Clinical trials: Standard treatment
Ileostomy - Stoma
Investigating the Safety and Performance of a New 2-piece Ostomy Product Compared With SenSura Click 2-piece
The aim of the current investigation is to investigate the performance of a new 2-piece ostomy product
- Trial name
- NCT01957553
- Testing
- Coloplast test product, SenSura
- Where
- 17 sites in Belgium, Denmark and 3 more
- Volunteers
- 130 people
- Sponsor
- Coloplast A/S
Chronic Pain, Chronic Insomnia
Improving Sleep and Reducing Opioid Use in Individuals With Chronic Pain
The goal of this study is to test two behavioral interventions for chronic insomnia in individuals with chronic pain and use prescribed opioid medication to treat their chronic pain.
- Conditions
- Chronic Pain, Chronic Insomnia, Opioid Use
- Trial name
- NCT06345872
- Testing
- CBT-I, Treatment as usual, Tapered Withdrawal
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Prostate Cancer, Prostate Cancer Metastatic
Fecal Microbiota Transplant and Pembrolizumab for Men With Metastatic Castration Resistant Prostate Cancer.
All patients will be required to have a biopsy of a metastatic tumor deposit at study entry. Pembrolizumab will be administered at a dose of 200 mg as a 30 minute IV infusion every 3 weeks.
- Trial name
- NCT04116775
- Testing
- Fecal microbiota transplant, Pembrolizumab, Enzalutamide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Julie Graff, MD
Melanoma (Skin Cancer)
Comparing Intravenous or Intradermal Administration of Anti-CTLA-4 in Combination With Anti-PD1 Treatment in Patients With Melanoma
This study investigates whether a single intradermal (i.d.) injection of low-dose anti-CTLA-4 (ipilimumab), given at the tumour site, can enhance immune activation when combined with standard intravenous (i.v.) anti-PD-1 therapy…
- Trial name
- IpiD (NCT07615881)
- Testing
- Group 1 - Intradermal ipilimumab, Group 2 - Conventional treatment
- Volunteers
- 18 people
- Sponsor
- Amsterdam UMC, location VUmc
Multiple Sclerosis
Promoting Aerobic Training in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic neurological disease characterized by inflammation and degeneration within the central nervous system.
- Trial name
- NCT05212805
- Testing
- Aerobic exercise, Task-oriented upper-limb training, Sport events participation
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- Fondazione Italiana Sclerosi Multipla
HIV, Neonatal HIV Early-Infant-Diagnosis (EID), Point-of-Care Testing (PoC)
Neonatal HIV Early Infant Diagnosis (EID) Versus Standard of Care EID- Long Term Impact on inFant hEalth (LIFE)
This study we will evaluate the benefit of HIV testing in neonates born from HIV-infected mothers in Tanzania and Mozambique. The study will use and evaluate novel point-of-care diagnostic systems, that can provide neonatal HIV…
- Trial name
- LIFE (NCT04032522)
- Testing
- point-of care (PoC) neonatal HIV early infant diagnosis (EID)
- Where
- 2 sites in Mozambique, Tanzania
- Volunteers
- 6,602 people
- Sponsor
- Michael Hoelscher
COVID19 Pneumonia
Trial Evaluating Efficacy and Safety of Anticoagulation in Patients With COVID-19 Infection, Nested in the Corimmuno-19 Cohort
COVID-19 is a respiratory disease caused by a novel coronavirus (SARS-CoV-2) and causes substantial morbidity and mortality. There is currently no vaccine to prevent Covid-19 or infection with SARS-CoV-2 or therapeutic agent to…
- Trial name
- CORIMMUNO-COAG (NCT04344756)
- Testing
- Tinzaparin or unfractionated heparin
- Where
- 3 sites in France
- Volunteers
- 808 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
In Vitro Fertilization, Assisted Reproductive Techniques
Optimizing IVF Treatment - the Impact of Time-lapse Culture and Preimplantation Factor (PIF) on Embryo Development.
The aims of this study are to evaluate: 1. the possible effect of time-lapse culture from day zero (day of oocyte retrieval) on fertilisation rates and embryo quality in standard IVF. 2.
- Trial name
- NCT02222831
- Testing
- Day 0 denudation and time lapse culture on IVF-oocytes.
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Regionshospitalet Viborg, Skive
HIV, Mental Health
Stepped Care for Youth Living With HIV
Optimizing the HIV Treatment Continuum with a Stepped Care Model for Youth Living with HIV (YLH) aims to achieve viral suppression among YLH.
- Conditions
- HIV, Mental Health, Illicit Substance Use, Sexually Transmitted Infections (STI)
- Trial name
- NCT03109431
- Testing
- Level 1, Level 2, Level 3
- Where
- 2 sites in United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hemangioma
Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH)
This is a prospective randomized, double-blind study to compare the clinical efficacy of infantile hemangioma treatment using propranolol with corticosteroids as compared to therapy with corticosteroids and placebo.
- Trial name
- NCT01074437
- Testing
- Prednisolone (Corticosteroid), Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Seattle Children's Hospital
Acute Upper Respiratory Tract Infections
Trial of Chinese Herbal Medicine in the Treatment of Upper Respiratory Tract Infections (URTIs)
Upper respiratory tract infections (URTIs) are the most common illnesses in primary medical services but there is no established cure for these conditions in Western medicine.
- Trial name
- NCT00887172
- Testing
- Jing Fang Bai Du san, Ying Qiao san
- Where
- China
- Volunteers
- 327 people
- Sponsor
- The University of Hong Kong
Gastrointestinal Stromal Tumor
Imatinib Mesylate With or Without Surgery in Treating Patients With Metastatic Gastrointestinal Stromal Tumor That is Responding to Imatinib Mesylate
RATIONALE: Surgery may remove residual disease in patients with gastrointestinal stromal tumor that is responding to imatinib mesylate.
- Trial name
- NCT00956072
- Testing
- imatinib mesylate, therapeutic conventional surgery
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
COPD
The Effect of Oxygen Therapy With Airvo High-flow Heated Humidification
The purpose of our study is to establish whether domiciliary use of the Airvo warm passover humidifier can reduce the number of exacerbations in patients with respiratory insufficiency.
- Trial name
- HHCOPD (NCT02731872)
- Testing
- Airvo humidifier
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Birgitte Schantz Laursen
Non-small Cell Lung Cancer, Radiation Toxicity
Detecting Radiation-Induced Cardiac Toxicity After Non-Small Cell Lung Cancer Radiotherapy
Lung cancer is the most common cause of cancer death in Canada. For approximately 30% of patients that present with locally-advanced non-small cell lung cancer (NSCLC), the standard treatment is curative-intent concurrent…
- Trial name
- RICT-LUNG (NCT03416972)
- Testing
- Standard platinum-based chemoradiotherapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Malaria
Artemisinin Resistance In Malaria Treated With IV Artesunate
The spread of artemisinin resistant falciparum malaria presents new challenges to both the control and treatment of malaria. Loss of ring stage susceptibility to the artemisinins might jeopardize the use of parenteral artesunate…
- Trial name
- ARIMTIA (NCT02640495)
- Testing
- Intravenous Artesunate as part of standard medical practice
- Sponsor
- University of Oxford
Dry Skin, Xerosis Cutis
The Effectiveness of Herbal Creams Compared to Urea in Dry Skin Treatment
The goal of this Clinical trial is to Determine the effectiveness of a cream combining Gayo Arabica coffee bean extract and Aceh patchouli compared to urea cream for dry skin in Patients with dry skin, aged 18-65 years old who…
- Trial name
- NCT07360639
- Testing
- combination cream, control cream
- Where
- Indonesia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universitas Syiah Kuala
Chronic Neck Pain, Neck Pain
Cost-Effectiveness Analysis of a Virtual Reality-Assisted Hypnotherapy Program on Quality of Life in Patients with Chronic Neck Pain: a Multicenter, Randomized, Prospective, Comparative, Open-Label, Parallel-Group Study
This randomized, prospective study aims to evaluate the effectiveness and cost-efficiency of a Virtual Reality (VR)-assisted hypnotherapy program on quality of life in patients with chronic neck pain.
- Trial name
- NCT06697795
- Testing
- Virtual Reality-Assisted Hypnotherapy, Standard Physical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- University of Beykent
Gram Positive Bacterial Infection
Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjects Receiving Prophylactic Antibiotics
This is a research study designed to look at the pharmacokinetics (distribution, breakdown, and removal) and tolerability of a single dose of daptomycin in patients aged 3 months to 24 months who have proven or suspected…
- Trial name
- NCT01019395
- Testing
- Daptomycin
- Where
- 8 sites in United States
- Volunteers
- 23 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Breast Carcinoma
Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer
This phase II trial tests whether low-dose aspirin can affect markers of inflammation in postpartum (after childbirth) women planning to have a breast biopsy.
- Trial name
- NCT05557877
- Testing
- Biospecimen Collection, Low-Dose Aspirin, Questionnaire Administration
- Where
- 5 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Impaired Wound Healing
A Prospective, Randomized, Controlled, Multi-Center, Study Evaluating AutoloGel Therapy for Complete Closure of Wagner Grade 1-4 Diabetic Foot Ulcers, Venous Leg Ulcers and Stage II-IV Pressure Ulcers
This study is designed to demonstrate the outcome of complete ulcer closure of patients with Wagner Grade 1-4 DFUs, VLUs or Stage II-IV PUs using AutoloGel versus Usual and Customary Care (UCC).
- Trial name
- NCT02248077
- Testing
- AutoloGel, Usual and Customary Care (UCC)
- Sponsor
- Cytomedix
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