Clinical trials: Sertraline
Alcoholism, Alcohol Dependence
Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)
This study will assess the ability of naltrexone (Revia) to reduce the risk of relapse in Alaska natives with alcohol dependence.
- Trial name
- NCT00000451
- Testing
- sertraline, naltrexone
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Yale University
PTSD, PTSD - Post Traumatic Stress Disorder
Efficacy of Eye Movement Desensitization and Reprocessing (EMDR) Therapy Versus Selective Serotonin Reuptake Inhibitors (SSRIs) in the Treatment of Post-Traumatic Stress Disorder
This randomized controlled trial aims to compare the efficacy of Eye Movement Desensitization and Reprocessing (EMDR) therapy versus Selective Serotonin Reuptake Inhibitors (SSRIs) in the treatment of Post-Traumatic Stress…
- Trial name
- NCT06955845
- Testing
- Eye Movement Desensitization and Reprocessing Therapy, Selective serotonin reuptake inhibitors
- Where
- 2 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Asad Ullah Jan
Bipolar Disorder, Depressive Disorder
Acute Effectiveness of Additional Drugs to the Standard Treatment of Depression
This study will compare the effectiveness of relatively new antidepressants which have different mechanisms of action. Buproprion (Wellbutrin) works on dopamine and the dopaminergic pathway.
- Trial name
- NCT00001483
- Testing
- buproprion (Wellbutrin), sertraline (Zoloft), venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Mental Health (NIMH)
Obsessive-Compulsive Disorder, Anxiety Disorders
Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients
The purpose of this study is to evaluate the efficiency of SSRIs（Selective Serotonin Reuptake Inhibitor） ,ERP（Exposure and Response Prevention） and the combination of the two therapies for OCD(Obsessive-Compulsive Disorder)…
- Conditions
- Obsessive-Compulsive Disorder, Anxiety Disorders, Mental Disorders
- Trial name
- NCT02022709
- Testing
- Fluoxetine, Sertraline, Paroxetine
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder (MDD)
Pattern Separation in Major Depressive Disorder
This study seeks to examine the effects of treatment with a selective serotonin reuptake inhibitor (SSRI), escitalopram, a first-line treatment for depression, in combination with placebo or with extended-release memantine, on…
- Trial name
- NCT07139834
- Testing
- SSRI (escitalopram or sertraline), Extended-Release Memantine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jeffrey Miller
Acupuncture, Depression
Moderate Depressive Disorder With Cheek Acupuncture
This study intends to use a randomized controlled clinical study to clarify the clinical efficacy of cheek acupuncture therapy in patients with moderate depressive disorder.
- Trial name
- NCT05923021
- Testing
- cheek acupuncture
- Volunteers
- 126 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Major Depressive Disorder
Safety and Efficacy of Levomilnacipran ER (F2695 SR) in Adults With Fatigue Associated With Major Depressive Disorder
The purpose of the study is to evaluate the efficacy, safety and tolerability of Levomilnacipran ER for the treatment of fatigue associated with major depressive disorder (MDD).
- Trial name
- NCT01254305
- Testing
- Levomilnacipran ER, Paroxetine, Sertraline, Citalopram or Fluoxetine.
- Where
- 20 sites in United States
- Volunteers
- 262 people
- Sponsor
- Forest Laboratories
Traumatic Brain Injury
Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury
The purpose of this study is to examine the efficacy of sertraline to prevent the onset of mood and anxiety disorders during the first six months after traumatic brain injury.
- Trial name
- NCT00704379
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Baylor College of Medicine
Depression
Bioequivalency Study of Sertraline Under Fed Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Sertraline Tablets, 100 mg, to Zoloft® Tablets, 100 mg (Pfizer) under fed conditions using a single-dose, 2-treatment, 2-period, crossover design.
- Trial name
- NCT00601588
- Testing
- Sertraline
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Treatment Resistant Depression
Multiple Ascending Dose Phase 1 Study of ALA-3000
This is a randomized, double-blind, placebo-controlled, multiple-dose study of ALA-3000 designed to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy in subjects with treatment-resistant depression…
- Trial name
- NCT06965569
- Testing
- ALA-3000, escitalopram, sertraline, duloxetine or venlafaxine XR
- Where
- 4 sites in United States
- Volunteers
- 37 people
- Sponsor
- Alar Pharmaceuticals Inc.
Schizophrenia
The Treatment Efficacy of Combination Atypical Antipsychotics With Sertraline in Patients With Schizophrenia
A randomized, double-blind trial of the treatment effect of dose-low antipsychotics combined with low-dose sertraline in 1640 schizophrenia patients
- Trial name
- NCT04076371
- Testing
- olanzapine-sertraline combination, only olanzapine, risperidone-sertraline combination
- Volunteers
- 1,640 people
- Sponsor
- Beijing HuiLongGuan Hospital
Healthy
A Relative Bioavailability Study of Sertraline HCl 100 mg Tablets Under Fasting Conditions
To compare the rate of absorption and oral bioavailability of a test formulation of Sertraline 100 mg tablets manufactured by Purepac Pharmaceutical Company to an equivalent oral dose of the commercially available reference…
- Trial name
- NCT00864344
- Testing
- Sertraline HCl 100 mg tablets, single dose, Zoloft® 100 mg tablets, single dose
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Actavis Inc.
Depression
Treatment of Post-Traumatic Brain Injury (TBI) Depression
Randomized clinical trial of sertraline vs. placebo for post-TBI depression
- Trial name
- NCT00233103
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Convulsion, Non-Epileptic, Conversion Disorder
Treatment Trial for Psychogenic Nonepileptic Seizures
The investigators propose that patients who receive targeted pharmacotherapy (sertraline) or focused psychotherapy (cognitive behavioral therapy-informed psychotherapy (CBT-ip) for NES) or combined treatment (CBT-ip + sertraline)…
- Conditions
- Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic
- Trial name
- NEST-T_1 (NCT00835627)
- Testing
- sertraline, CBT-ip, Combined (sertraline + CBT-ip)
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Rhode Island Hospital
Heart Failure, Congestive, Chronic Heart Failure
Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure
This study will examine the effect of antidepressant medication on rates of death and disease in depressed people with chronic heart failure.
- Conditions
- Heart Failure, Congestive, Chronic Heart Failure, Depression
- Trial name
- SADHART-CHF (NCT00078286)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 469 people
- Sponsor
- Duke University
Major Depression
Selenium as Augmentation Treatment for Sertraline Resistant Major Depression
The main goals of antidepressant treatments are to achieve remission of depressive episodes and prevent recurrences. However, clinical trials designed to approve antidepressants targets a response rate of at least 50%, which is…
- Trial name
- NCT02890212
- Testing
- selenium supplementation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Healthy
A Study Comparing the Drug Exposure in Humans After Administration of a 50 mg Tablet of Sertraline Hydrochloride as Compared to a 50 mg Capsule of Sertraline Hydrochloride Under Fasted (Nonfed) Conditions
This study is designed to determine differences in drug exposure in subjects after being administered 50 mg tablets of sertraline hydrochloride as compared to drug exposure after administering 50 mg capsules of sertraline…
- Trial name
- NCT01235195
- Testing
- sertraline hydrochloride
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Post-Traumatic Stress Disorder
Patient-Centered Collaborative Care for Preventing Post-Traumatic Stress Disorder After Traumatic Injury
This study will evaluate the effectiveness of patient-centered collaborative care that combines behavioral therapy and drug therapy as compared to usual care in reducing symptoms of post-traumatic stress disorder in people who…
- Trial name
- TSOS II (NCT00270959)
- Testing
- Cognitive Behavioral Therapy, Motivational Interviewing, FDA-Approved Anti-Anxiety Medications
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- University of Washington
Depression, Inflammation
Precision Psychiatry for Depression: Immune Response and Affective Symptoms as Predictors of Response to Antidepressants
Objectives: To identify in patients with major depression different peripheral markers of neuroinflammation in relation to affective symptoms (anxiety, depression, irritability), fatigue and cognitive symptoms; and its…
- Conditions
- Depression, Inflammation, Antidepressants, Immunity
- Trial name
- LYMPHODEP (NCT06337539)
- Testing
- SSRI
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Germans Trias i Pujol Hospital
Cardiovascular Diseases, Depression
Omega-3 Fatty Acids to Improve Depression and Reduce Cardiovascular Risk Factors
This study will determine the effects of omega-3 fatty acid (FA) augmentation of sertraline on depression and cardiac endpoints after myocardial infarction (MI).
- Conditions
- Cardiovascular Diseases, Depression, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00116857
- Testing
- Sertraline/omega-3, Sertraline/Corn Oil
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Washington University School of Medicine