Clinical trials: Standard treatment
Acute Ischemic Stroke
Feasibility Study of RapidPulseTM Aspiration System as Frontline Approach for Stroke Patients
A Feasibility Study to evaluate the initial safety and performance of the RapidPulseTM Aspiration System in the treatment of patients with Acute Ischemic Stroke (AIS) due to Large Vessel Occlusion (LVO).
- Trial name
- RapidPulseFS (NCT05122637)
- Testing
- RapidPulseTM Aspiration System, Standard of Care Aspiration Thrombectomy System
- Where
- 5 sites in Brazil, Denmark and 3 more
- Volunteers
- 80 people
- Sponsor
- RapidPulse, Inc
Low Back Pain
A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy
This is a multi-site feasibility trial of an embedded emergency department (ED) physical therapy care model for low back pain at two EDs in the Northwestern Medicine and University of Utah Health systems.
- Trial name
- FEED-PT (NCT07224945)
- Testing
- Embedded Emergency Department Physical Therapy, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Northwestern University
Cytomegalovirus Infection
Alternate Donor Study of Pre-Emptive Cellular Therapy
The purpose of this study is to evaluate the potential clinical benefit of pre-emptive cytomegalovirus (CMV)-specific adoptive cellular therapy following T cell depleted allogeneic hematopoietic stem cell transplantation (HSCT)…
- Trial name
- CMV-ACE/ASPECT (NCT01220895)
- Testing
- CMV-specific T-cells, single infusion following single positive CMV PCR result
- Where
- 9 sites in United Kingdom
- Volunteers
- 52 people
- Sponsor
- Cell Medica Ltd
Human Immunodeficiency Virus
Cooperative Re-Engagement Controlled Trial (CoRECT)
CoRECT will help identify the important components of a data-sharing partnership between health departments and HIV care providers, and determine the extent to which a health department intervention can increase the number of…
- Trial name
- CoRECT (NCT02693145)
- Testing
- Anti-Retroviral Treatment and Access to Services (ARTAS)
- Where
- 3 sites in United States
- Volunteers
- 1,893 people
- Sponsor
- Centers for Disease Control and Prevention
Posterior Vitreous Detachment, Vitreomacular Traction
Vitreopapillary Interface and Optic Disc Morphology
The vitreous fills the posterior chamber of the eye and is firmly attached, at the posterior pole, to the macula and the optic nerve head (ONH).
- Conditions
- Posterior Vitreous Detachment, Vitreomacular Traction, Glaucoma, Vitreopapillary Traction
- Trial name
- NCT02290795
- Testing
- OCT imaging/HRT imaging
- Where
- Belgium
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Health-Related Behavior
Effectiveness of a mHealth App for Supporting the First 1000 Days of Life
Recent development in information and communication technologies has enabled the disruptive expansion of electronic health (eHealth) and mobile health (mHealth).
- Trial name
- CARE1000 (NCT05500339)
- Testing
- M-health App, Standard care
- Where
- Italy
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- IRCCS Burlo Garofolo
Breast Cancer
Long Term Results of the Canadian Breast IMRT Study
Women diagnosed with an early stage cancer of the breast usually have the cancer removed by lumpectomy and then have radiation treatments to the entire breast.
- Trial name
- IMRT-FU (NCT01803139)
- Testing
- Adjuvant breast radiotherapy
- Where
- 2 sites in Canada
- Volunteers
- 358 people
- Sponsor
- Sunnybrook Health Sciences Centre
Conduct Disorder, ADHD
Investigation of Psychophysiological Response to Aversive Stimuli Over Time With Omega-3
This study investigates the psychophysiological responses to aversive stimuli in a population of 133 children clinically diagnosed with conduct disorder (CD) and/or attention-deficit/hyperactivity disorder (ADHD).
- Conditions
- Conduct Disorder, ADHD, Oppositional Defiant Disorder
- Trial name
- NCT03749824
- Testing
- Omega-3
- Volunteers
- 133 people
- Sponsor
- Yale-NUS College
Emotional Distress
Mindfulness Interventions and Emotional Distress: A Daily Study
This study hopes to explore whether the changes in rumination exhibited in Daily Diary mediates the effects of mindfulness intervention on alleviating emotional distress
- Trial name
- NCT06785259
- Testing
- Mindfulness Intervention for Emotional Distress(MIED)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University
Obstructive Sleep Apnea, Snoring
Childhood Adenotonsillectomy Study for Children With OSAS
The purpose of this research is to determine the effect of adenotonsillectomy surgery (removal of tonsils and adenoids) on obstructive sleep apnea syndrome (OSAS) in children.
- Trial name
- CHAT (NCT00560859)
- Testing
- Adenotonsillectomy (AT) - removal of adenoids and tonsils, Watchful Waiting
- Where
- 6 sites in United States
- Volunteers
- 453 people
- Sponsor
- University of Pennsylvania
Lung Resection Surgery, Anesthesia General
Effect of Oxygen Administration in the Non-dependent Lung on Postoperative Complications After Lung Surgery
The purpose of this study is to analyze the effectiveness of apneic oxygenation and CPAP applied to the non-dependent lung during pulmonary resection surgery in reducing inflammatory response, ischemia-reperfusion injury, and…
- Trial name
- NCT07461779
- Testing
- Medicinal gas - oxygen (Nippon Gases 200 bar), CPAP, Oxygen therapy according to standard clinical practice
- Where
- Spain
- Volunteers
- 177 people
- Sponsor
- Francisco Andres de la Gala
Osteo Arthritis Knee
Comprehensive Geriatric Assessment in Knee Osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis, and is characterized by joint pain and stiffness leading to functional decline and relevant loss in quality of life.
- Trial name
- NCT05659979
- Testing
- Comprehensive geriatric assessment
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Acute Myeloid Leukemia (AML), Acute Myelocytic Leukemia
Lenalidomide in Combination With Microtransplantation as Post-remission Therapy in AML
This research study is evaluating the safety and tolerability of the drug lenalidomide in combination with and following mismatched related donor microtransplantation in high risk AML patients in first remission.
- Conditions
- Acute Myeloid Leukemia (AML), Acute Myelocytic Leukemia, Acute Myelogenous Leukemia, Acute Granulocytic Leukemia
- Trial name
- NCT02255162
- Testing
- Lenalidomide, HLA-mismatched stem-cell Microtransplantation, Cytarabine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Non-small Cell Lung Cancer (NSCLC)
Assess the Efficacy, Safety and Tolerability of Gefitinib (Iressa® 250mg) as Maintenance Therapy in Locally Advanced or Metastatic (Stage IIIB/IV) Non Small Cell Lung Cancer (NSCLC)
This is a double blind, multicentre, randomized, placebo-controlled study. The eligible patients will be randomized to receive gefitinib or placebo at 1:1 ratio.
- Trial name
- INFORM (NCT00770588)
- Testing
- Gefitinib
- Where
- 14 sites in China
- Volunteers
- 296 people
- Sponsor
- AstraZeneca
Root Canal Infection, Periapical Abscess
Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.
The basic aim of root canal treatment is to reduce the microbial content and prevent further recontamination in the canal. Every tooth has a variable, complex canal anatomy consisting of ramifications, accessory and lateral…
- Conditions
- Root Canal Infection, Periapical Abscess, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT05778227
- Testing
- Ethylene Diamine Tetra Acetic acid, smearOFF, Etidronic acid /sodium hypochlorite
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Indication for Lumbar Puncture
The Effectiveness of a Pediatric Lumbar Puncture Restraint Device
This is a pilot study to evaluate a restraint device for lumbar punctures. Designed to help improve the restraint techniques for lumbar puncture, the restraint device will be compared to the current standard of manual physical…
- Trial name
- SNOWBOARD (NCT00980070)
- Testing
- Pediatric Restraint for Lumbar Puncture, Lumbar Puncture Device, Standard of Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nebraska
Aspergillosis Invasive, Fungal Infection
CYP2C19 Genotype-Specific Dosing Plus TDM on Reaching Therapeutic Voriconazole Blood Levels
Invasive aspergillosis is a fungal infection which left untreated, is a significant cause of morbidity and mortality. Immunocompromised patient populations such as solid organ transplant and malignant hematology patients are…
- Trial name
- NCT03731169
- Testing
- Voriconazole genotype-specific dosing, Standard of Care
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer
Abi/Pred + ADT vs ADT in PSMA-Positive, Conventionally Node-Negative Prostate Cancer
The advent of PSMA-PET has improved sensitivity and specificity in staging prostate cancer, particularly in intermediate- and high-risk disease.
- Trial name
- NCT07237269
- Testing
- Androgen Deprivation Therapy (ADT), Abiraterone, Prednisone
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Nebraska
Acute Myeloid Leukemia
Study to Assess Length of Remission With Intensive Chemotherapy in Rapidly Responding AML Patients.
We previously reported results of a prospective observational study demonstrating that early response defined as reduction in bone marrow (BM) blast counts to less than 5% of BM cells by the fifth day of induction therapy is a…
- Trial name
- AML (NCT03902769)
- Testing
- Prescribing conventional chemotherapy while with holding allo-SCT
- Volunteers
- 160 people
- Sponsor
- Rambam Health Care Campus
Diabetes Mellitus
Oral Anti Diabetic Agents in the Hospital
This randomized controlled clinical trial will assess whether continuation of home oral antidiabetic agents during hospitalization can be used as a safe and effective alternative to insulin therapy in the management of diabetes…
- Trial name
- NCT04416269
- Testing
- Oral Anti-diabetes Drugs alone, Basal bolus insulin, Supplemental insulin
- Where
- 3 sites in United States
- Volunteers
- 85 people
- Sponsor
- Emory University
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