Clinical trials: Standard treatment
Refractory Ascites in Children With Cirrhosis
Efficacy and Safety of Midodrine in Refractory or Recurrent Ascites in Children With Cirrhosis.
Refractory ascites is seen in 17% of cirrhotic patients with the 1year mortality rate being high, upto 20-50% [1]. The pathogenesis of cirrhotic ascites includes release of vasodilatory molecules like nitric oxide, damage…
- Trial name
- NCT05084534
- Testing
- Midodrine, Standard medical treatment
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
COVID-19
Ivermectin for Severe COVID-19 Management
In this multicenter study; it was aimed to investigate the effectiveness and safety of ivermectin use in the treatment of patients with severe COVID-19 pneumonia that have no mutations which alter ivermectin metabolism and cause…
- Trial name
- NCT04646109
- Testing
- Ivermectin
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Diabetes (DM), Dry Mouth
Effects of Chewing Gum for Dry Mouth in Diabetes
Dry mouth can seriously affect the quality of life of individuals because it affects chewing and swallowing functions. One of the diseases in which dry mouth occurs as a side effect of many diseases and/or treatments is diabetes…
- Trial name
- NCT07084532
- Testing
- Chewing gum, Standart therapy group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Çankırı Karatekin University
Periodontal Disease, Stroke
PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke
The PREMIERS study is a proposal for conducting an adequately powered two center phase III randomized controlled trial to test whether intensive periodontal treatment reduces the risk of recurrent vascular events among ischemic…
- Conditions
- Periodontal Disease, Stroke, TIA
- Trial name
- PREMIERS (NCT02541032)
- Testing
- Intensive dental treatment, Standard dental treatment, Arestin
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of South Carolina
Breast Cancer, Triple Negative Breast Cancer
Study of Antivascular Therapy Combined With Chemotherapy Versus Chemotherapy in Adjuvant Therapy of TNBC-BLIS Patients (BCTOP-T-A03)
This is a randomized, open-label phase III clinical trial comparing antivascular therapy combined with standard chemotherapy and standard chemotherapy in adjuvant therapy for patients with triple-negative breast cancer…
- Trial name
- NCT05909332
- Testing
- Antivascular therapy, Chemotherapy
- Where
- 15 sites in China
- Volunteers
- 764 people
- Sponsor
- Fudan University
Platelet Reactivity
Ticagrelor and Clopidogrel on Platelet Aggregation in Clopidogrel Resistance's Patients With CHD
The study sought to observe the effects of optimal dose of ticagrelor（90 mg qd）ticagrelor and double standard-dose clopidogrel on platelet reactivity in coronary heart disease patients with high on-treatment platelet reactivity…
- Trial name
- NCT03614832
- Testing
- Ticagrelor 90 mg, Clopidogrel 150 mg
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Telerehabilitation, COPD
Long-term Home-based Exercise for Patients With COPD: the COPDtoParis Project
This randomised controlled trial (RCT) aims to investigate the effect of long-term, interactive home-based cycle-exercise on patients with Chronic Obstructive Pulmonary Disease (COPD) after a COPD exacerbation requiring…
- Conditions
- Telerehabilitation, COPD, Quality of Life, Mobility Limitation
- Trial name
- COPDtoParis (NCT06235502)
- Testing
- Home-based cycle-exercise for COPD patients, Standard of Care
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aalborg University Hospital
Dry Eye Syndrome
SYSTANE® Family - Meibomian Deficiency
The purpose of this study was to assess the efficacy of the SYSTANE® family of products (SYSTANE® Lid Wipes, SYSTANE® BALANCE Lubricant Eye Drops, and SYSTANE® Vitamins) on meibomian gland functionality in subjects with lipid…
- Trial name
- M-12-077 (NCT01733745)
- Testing
- SYSTANE® Lid Wipes, SYSTANE® BALANCE, SYSTANE® Vitamins
- Volunteers
- 26 people
- Sponsor
- Alcon Research
Inflammatory Bowel Disease
Study to Evaluate the Testicular Safety of Filgotinib in Adult Males With Moderately to Severely Active Inflammatory Bowel Disease
The primary objective of this study is to evaluate the testicular safety of filgotinib in adult males with moderately to severely active inflammatory bowel disease (IBD).
- Trial name
- MANTA (NCT03201445)
- Testing
- Filgotinib, Standard of Care
- Where
- 56 sites in United States, Australia and 9 more
- Volunteers
- 139 people
- Sponsor
- Lakefront Biotherapeutics NV
Obesity, Morbid
Clinical Efficacy of a Virtual Reality Tool for the Treatment of Obesity
The objective of the study, which is framed within European Union's H2020 project titled SOCRATES, is to assess the clinical efficacy of a Virtual Reality (VR) embodiment tool for treating obesity and to compare it to usual care…
- Trial name
- SOCRATES (NCT05094557)
- Testing
- Experimental Group 1: Body swapping VR intervention + psychoeducational video + Treatment As usual, Experimental Group 2: VR intervention without body swapping + psychoeducational video + Treatment As usual, Control Group: Psychoeducational video + Treatment As usual
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Heart Failure, Vitamin D Deficiency
Effects of Cholecalciferol Supplementation in Patients With Chronic Heart Failure and LOw vITamind D Levels
The purpose of this study is to determine whether cholecalciferol supplementation in patients with chronic heart failure and low vitamin D levels improves: 1. performance at six minutes walking test 2.
- Trial name
- ECSPLOIT -D (NCT01477801)
- Testing
- CHOLECALCIFEROL
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Azienda Unita' Sanitaria Locale Di Modena
Addiction Opiate, Chronic Pain
Suboxone User Perioperative Early Referral and Enhanced Recovery After Surgery- Orthopaedic Trauma Surgery Population
This is a randomized controlled trial. Patients will be randomly assigned to either the control or treatment group, with equal allocation using block randomization.
- Conditions
- Addiction Opiate, Chronic Pain, Fractures, Bone, Buprenorphine Dependence
- Trial name
- SUPER-ERAS (NCT04464512)
- Testing
- Sufentanil
- Where
- United States
- Sponsor
- West Virginia University
Acute Lymphoblastic Leukemia,B-Cell, Non-hodgkin Lymphoma,B Cell
CD19-BAFF CAR-T Cells Therapy for Patients With Relapsed / Refractory B-cell ALL and B-cell NHL
Clinical Trial for the safety and efficacy of CD19-BAFF CAR-T cells therapy for refractory/relapsed B-cell acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma.
- Trial name
- NCT06346912
- Testing
- CD19-BAFF Targeted CAR T-cells
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang University
Pressure Ulcer, Foot Ulcer, Diabetic
Use of Santyl Within an Accountable Care Organization
This study is designed to assess the comparative effectiveness of SANTYL® versus standard of care in the treatment of pressure ulcers and diabetic foot ulcers within the continuum of care of an ACO.
- Trial name
- NCT02716519
- Testing
- Santyl, Standard Care
- Where
- United States
- Sponsor
- Smith & Nephew, Inc.
Stress, Depression
Mission Reconnect: Promoting Resilience and Reintegration of Post-Deployment Veterans and Their Families
An urgent and growing need exists for interventions that support the long-term adjustment and mental health needs of OIF/OEF veterans and their relationship partners after the return from deployment.
- Conditions
- Stress, Depression, PTSD, Sleep
- Trial name
- NCT01680419
- Testing
- Mission Reconnect, PREP
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Collinge and Associates, Inc.
Pleural Infection, Pleural Infections
Role of Medical Thoracoscopy in Pleural Infection (PROMPT Trial)
The PROMPT study is testing whether an early keyhole procedure called Medical Thoracoscopy, which lets doctors look inside the chest and remove infected fluid, works better than current standard treatment (medicines to break up…
- Conditions
- Pleural Infection, Pleural Infections, Pleural Infections and Inflammations
- Trial name
- PROMPT (NCT07550530)
- Testing
- medical thoracoscopy, Standard of Care
- Volunteers
- 170 people
- Sponsor
- Università Politecnica delle Marche
Acute Pain
Open Label Placebo to Reduce Prescription Opioid Use
The goal of the proposed study is to examine the efficacy of using an honest placebo to relieve pain for patients with an acute pain condition.
- Trial name
- NCT05014230
- Testing
- Opioid medication as part of standard care
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Brown University
Peri-Implantitis
Laser-Assisted Regenerative Surgical Therapy for Peri-implantitis
The purpose of the study is to evaluate if using Erbium-doped yttrium aluminium garnet laser, Erbium YAG laser (Er:YAG) laser could have adjunctive benefits to the conventional standard mechanical debridement to ablate the…
- Trial name
- NCT03127228
- Testing
- Standard mechanical debridement, Er:YAG laser-assisted debridement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sleep Apnea, Obstructive, Anovulation
Using CPAP to Improve Menstruation in Women With Polycystic Ovarian Syndrome and Obstructive Sleep Apnea
The purpose of this study is to determine if treatment of obstructive sleep apnea (OSA) with continuous positive airway pressure in women with both OSA and polycystic ovarian syndrome will improve the regularity of the women's…
- Conditions
- Sleep Apnea, Obstructive, Anovulation, Polycystic Ovarian Syndrome
- Trial name
- NCT03155828
- Testing
- CPAP
- Where
- United States
- Sponsor
- University of Louisville
Systemic Lupus Erythematosus
ELEVATE - (Empower Lupus Erythematosus Patients Via Allowing RemoTe Evaluation)
To explore the potential for use of DxTerity's AIP IFN-1 test as personalized guided care and monitoring module in patients with Systemic lupus erythematosus(SLE) using consented patient health information
- Trial name
- ELEVATE (NCT05347992)
- Where
- United States
- Volunteers
- 423 people
- Sponsor
- DxTerity Diagnostics
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