Clinical trials: Standard treatment
Obesity Hypoventilation Syndrome (OHS)
Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation Syndrome
It remains unclear whether CPAP therapy should be prescribed if significant hypoxemia persists during CPAP titration, despite optimization of upper airway obstructive events, if maximum CPAP pressure is reached.
- Trial name
- AVAPS (NCT06442163)
- Testing
- AVAPS study was performed within 1 week of the CPAP titration attempt failure, using the auto-titrating EPAP (AE), the OmniLab Advanced +, System One device (Philips Respironics, Murrysville, PA, U.S.
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Anticoagulants, Drug Interactions
Shared Decision for Drug Interactions in Oral Anticoagulation
The purpose of this project is to implement and evaluate a shared-decision making (SDM) tool called DDInteract that was developed to support decision making for drug-drugs interactions while on oral anticoagulants.
- Trial name
- DDInteract (NCT06401863)
- Testing
- Shared Decision Making Tool
- Where
- 3 sites in United States
- Volunteers
- 610 people
- Sponsor
- University of Utah
Dyspnea, Cardiopulmonary Dysfunction
Effect of Different Breathing Techniques on Dyspnea and Cardiopulmonary Parameters Among Patients After Open Heart Surgery
Open heart surgery is often associated with postoperative pulmonary complications, reduced lung expansion, dyspnea, and impaired cardiopulmonary function.
- Conditions
- Dyspnea, Cardiopulmonary Dysfunction, Postoperative Respiratory Dysfunction, Coronary Artery Disease
- Trial name
- NCT07591987
- Testing
- Segmental Breathing Exercises, Active Cycle Breathing Technique, Standard postoperative care
- Where
- 3 sites in Iraq
- Volunteers
- 99 people
- Sponsor
- University of Baghdad
Chagas Disease
Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age
The investigators are proposing to perform a double-blinded, non-inferiority randomized controlled trial comparing a short 30-day treatment with BZN 150mg/day (30d/150mg) vs. a 60-day treatment with BZN 300 mg/day (60d/300mg).
- Trial name
- BETTY (NCT03672487)
- Testing
- Benznidazole
- Where
- 3 sites in United States, Argentina
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Tulane University School of Public Health and Tropical Medicine
HIV
The TracTOR (Tracking and Tracing Operations Research) Study -- Zimbabwe
This study evaluates the effectiveness of an enhanced package of support for activities described in the "Standard Operating Procedures (SOP) for Patient Tracing in Health Facilities in Zimbabwe".
- Trial name
- TracTOR (NCT02552693)
- Testing
- Enhanced training, supervision and support
- Where
- Zimbabwe
- Volunteers
- 946 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Burns
Comparison of High Flow vs Standard Nasal Cannula in Children With Burns Under Sedoanalgesia
The aim of this study is to investigate the positive effects of high-flow oxygen therapy on the reduction of airway adverse events and recovery time compared to conventional nasal oxygen therapy in pediatric burns treated with…
- Trial name
- NCT06663293
- Testing
- Conventional Nasal Cannula, High-flow nasal cannula, midazolam, ketamine, propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Zeliha Alicikus
Asthma in Children, Asthma Attack
Wearable Electronic Breath Sound Sensing Device
This study will assess the ability of a wearable stethoscope to monitor wheezing in high-risk asthma patients admitted at Children's Healthcare of Atlanta.
- Trial name
- WEBSS (NCT06734793)
- Testing
- Wearable stethoscope, Routine Clinical lung Auscultation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Emory University
Facial Paralysis
Mindfulness in Nonflaccid Facial Paralysis
The purpose of this study is to learn more about how mindfulness techniques can help reduce anxiety, depression and body image disturbance as well as improve synkinesis in individuals with non-flaccid facial paralysis.
- Trial name
- NCT07127016
- Testing
- Mindfulness Sessions, No Mindfulness Sessions
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Brain Injuries, Infant, Premature
SafeBoosC - a Phase II Trial
Background 25,000 infants are born extremely preterm every year in Europe. This group of infants carries a high risk of death and subsequent cerebral impairment for the infant, especially in the first 72 hours of life.
- Trial name
- SafeBoosC (NCT01590316)
- Testing
- Cerebral NIRS oximetry
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Gorm Greisen
Breast Cancer Screening
Effect of Information About the Benefits and Harms of Mammography on Women's Decision Making
The aim of this study is to assess the effect of receiving information about the benefits and harms of mammography screening on informed choice, decisional conflict, intention to participate in the Early Detection of Breast…
- Trial name
- InforMa (NCT03046004)
- Testing
- Decision aid for breast cancer screening, Standard leaflet
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Status Asthmaticus
Comparison of Albuterol for Status Asthmaticus
This study is designed to compare the length of continuous albuterol administration between two different albuterol formulations, BAC containing albuterol versus preservative free albuterol.
- Trial name
- NCT02966184
- Testing
- preservative free albuterol
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Norton Healthcare
Melanoma Stage III or IV
CARDiac Toxicity Following ImmunOtherapy Treatment for Melanoma
People who develop a type of skin cancer known as 'melanoma' are often treated with immunotherapy. The type of immunotherapy used for patients with melanoma is known as Immune Checkpoint Inhibitors (ICI).
- Trial name
- CARD-IO (NCT06605833)
- Testing
- 12-Lead ECG, Transthoracic Echocardiogram, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in Inflammatory Rheumatic Disease (PREVENER)
PREVENER is a randomized, open-label, multicenter, phase IV clinical trial designed to evaluate the efficacy and safety of a carotid ultrasound-based strategy for the primary prevention of cardiovascular events in patients with…
- Conditions
- Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Axial Spondy, Systemic Lupus Erythematosus (SLE)
- Trial name
- PREVENER (NCT07611747)
- Testing
- Carotid Ultrasound, High-intensity lipid-lowering therapy, Standard care according to ESC 2021 guidelines
- Where
- 17 sites in Spain
- Volunteers
- 1,944 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Prosthetic-joint Infection, Arthroplasty Complications
Knee Prosthetic Joint Infection Antibiotic Elution
Patients presenting with prosthetic joint infections of a total knee replacement who are treated with an antibiotic spacer will be observed prospectively for their response to treatment and antibiotic elution profiles will be…
- Trial name
- NCT06023238
- Testing
- Treatment of Chronic TKA PJI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Duchenne Muscular Dystrophy (DMD)
DMD and Gamified Physiotherapy
Duchenne Muscular Dystrophy (DMD) is a progressive neuromuscular disease that limits children's physical function, mobility, and participation in daily life.
- Trial name
- Gamified DMD (NCT07368400)
- Testing
- Gamified Mobile Physiotherapy Exercise Application, Standard Home Exercise Instructions
- Volunteers
- 46 people
- Sponsor
- Başak Çağla Arslan
Blood Pressure, Hypertension
Effect of Dietary Salt Reduction on Blood Pressure in Kidney Transplant Recipients
Cardiovascular morbidity and mortality is increased in kidney transplant patients. High blood pressure (BP) contributes significantly to this risk and is also associated with shortened allograft survival.
- Conditions
- Blood Pressure, Hypertension, Kidney Transplant; Complications, Dietary Modification
- Trial name
- NCT03373500
- Testing
- Dietary salt reduction
- Where
- United Kingdom
- Volunteers
- 66 people
- Sponsor
- Epsom and St Helier University Hospitals NHS Trust
Breast Cancer
Guided Relaxation Training for the Reduction of Self-Reported Stress in Individuals With Newly Diagnosed Breast Cancer
The primary objectives of this study are to determine if the use of Guided Relaxation Training (GRT) during cancer treatment in individuals with newly diagnosed breast cancer increases their ability to cope as measured by the…
- Trial name
- 09-IM-01 (NCT00945607)
- Testing
- GRT (Guided Relaxation Training)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Trinitas Comprehensive Cancer Center
Spinal Disorder
Multimodal Pain Package vs. Regular Formulation for Pain Management in Ambulatory Spinal Surgery
The purpose of this research is to compare two outpatient pain management strategies in patients undergoing spinal surgeries such as microdiscectomies, foraminotomies, and spinal decompressions.
- Trial name
- NCT05965492
- Testing
- Acetaminophen, Celebrex, Gabapentin
- Sponsor
- University of Miami
Healthy
Effect of Multisensory (Snoezelen) Environment on Birth Outcomes
Giving birth is a fundamental life event that women will remember throughout their lives. While seeking perfection for the birth environment, much can be learned from other areas of expertise and different pursuits can be…
- Trial name
- NCT06732544
- Testing
- snoezelen room, routine delivery room
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Amasya University
Covid19, AKI
Efficacy and Safety of a Highly Selective Semipermeable Membrane (AN-69 Oxiris) vs (Standard AN-69) in COVID-19
Abstract Title: Randomized,open-label, controlled trial to evaluate efficacy and safety of a highly selective semipermeable membrane (AN69-Oxiris) in comparison with a selective semipermeable membrane ( standard AN69) in COVID-19…
- Trial name
- oXAKI-COV (NCT04597034)
- Testing
- AN69-Oxiris, AN69-Standard
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
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