Clinical trials: Sertraline
Heart Failure, Depression
Depression and Self-care in Heart Failure
The purpose of the study is to test whether Cognitive Behavior Therapy (CBT) plus heart failure self-care education is superior to "usual care" for depression.
- Trial name
- DASH (NCT01028625)
- Testing
- Cognitive Behavior Therapy, Heart Failure Self-care Education
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Washington University School of Medicine
Sleep Initiation and Maintenance Disorders, Depression
TRIAD - Treatment of Insomnia and Depression
The aim of the proposed three-site study is to increase the rate of full remission from major depressive disorder (MDD) at the end of 16 weeks of treatment for people who experience both major depressive disorder and insomnia.
- Trial name
- NCT00767624
- Testing
- Antidepressant, Desensitization Therapy for Insomnia, Cognitive Behavioral Therapy for Insomnia
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Stanford University
Depression
Treatments for Depression: Drug Versus Psychotherapy
This 4-8 month study, with a 2-year follow up period, will compare sertraline (Zoloft®), venlafaxine (Effexor®), supportive-expressive psychotherapy, and placebo to determine which is more effective in treating major depression.
- Trial name
- NCT00043550
- Testing
- Supportive Expressive Therapy, Sertraline, Venlafaxine
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- University of Pennsylvania
Healthy, Major Depressive Disorder (MDD)
Neurobiological and Genomic Predictors of Relapse in Depression
The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters.
- Trial name
- MDD (NCT07328373)
- Testing
- Antidepressant Medications
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Mehmet Kemal Arikan
Major Depression, Diabetes
Preventing Depression Recurrence in Diabetes
To study the effectiveness of sertraline (Zoloft) in treating depression in adults with diabetes. The study will also determine whether depressed diabetic patients who have successfully responded to sertraline (Zoloft) are more…
- Trial name
- NCT00374426
- Testing
- sertraline
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Treatment Resistant Depression
Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant Depression
The present study has been designed to compare the efficacy and safety of augmentation of SSRIs with Amantadine vs Pramipexole vs the recommended Quetiapine augmentation in Treatment-Resistant Depression (TRD) and correlate the…
- Trial name
- APQ-TRD (NCT04936126)
- Testing
- Quetiapine, Amantadine, Pramipexole
- Where
- India
- Volunteers
- 150 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Major Depressive Disorder
Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic Assessment
Background. Depression is a highly frequent condition in the elderly, with a huge impact on quality of life, life expectancy, and medical outcomes.
- Trial name
- VESPA (NCT03779789)
- Testing
- Vortioxetine, Sertraline, citalopram
- Where
- 3 sites in Italy
- Volunteers
- 362 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Lumbar Spinal Stenosis
Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)
BACKGROUND: Lumbar spinal stenosis - known by patients as "arthritis of the spine" - is a condition that is very common; found in about 30% of older adults.
- Trial name
- NCT01943435
- Testing
- NSAIDs; adjunctive analgesics; adjunctive anti-depressants, Lumbar epidural injection, Joint Mobilizations (spine, sacroiliac, hip)
- Where
- United States
- Volunteers
- 259 people
- Sponsor
- Michael Schneider, DC, PhD
Major Depressive Disorder, Severe Depressive Episode Without Psychotic Symptoms
The Friendship Bench Plus Trial
The goal of this randomised controlled trial is to enhance the Friendship Bench intervention with antidepressants in adults with moderate to severe depression. The main questions it aims to answer are: 1.
- Trial name
- NCT06384209
- Testing
- Fluoxetine, Sertraline Pill, Friendship Bench Intervention- Problem Solving Therapy
- Where
- Zimbabwe
- Volunteers
- 296 people
- Sponsor
- University of Bern
Emotional Distress, Emotional Disorder
The Mechanism of Mindfulness Intervention to Alleviate Emotional Distress in Patients With Emotional Disorders
This study hopes to: 1. explore whether offline and online mindfulness interventions can significantly alleviate individual emotional distress,experiential avoidance and improve cognitive flexibility,distress tolerance level. 2.
- Trial name
- NCT05891015
- Testing
- Mindfulness Intervention for Emotional Distress(MIED)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University
Major Depressive Disorder
Adjunctive Mixed Salts Amphetamine for Depressed Adults With Incomplete Response to Current Antidepressant Therapy
In this Phase 4 trial we will study the safety, tolerability and efficacy of mixed salts amphetamine (MSA), trade name Adderall, augmentation of antidepressant therapy for Major Depressive Disorder (MDD) in depressed outpatient…
- Trial name
- NCT02058693
- Testing
- mixed salts amphetamine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Rush University Medical Center
Major Depression
Treatment of Major Depression With St. John's Wort (Hypericum)
The purpose of this trial is to study the acute efficacy and safety of a standardized extract of the herb Hypericum perforatum (St.
- Trial name
- NCT00005013
- Testing
- Sertraline, Hypericum perforatum (St. John's wort)
- Where
- 12 sites in United States
- Sponsor
- National Institute of Mental Health (NIMH)
Stress Disorders, Post-Traumatic, Alcohol Abuse
Combined Treatment for Alcohol-Dependent Individuals With PTSD
This treatment intervention trial is designed for men and women with either alcohol misuse (e.g. hazardous or binge drinking) or alcohol use disorders (alcohol abuse or dependence) and comorbid PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
- Trial name
- NCT00262223
- Testing
- Seeking Safety, Sertraline
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Augmentation Study of Levetiracetam in Obsessive Compulsive Disorder
The purpose of this study is to evaluate the effectiveness of Levetiracetam augmentation relative to Placebo in SSRI non-remitters with obsessive compulsive disorder.
- Trial name
- NCT00299611
- Testing
- Sertraline, Levetiracetam
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Major Depression
Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in Korea
The primary purpose of this study is to investigate medication utilization pattern and risk of adverse outcomes among commonly used antidepressants by using nationwide claims database, in order to assess overall clinical benefit…
- Trial name
- NCT04446039
- Testing
- Escitalopram, Paroxetine, Fluoxetine
- Where
- South Korea
- Volunteers
- 370,212 people
- Sponsor
- Pfizer
Depressive Disorder, Major
NMDA Modulation in Major Depressive Disorder in Late- Life
Major depressive disorder (MDD) is a complex and multi-factorial disorder. Most of the current antidepressants are based upon the monoamine hypothesis which cannot fully explain the etiology of depression.
- Trial name
- NCT03414931
- Testing
- NMDA, Sertraline
- Where
- 2 sites in Taiwan
- Volunteers
- 136 people
- Sponsor
- Chang Gung Memorial Hospital
Major Depressive Disorder
The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope
Recently, there are increasing data about intensity dependent amplitude change (IDAP: N100 amplitude slope) of auditory evoked Event Related Potential (ERP) components for its role on surrogate marker of central serotonergic…
- Trial name
- NCT01357967
- Testing
- SSRI monotherapy, Seroquel XR adjunctive
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Inje University
Major Depressive Disorder (MDD), Probiotic Intervention
Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression
The objective of this clinical trial is to evaluate the efficacy and safety of sertraline combined with multi-strain probiotics in adolescents aged 12-18 with major depressive disorder.
- Trial name
- NCT07645157
- Testing
- Sertraline
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Geriatric Depression, Cognitive Impairment
Electronic Training of Elderly Depression With Cognitive Impairment
late-life depression (LLD) is the most common mental illness in the elderly. Due to the increasing prevalence of population aging, it has become one of the important factors affecting the quality of life of the elderly.
- Trial name
- NCT05588102
- Testing
- Selective Serotonin Reuptake Inhibitor（SSRIs，Fluoxetine, paroxetine, fluvoxamine, sertraline, citalopram, escitalopram）
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Capital Medical University
Stereotyped Behavior, Mental Retardation
Phase II Study of Stereotypes and Mental Retardation: Neurobiological Basis
OBJECTIVES: I. Determine differences between persons with repetitive behavior disorders and matched controls on measures of motor control relevant to basal ganglia pathophysiology. II.
- Trial name
- NCT00004300
- Testing
- bromocriptine, sertraline hydrochloride
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)