Clinical trials: Standard treatment
Corneal Diseases, Effectiveness of Microdrops
Efficacy of Nanodropper-mediated Topical Anesthetic
The goal of this clinical trial is to compare the onset and duration of numbness of the surface of the eye following the administration of numbing drops, called proparacaine, using either a standard eye drop bottle or a…
- Trial name
- NCT06636708
- Testing
- Nanodropper and Proparacaine HCl 0.5%, Standard Eye Drop Bottle with Proparacaine HCl 0.5%
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Columbia University
HPV-Related Oropharynx Squamous Cell Carcinoma
The Minimalist Trial-2
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer. Oropharynx SCC (OPSCC) is a common sub-type of HNSCC. Each year, 16,000 new cases of OPSCC are diagnosed in the USA.
- Trial name
- MINT-2 (NCT06702033)
- Testing
- Radiation therapy, Cisplatin, Surgery
- Where
- 3 sites in United States
- Volunteers
- 142 people
- Sponsor
- Washington University School of Medicine
Cigarette Smoking
Text Messaging for Smoking Cessation in College Health Clinics
This study is a randomized-controlled clinical trial which evaluates the efficacy of physician brief advice, nicotine replacement therapy and a 6-week course of text messaging in promoting cigarette smoking in smokers enrolled in…
- Trial name
- NCT02191033
- Testing
- Smoking counseling, Text messaging, Nicotine patch
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Gastric Cancer (GC), Sentinel Lymph Node Biopsy (SLNB)
Sentinel Lymph Node Detection in Gastric Cancer Using a Dual Tracer (Superparamagnetic Iron Oxide and Methylene Blue): A Prospective Study With Histological and OSNA Validation
Gastric cancer (GC) remains an oncological challenge, where lymph node involvement is a key prognostic factor. Sentinel lymph node (SLN) mapping may improve staging and reduce surgical morbidity.
- Trial name
- SLN_GC_SPIO (NCT07147452)
- Testing
- Dual tracer: The infiltration of the Supermagnetic Iron Oxide (SPIO) and Methylene Blue, OSNA AND H-E
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital del SAS de Jerez
Clinical Stage IV Cutaneous Melanoma AJCC v8, Melanoma of Unknown Primary
Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases
This phase I trial finds out the side effects and possible benefits of stereotactic radiosurgery and immune checkpoint inhibitors with NovoTTF-100M for the treating of melanoma that has spread to the brain (brain metastases).
- Conditions
- Clinical Stage IV Cutaneous Melanoma AJCC v8, Melanoma of Unknown Primary, Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma
- Trial name
- NCT05341349
- Testing
- Ipilimumab, Nivolumab, Pembrolizumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Emory University
Obesity
Engaging Men From Blue-collar Industries in Weight Loss
Objectives*: Primary Objective: Aim 1: Examine the acceptability of tailored behavioral weight loss program and a standard program in men working in blue-collar occupations.
- Trial name
- NCT05386238
- Testing
- Standard behavioral weight loss program, Tailored behavioral weight loss program
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Anxiety Disorders, Depressive Disorder
Islamic-Oriented vs. Standard Ericksonian Hypnotherapy for Anxiety and Depression
This randomized controlled trial (RCT) aims to compare the effectiveness of Islamic-Oriented Ericksonian Hypnotherapy (IEH) and Standard Ericksonian Hypnotherapy (SEH) in reducing symptoms of anxiety and depression.
- Trial name
- IEH-RTC (NCT06844058)
- Testing
- Islamic-Oriented Ericksonian Hypnotherapy (IEH), Standard Ericksonian Hypnotherapy (SEH)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Nisantasi University
Acute Myeloid Leukemia, Leukemia, Myeloid
Studying Malnutrition And Sarcopenia In Older Adults With Acute Myeloid Leukemia
This study will explore how malnutrition (poor nutrition/diet) and sarcopenia (a condition that causes a loss of muscle and bone mass) affects study participants over the age of 60 with acute myeloid leukemia (AML) who will…
- Trial name
- NCT05458258
- Testing
- Bioelectrical Impedence Analysis Device, 6 Minute Walk Test, Computed Tomography Scans to Measure Skeletal Muscular Index
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- University of Chicago
Vasoplegia Syndrome
Effects of Vitamin C on Shock Duration and Microcirculation in Patients With Vasoplegia Syndrome After Cardiac Surgery
This pilot study intends to observe the effect of intravenous vitamin C on the prognosis and sublingual microcirculation in patients with vasoplegia syndrome after cardiac surgery through a prospective randomized controlled study…
- Trial name
- NCT06723626
- Testing
- Vit C, Standard Preparation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Asthma
Comparison of Nebulizers in ED in Pediatric Asthma Patients
The primary objective will be, in an open-label randomized trial, a comparison of emergency department (ED) length of stay (LOS) between children experiencing acute asthma treated with two different nebulizers.
- Trial name
- NCT01951378
- Testing
- Hudson RCI® nebulizer, NebuTech® HDN® nebulizer, Albuterol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seton Healthcare Family
Obesity
Modifying Diet to Improve Gut Microbiome
The investigators will conduct a 2-arm randomized controlled pilot, feasibility feeding study in which 28 participants will be randomized to receive either a calorie-restricted Dietary Approaches to Stop Hypertension (DASH) diet…
- Trial name
- NCT03924778
- Testing
- DASH diet, standard American diet
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Breast Cancer
Three Doses of TAS-108 to Treat Recurrent or Recurrent Inoperable Breast Cancer
This study is being done to find out how safe TAS-108 is and how well TAS-108 works on recurrent or recurrent inoperable breast cancer.
- Trial name
- NCT00166543
- Testing
- TAS-108
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- SRI International
Cervical Spondylosis
Upper Trapezius Stretching in Patients With Cervical Spondylosis
This study aims to investigate the effectiveness of upper trapezius stretching exercises on pain intensity, neck range of motion, and disability in patients with cervical spondylosis.
- Trial name
- NCT05920564
- Testing
- Upper fibers of trapezius stretching, Standard care
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Ahram Canadian University
Dengue Fever With Warning Signs
Effectiveness Of High Dose Melatonin As Adjunctive Therapy For Dengue Fever With Warning Signs
Dengue Hemorrhagic Fever is a mosquito-borne viral disease endemic in the Philippines which caused multiple epidemics. Most points to the activation of the complement system secondary to humoral respond leading to cytokine…
- Trial name
- NCT05034809
- Testing
- Melatonin 20 MG
- Volunteers
- 140 people
- Sponsor
- Ilocos Training and Regional Medical Center
Anal Cancer
Shortening Radiation Course Duration Using Simultaneous Integrated Boost With Lower Intensity Elective Nodal Dosing and Concurrent Chemotherapy for High-Risk Anal Squamous Cell Carcinoma
This phase 2 single-arm study will evaluate whether a shortened course of mildly hypofractionated radiation therapy given with standard concurrent chemotherapy (mitomycin C and capecitabine) can provide acceptable tumor control…
- Trial name
- SSIBLING (NCT07775209)
- Testing
- Hypofractionated Radiation Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Vermont Medical Center
Ovarian Epithelial Carcinoma, Fallopian Tube Carcinoma
Standardized Extract of Cultured Lentinula Edodes Mycelia (AHCC®) in Ovarian Cancer Patients on Adjuvant Chemotherapy
This is a pilot phase, randomized, double-blinded feasibility pilot study of AHCC in participants with ovarian cancer.
- Conditions
- Ovarian Epithelial Carcinoma, Fallopian Tube Carcinoma, Peritoneal Carcinoma
- Trial name
- NCT05763199
- Testing
- AHCC, Chemotherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Breast Adenocarcinoma, DS Stage I Plasma Cell Myeloma
Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement
This randomized phase III trial studies two different schedules of zoledronic acid to compare how well they work in reducing bone-related complications in patients with breast cancer, prostate cancer, or multiple myeloma that has…
- Conditions
- Breast Adenocarcinoma, DS Stage I Plasma Cell Myeloma, DS Stage II Plasma Cell Myeloma, Metastatic Malignant Neoplasm to the Bone
- Trial name
- NCT00869206
- Testing
- zoledronic acid
- Where
- 504 sites in United States, Puerto Rico
- Volunteers
- 1,822 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Subarachnoid Hemorrhage, Stroke
Clinical, Pharmacological and Molecular Effects of IV and Oral Acetaminophen in Adults With aSAH
This study compares the bioavailability of IV and PO acetaminophen in both blood and the cerebrospinal fluid (CSF) of patients following subarachnoid hemorrhage.
- Trial name
- aSAH (NCT02549716)
- Testing
- IV acetaminophen, Oral acetaminophen
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
Facial Photo Damage, Periocular Fine Wrinkles
A Trial of Skin Care Protocols for Facial Resurfacing
The aims of the Skin Product Assessment Research study were to (1) develop an infrastructure and process for industry-sponsored, Plastic Surgery Educational Foundation (PSEF) research in facial aesthetic surgery and (2) test the…
- Conditions
- Facial Photo Damage, Periocular Fine Wrinkles, Perioral Fine Wrinkles
- Trial name
- SPAR (NCT01113606)
- Testing
- Obagi New-Derm System, Standard of Care
- Where
- 9 sites in United States
- Sponsor
- The Plastic Surgery Foundation
Core Binding Factor Acute Myeloid Leukemia
Combination of Sorafenib With Standard Therapy in Newly Diagnosed Adult CBF AML
Core-binding factor acute myeloid leukemia accounts for 10-15% of AML and is categorized as favorable-risk AML. However, the 5-year CIR was up to 40% in this group of patients.
- Trial name
- NCT05404516
- Testing
- Sorafenib, Idarubicin, Cytarabine
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Nanfang Hospital, Southern Medical University
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