Clinical trials: Standard treatment
Low Back Pain
A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy
This is a multi-site feasibility trial of an embedded emergency department (ED) physical therapy care model for low back pain at two EDs in the Northwestern Medicine and University of Utah Health systems.
- Trial name
- FEED-PT (NCT07224945)
- Testing
- Embedded Emergency Department Physical Therapy, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Northwestern University
Fibromyalgia, Psychological Trauma
Augmentation of EMDR With tDCS in the Treatment of Fibromyalgia
Fibromyalgia (FM) is a generalized, widespread chronic pain disorder and has an estimated prevalence of 2%-4% in the general population.
- Conditions
- Fibromyalgia, Psychological Trauma, Depressive Symptoms, Anxiety
- Trial name
- NCT04084795
- Testing
- Eye Movement Desensitization and Reprocessing therapy, transcranial Direct Current Stimulation
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Parc de Salut Mar
Thrombotic Thrombocytopenic Purpura
Use of Rituximab Treatment in Addition to Standard Care for Newly Presenting Thrombotic Thrombocytopenic Purpura
The purpose is to evaluate safety and feasibility of the use of Rituximab as an adjunct to standard therapy (plasmapheresis + steroids) for patients with thrombotic thrombocytopenic purpura (TTP).
- Trial name
- NCT00251277
- Testing
- Rituximab
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Breast Cancer
Comparing (SIS.NET) to Standard Care in Patients Who Have Completed the Acute Phase of Treatment for Early Breast Cancer
This is a pilot study that will compare two systems of breast cancer follow up care and will evaluate a number of parameters indicating quality and efficiency of care delivery as well as patient satisfaction with care.
- Trial name
- CC077515 (NCT01308775)
- Testing
- SIS.NET, Routine Follow-up
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of California, San Francisco
Lateral Epicondylitis, Lateral Epicondylitis, Unspecified Elbow
Pain Pressure Threshold Algometry in Lateral Epicondylitis: Intra- and Inter-rater Reliability
This clinical trial aims to investigate the intra- and inter-rater reliability of pain pressure threshold algometry in lateral epicondylitis patients.
- Trial name
- NCT05771701
- Testing
- Pain pressure threshold measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uskudar State Hospital
Ischemic Stroke
SITS (Safe Implementation of Treatments in Stroke) Open Artery by Thrombectomy in Acute Occlusive Stroke Study
Ischemic stroke, i.e. irreversible damage of a part of the patient's brain, is caused by the formation of blood clot in the major vessel which gives blood supply to a certain part of the brain.
- Trial name
- SITS Open (NCT02326428)
- Testing
- Stent retriever endovascular device for thrombectomy, Intravenous thrombolysis by alteplase (Actilyse) (optional)
- Where
- Sweden
- Volunteers
- 341 people
- Sponsor
- Karolinska Institutet
Bariatric Surgery Candidate, Postoperative Pain
Postoperative VR for Recovery After Bariatric Surgery
The objective of this study is to investigate whether the addition of immersive virtual reality (VR) in the immediate postoperative period to an enhanced recovery after surgery (ERAS) protocol could improve postoperative recovery…
- Conditions
- Bariatric Surgery Candidate, Postoperative Pain, Postoperative Complications
- Trial name
- NCT04754165
- Testing
- Virtual Reality Immersive Relaxation
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Beth Israel Deaconess Medical Center
Breast Cancer, Advanced Breast Cancer
Trastuzumab Deruxtecan and Lovastatin in HER2-low and Ultralow Advanced or Metastatic Breast Cancer
The purpose of this study is to evaluate the use of lovastatin, a cholesterol-depleting pro-drug that may lower CAV-1 levels, in order to increase HER2 expression on the cell surface of cancer cells and enhance the uptake and…
- Conditions
- Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer
- Trial name
- NCT07619365
- Testing
- Trastuzumab deruxtecan, Lovastatin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Esophageal Disease
Treatment Response of High-dose and Standard-dose Rabeprazole for Extra-esophageal Reflux.
This is a single-center, randomized, open-label clinical study to assess the treatment response of high-dose rabeprazole compared with standard-dose rabeprazole in patients with extra-esophageal manifestations of gastroesophageal…
- Trial name
- NCT04001400
- Testing
- Rabeprazole 20mg bid, Rabeprazole 20mg qd
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Seoul National University Hospital
Hip Osteoarthritis, Knee Osteoarthritis
The WHERE Study: Waiting for Hip and KneE REplacement
Total hip and knee replacements (TJR) for osteoarthritis are common orthopaedic procedures performed in Canada. Waits for these procedures are already common and lengthy, and the COVID-19 pandemic has resulted in the further of…
- Trial name
- WHERE (NCT06074900)
- Testing
- prospective cohort study
- Where
- Canada
- Volunteers
- 3,008 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Healthy
Study Assessing Dosing Time and Calcium and Vitamin D on the Relative BA of 35 mg DR Risedronate Dosed With Food
Randomized, open-label, single dose, 3-treatment, 3-period crossover study, with a 14- to 17-day washout period between doses. The study will consist of a screening visit, study center admission (preceding Treatment Periods 1, 2…
- Trial name
- NCT00868907
- Testing
- 35 mg risedronate DR tablet
- Where
- 4 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Warner Chilcott
Schizophrenia, Schizotypal and Delusional Disorders, Bipolar Affective Disorder
Improving Work Outcome for People With Severe Mental Illness
The purpose of this study is to investigate the efficacy of IPS in Denmark and compare effects of 1. Individual Placement and Support (IPS) vs. 2. IPS + cognitive remediation and work-related social skills training vs. 3.
- Conditions
- Schizophrenia, Schizotypal and Delusional Disorders, Bipolar Affective Disorder, Recurrent Depressive Disorder
- Trial name
- NCT01722344
- Testing
- Individual Placement and support (IPS), IPS plus
- Where
- Denmark
- Volunteers
- 717 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Uncomplicated Lower Urinary Tract Symptoms
Self-management for Men With Uncomplicated Lower Urinary Tract Symptoms
Objective To test the hypothesis that a nurse-led self-management programme is effective for men with uncomplicated lower urinary tract symptoms.
- Trial name
- NCT00270309
- Testing
- Self-management
- Volunteers
- 168 people
- Sponsor
- The Royal College of Surgeons of England
Post Traumatic Stress Disorder
Noninvasive Brain Stimulation Combined With Written Exposure Therapy for PTSD in Military Personnel With TBI
In this study, the investigators are evaluating whether transcranial direct current stimulation (tDCS), a brain stimulation technique, can be combined with Written Exposure Therapy (WET), a standard talk therapy for posttraumatic…
- Trial name
- NCT07715799
- Testing
- Transcranial Direct Current Stimulator, Written Exposure Therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Hypertension
A Trial of Telmisartan Prevention of Cardiovascular Disease
The present research is conducted as a randomized, parallel-group, controlled, open study (using the PROBE method) to primarily verify the effects on various biomarkers in high-risk hypertensive patients treated with ARB…
- Trial name
- ATTEMPT-CVD (NCT01075698)
- Testing
- Non-ARB (standard therapy), ARB (Telmisartan)
- Where
- Japan
- Volunteers
- 1,228 people
- Sponsor
- Kumamoto University
Knee Osteoarthritis, Knee Arthropathy
Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
This study is a randomized controlled trial to assess whether the implementation of a TKA Personalized Outcome Prediction Tool to set expectation, in addition to targeted interventions to address patients with poor baseline…
- Conditions
- Knee Osteoarthritis, Knee Arthropathy, Surgery
- Trial name
- NCT06298721
- Testing
- Personalized outcome prediction tool + targeted interventions, Standard of Care TKA
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Cleveland Clinic
Chronic Low-back Pain
ReActiv8 Stimulation Therapy vs Optimal Medical Management: A Randomized Evaluation
This study is a prospective, randomized study comparing ReActiv8 Therapy to Optimal Medical Management (OMM).
- Trial name
- RESTORE (NCT04803214)
- Testing
- ReActiv8
- Where
- 28 sites in United States
- Volunteers
- 203 people
- Sponsor
- Mainstay Medical
Upper Limb Rehabilitation, Stroke
Activities of Daily Living (ADL) Virtual Reality (VR) for Acquired Brain Injury (ABI) Upper-Limb Rehabilitation
Acquired brain injury (ABI) individuals have shown greater engagement and functional recovery when trained in virtual reality (VR)-assisted rehabilitation therapies.
- Trial name
- NCT07026630
- Testing
- Cooking In the Kitchen
- Where
- United States
- Sponsor
- Indiana University
Sepsis
Curcumin in Critically Ill Patients With Sepsis
Sepsis is a life-threatening condition that occurs when the body's response to an infection becomes overwhelming and damages its own organs.
- Trial name
- NCT07436130
- Testing
- Curcumin
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Hospital Civil de Guadalajara
Dental Implants
Implant Primary Stability and Ridge Dimensional Changes Utilizing the Osseodensification Protocol
The purpose of this study is to compare ridge dimensional changes between densification and standard drilling protocols and to compare primary and secondary stability of implants placed by bone densification and standard drilling…
- Trial name
- NCT05283928
- Testing
- OsseoDensification (OD) protocol, standard drilling (SD) protocol (NobelReplace® Conical)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
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