Clinical trials: Simvastatin
Healthy
A Study of LY3502970 in Healthy Participants
The main purposes of this study are to determine: The safety of LY3502970 and any side effects that might be associated with it. How much LY3502970 gets into the bloodstream and how long it takes the body to get rid of it.
- Trial name
- NCT03929744
- Testing
- LY3502970, Atorvastatin, Simvastatin
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Hyperlipidemia
Comparison of the Combination of Fenofibrate and Simvastatin Versus Pravastatin
Mixed or combined hyperlipidemia is a common metabolic disorder characterized by both hypercholesterolemia and hypertriglyceridemia.
- Trial name
- NCT00362206
- Testing
- Fenofibrate/Simvastatin, Pravastatin
- Where
- 41 sites in Greece, Israel and 3 more
- Volunteers
- 423 people
- Sponsor
- Solvay Pharmaceuticals
Multiple Myeloma
The Effect of High Dose Simvastatine on Multiple Myeloma
The purpose of the study is to evaluate the effect of high doses of Simvastatine on bone metabolisme and biochemical markers of disease in Multiple Myeloma
- Trial name
- NCT00281476
- Testing
- Simvastatine
- Volunteers
- 10 people
- Sponsor
- Vejle Hospital
Metastatic Colorectal Cancer
Immunotheray Combined With Simvastatin and Target Therapy and Chemotharepy for Advanced Colorectal Cancer
Metastatic colorectal cancer with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) molecular phenotypes could significantly benefit from immune checkpoint inhibitor therapy, ushering in the MSI era of…
- Trial name
- NCT07718490
- Testing
- Adebrelimab
- Where
- 2 sites in China
- Volunteers
- 43 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
HYPERTENSION, HYPERCHOLESTEROLEMIA
A 10-12 Week Study to Evaluate the Safety and Efficacy of 320 mg Valsartan and 80 mg Simvastatin in Combination and as Monotherapies in Treating Hypertension and Hypercholesterolemia
This 10-12 week study will provide data on the safety and efficacy of using 320 valsartan and 80 mg simvastatin together compared to using either one alone in lowering blood pressure and LDL cholesterol.
- Trial name
- NCT00171093
- Testing
- valsartan + simvastatin
- Where
- United States
- Volunteers
- 369 people
- Sponsor
- Novartis
Intestinal Neoplasm, Perioperative Care
Simvastatin in Colorectal Surgery
Statins (HMG-CoA reductase inhibitors) are a widely used class of cholesterol-lowering drugs that have an established role in the medical management of cardiovascular disease.
- Trial name
- StatCol (NCT00994903)
- Testing
- Simvastatin
- Where
- 3 sites in New Zealand
- Volunteers
- 132 people
- Sponsor
- University of Auckland, New Zealand
Pulpitis - Irreversible
Efficacy of Combination of Biodentine and Simvastatin as a Pulp Capping Materials in Vital Pulpotomy of Primary Molars
Objective: This study was conducted to evaluate the efficacy of combination of biodentine with simvastatin as a pulpotomy agent for vital primary molars clinically and radiographically.
- Trial name
- NCT05582317
- Testing
- Biodentine, Simvastatin
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Suez Canal University
Cirrhosis, Portal Hypertension
Efficacy and Safety of Simvastatin in the Treatment of Portal Hypertension
The purpose of this study is to evaluate the effects of continuous simvastatin administration on the hepatic venous pressure gradient (HVPG), as a surrogate marker of prognosis, and its safety in patients with cirrhosis and…
- Trial name
- NCT00594191
- Testing
- Simvastatin
- Where
- 3 sites in Spain
- Volunteers
- 59 people
- Sponsor
- Hospital Clinic of Barcelona
Prostate Cancer
Intensive Cholesterol-Lowering and CD8+ T Cells in Prostate Cancer
To test the hypothesis that intensive cholesterol lowering (iCL) therapy has anti-tumor immune modulating activity, the investigators will conduct an open-label, single-arm phase II trial in prostate cancer patients who are in…
- Trial name
- NCT06437574
- Testing
- Vytorin, Ezetimibe
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Cedars-Sinai Medical Center
Schizophrenia, Schizoaffective Disorder
Simvastatin Addition for Patients With Recent-onset Schizophrenia
Rationale: There is ample evidence that inflammatory processes play a role in the pathophysiology of schizophrenia. Although Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have been shown to be able to reduce symptoms in these…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Psychosis NOS
- Trial name
- NCT01999309
- Testing
- Simvastatin
- Where
- 2 sites in Netherlands
- Volunteers
- 121 people
- Sponsor
- Iris Sommer
Pain, Weakness
Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms
This study will evaluate whether a dietary supplement, coenzyme Q10 (CoQ10), will improve muscle symptoms, such as muscle aches, pains, cramps, and/or weakness, which are experienced by some individuals who use statin medications.
- Conditions
- Pain, Weakness, Cramps, Myalgia or Myositis Nos
- Trial name
- NCT01032993
- Testing
- Coenzyme Q10
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Catherine Buettner
Invasive Breast Carcinoma, Stage I Breast Cancer AJCC v7
The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer
The purpose of this pilot phase II trial is to identify the molecular and genetic mechanisms by which statins influence breast cancer cell proliferation.
- Conditions
- Invasive Breast Carcinoma, Stage I Breast Cancer AJCC v7, Stage IA Breast Cancer AJCC v7, Stage IB Breast Cancer AJCC v7
- Trial name
- NCT03454529
- Testing
- Laboratory Biomarker Analysis, Simvastatin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Michael Simon
Uveitis
Use of Simvastatin as a Steroid Sparing Agent for Uveitis Patients
The trial will compare the effect on disease control and immunosuppression treatment of adding simvastatin 80mg once daily, over a follow-up and treatment period of 2 years.
- Trial name
- NCT02252328
- Testing
- Simvastatin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
HDL Cholesterol
Crossover of Higher Dose Statins in Patients With Low High-density Lipoproteins Cholesterol (HDLc)
Summary: Background: There is a lot of interest in the function and role of HDL to prevent and mitigate atherosclerosis in patients who are at or near LDLc targets.
- Trial name
- NCT00736463
- Testing
- Simvastatin, Atorvastatin 80 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Oregon Health and Science University
Atherosclerotic Cardiovascular Disease
Lipoprotein(a) Levels in Patients With Atherosclerotic Cardiovascular Diseases in Russia
This study has the purpose to answer how the Lipoprotein(a) (Lp(a)) level is distributed among Atherosclerotic cardiovascular disease (ASCVD) patients in Russia, and what is the connection between elevated levels of this…
- Trial name
- STaRT (NCT06858332)
- Testing
- Atorvastatin, Simvastatin, Rozuvastatin
- Where
- 20 sites in Russia
- Volunteers
- 2,382 people
- Sponsor
- Novartis Pharmaceuticals
Metabolic Syndrome
Gut Microbiomes in Patients With Metabolic Syndrome
Metabolic syndrome (MS) is defined by a manifestation of cardiometabolic risk factors including high blood pressure, glucose and triglycerides, low high-density lipoprotein (HDL) cholesterol, and abdominal obesity.
- Trial name
- NCT03489317
- Testing
- Metformin, lifestyle modification, Simvastatin 10mg
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Diabetic Kidney Disease (DKD), Type 2 Diabetes
A Study on the Safety and Clinical Efficacy of Guominkang in the Treatment of Diabetic Kidney Disease
We are conducting this clinical trial to find out whether Guominkang-a traditional Chinese herbal formula-is safe and effective for people with diabetic kidney disease (DKD).
- Conditions
- Diabetic Kidney Disease (DKD), Type 2 Diabetes, Albuminuria
- Trial name
- NCT07907965
- Testing
- Guominkang Granules, Standard Antihypertensive, Antidiabetic, and Lipid-Lowering Regimen
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Beijing University of Chinese Medicine
Hypertension, Pulmonary
A Study of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
The purpose of this study is to determine whether aspirin and simvastatin are safe and effective for the treatment of pulmonary arterial hypertension (PAH).
- Trial name
- NCT00384865
- Testing
- Simvastatin, Aspirin
- Where
- 4 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Pennsylvania
Hypercholesterolemia
Effect Of Ezetimibe Coadministration With Simvastatin In A Middle Eastern Population: A Prospective, Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial (0653-151)
The primary outcome was percentage reduction of LDL-C after 6 weeks of randomization.
- Trial name
- NCT00652444
- Testing
- ezetimibe, simvastatin
- Volunteers
- 120 people
- Sponsor
- Organon and Co
Vitiligo
Clinical Trial of Simvastatin to Treat Generalized Vitiligo
The investigators purpose is to initiate a phase II, randomized, placebo-controlled clinical trial to test simvastatin, an FDA-approved medication for hypercholesterolemia, as a new treatment for vitiligo.
- Trial name
- NCT01517893
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- John Harris