Clinical trials: Simvastatin
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer
This early phase I trial tests whether letrozole with simvastatin works better than letrozole alone to stop tumor cell proliferation in patients with stage I-III hormone receptor positive, HER2 negative invasive breast cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma
- Trial name
- NCT05464810
- Testing
- Letrozole, Simvastatin
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Rheumatic Heart Disease, Congenital Heart Disease
Effect of Simvastatin on Cardiac Function
It is well know that statins have been used to low cholesterol to prevent and treat coronary artery disease for many years. It was also reported that statins could protect endothelial function and cardiac function during coronary…
- Conditions
- Rheumatic Heart Disease, Congenital Heart Disease, Aneurysm, Heart Valve Disease
- Trial name
- NCT01178710
- Testing
- Simvastatin
- Where
- China
- Volunteers
- 151 people
- Sponsor
- Sun Yat-sen University
Hypercholesterolemia
Coadministration of Ezetimibe and Simvastatin in Patients With Primary Hypercholesterolemia (P05457)
Evaluate the safety of the long-term (1 year) coadministration of ezetimibe and simvastatin in patients with hypercholesterolemia who have not reached low density lipoprotein (LDL)-cholesterol target with…
- Trial name
- NCT00653523
- Testing
- Ezetimibe, Simvastatin
- Volunteers
- 151 people
- Sponsor
- Organon and Co
Dyslipidemias
Effects of Statin Medications on Mental Processes, Behavior, and Serotonin Levels
Statins are cholesterol-lowering medications that are often prescribed for individuals with high cholesterol and who are at risk for heart disease.
- Trial name
- NCT00330980
- Testing
- 40 mg Pravastatin (Pravachol), 20 mg Simvastatin
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hyperlipidemia
Ezetrol Post-Marketing Study
To compare the lipid lowering efficacy of adding ezetimibe to statin vs. statin alone.
- Trial name
- NCT00753883
- Testing
- simvastatin, Ezetimibe
- Volunteers
- 40 people
- Sponsor
- Merck Sharp & Dohme LLC
Carotid Artery Disease
Feasibility Study of Simvastatin in Hodgkin's Lymphoma Survivors
Lay abstract: Study Purpose With contemporary combined modality therapy the expected longterm survival of children and adolescents with Hodgkin's disease (HD) is exceedingly high.
- Trial name
- NCT00746603
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Columbia University
Subarachnoid Hemorrhage
Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)
The primary objective of this project is to investigate the effect of statin therapy on cerebral blood flow in patients with aneurysmal SAH who are randomized to receive or not receive statins in a blinded design.
- Trial name
- NCT00795288
- Testing
- Simvastatin, 80 mg/day for 21 days
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Relapsing Remitting Multiple Sclerosis
Simvastatin as an add-on Treatment to Copaxone for the Treatment of Relapsing Multiple Sclerosis
A Double Blind, Randomised, Placebo Controlled Study Investigating Simvastatin as an add-on Treatment to Copaxone for the Treatment of Relapsing Multiple Sclerosis in patients treated with Copaxone for at least 3 months
- Trial name
- NCT00429442
- Testing
- Simvastatin
- Where
- Denmark
- Sponsor
- Anna Tsakiri
Elevated LDL Cholesterol
A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol
This study evaluates the effect on LDL cholesterol of the 3 drugs given together in the cardiovascular fixed dose combination pill (acetylsalicylic acid, simvastatin, and ramipril) as compared to the effect on LDL cholesterol of…
- Trial name
- NCT01004705
- Testing
- Cardiovascular fixed dose combination pill (acetylsalicylic acid, simvastatin and ramipril),, Simvastatin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Ferrer Internacional S.A.
Secondary Progressive Multiple Sclerosis (SPMS)
Multiple Sclerosis-Simvastatin Trial 2
Multiple Sclerosis (MS) is a progressive neurological disorder of the brain and spinal cord. It affects approximately 120,000 people in the United Kingdom and 2.5 million people globally.
- Trial name
- MS-STAT2 (NCT03387670)
- Testing
- Simvastatin
- Where
- 31 sites in United Kingdom
- Volunteers
- 964 people
- Sponsor
- University College, London
Cardiovascular Diseases, Coronary Disease
HDL-Atherosclerosis Treatment Study (HATS)
To measure the effects of lipid-lowering drugs and/or antioxidant vitamins on progression or regression of coronary heart disease as measured by quantitative angiography in patients with low high density lipoprotein (HDL)…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Ischemia
- Trial name
- NCT00000553
- Testing
- simvastatin, niacin, antioxidants
- Sponsor
- University of Washington
The Main Focus of This Study is to Evaluate the Safety of Zingiber Officinale L. Tablets as Hypolipidemic Agent in Hypertensive Patients
Protective Effect of Zingiber Officinale L. Extract in Hypertensive Patients
Hyperlipidemia is a well-known risk factor for cardiovascular diseases (CVDs). Coronary heart disease, stroke, and atherosclerosis are among the primary cause of death.
- Trial name
- NCT05682911
- Testing
- Zingiber officinale L. tablets, Simvastatin 20mg
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Jinnah Sindh Medical University
Cystic Fibrosis, Systemic Inflammation
Statins To Treat Adult Cystic Fibrosis
Cystic fibrosis (CF) is a lethal genetic condition that affects 30,000 children and adults in the United States. Although CF management has improved substantially over the past two decades, there is still no cure and most…
- Trial name
- CFStatin (NCT01092572)
- Testing
- Simvastatin
- Sponsor
- University of British Columbia
Diabetes Mellitus, Type 2
Statin and Bone Health
This study aims to evaluate the impact of simvastatin on the bone density of postmenopausal women with type 2 diabetes over a duration of 18 months, using a randomized controlled trial design.
- Trial name
- NCT05613400
- Testing
- Simvastatin 10mg, Ezetimibe 10mg
- Where
- Hong Kong
- Volunteers
- 240 people
- Sponsor
- The University of Hong Kong
Hypercholesterolemia
Using Nudges to Implement Comparative Effectiveness
Behavioral economics represents a powerful, albeit underutilized tool to influence provider and systems behavior in a large-scale, meaningful, and sustainable way.
- Trial name
- NCT01575171
- Testing
- Nudge
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- NYU Langone Health
Hypercholesterolemia, Dyslipidemia
Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin
The purpose of this study is to compare the efficacy and safety of pitavastatin with that of simvastatin.
- Trial name
- NCT00309777
- Testing
- Pitavastatin, Simvastatin
- Where
- 42 sites in Finland, Italy and 3 more
- Volunteers
- 857 people
- Sponsor
- Kowa Research Europe
Alzheimer's Disease, Aging
Do HMG CoA Reductase Inhibitors Affect Abeta Levels?
Recent evidence suggests that there is a significant overlap between AD and cerebrovascular disease. In fact, AD and cerebrovascular disease may share some of the same risk factors, including hypercholesterolemia.
- Trial name
- NCT00303277
- Testing
- simvastatin, pravastatin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Acute Kidney Injury
A Study of the PK Interaction of CXA-10 With Pravastatin and Vytorin® in Healthy Males
This is an exploratory study in a small, well controlled group of healthy subjects to explore the effect of CXA-10 on pravastatin and Vytorin® (combination of simvastatin and ezetimibe).
- Trial name
- DDI (NCT02547402)
- Testing
- CXA-10, pravastatin, Vytorin® (combination of simvastatin and ezetimibe)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Complexa, Inc.
Healthy
Pharmacokinetics of Simvastatin and Its Metabolite Simvastatin Acid With and Without Concomitant Administration of Telmisartan in Healthy Subjects
To assess the pharmacokinetics of simvastatin and simvastatin acid with/without concomitant administration of telmisartan
- Trial name
- NCT02187536
- Testing
- Telmisartan, Simvastatin
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Microvascular Angina
Ranolazine and Microvascular Angina by PET in the Emergency Department
The purpose of this study is to determine the effectiveness of Ranolazine for the treatment chest pain from disease of small vessels of the heart also known as 'microvascular angina'.
- Trial name
- RAMP-ED (NCT02052011)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University