Clinical trials: Sitagliptin, completed
Diabetes Mellitus, Type 2
Study Of Safety And Efficacy Of Ertugliflozin (PF-04971729, MK-8835) In Participants With Type 2 Diabetes (MK-8835-016)
MK-8835-016 (B1521006) is designed to evaluate the safety and efficacy of an investigational drug, ertugliflozin (MK-8835, PF-04971729) in participants with Type 2 diabetes mellitus.
- Trial name
- NCT01059825
- Testing
- Ertugliflozin 1 mg, Ertugliflozin 5 mg, Ertugliflozin 25 mg
- Volunteers
- 375 people
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
Drug Transporter Interaction Study PHENTRA_2015_KPUK
The objective of the present study is to contribute to establishing in vivo phenotyping procedures for organic anionic transporter polypeptide 1B1 (OATP1B1), organic cation transporters 1 and 2 (OCT1/2), multidrug and toxic…
- Trial name
- NCT02743260
- Testing
- pitavastatin, Metformin, digoxin
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Cologne
Diabetes Mellitus, Type 2
Pioglitazone Add-on Study in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to determine the safety and efficacy of an investigational drug in patients with type 2 diabetes mellitus.
- Trial name
- NCT00086502
- Testing
- Comparator: Sitagliptin, Comparator: Pioglitazone, Metformin
- Volunteers
- 353 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus
Effect of Sitagliptin on Incretin Effect in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to assess the effect of the DPP-4 inhibitor sitagliptin on the incretin effect in patients with type 2 diabetes mellitus.
- Trial name
- NCT00551590
- Testing
- Sitagliptin tablet, Saline infusion, Exendin(9-39) infusion
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Type 2 Diabetes Mellitus
Treatment of Diabetes After Gastric Bypass With Sitagliptin
The purpose of this study is to assess whether Januvia (sitagliptin phosphate 100mg) is safe and effective for the treatment of Type 2 Diabetes in patients who have had Gastric Bypass.
- Trial name
- LAF33 (NCT01512797)
- Testing
- Sitagliptin phosphate
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Blandine Laferrere
Type2 Diabetes
GA 6: The Blood Glucose-lowering Effect of Glucose-dependent Insulinotropic Polypeptide
This study will investigate if the effect of DPP-4 inhibitors is mediated in part by Glucose-dependent insulinotropic polypeptide.
- Trial name
- NCT03845179
- Testing
- GIP receptor antagonist, DPP-4 inhibitor
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Type 2 Diabetes
Study of the QOL Evaluation of Trelagliptin in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to assess the reduction in treatment burden during 12 weeks of trelagliptin administration in patients with type 2 diabetes on diet and exercise therapy only.
- Trial name
- TRENDS (NCT03014479)
- Testing
- Trelagliptin, Daily DPP-4 inhibitor
- Where
- 27 sites in Japan
- Volunteers
- 219 people
- Sponsor
- Takeda
Diabetes Mellitus, Type 2
BI 10773 add-on to Metformin in Patients With Type 2 Diabetes
The objective of the current study is to investigate the efficacy, safety and pharmacokinetics of five doses of BI 10773 compared to placebo given for 12 weeks as add-on therapy to on going metformin therapy in patients with T2DM…
- Trial name
- NCT00749190
- Testing
- BI 10773, sitagliptin
- Where
- 116 sites in United States, Argentina and 14 more
- Volunteers
- 495 people
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes
Variable Effects of Anti-diabetics on Stress Hyperglycemia Ratio
A blood glucose level of equal to or greater than 180 mg/dL that occurred during stress in a patient without diabetes mellitus (DM) is termed stress hyperglycemia (SH).
- Trial name
- NCT05822674
- Testing
- Sitagliptin/metformin ( 50/500mg) Oral Tablet, Empagliflozin/metformin(10/500mg) Oral Tablet
- Where
- Iraq
- Volunteers
- 80 people
- Sponsor
- University of Diyala
Type 2 Diabetes
A Study of the Effects of Sitagliptin (MK0431) and Metformin on Incretin Hormone Concentrations (0431-050)(COMPLETED)
This study will determine the effect of concomitant administration of sitagliptin and metformin on post-meal incretin hormone concentrations in healthy adults.
- Trial name
- NCT00975052
- Testing
- sitagliptin phosphate, Comparator: metformin, Comparator: sitagliptin and metformin
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes, Type 2
Comparison of Hypoglycaemic Regimens During Ramadan Fasting in Type 2 Diabetes
Type 2 diabetic patients who fast during Ramadan experience swings in glycaemic control between hypoglycaemic troughs and hyperglycaemic spikes.
- Trial name
- NCT01624116
- Testing
- Acarbose, Diet and lifestyle, Metformin
- Where
- Pakistan
- Volunteers
- 161 people
- Sponsor
- Services Hospital, Lahore
Diabetes, Heart Failure
The Effects of Neprilysin on Glucagon-like Peptide-1
In the current study we wish to investigate the effects on glucagon-like peptide-1 (GLP-1) of a neprilysin inhibitor
- Trial name
- NEP (NCT03717688)
- Testing
- Entresto, Sitagliptin 100mg
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Nicolai Jacob Wewer Albrechtsen
Type 2 Diabetes
Study of Sitagliptin in Older Type 2 Diabetics (0431-047)(COMPLETED)
To evaluate the effect of treatment with sitagliptin compared to placebo in elderly patients with type 2 diabetes mellitus who have poor glycemic control with diet and exercise.
- Trial name
- NCT00305604
- Testing
- sitagliptin phosphate
- Volunteers
- 206 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 2, Heart Failure With Preserved Ejection Fraction (HFPEF)
Emulation of the SUMMIT Heart Failure Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real-world data through large-scale emulation of randomized controlled trials.
- Trial name
- DUP-SUMMIT (NCT06914154)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 11,265 people
- Sponsor
- Brigham and Women's Hospital
Type II Diabetes
Clinical Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LEZ763
This study is a three part study to assess the safety and efficacy of LEZ763 on normal healthy volunteers and patients with Type 2 Diabetes.
- Trial name
- NCT01619332
- Testing
- Sitagliptin, LEZ763
- Where
- 6 sites in United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Healthy Subjects
Bioequivalence of Sitagliptin Phosphate/Metformin Hydrochloride Tablets in Healthy Chinese Subjects
An open-label, randomized, single-dose, two-period, two-group, crossover study was conducted in 48 healthy Chinese volunteers under fasted or fed conditions (24 volunteers for each condition) to assess the bioequivalence between…
- Trial name
- NCT04877106
- Testing
- Sitagliptin Phosphate/metformin Hydrochloride Tablets(JANUMET®,50mg/850mg), Sitagliptin Phosphate/metformin Hydrochloride Tablets (50mg/850mg)
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Type 1 Diabetes
A Pilot Study to Assess the Glucose Lowering Effect of Metformin and Sitagliptin in Adolescents With Type 1 Diabetes
The purpose of this study is to see if the use of metformin and sitagliptin used in conjunction with insulin can improve the blood sugars of teenagers with Type 1 diabetes.
- Trial name
- NCT01718093
- Testing
- Sitagliptin, Metformin, Sitagliptin + Metformin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Baylor College of Medicine
Diabetes Mellitus, Type 2, Obesity
Role of Interleukin-6 in Exercise
The purpose of the study is to understand the role of interleukin-6 during physical activity in patients with type 2 diabetes.
- Trial name
- Exil-6 (NCT01073826)
- Testing
- Sport, Tocilizumab, Sitagliptin
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University of Zurich
Randomized Controlled Trial, Diabetes Mellitus
Effect of Apple Cider Vinegar in Type 2 Diabetics
Background: apple cider vinegar is natural traditional health beneficial nutraceutical used for many aliments. Diabetes mellitus (DM) has been considered a globally major health problem and posing health burden on families and…
- Trial name
- NCT03593135
- Testing
- Apple Cider Vinegar and tablet Tagipmet (Metformin + Sitagliptin group), Water with Apple Cider vinegar flavor and tablet Tagipmet (Metformin + Sitagliptin group)
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Type 2 Diabetes Mellitus
Controlled Study of MK-0431/ONO-5435 in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to determine the safety and efficacy of MK-0431/ONO-5435 in patients with Type 2 diabetes mellitus who have inadequate glycemic control on diet/exercise therapy and metformin as monotherapy
- Trial name
- NCT00363948
- Testing
- Sitagliptin phosphate
- Where
- 8 sites in Japan
- Volunteers
- 188 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.