Clinical trials: Sevoflurane, completed
Aortic Valve Stenosis, Remimazolam
Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR
Anesthetic agents can cause hypotension, and be especially dangerous in patients with severe aortic stenosis, which can lead to even circulatory collapse. Remimazolam is known for its hemodynamic stability compared to propofol.
- Trial name
- NCT05864625
- Testing
- Remimazolam besylate, Propofol/ Sevoflurane
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Pusan National University Yangsan Hospital
Delayed Graft Function, Renal Outcome After Kidney Transplantation
Volatile Anesthetic Protection Of Renal Transplants 2
To compare the effect of a sevoflurane based anesthesia versus a propofol based anesthesia on the incidence of DGF in recipients of kidneys of donation after circulatory death (DCD) and donation after brain death (DBD) donors
- Conditions
- Delayed Graft Function, Renal Outcome After Kidney Transplantation, Acute Rejection (AR) of Transplanted Kidney, Graft Survival
- Trial name
- VAPOR-2 (NCT02727296)
- Testing
- sevoflurane, propofol
- Where
- 5 sites in Denmark, Netherlands and 2 more
- Volunteers
- 488 people
- Sponsor
- University Medical Center Groningen
Advanced Chronic Rhinosinusitis
Total Intravenous Anesthesia in Sinus Surgery
Utilization of total intravenous anesthesia (TIVA) has been proposed as a method to improve visualization during endoscopic sinus surgery (ESS), largely due to its physiologic decrease in cardiac output without the peripheral…
- Trial name
- NCT02578862
- Testing
- Propofol, Sevoflurane
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Craniotomy Surgery, Pediatric Patient Safety
The Effect Of Positive End-Expiratory Pressure on Optic Nerve Sheath Diameter In Pediatric Patients Undergoing Craniotomy in Supine Position
This study evaluated the effect of positive end-expiratory pressure (PEEP) on optic nerve sheath diameter (ONSD), an indicator of intracranial pressure, in pediatric patients undergoing craniotomy in the supine position.
- Conditions
- Craniotomy Surgery, Pediatric Patient Safety, Pediatric Patient, Positive End-expiratory Pressure (PEEP)
- Trial name
- NCT07370779
- Testing
- General Anesthesia, Anesthetic Agents, mechanical ventilation (MV)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Postoperative Delirium, Hemodynamic Instability
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies
In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1.
- Conditions
- Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
- Trial name
- PATHFINDERII (NCT05279898)
- Testing
- EEG Monitoring, Ropivacaine, Ketamine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center
Surgical Procedure, Unspecified
Thoracic Epidural Versus General Anaesthesia in Cholecystectomy
CONTEXT AND AIMS: The aim of the study is to compare patients satisfaction of thoracic epidural and general anesthesia procedures in patients undergoing elective laparoscopic cholecystectomy.
- Trial name
- EVGAC (NCT03107832)
- Testing
- thoracic epidural anesthesia procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Abant Izzet Baysal University
Delirium, Postoperative Complications
Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium
Surgery is one of the major treatment methods for patients with malignant tumor. And, alone with ageing process, more and more elderly patients undergo surgery for malignant tumor.
- Conditions
- Delirium, Postoperative Complications, Postoperative Cognitive Dysfunction
- Trial name
- NCT02662257
- Testing
- Sevoflurane, Propofol
- Where
- 17 sites in China
- Volunteers
- 1,228 people
- Sponsor
- Peking University First Hospital
High Altitude Pulmonary Hypertension
Altitude Related Adverse Health Effects (ARAHE) in Patients With Precapillary Pulmonary Hypertension During 30h Exposure to 2500m
The interest of journeys to high altitude regions for recreational or professional purposes is increasing, also among potentially vulnerable groups including patients with chronic cardiopulmonary diseases such as pulmonary…
- Trial name
- NCT05107700
- Testing
- Stay at altitude 2500 m above sea level (high altitude), Stay at altitude 470 m above sea level (low altitude)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Restlessness, Pain
Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia
Dexmedetomidine is a highly selective α2 adrenoreceptor agonist approved by the US FDA for short-term postoperative sedation and analgesia.It can also reduce the stress response without respiratory depression.
- Trial name
- NCT01517932
- Testing
- dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Fang Luo
Postoperative Pain
Propofol Versus Sevoflurane on Acute Postoperative Pain
This study was performed to compare the acute postoperative pain intensity and opioid consumption after total shoulder arthroplasty between propofol-remifentanil and sevoflurane-remifentanil anesthesia.
- Trial name
- NCT04333992
- Testing
- propofol and remifentanil, sevoflurane and remifentanil
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yeungnam University College of Medicine
Deep Inferior Epigastric Artery Perforator Flap Breast Reconstruction
The Effect of Volatile Anesthesia and Total Intravenous Anesthesia on Shedding of the Endothelial Glycocalyx in Patients Undergoing Mastectomy and Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Free Flap
The aim of this study was to investigate the effects of total intravenous and inhalation anesthesia on the damage of endothelial glucocorticoids by comparing the concentration of syndecan-1 in patients undergoing mastectomy and…
- Trial name
- NCT05136508
- Testing
- Propofol, Sevoflurane
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yonsei University
Lumbar Spine Fusion Surgery
Multimodal GA for Lumbar Spine Surgery
To evaluate the effects of multimodal general anesthesia on the recovery profile of elder patients undergoing lumbar spine fusion surgery.
- Trial name
- NCT05247177
- Testing
- dexmedetomidine, ketamine co-administration with sevoflurane for general anesthesia, Conventional general anesthesia by administration of sevoflurane alone
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Spinal Stenosis, Lumbosacral Region
Stability Comparison of TIVA and Sevoflurane in Prone Spinal Surgery(TIVA:Total Intravenous Anesthesia)
Key Points: 1. Objective: o To compare the effects of Total Intravenous Anesthesia (TIVA) and sevoflurane anesthesia on respiratory mechanics, hemodynamic parameters, and neuromonitoring during prone position spinal surgeries. 2.
- Trial name
- TIVA (NCT06558695)
- Testing
- Sevoflurane, TIVA
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
General Anesthesia
Effect of Sevoflurane and Propofol on Hepato-splanchnic Pressure and Flow During Hepatobiliary Surgery
Blood loss in hepatobiliary surgery is correlated with an increase in postoperative complications (e.g. transfusion related lung injury and tumor recurrence) and reduced longterm survival.
- Trial name
- NCT03772106
- Testing
- Propofol Fresenius, sevorane
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- University Hospital, Ghent
Prostate Cancer
Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing RALP
The purpose of this study was to evaluate the effect of anesthetic method on the optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic prostatectomy.
- Trial name
- NCT03529643
- Testing
- Dexmedetomidine, Without dexmedetomidine
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Asan Medical Center
Blood Pressure, Hypotension Drug-Induced
Comparison Between Inhalation and Intravenous Induction of Anaesthesia During Interventional Mitral Valve Repair
The induction of anaesthesia is one of the most critical situations for high-risk-patients undergoing interventions surgery. For several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this…
- Trial name
- COMPETENT (NCT04865614)
- Testing
- Etomidate, Sevoflurane
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Heidelberg University
Postoperative Sleep Quality
Postoperative Sleep Quality of Patients Anesthesia With Propofol or Sevoflurane Undergoing Thyroidectomy
The investigators designed a study to determine whether Propofol or Sevoflurane would provide same postoperative sleep quality in patients undergoing thyroidectomy.
- Trial name
- NCT02146976
- Testing
- propofol, sevoflurane
- Where
- China
- Volunteers
- 124 people
- Sponsor
- China Medical University, China
Emergence Agitation
Propofol Versus Dexmedetomidine Effect on Prevention Emergence Agitation
The goal of this clinical trial is to compare Propofol versus Dexmedetomidine in children undergoing squint surgery. The main question it aims to answer is: Which drug is more effective in preventing the appearance of Emergence…
- Trial name
- NCT06312618
- Testing
- Propofol, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia; Adverse Effect
Different Anesthetic Technique For ERCP
Providing the appropriate anesthetic technique for endoscopic retrograde cholangiopancreatography (ERCP) in remote locations can be challenging.
- Trial name
- NCT04087668
- Testing
- Monitored Anesthesia Care, General Anesthesia, Induction Without Neuromuscular Blockade
- Where
- China
- Volunteers
- 405 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Metabolic Acidosis
Substitution of Propofol by Sevoflurane During Pediatric Cardiopulmonary Bypass
Propofol has been routinely used for general anesthesia during pediatric cardiopulmonary bypass at our institution without complications.
- Trial name
- PRISKIKO (NCT01295190)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Schleswig-Holstein