Clinical trials: Standard treatment
Cancer
Determination of Amifostine Levels During Radiation Therapy
Currently, there are no published methods for easily determining the level of amifostine in the blood or saliva. A method has been developed within the Department of Radiation Oncology by Drs.
- Trial name
- NCT00286611
- Testing
- Blood and salivary sampling of amifostine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Iowa
Hypoxic Ischaemic Encephalopathy
Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth
This study examines the effect of inhaled xenon gas in the treatment of newborn infants with hypoxic-ischemic encephalopathy (HIE) in combination with cooling, which is the standard treatment for this condition.
- Trial name
- CoolXenon2 (NCT01545271)
- Testing
- xenon gas, Whole body cooling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University Hospitals Bristol and Weston NHS Foundation Trust
NonST Elevation Myocardial Infarction, Myocardial Infarction
Fractional Flow Reserve Versus Angiographically Guided Management to Optimise Outcomes in Unstable Coronary Syndromes
Background: In patients with acute non-ST elevation myocardial infarction (NSTEMI) coronary arteriography is usually recommended however visual interpretation of the coronary angiogram is subjective.
- Trial name
- FAMOUS NSTEMI (NCT01764334)
- Testing
- Fractional flow reserve
- Where
- 6 sites in United Kingdom
- Volunteers
- 350 people
- Sponsor
- NHS National Waiting Times Centre Board
Tobacco Smoking
Development of a Tailored Smoking Cessation Program for Individuals With HIV Infection in Washington, D.C.
Morbidity and mortality from smoking-related diseases among people living with HIV (PLWH) in the U.S. surpasses that due to HIV itself. Conventional smoking cessation treatments have not demonstrated strong efficacy among PLWH.
- Trial name
- NCT04594109
- Testing
- Tailored behavioral counseling, Standard of Care
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Colorado State University
HNSCC
Adebrelimab Combined With Dalpiciclib Isethionate Plus Chemotherapy for Neoadjuvant Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma
This single-center, open-label Phase II trial aims to evaluate the efficacy and safety of neoadjuvant combination therapy with Adebrelimab (anti-PD-L1), Dalpiciclib Isethionate (CDK4/6 inhibitor), and cisplatin chemotherapy in…
- Trial name
- NCT07778732
- Testing
- Adebrelimab Injection, Dalpiciclib Isethionate, Cisplatin
- Volunteers
- 32 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Hearing Impairment
Use of Electropalatography to Improve Speech Sound Production
The purpose of this proposed study is to examine the benefits of using electropalatography (EPG) during speech therapy with adult individuals who are either congenitally deaf or adventitiously deaf and use a cochlear implant.
- Trial name
- NCT04055987
- Testing
- Visual biofeedback, auditory feedback and models
- Sponsor
- Molloy College
Hemodialysis
Patient-Centered Physical Activity Program for Hemodialysis Patients
Individuals undergoing HD generally have very low physical activity levels, which consequently contributes to elevated levels of perceptions of fatigue, poor physical function, and a decline in overall quality of life, all of…
- Trial name
- NCT07080593
- Testing
- Novel Physical Activity Program, Standard of Care Physical Activity Program
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Illinois at Urbana-Champaign
Venous Ulcers
Safety and Efficacy of Gaseous Nitric Oxide on Venous Stasis Leg Ulcers
The purpose of this study is to determine whether nitric oxide (NO)gas is effective in the treatment of venous ulcers of the lower leg.
- Trial name
- NCT00613808
- Testing
- Nitric Oxide 200ppm Group B
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Nitric BioTherapeutics, Inc
Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma
Meloxicam vs Placebo for Mobilization
This research study is evaluating a drug called meloxicam to see if it provides a benefit to people receiving Autologous Hematopoietic Stem Cell Transplantation (AHSCT).
- Conditions
- Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma, Multiple Myeloma, Hematopoietic Stem Cells
- Trial name
- NCT02003625
- Testing
- GCSF, meloxicam
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
Non Small Cell Lung Cancer
MK-0646 Insulin Growth Factor 1 Receptor Antibody in Stage IIIb or IV Metastatic Non-Squamous Lung Cancer
This study will compare the rate of chemotherapy: pemetrexed and cisplatin compared with the combination of pemetrexed/cisplatin with MK-0646.
- Trial name
- IMPACT (NCT00799240)
- Testing
- Arm A: Pemetrexed Cisplatin, Arm B Pemetrexed, Cisplatin and MK-0646
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Kansas
Bariatric Surgery, Postoperative Nausea and Vomiting
Low-Volume Oral Carbohydrate Feeding in Bariatric Surgery: Effects on PONV and Recovery
This randomized controlled trial aims to evaluate the effects of preoperative oral administration of 200 ml 12.5% carbohydrate solution on postoperative nausea, vomiting, and recovery in bariatric surgery patients.
- Trial name
- NCT07018440
- Testing
- Low-Volume Oral Carbohydrate Loading (200 mL of 12.5% solution)
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Marmara University
Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation
REPRESENT-PF Registry
This pragmatic, prospective, single-arm, multi-center, observational registry will evaluate the safety and effectiveness of PFA for the treatment of atrial fibrillation in underrepresented minority patients using FDA approved…
- Trial name
- REPRESENT-PF (NCT07535268)
- Testing
- FARAWAVE Pulsed Field Ablation Catheter
- Where
- 2 sites in United States
- Volunteers
- 275 people
- Sponsor
- Vivek Reddy
Hypoparathyroidism, Endocrine System Diseases
A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH in Adults With Hypoparathyroidism
During the first four weeks of the trial, participants were randomly assigned to one of four groups: three groups received fixed doses of TransCon PTH and one group received placebo.
- Conditions
- Hypoparathyroidism, Endocrine System Diseases, Parathyroid Diseases
- Trial name
- PaTH Forward (NCT04009291)
- Testing
- TransCon PTH
- Where
- 15 sites in United States, Canada and 4 more
- Volunteers
- 59 people
- Sponsor
- Ascendis Pharma A/S
Deep Brain Stimulation
Evaluation of Advanced Imaging and Visualization for Clinical Deep Brain Stimulation
The objective of this project is to evaluate next generation visualization tools and surgical targeting models for clinical deep brain stimulation (DBS).
- Trial name
- NCT06191874
- Testing
- Standard-of-care (SOC) surgery plan, HoloDBS hypothetical surgery plan
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Pediatric Cancer, Quality of Life
Enabling Symptom Identification and Tracking in Children Receiving Cancer Treatment
Children with cancer and hematopoietic stem cell transplant (HSCT) recipients suffer from severe and bothersome symptoms because treatments are intense.
- Conditions
- Pediatric Cancer, Quality of Life, Symptom Screening
- Trial name
- NCT03495518
- Testing
- Symptom feedback to Health Care Provider, Standard of care
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Anemia
Efficacy and Safety of Spironolactone in Pediatric Hemodialysis Patients With Anemia.
The goal of this clinical trial is to learn if Spironolactone drug works to treat anemia in hemodialysis pediatric patients. It will also learn about the safety of Spironolactone drug.
- Trial name
- NCT07715318
- Testing
- Spironolactone (drug), Iron Supplement, Erythropoietin stimulating agent
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Opioid Dependence Fentanyl
Buprenorphine Induction for Fentanyl Dependent Opioid Users
The overall goal of this pilot study is to characterize illicit fentanyl and combination fentanyl and opioid dependence explicitly, by assessing physiologic barriers to effective buprenorphine induction.
- Trial name
- NCT04794790
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Lung Cancer, Nonsmall Cell, Quality of Life
Use of the ADL-Glittre Test in the Pre and Postoperative Period of Patients With Lung Cancer
Lung cancer is the most common type of cancer and the leading cause of cancer death worldwide, in both men and women. Improvements in earlier preoperative staging and more effective adjuvant treatment have improved survival in…
- Conditions
- Lung Cancer, Nonsmall Cell, Quality of Life, Physical Disability, Surgery
- Trial name
- NCT05863013
- Testing
- ADL-Glittre Test
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Centro Universitário Augusto Motta
Congenital Heart Disease
Inhaled NO as an Anti-inflammatory and Anti-reperfusion Agent in Infants and Children Undergoing Cardiopulmonary Bypass
Each year, there are over 400,000 cardiac surgical operations performed in the United States; of which 10,000 are performed on children.
- Trial name
- NCT00585013
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Washington University School of Medicine
Ulcerative Colitis
Vedolizumab Monotherapy Vs Combination Therapy With Tacrolimus in UC
The aim of this study is to assess if a combination therapy of tacrolimus and vedolizumab is superior to vedolizumab monotherapy for induction of remission in moderate to severe UC, and its effect on long and short-term outcomes…
- Trial name
- COVET (NCT02954159)
- Testing
- Tacrolimus, Vedolizumab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medical College of Wisconsin
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