Clinical trials: Standard treatment
Obesity
Study Assessing the Contribution of Telemedicine Monitoring in Addition to Standard Follow-up of an Obesity Program
STROBERRY Study is a Prospective, monocentric, randomized, open-label study assessing the contribution of telemedicine, in addition to standard follow-up, strengthening an Obesity program in Berry (France).
- Trial name
- STROBERRY (NCT05954377)
- Testing
- Quarterly remote motivational interviews
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Elsan
Foot Fusion
Augment® Bone Graft (Formerly GEM OS™1 Bone Graft) Compared to Autologous Bone Graft in Foot and Ankle Fusions
STUDY OBJECTIVES: Demonstrate equivalent clinical and radiologic outcomes to the "gold standard" (ABG) in a representative clinical model (hindfoot and ankle fusions) STUDY HYPOTHESIS: Augment® Bone Graft is an equivalent bone…
- Trial name
- NCT00583375
- Testing
- Augment® Bone Graft, Standard of Care
- Where
- 37 sites in United States, Canada
- Volunteers
- 414 people
- Sponsor
- BioMimetic Therapeutics
Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation
Individualized Medical Nutrition Therapy in Adults With Type 2 Diabetes Mellitus
This study aims to investigate the effects of intensive medical nutrition therapy on blood sugar control, systemic inflammation, and gut barrier function in adults with type 2 diabetes mellitus.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation, Intestinal Permeability, Glycemic Control
- Trial name
- NCT07037212
- Testing
- Intensive Medical Nutrition Therapy (MNT), Standard Dietary Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Serap Balaban Barta
Multi-drug Resistant Tuberculosis, Extensively Drug-Resistant Tuberculosis
Economic Evaluation of New MDR TB Regimens
The current treatment regimen for MDR-TB has poor outcomes and costs of treating MDR-TB are greater than treating drug susceptible TB, both in terms of health service and patient-incurred costs.
- Conditions
- Multi-drug Resistant Tuberculosis, Extensively Drug-Resistant Tuberculosis, Pulmonary Tuberculoses
- Trial name
- PRACTECAL-EE (NCT04207112)
- Testing
- Bedaquiline, Pretomanid, Moxifloxacin
- Where
- 7 sites in Belarus, South Africa and 1 more
- Volunteers
- 73 people
- Sponsor
- Medecins Sans Frontieres, Netherlands
Cannabis Use Disorder
A Cannabis E-intervention for Young Cannabis Users With Early Psychosis (iCC)
The concerning lack of research related to technology-based psychological interventions in individuals with psychosis and cannabis use disorder (CUD) led to the design a randomized control trial (RCT) with an innovative mobile…
- Trial name
- iCC (NCT05310981)
- Testing
- iCanChange
- Where
- 5 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
COVID-19
Hyperbaric Oxygen for COVID-19 Patients
Hyperbaric oxygen therapy (HBOT) treatment will be provided to patients as an adjunct to standard therapy for a cohort of 40 COVID19-positive patients with respiratory distress at NYU Winthrop Hospital.
- Trial name
- NCT04332081
- Testing
- hyperbaric oxygen therapy (HBOT)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- NYU Langone Health
Fluid Overload
Body Composition Monitoring(BCM) for Determination of the Fluid Status in Patients Undergoing General Anesthesia
The purpose of this study is to evaluate a recently developed device, which measures body composition (i.e. the water content of the body) in the perioperative setting.
- Trial name
- BCM (NCT01945541)
- Testing
- Body Composition Monitoring
- Where
- Austria
- Volunteers
- 73 people
- Sponsor
- Medical University of Vienna
Malaria
Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites
It is possible to safely protect human volunteers immunized with P. vivax irradiated sporozoites from P. vivax challenge with live sporozoites.
- Trial name
- SPZ-Irrad (NCT01082341)
- Testing
- Immunization with P. vivax irradiated sporozoites
- Where
- Colombia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Malaria Vaccine and Drug Development Center
Cigarette Smoking, Veterans
Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment
Veterans with substance use disorders smoke at extraordinarily high rates and have high rates of smoking-related death and disease.
- Trial name
- Co-STOP (NCT07809854)
- Testing
- Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- VA Office of Research and Development
Urinary Tract Infections, Urological System Complication of Procedure
Potentiated Aminoglycosides in Postoperative Urinary Tract Infection Prophylaxis
Urinary tract hardware such as pig-tail catheters are are frequently used for management of urolithiasis or other obstructive pathologies. They are readily colonized by urogenital flora leading to asymptomatic bacteriuria.
- Trial name
- UROPOT (NCT05761405)
- Testing
- mannitol-enhanced aminoglycoside, Ceftriaxon, Amikacin
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Mild Cognitive Impairment (MCI), Alzheimer Disease (AD)
Digital Lifestyle Coaching for Alzheimer's Disease Prevention in APOE4 Carriers
Wellderly Brain is a randomized, direct-to-participant trial evaluating whether a virtually delivered, multidomain lifestyle coaching intervention can favorably impact plasma biomarkers of Alzheimer's disease (AD) in adults aged…
- Trial name
- WellderlyBrain (NCT07646054)
- Testing
- Education
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Scripps Translational Science Institute
Cerebral Metastases Patients
Neurococognitive and Functioal Assessment of Patients With Brain Metastases
The investigators seek to perform an observational study in patients with brain metastases that are to undergo whole brain radiation therapy (WBRT) or stereotactic radiosurgery (SRS) treatment in order to quantify any baseline…
- Trial name
- NCT01861405
- Testing
- neuropsychological testing and quality of life assessments, Standard of Care WBRT or SRS, Functional magnetic resonance imaging
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Post Operative Pain Control
Pectoralis and Serratus Muscle Blocks
The overall research plan is PECS/SAP blocks with liposomal bupivacaine improve the Overall Benefit Analgesia Score averaged over the postoperative days 1, 2, and 3.
- Trial name
- NCT03743194
- Testing
- Exparel 266 MG Per 20 ML Injection
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- The Cleveland Clinic
Gastric Intestinal Metaplasia, Treatment
RFA for GIM Treatment
Use radiofrequency ablation (RFA) for Gastric intestinal metaplasia (GIM) treatment.
- Conditions
- Gastric Intestinal Metaplasia, Treatment, Radio-frequency Ablation
- Trial name
- NCT04348266
- Testing
- Radiofrequency ablation (RFA)
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Metastatic Prostate Cancer
TOward a comPrehensive Supportive Care Intervention for Older Men With Metastatic Prostate Cancer
TOPCOP3 is a pilot factorial RCT of geriatric assessment and management, remote symptom monitoring, both interventions or neither, accompanied by an embedded process evaluation.
- Trial name
- TOPCOP3 (NCT05582772)
- Testing
- GA+M Intervention, RSM intervention, GA+RSM intervention
- Where
- 3 sites in Canada
- Volunteers
- 168 people
- Sponsor
- University Health Network, Toronto
Cicatrix
Efficacy and Safety of Intradermal RN1001 (Avotermin) in Elderly Subjects.
An exploratory Phase-II trial with intradermal RN1001 (Avotermin) to investigate scar prevention and reduction and acceleration of healing.
- Trial name
- NCT00847795
- Testing
- Avotermin
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Renovo
Tobacco Use Cessation
Improving Adherence to Smoking Cessation Medication Among PLWHA
Smoking rates among individuals living with HIV/AIDS range between 47% and 65%, a prevalence that is roughly three times the rate of the general population.
- Trial name
- HIV (NCT01898195)
- Testing
- Varenicline, Text Message, Adherence Behavioral Therapy
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- NYU Langone Health
Breast Cancer, Estrogen Receptor-positive Breast Cancer
Evaluation of Endocrine Therapy Effects of Host Immunity in Early Stage Breast Cancer
The purpose of this research study is to learn about the effects that standard of care endocrine therapies have on the immune system's response to cancer by looking at the number and types of immune cells present and how they…
- Conditions
- Breast Cancer, Estrogen Receptor-positive Breast Cancer, Healthy
- Trial name
- NCT03719495
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Duke University
Branch Retinal Vein Occlusion
Proof of Concept Study of Re-treatment in BRVO With Ranibizumab Guided by OCT
The aim of the trial is to evaluate the efficacy and safety of intravitreal injections of ranibizumab for the treatment of macular edema due to BRVO if the re-treatment regimen is guided by morphological macular changes detected…
- Trial name
- RabOCT (NCT01968239)
- Testing
- Ranibizumab
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University of Leipzig
Post COVID-19
Value of Montelukast as a Potential Treatment of Post COVID-19 Persistent Cough
As of September 2020, the COVID-19 pandemic has affected millions of people in 196 countries and left hundreds of thousands dead.
- Trial name
- NCT05447039
- Testing
- Montelukast Sodium Tablets
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
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