trial name
- NCT00150306
- Testing
- Zoloft (Sertraline)
- Where
- 23 sites in United States
- Volunteers
- 160 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.