Clinical trials: Standard treatment
Cancer of Head and Neck
Tertiary Prevention of Head and Neck Cancer With a Dietary Intervention
This is an open-label randomized phase II multicenter trial. An estimated 350 patients deemed to be in complete remission at month 3 after curative treatment are considered for this trial.
- Trial name
- DietINT (NCT02869399)
- Testing
- dietary intervention in addition to standard recommendations
- Where
- 6 sites in Austria, Germany and 4 more
- Volunteers
- 94 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Suicidal Ideation
Suicide Prevention in Chinese Older Adults
This project aims to develop and refine a suicide intervention protocol, and pilot test a culturally tailored randomized control trial to reduce suicidal thoughts among U.S. Chinese older adults.
- Trial name
- NCT02096432
- Testing
- Behavior Activation, Usual Community Care
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Rush University Medical Center
Reversible Pulpitis, Ibuprofen
Pain Management in Teeth With Reversible Pulpitis
Effective intraoperative pain management is vital in paediatric dentistry, especially during vital pulp therapy (VPT) for reversible pulpitis.
- Trial name
- NCT07114198
- Testing
- Ibuprofen 10 mg/kg
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Inonu University
Mental Illness Persistent, Cardiovascular Prevention
Cardiac Rehabilitation for Cardiovascular Risk Reduction in People With Severe and Persistent Mental Illness
The goal of this prospective, randomized trial is to explore the link between cardiovascular disease and mortality in individuals with severe and persistent mental illness (SPMI).
- Trial name
- NCT05659498
- Testing
- Cardiac Rehabilitation Program
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Spastic Diplegic Cerebral Palsy
A New Multimodal Treatment Approach for Children With Spastic Diplegic Cerebral Palsy
Combining the advantages of both Neuromuscular electrical stimulation and lower limb serial casting to a selected physical therapy program in children with spastic diplegic cerebral palsy to overcome the adverse effects during…
- Trial name
- NCT05504798
- Testing
- Selected physical therapy program, Interrupted serial casting, Neuromuscular electrical stimulation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Stroke, Acute, Ischemic Stroke, Acute
Endovascular Therapy for Large Core Patients With Uncertain Response to Thrombectomy
The purpose of this study is to assess the safety and efficacy of endovascular thrombectomy in both an early and extended time window in patients with large strokes due to large artery occlusion.
- Trial name
- OUTER LIMITS (NCT06961487)
- Testing
- EndovascularThrombectomy, Endovascular thrombectomy with any FDA-approved device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Obesity Adult Onset, Eating Behavior
Alternative Healthcare Delivery Strategies to Prevent Weight Regain After Bariatric Surgery
Bariatric surgery is the most effective treatment for severe obesity, yet a significant percentage of patients achieve suboptimal results or present long-term weight regain.
- Trial name
- NCT05946187
- Testing
- Apolo_Bari Stepped-care intervention, Treatment as Usual for Bariatric Surgery
- Where
- Portugal
- Volunteers
- 144 people
- Sponsor
- University of Minho
Brain Tumor, Pediatric Brain Tumor
Understanding the Late Effects of Surviving a Pediatric Brain Tumor
The goal of this study is to learn about the cognitive and behavioral functioning of children being treated for cancer.
- Conditions
- Brain Tumor, Pediatric Brain Tumor, Pediatric Cancer
- Trial name
- NCT03208387
- Testing
- Diffusion tensor imaging (DTI), Resting state functional connectivity MRI (rs-fcMRI), Wechsler Intelligence Scale for Children - 5th edition (WISC-V)
- Where
- 4 sites in United States
- Volunteers
- 42 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Pain, Child, Only
The Development and Evaluation of Pain Neuroscience Education in Children
The International Association for the Study of Pain and The International Classification of Diseases (ICD) 11 define chronic pain as pain lasting more than 3 months, regardless of the cause.
- Trial name
- NCT05943587
- Testing
- culture-sensitive PNE4kids, standard education
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Akdeniz University
Chronic Low-back Pain
Osteopathic Single CAse Research for Patients With Chronic Low Back Pain
This study aims to collect primary data from patients with low back pain to assess the effect of standard osteopathic management and biopsychosocially-informed osteopathic care using a Single-Case Experimental Design.
- Trial name
- OSCAR (NCT05120921)
- Testing
- Osteopathic Manual Treatment, Self-management, Reassurance
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University College of Osteopathy
Advanced Solid Tumor
CTLA-4 and PD-1 Antibodies Expressing EGFR-CAR-T Cells for EGFR Positive Advanced Solid Tumor
This is a single-arm, open-label, one center clinical study, to determine the safety and efficacy of infusion of autologous T cells engineered to express immune checkpoint antibodies (CTLA-4 and PD-1) and chimeric antigen…
- Trial name
- NCT03182816
- Testing
- anti-CTLA-4/PD-1 expressing EGFR-CAR-T
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Cell Therapy Research Institute
Cystic Fibrosis, MRSA
Epidemiology and Treatment of Small-colony Variant Staphylococcus Aureus in Cystic Fibrosis
Methicillin-susceptible (MSSA) and Methicillin-resistant (MRSA) Staphylococcus aureus (SA) are two of the most important infectious pathogens in CF, with 69% of CF patients having lung infection with MSSA or MRSA in the last…
- Trial name
- NCT02547116
- Testing
- Rifampin
- Where
- United States
- Sponsor
- Johns Hopkins University
Relapsed/Refractory Multiple Myeloma
A Study of Real-Life Current Standards of Care in Participants With Relapsed and/or Refractory Multiple Myeloma
The purpose of this study is to assess in real-life clinical practice, over a 24-month period, the effectiveness and safety and patient-reported outcomes (PROs) associated with standard of care (SOC) antimyeloma treatments in…
- Trial name
- MoMMent (NCT05160584)
- Testing
- No intervention
- Where
- 90 sites in Austria, Belgium and 10 more
- Volunteers
- 300 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Chronic Insomnia
Effect of Yoga in Chronic Insomnia
This study will evaluate the effect of the yoga in participants with chronic insomnia. The primary objective is to determine whether adding yoga to standard care improves insomnia severity, as measured by the Insomnia Severity…
- Trial name
- NCT07419152
- Testing
- Yoga-intervention, Stretching Exercises
- Where
- India
- Volunteers
- 72 people
- Sponsor
- All India Institute of Medical Sciences
Generalized Anxiety Disorder
Efficacy of Adding Interpersonal and Emotional Processing Therapy Techniques to Cognitive Behavioral Therapy to Treat Generalized Anxiety Disorder
This study will test a version of cognitive behavioral therapy for generalized anxiety disorders that incorporates interpersonal and emotional processing techniques.
- Trial name
- NCT00951652
- Testing
- CBT, Interpersonal and emotional processing therapy, supportive listening
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Michelle G. Newman
Malnutrition, Severe Acute, Malnutrition, Child
Slow Introduction of Nutrition for Ill Malnourished Children
The goal of this clinical trial is to learn if giving lower calorie feeds during the first stage of treatment helps improve survival in severely malnourished children who are ill.
- Conditions
- Malnutrition, Severe Acute, Malnutrition, Child, Malnutrition, Infant
- Trial name
- F50 (NCT06846749)
- Testing
- F75 milk feeds, F50 milk feeds, F35 milk feeds
- Where
- 2 sites in Bangladesh, Malawi
- Volunteers
- 135 people
- Sponsor
- The Hospital for Sick Children
HIV Infections, Cervix, Dysplasia
A Phase III Randomized Trial of Topical Vaginal Fluorouracil (5-Fluorouracil, 5-FU) Maintenance Therapy Versus Observation After Standard Treatment for High-Grade Cervical Dysplasia in HIV-Infected Women
To determine the efficacy and safety of intravaginal fluorouracil administered as prophylaxis in HIV-infected women who have received standard ablative therapy (surgery) for high-grade cervical dysplasia (pre-cancer of the…
- Trial name
- NCT00000758
- Testing
- Fluorouracil
- Where
- 21 sites in United States, Puerto Rico
- Volunteers
- 158 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Generalized Pustular Psoriasis
Study to Evaluate the Long-Term Safety and Efficacy of Imsidolimab (ANB019) in the Treatment of Subjects With GPP
This is a Phase 3, long term extension study to evaluate the safety and efficacy of imsidolimab compared with placebo in adult subjects with generalized pustular psoriasis (GPP).
- Trial name
- GEMINI-2 (NCT05366855)
- Testing
- Double-blind 200 mg imsidolimab, Open-label 200 mg imsidolimab, Standard of Care (SOC)
- Where
- 65 sites in United States, Australia and 13 more
- Volunteers
- 42 people
- Sponsor
- Vanda Pharmaceuticals
Stroke Gait Rehabilitation
The Effect of Cupping on Spasticity and Function of the Lower Extremity During Rehabilitation After Stroke
Physical therapists use dry static cupping for the treatment of many conditions, including spasticity for patients post-stroke. While research better describes the effects of dry static cupping for patients with orthopedic…
- Trial name
- NCT06653855
- Testing
- Dry Static Cupping, Standard physical therapy treatment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Scott Getsoian
Musculoskeletal Disease
Functional Task Kinematic in Musculoskeletal Pathology.
The aim of this project is to create references values to patients with musculoskeletal pathology using functional tasks and measuring with a smartphone and video imaging (3D motion capture cameras).
- Trial name
- NCT03293095
- Testing
- Standard Care
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Malaga
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