Clinical trials: Standard treatment
Kidney Transplant
Tacrolimus and Risk Factors for Glucose Metabolism Disorders in Kidney Transplant Patients
Many people who receive a kidney transplant develop problems with how their body processes sugar (glucose). This includes conditions like prediabetes and diabetes, which can lead to more health issues, such as heart problems and…
- Trial name
- TARGET (NCT06833463)
- Testing
- LCP Tacro (tacrolimus)
- Where
- 6 sites in Poland
- Volunteers
- 120 people
- Sponsor
- Chiesi Poland Sp. z o.o.
Smoking Cessation, Weight Loss
Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain
The purpose of this research study is to better understand (1) why people gain weight when they quit smoking and (2) whether certain types of smoking cessation (i.e.
- Trial name
- NCT02906787
- Testing
- BAS+, SC
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Gastrointestinal Diseases
Utility of Pharmacogenomic Testing in Patients With Gastrointestinal Disorders
Researchers are trying to learn more about how individuals break down and process specific medications based on their genes. Pharmacogenomics (PGx) is a new, specialized field within individualized medicine.
- Trial name
- NCT05572593
- Testing
- Pharmacogenomics (PGx) genetic testing
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Mayo Clinic
Parkinson's Disease (PD)
A Study to Evaluate the Efficacy and Safety of ENERGI-F705 Tablets for Parkinson's Disease
The goal of this clinical trial is to learn if this study drug, ENERGI-F705 Tablets, is safe and works to treat participants who have Parkinson's disease and are currently on standard-of-care antiparkinsonian medications.
- Trial name
- NCT07647614
- Testing
- 60 milligrams of ENERGI-F705 Tablets, 120 milligrams of ENERGI-F705 Tablets
- Where
- 2 sites in Taiwan
- Volunteers
- 105 people
- Sponsor
- Energenesis Biomedical Co., Ltd.
Stroke, Parkinson's Disease
Inpatient Physical Activity Function Through Enhanced Participation Levels in Animal-Assisted Therapy Programs
Thousands of canines are used for therapy in health care centers throughout the United States as part of a volunteer therapy team, yet little is known about the outcomes provided by these teams.
- Conditions
- Stroke, Parkinson's Disease, Muscle Weakness
- Trial name
- NCT02606006
- Testing
- Canine Animal-Assisted Therapy, Standard of Care Physical Therapy
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Diurnal Enuresis
Urotherapy vs. Urotherapy With Constipation Treatment for Children With Lower Urinary Tract Dysfunction
Constipation treatment has been found to ameliorate symptoms in some patients with lower urinary tract dysfunction (including day time or combined day time/night time urinary incontinence).
- Trial name
- NCT02336906
- Testing
- polyethylene glycol 3350, Constipation behavioral therapy, Urotherapy
- Where
- Israel
- Sponsor
- Rabin Medical Center
Heart Disease, Coronary, Chest Pain
The Computed Tomography-derived Fractional Flow Reserve STAT Trial
This study is designed to directly compare Standard Care and CT fractional flow reserve (CTFFR) for diagnosis of chest pain patients with definite coronary artery disease (CAD) on heart computed tomography (CT) scans.
- Conditions
- Heart Disease, Coronary, Chest Pain, Acute Coronary Syndrome
- Trial name
- CTFFR-STAT (NCT03263806)
- Testing
- CTFFR-Guided Group Management, SOC Group Management
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Corewell Health East
Acute Kidney Injury, Congenital Heart Disease
Nitric Oxide During Cardiopulmonary Bypass in Neonates to Reduce Risk of Acute Kidney Injury
Acute kidney injury following cardiac surgery for congenital heart defects in children is a major cause of both short- and long-term morbidity and mortality, affecting up to 60% of high risk patients.
- Trial name
- NCT04259684
- Testing
- gases Nitric Oxide (gNO)
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Prostate Cancer, Node; Prostate
Pelvic Nodes Ultra-Hypo vs Conventionally Fractionated IMRT With HDR Boost in Prostate Cancer.
Randomized Phase III study, comparing pelvic ultra-hypo fractionated radiotherapy (UHF: 5Gy/fraction) to a standard or moderate hypo-fractionation (1.8-2.15Gy/fraction), both associated to an HDR prostate +/- adjacent seminal…
- Conditions
- Prostate Cancer, Node; Prostate, Radiotherapy Side Effect
- Trial name
- PCS-XI (NCT05820633)
- Testing
- Report and compare changes in a non-inferiority analysis of the International Prostate Symptom Score (I-PSS), Report and compare changes in a non-inferiority analysis of the expanded prostate cancer index composite" (EPIC-26):, Report and compare changes in a non-inferiority analysis of the Sexual Health Inventory for Men (SHIM)
- Where
- 11 sites in Canada
- Volunteers
- 500 people
- Sponsor
- CHU de Quebec-Universite Laval
Taste Disorders, Breast Cancer
Incidence of Dysgeusia in Breast Cancer Patients Undergoing Chemotherapy
The goal of this observational study is to examine how frequently changes in taste occur in people with early-stage breast cancer who receive chemotherapy.
- Conditions
- Taste Disorders, Breast Cancer, Quality of Life, Taste Perception
- Trial name
- GustiAmo (NCT07317752)
- Testing
- Taste Assessment / Nutritional Assessment / Quality of Life Assessment
- Volunteers
- 40 people
- Sponsor
- Azienda Sanitaria Locale CN2 Alba-Bra
Bone Metastases
A Phase III Randomized Trial Comparing Stereotactic Body Radiation Therapy (SBRT) vs Conventional Palliative Radiation Therapy for Painful Bone Metastases
To compare increasing doses and different treatment schedules of stereotactic body radiation therapy (SBRT) against standard treatment scheduling.
- Trial name
- NCT06065449
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Non Small Cell Lung Cancer, Stage III Non-small-cell Lung Cancer
Real-world Treatment Patterns and Clinical Outcomes in EGFR-mutant Unresectable Locally Advanced NSCLC
The investigators will obtain a cohort of patients from multiple large cancer centers in China and try to unravel the efficacy of "radiotherapy combined with EGFR-TKI", which may provide some evidences for the treatment of stage…
- Conditions
- Non Small Cell Lung Cancer, Stage III Non-small-cell Lung Cancer, EGFR Mutation-Related Tumors
- Trial name
- NCT04304638
- Testing
- radiation or chemo-radiation, EGFR-TKI Inhibitor
- Volunteers
- 450 people
- Sponsor
- Chinese Academy of Medical Sciences
Edentulous Alveolar Ridge Atrophy
Immediate Implants With Customized Abutments
Tooth extraction is followed by marked alterations of the tissue volume. The resorption process of at least the surrounding mucosa can be altered by using immediate implant placement and additional features such as immediate…
- Trial name
- NCT05638958
- Testing
- Immediate post-extractive Implant placement
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Geneva
Uncontrolled Hypertension
Reducing Inequities in Care of Hypertension, Lifestyle Improvement for Everyone (RICH LIFE Project)
The RICH LIFE Project is a two-armed, cluster-randomized trial, comparing the effectiveness of an enhanced standard of care arm, "Standard of Care Plus" (SCP), to a multi-level intervention, "Collaborative Care/Stepped Care"…
- Trial name
- RICH LIFE (NCT02674464)
- Testing
- Provider Audit-Feedback, Stratified by Race and Ethnicity, Blood Pressure Measurement Standardization, System Level Leadership Intervention
- Where
- United States
- Volunteers
- 1,820 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Traumatic Brain Injury, Cerebral Hemorrhage
Effect of Median Nerve Electrical Stimulation Combined With Auricular Acupuncture on Consciousness Disturbance in Patients With Craniocerebral Injury
This study aims to evaluate the effects of auricular press needle therapy, combined with conventional treatment and median nerve electrical stimulation, on promoting arousal and neurological recovery in patients with disorders of…
- Trial name
- ANECT-CCI (NCT07273864)
- Testing
- Conventional Neurosurgical and Supportive Care, Right Median Nerve Electrical Stimulation, Auricular Press-Needle Therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Li Hai
Metastatic Cancer, Solid Tumors
Arginase Inhibitor INCB001158 as a Single Agent and in Combination With Immune Checkpoint Therapy in Patients With Advanced/Metastatic Solid Tumors
This study is an open-label Phase 1/Phase 2 evaluation of INCB001158 as a single agent and in combination with immune checkpoint therapy in patients with advanced/metastatic solid tumors.
- Conditions
- Metastatic Cancer, Solid Tumors, Colorectal Cancer (CRC), Gastric Cancer
- Trial name
- NCT02903914
- Testing
- INCB001158, Pembrolizumab
- Where
- 20 sites in United States, Italy and 2 more
- Volunteers
- 260 people
- Sponsor
- Incyte Corporation
Seizures, Subdural Hematoma
Diagnostic Subdural EEG-electrode And Subdural hEmatoma (DISEASE)
Epileptic seizures are one of the frequent complications in patients with traumatic brain injury; the incidence lies approximately at 20%.
- Trial name
- NCT04211233
- Testing
- invasive subdural grid electrode, Control arm
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Clinic Frankfurt
Aphthous Ulcer
Effects of Photobiomodulation (PBM) on Pain After Presentation of Aphthous Ulcers in Pediatric Dental Patients
The purpose of this study is to compare the efficacy of laser photobiomodulation and "Magic Mouthwash" for treatment of pain in pediatric patients with aphthous ulcers , to assess how photobiomodulation influences the rate of…
- Trial name
- NCT06819033
- Testing
- PBM Therapy, Maalox plus Benadryl
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center, Houston
HIV Infections
Standard Antiretroviral v. Multi-class Therapy in Acutely HIV-1 Infected Antiretroviral-Naïve Subjects (ADARC 2007-01)
The researchers are involved in a phase II, randomized, two-arm study, comparing the efficacy, safety, and tolerability of open-label ritonavir (RTV)-enhanced darunavir with Truvada to a 5-drug multi-class regimen including…
- Trial name
- NCT00525733
- Testing
- darunavir 800 mg, FTC 200 mg/TDF 300mg, Maraviroc
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Rockefeller University
Anesthesia, Surgery
Veterans Enhanced Recovery Using Integrative Treatments Around Surgery
The study aims to assess the implementation and effectiveness of Integrative Treatments - Music Medicine, Aromatherapy, and Battlefield Acupuncture - in the management of perioperative pain and anxiety, and in the reduction of…
- Conditions
- Anesthesia, Surgery, Knee Arthropathy
- Trial name
- VERITAS (NCT06333938)
- Testing
- Nonpharmacologic Treatment, Standard Care
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Durham VA Medical Center
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