Clinical trials: Sertraline
Epilepsy, Anxiety
Does Pregabalin Improve Symptoms of Anxiety in Patients With Epilepsy? A Comparison With Sertraline
The aim of the study is to compare the safety \& efficacy of sertraline (up to a dose of 200mg/day) \& pregabalin (up to a dose of 300mg/day) for the treatment of symptoms of anxiety in patients with epilepsy.
- Trial name
- NCT01309074
- Testing
- Pregabalin-Lyrica, Sertraline
- Where
- United States
- Sponsor
- Rush University Medical Center
Major Depressive Disorder (MDD
Psychoeducational Group for Depression
The study aims to investigate the efficacy of a psychoeducational program as an adjunctive treatment for depression. The study will involve 338 patients diagnosed with Major Depressive Disorder (MDD) of moderate severity.
- Trial name
- PEG-D (NCT06467474)
- Testing
- PEG-D program, TAU
- Where
- Brazil
- Volunteers
- 338 people
- Sponsor
- Ricardo Alberto Moreno, M.D., Ph.D.
Depressive Disorder, Major
Multicentre Trial to Evaluate the Safety and Efficacy of CP-316,311 in Major Depressive Disorder
A six week, fixed dose, double-blind, double-dummy, placebo, and active controlled, multicentre trial to evaluate the safety and efficacy of CP-316,311 in outpatients with major depressive disorder.
- Trial name
- NCT00143091
- Testing
- CP-316,311, Sertraline
- Where
- 10 sites in United States, Russia and 1 more
- Volunteers
- 200 people
- Sponsor
- Pfizer
Traumatic Brain Injury
Sertraline vs. Placebo for Symptoms Following Traumatic Brain Injury
The purpose of this study is to investigate the efficacy of an SSRI, sertraline for the use of post-concussive symptoms following a traumatic brain injury.
- Trial name
- NCT00208585
- Testing
- sertraline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Healthy
Study of Sertraline Hydrochloride Tablets 100 mg and Zoloft® Tablets 100 mg
The objective of this study was to investigate the bioequivalence of Mylan's sertraline hydrochloride 100 mg tablets to Pfizer's Zoloft® 100 mg tablets following a single, oral 100 mg (1 x 100 mg) dose administered under fasting…
- Trial name
- NCT00650325
- Testing
- Sertraline Hydrochloride Tablets 100 mg, Zoloft® Tablets 100 mg
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Generalised Anxiety Disorder
Trial of Sertraline Versus Cognitive Behaviour Therapy for Generalised Anxiety
Generalised Anxiety Disorder (GAD) is common, causes unpleasant symptoms and impairs people's functioning. It is often chronic and may be accompanied by depression and other anxiety disorders.
- Trial name
- ToSCA (NCT02347033)
- Testing
- Sertraline, Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University College, London
Hypertension
A Randomized Controlled Trial of Sertraline in Paroxysmal Arterial Hypertension
There is currently no established treatment for paroxysmal hypertension, but selective serotonin reuptake inhibitors showed good effect in previous reports.
- Trial name
- ATRAX (NCT02641652)
- Testing
- Sertraline
- Volunteers
- 136 people
- Sponsor
- University Hospital Olomouc
Treatment-resistant Depression
A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
The purpose of this study is to compare the efficacy and safety of switching treatment-resistant depression (TRD) subjects from a prior antidepressant treatment (to which they have not responded) to either intranasal esketamine…
- Trial name
- TRANSFORM-2 (NCT02418585)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral antidepressant)
- Where
- 48 sites in United States, Czechia and 3 more
- Volunteers
- 236 people
- Sponsor
- Janssen Research & Development, LLC
Autism Spectrum Disorder, Anxiety
Specifying and Treating Anxiety in Autism Research
In the Specifying and Treating the Anxiety Phenotype in Autism Spectrum Disorder (STAAR) study, we conducted a16-week randomized comparative treatment trial of the Behavioral Intervention for Anxiety in Children with Autism…
- Trial name
- STAAR (NCT03279471)
- Testing
- Sertraline, CBT/BIACA
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Davis
Depressive Disorder, Major
Study of Medication and Placebo Response in Major Depression
The primary purpose of the research study is to use recordings of brain electrical activity (through electroencephalogram, or EEG) and symptom measurements to determine whether patients are likely to show a response to medication…
- Trial name
- NCT00229476
- Testing
- sertraline (Zoloft)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Depression
Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight
This study will determine whether the drug metformin improves the effects of traditional antidepressant medications in people who are overweight.
- Trial name
- NCT00834652
- Testing
- Sertraline, Metformin
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Washington University School of Medicine
Depression, Postpartum
Effectiveness of Sertraline Alone and Interpersonal Psychotherapy Alone in Treating Women With Postpartum Depression
This study will evaluate the effectiveness of antidepressant medication alone and interpersonal psychotherapy alone in treating women with postpartum depression.
- Trial name
- NCT00602355
- Testing
- Sertraline, Interpersonal psychotherapy (IPT), Clinical management
- Where
- 2 sites in United States
- Volunteers
- 162 people
- Sponsor
- Women and Infants Hospital of Rhode Island
COPD, Anxiety
Safety of Anti-Depressant for Chronic Obstructive Pulmonary Disease (SAD-COPD)
Objective: Determine whether treatment of perceived stress, anxiety, and depression with anti-depressant therapy improves dyspnea scores, 6-minute walk (6MW) distance and quality of life (QoL) in patients with Chronic Obstructive…
- Conditions
- COPD, Anxiety, Depression, Stress
- Trial name
- SAD-COPD (NCT02813447)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Pharmacokinetics, Antidepressive Agents
Serum Concentrations of Antidepressant Drugs in Pregnant Women - a Naturalistic Study
The study was a prospective naturalistic PK study of five frequently used antidepressant drugs in pregnant women; citalopram (CIT), escitalopram (ECIT), sertraline (SERT), mirtazapine (MIRT) and venlafaxine VEN) and their major…
- Conditions
- Pharmacokinetics, Antidepressive Agents, Pregnancy
- Trial name
- PAPA (NCT04806230)
- Testing
- sertraline, mirtazapine, venlafaxine, citalopram, escitalopram
- Where
- Sweden
- Volunteers
- 81 people
- Sponsor
- Linkoeping University
Major Depressive Disorder
Riluzole Augmentation Pilot in Depression (RAPID) Trial
The investigators are doing a research study to find out if riluzole, when taken along with a standard antidepressant (sertraline) can help people with major depression.
- Trial name
- RAPID (NCT01703039)
- Testing
- Riluzole, Sertraline
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression
Late-life Depression and Cerebral Perfusion
The long-term goal is to determine if decreased blood flow to the brain (cerebral hypoperfusion) is predictive of antidepressant outcomes in late-life depression (LLD).
- Trial name
- NCT01751828
- Testing
- Sertraline
- Where
- United States
- Sponsor
- Vanderbilt University
Depression
Sequenced Treatment Alternatives to Relieve Depression (STAR*D)
STAR*D focuses on non-psychotic major depressive disorder in adults who are seen in outpatient settings. The primary purpose of this research study is to determine which treatments work best if the first treatment with medication…
- Trial name
- NCT00021528
- Testing
- citalopram, BuproprionSR, buspirone
- Where
- 41 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Quantitative EEG (QEEG) as a Predictor of Treatment Outcome in Depression
The purpose of the study is to try to see if antidepressant medications cause changes in QEEG measurements in the brain. QEEG is a mathematical analysis of electrical currents in the brain using electrodes placed on the scalp.
- Trial name
- NCT00157547
- Testing
- Selective serotonin reuptake inhibitors (SSRI)
- Volunteers
- 95 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Sertraline Versus Escitalopram in South Asian Participants With Moderate to Severe Major Depressive Disorder
Objective: The aim of this randomized controlled trial was to compare the efficacy and safety of sertraline and escitalopram in participants with moderate to severe major depressive disorder (MDD).
- Trial name
- NCT05950061
- Testing
- Sertraline, Escitalopram
- Where
- Pakistan
- Volunteers
- 744 people
- Sponsor
- KRL Hospital, Islamabad
Post-Traumatic Stress Disorder
Risperidone Augmentation for PTSD
The purpose of this study is to (1) compare the response of civilians with Posttraumatic Stress Disorder(PTSD) currently receiving sertraline without an optimal response to risperidone augmentation vs.
- Trial name
- NCT00215241
- Testing
- sertraline and risperidone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Duke University